DE19851334C2 - Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung - Google Patents
Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE19851334C2 DE19851334C2 DE19851334A DE19851334A DE19851334C2 DE 19851334 C2 DE19851334 C2 DE 19851334C2 DE 19851334 A DE19851334 A DE 19851334A DE 19851334 A DE19851334 A DE 19851334A DE 19851334 C2 DE19851334 C2 DE 19851334C2
- Authority
- DE
- Germany
- Prior art keywords
- solution
- fibrinogen
- fibrin
- wound dressing
- fleece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 108010073385 Fibrin Proteins 0.000 title claims abstract description 51
- 102000009123 Fibrin Human genes 0.000 title claims abstract description 51
- 229950003499 fibrin Drugs 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims description 17
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 41
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 41
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 41
- 239000000243 solution Substances 0.000 claims description 42
- 206010052428 Wound Diseases 0.000 claims description 32
- 208000027418 Wounds and injury Diseases 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 108090000190 Thrombin Proteins 0.000 claims description 16
- 229960004072 thrombin Drugs 0.000 claims description 16
- 238000000502 dialysis Methods 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 239000008139 complexing agent Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000004108 freeze drying Methods 0.000 claims description 7
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000385 dialysis solution Substances 0.000 claims description 6
- 230000023597 hemostasis Effects 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000012876 carrier material Substances 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 108010071289 Factor XIII Proteins 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 150000001447 alkali salts Chemical class 0.000 claims description 2
- 229940012444 factor xiii Drugs 0.000 claims description 2
- 235000006408 oxalic acid Nutrition 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 5
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 10
- 102000008186 Collagen Human genes 0.000 description 9
- 108010035532 Collagen Proteins 0.000 description 9
- 229920001436 collagen Polymers 0.000 description 9
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002324 minimally invasive surgery Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 108010019393 Fibrin Foam Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- LTKVFMLMEYCWMK-UHFFFAOYSA-N amiloride hydrochloride dihydrate Chemical compound [H+].O.O.[Cl-].NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N LTKVFMLMEYCWMK-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009297 electrocoagulation Methods 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0042—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S602/00—Surgery: splint, brace, or bandage
- Y10S602/90—Method of making bandage structure
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19851334A DE19851334C2 (de) | 1998-11-06 | 1998-11-06 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
| DE59908453T DE59908453D1 (de) | 1998-11-06 | 1999-10-27 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
| EP99121382A EP0998949B1 (de) | 1998-11-06 | 1999-10-27 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
| AT99121382T ATE258809T1 (de) | 1998-11-06 | 1999-10-27 | Flexible wundauflage auf fibrinbasis und verfahren zu ihrer herstellung |
| ES99121382T ES2213961T3 (es) | 1998-11-06 | 1999-10-27 | Aposito flexible para heridas a base de fibrina y procedimiento para su preparacion. |
| DK99121382T DK0998949T3 (da) | 1998-11-06 | 1999-10-27 | Fleksibel sårforbinding på fibrinbasis og fremgangsmåde til fremstilling deraf |
| CA002288539A CA2288539C (en) | 1998-11-06 | 1999-11-03 | Flexible wound covering based on fibrin and process for its production |
| AU58327/99A AU771403B2 (en) | 1998-11-06 | 1999-11-05 | Flexible wound covering based on fibrin and process for its production |
| JP31498399A JP4700157B2 (ja) | 1998-11-06 | 1999-11-05 | フィブリンをベースにした柔軟性創傷被覆物およびその製造方法 |
| US09/434,104 US6310267B1 (en) | 1998-11-06 | 1999-11-05 | Flexible wound covering based on fibrin and process for its production |
| KR1019990048801A KR100758137B1 (ko) | 1998-11-06 | 1999-11-05 | 피브린을 기본으로 하는 유연성 창상 커버재의 제조방법 |
| US09/846,320 US6486377B2 (en) | 1998-11-06 | 2001-05-02 | Flexible wound covering based on fibrin and process for its production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19851334A DE19851334C2 (de) | 1998-11-06 | 1998-11-06 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19851334A1 DE19851334A1 (de) | 2000-05-11 |
| DE19851334C2 true DE19851334C2 (de) | 2000-09-28 |
Family
ID=7886989
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19851334A Expired - Fee Related DE19851334C2 (de) | 1998-11-06 | 1998-11-06 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
| DE59908453T Expired - Lifetime DE59908453D1 (de) | 1998-11-06 | 1999-10-27 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59908453T Expired - Lifetime DE59908453D1 (de) | 1998-11-06 | 1999-10-27 | Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6310267B1 (https=) |
| EP (1) | EP0998949B1 (https=) |
| JP (1) | JP4700157B2 (https=) |
| KR (1) | KR100758137B1 (https=) |
| AT (1) | ATE258809T1 (https=) |
| AU (1) | AU771403B2 (https=) |
| CA (1) | CA2288539C (https=) |
| DE (2) | DE19851334C2 (https=) |
| DK (1) | DK0998949T3 (https=) |
| ES (1) | ES2213961T3 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2808195B1 (fr) * | 2000-04-28 | 2006-12-08 | Lyophilisation Alimentaire | Patch cosmetique ou dermatologique lyophilise |
| US7526440B2 (en) * | 2000-06-12 | 2009-04-28 | Walker Digital, Llc | Method, computer product, and apparatus for facilitating the provision of opinions to a shopper from a panel of peers |
| US20020168398A1 (en) * | 2001-03-06 | 2002-11-14 | Yves Delmotte | Elongated biopolymer structure containing fibrin |
| IL144446A0 (en) * | 2001-07-19 | 2002-05-23 | Prochon Biotech Ltd | Plasma protein matrices and methods for their preparation |
| US7279177B2 (en) | 2002-06-28 | 2007-10-09 | Ethicon, Inc. | Hemostatic wound dressings and methods of making same |
| US20040101546A1 (en) * | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
| US20040101548A1 (en) * | 2002-11-26 | 2004-05-27 | Pendharkar Sanyog Manohar | Hemostatic wound dressing containing aldehyde-modified polysaccharide |
| US20040120993A1 (en) * | 2002-12-20 | 2004-06-24 | Guanghui Zhang | Hemostatic wound dressing and fabric and methods of making and using same |
| US20040101547A1 (en) * | 2002-11-26 | 2004-05-27 | Pendharkar Sanyog Manohar | Wound dressing containing aldehyde-modified regenerated polysaccharide |
| US7252837B2 (en) * | 2002-06-28 | 2007-08-07 | Ethicon, Inc. | Hemostatic wound dressing and method of making same |
| US20040106344A1 (en) * | 2002-06-28 | 2004-06-03 | Looney Dwayne Lee | Hemostatic wound dressings containing proteinaceous polymers |
| JP3640655B2 (ja) * | 2002-10-23 | 2005-04-20 | 一知 井上 | 血管新生誘導剤 |
| EP1592373B1 (en) | 2003-01-30 | 2013-04-24 | ProChon Biotech Ltd. | Freeze-dried fibrin matrices and methods for preparation thereof |
| US7019191B2 (en) | 2003-03-25 | 2006-03-28 | Ethicon, Inc. | Hemostatic wound dressings and methods of making same |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US20040241212A1 (en) * | 2003-05-30 | 2004-12-02 | Pendharkar Sanyog Manohar | Biodegradable hemostatic wound dressings |
| US20040265371A1 (en) * | 2003-06-25 | 2004-12-30 | Looney Dwayne Lee | Hemostatic devices and methods of making same |
| KR20050086324A (ko) * | 2004-02-25 | 2005-08-30 | 김아란 | 3%부터 9%까지 셀라인 (염수) |
| US7335508B2 (en) * | 2004-07-22 | 2008-02-26 | Prochon Biotech Ltd. | Porous plasma protein matrices and methods for preparation thereof |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US20060257457A1 (en) * | 2004-10-20 | 2006-11-16 | Gorman Anne J | Method for making a reinforced absorbable multilayered hemostatic wound dressing |
| US20060258995A1 (en) * | 2004-10-20 | 2006-11-16 | Pendharkar Sanyog M | Method for making a reinforced absorbable multilayered fabric for use in medical devices |
| HUE026731T2 (en) * | 2004-10-20 | 2016-07-28 | Ethicon Inc | Reinforced, absorbable, multilayer tissue for application in medical devices and preparation process |
| CA2584698C (en) | 2004-10-20 | 2014-02-25 | Ethicon, Inc. | A reinforced absorbable multilayered hemostatic wound dressing and method of making |
| US9358318B2 (en) | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| EP1962751A2 (en) * | 2005-12-13 | 2008-09-03 | Den-Mat Corporation | Flexible wound dressing |
| EP2106263B1 (en) * | 2007-01-04 | 2016-12-21 | Hepacore Ltd. | Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| DE102007024220A1 (de) * | 2007-05-15 | 2008-11-20 | Aesculap Ag | Blutstillendes Vlies |
| WO2010020247A1 (en) | 2008-08-22 | 2010-02-25 | Reapplix Aps | Multilayered blood product |
| US20100331963A1 (en) * | 2009-06-30 | 2010-12-30 | Jackie Donners | Method of Making Suture-Less Hollow Scaffolds |
| US8758447B2 (en) * | 2009-06-30 | 2014-06-24 | Ethicon, Inc. | Device and method for repair of urological structures |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| US10016527B2 (en) | 2012-10-23 | 2018-07-10 | Orthovita, Inc. | Materials and methods for repair of cartilage defects |
| CN105007841A (zh) * | 2012-12-31 | 2015-10-28 | 乔治·D.·福卢什 | 用于大量出血的冻干纤维蛋白封闭剂 |
| EP3013294B1 (en) | 2013-06-28 | 2019-09-25 | 3M Innovative Properties Company | Fibrin-coated wound dressing |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| WO2016160541A1 (en) | 2015-03-27 | 2016-10-06 | 3M Innovative Properties Company | Fibrin composition, method and wound articles |
| WO2017118729A1 (en) | 2016-01-06 | 2017-07-13 | Reapplix Aps | Procoagulant factors suitable for subsequent autologous use |
| WO2018067628A1 (en) * | 2016-10-05 | 2018-04-12 | 3M Innovative Properties Company | Fibrin composition comprising carrier material, method and wound articles |
| EP3522941A4 (en) | 2016-10-05 | 2020-06-17 | 3M Innovative Properties Company | FIBRINOGEN COMPOSITION, METHOD AND ARTICLES FOR WOUNDS |
| WO2019106473A1 (en) * | 2017-11-29 | 2019-06-06 | 3M Innovative Properties Company | Collagen-fibrin composition, method and wound articles |
| US20220118153A1 (en) * | 2020-10-21 | 2022-04-21 | Reapplix A/S | Layered blood product for stopping/reducing bleeding in an open surgical wound |
| PL246410B1 (pl) | 2023-09-30 | 2025-01-20 | Keymed Spolka Z Ograniczona Odpowiedzialnoscia | Zestaw do wytwarzania autologicznego opatrunku z krwi, opatrunek, sposób jego wytwarzania i jego zastosowania |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2492458A (en) * | 1944-12-08 | 1949-12-27 | Jr Edgar A Bering | Fibrin foam |
| EP0068149A2 (de) * | 1981-06-25 | 1983-01-05 | Serapharm GmbH & Co. KG | Fibrinogen-haltiges Trockenpräparat, dessen Herstellung und Verwendung |
| DE3214337A1 (de) * | 1982-04-19 | 1983-10-27 | Serapharm - Michael Stroetmann, 4400 Münster | Resorbierbares flachmaterial zum abdichten und heilen von wunden und verfahren zu dessen herstellung |
| EP0485210A2 (en) * | 1990-11-08 | 1992-05-13 | Otogen Corporation | Fibrin/collagen membrane material for biomedical use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5439983A (en) * | 1977-09-05 | 1979-03-28 | Hiroyuki Sumi | Antithrombotic material |
| DE3037513C2 (de) | 1980-10-03 | 1983-05-05 | Steffan, Wolfgang, 8425 Neustadt | Kollagene Wundauflage |
| DE3105624A1 (de) * | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
| DE3171072D1 (en) * | 1981-06-25 | 1985-07-25 | Stroetmann M Serapharm | Enriched plasma derivative for promoting wound sealing and wound covering |
| US4442655A (en) * | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
| ATE20824T1 (de) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| DE3212412C2 (de) * | 1982-04-02 | 1986-01-02 | Dr. Ruhland Nachf. GmbH, 8425 Neustadt | Gewebeverklebbare kollagene Wundauflage |
| DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
| AT397203B (de) * | 1988-05-31 | 1994-02-25 | Immuno Ag | Gewebeklebstoff |
| FR2639958B1 (fr) * | 1988-12-06 | 1992-08-21 | Lille Transfusion Sanguine | Support biologique pour cultures cellulaires constitue de proteines plasmatiques coagulees par la thrombine, son utilisation pour la culture des keratinocytes, leur recuperation et leur transport a des fins d'utilisation therapeutique |
| DE4202667C1 (https=) * | 1992-01-29 | 1993-05-13 | Behringwerke Ag, 3550 Marburg, De | |
| US5702715A (en) * | 1995-10-27 | 1997-12-30 | Drying Technology | Reinforced biological sealants |
-
1998
- 1998-11-06 DE DE19851334A patent/DE19851334C2/de not_active Expired - Fee Related
-
1999
- 1999-10-27 AT AT99121382T patent/ATE258809T1/de active
- 1999-10-27 DK DK99121382T patent/DK0998949T3/da active
- 1999-10-27 ES ES99121382T patent/ES2213961T3/es not_active Expired - Lifetime
- 1999-10-27 EP EP99121382A patent/EP0998949B1/de not_active Expired - Lifetime
- 1999-10-27 DE DE59908453T patent/DE59908453D1/de not_active Expired - Lifetime
- 1999-11-03 CA CA002288539A patent/CA2288539C/en not_active Expired - Fee Related
- 1999-11-05 AU AU58327/99A patent/AU771403B2/en not_active Ceased
- 1999-11-05 KR KR1019990048801A patent/KR100758137B1/ko not_active Expired - Fee Related
- 1999-11-05 US US09/434,104 patent/US6310267B1/en not_active Expired - Lifetime
- 1999-11-05 JP JP31498399A patent/JP4700157B2/ja not_active Expired - Fee Related
-
2001
- 2001-05-02 US US09/846,320 patent/US6486377B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2492458A (en) * | 1944-12-08 | 1949-12-27 | Jr Edgar A Bering | Fibrin foam |
| EP0068149A2 (de) * | 1981-06-25 | 1983-01-05 | Serapharm GmbH & Co. KG | Fibrinogen-haltiges Trockenpräparat, dessen Herstellung und Verwendung |
| DE3214337A1 (de) * | 1982-04-19 | 1983-10-27 | Serapharm - Michael Stroetmann, 4400 Münster | Resorbierbares flachmaterial zum abdichten und heilen von wunden und verfahren zu dessen herstellung |
| EP0485210A2 (en) * | 1990-11-08 | 1992-05-13 | Otogen Corporation | Fibrin/collagen membrane material for biomedical use |
Also Published As
| Publication number | Publication date |
|---|---|
| DK0998949T3 (da) | 2004-06-07 |
| JP4700157B2 (ja) | 2011-06-15 |
| ATE258809T1 (de) | 2004-02-15 |
| KR20000035258A (ko) | 2000-06-26 |
| CA2288539A1 (en) | 2000-05-06 |
| KR100758137B1 (ko) | 2007-09-13 |
| EP0998949A3 (de) | 2000-05-24 |
| DE19851334A1 (de) | 2000-05-11 |
| AU771403B2 (en) | 2004-03-18 |
| ES2213961T3 (es) | 2004-09-01 |
| CA2288539C (en) | 2008-08-12 |
| EP0998949A2 (de) | 2000-05-10 |
| US6310267B1 (en) | 2001-10-30 |
| US6486377B2 (en) | 2002-11-26 |
| EP0998949B1 (de) | 2004-02-04 |
| US20010025154A1 (en) | 2001-09-27 |
| AU5832799A (en) | 2000-05-11 |
| JP2000140088A (ja) | 2000-05-23 |
| DE59908453D1 (de) | 2004-03-11 |
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