DE19827457C1 - Strukturprotein von AAV, seine Herstellung und Verwendung - Google Patents
Strukturprotein von AAV, seine Herstellung und VerwendungInfo
- Publication number
- DE19827457C1 DE19827457C1 DE19827457A DE19827457A DE19827457C1 DE 19827457 C1 DE19827457 C1 DE 19827457C1 DE 19827457 A DE19827457 A DE 19827457A DE 19827457 A DE19827457 A DE 19827457A DE 19827457 C1 DE19827457 C1 DE 19827457C1
- Authority
- DE
- Germany
- Prior art keywords
- structural protein
- protein according
- aav
- mutation
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 101710172711 Structural protein Proteins 0.000 title claims abstract description 55
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 230000035772 mutation Effects 0.000 claims abstract description 27
- 241000700605 Viruses Species 0.000 claims abstract description 18
- 230000008859 change Effects 0.000 claims abstract description 9
- 241000702421 Dependoparvovirus Species 0.000 claims abstract description 3
- 210000004027 cell Anatomy 0.000 claims description 36
- 108090000623 proteins and genes Proteins 0.000 claims description 27
- 210000000234 capsid Anatomy 0.000 claims description 24
- 238000003780 insertion Methods 0.000 claims description 21
- 230000037431 insertion Effects 0.000 claims description 21
- 150000007523 nucleic acids Chemical class 0.000 claims description 19
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 238000012217 deletion Methods 0.000 claims description 16
- 230000037430 deletion Effects 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 15
- 102000005962 receptors Human genes 0.000 claims description 14
- 108020003175 receptors Proteins 0.000 claims description 14
- 239000003446 ligand Substances 0.000 claims description 12
- 101000805768 Banna virus (strain Indonesia/JKT-6423/1980) mRNA (guanine-N(7))-methyltransferase Proteins 0.000 claims description 11
- 101000686790 Chaetoceros protobacilladnavirus 2 Replication-associated protein Proteins 0.000 claims description 11
- 101000864475 Chlamydia phage 1 Internal scaffolding protein VP3 Proteins 0.000 claims description 11
- 101000803553 Eumenes pomiformis Venom peptide 3 Proteins 0.000 claims description 11
- 101000583961 Halorubrum pleomorphic virus 1 Matrix protein Proteins 0.000 claims description 11
- 101710132601 Capsid protein Proteins 0.000 claims description 9
- 101710197658 Capsid protein VP1 Proteins 0.000 claims description 9
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 claims description 9
- 101710108545 Viral protein 1 Proteins 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 238000001415 gene therapy Methods 0.000 claims description 8
- 102000006240 membrane receptors Human genes 0.000 claims description 8
- 210000000170 cell membrane Anatomy 0.000 claims description 6
- 102000006495 integrins Human genes 0.000 claims description 6
- 108010044426 integrins Proteins 0.000 claims description 6
- 108020004084 membrane receptors Proteins 0.000 claims description 6
- 230000010415 tropism Effects 0.000 claims description 6
- 101710081079 Minor spike protein H Proteins 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 241000202702 Adeno-associated virus - 3 Species 0.000 claims description 4
- 241000972680 Adeno-associated virus - 6 Species 0.000 claims description 4
- 108091016585 CD44 antigen Proteins 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 claims description 4
- 229920002971 Heparan sulfate Polymers 0.000 claims description 4
- 108090000054 Syndecan-2 Proteins 0.000 claims description 4
- 230000008685 targeting Effects 0.000 claims description 4
- 241000580270 Adeno-associated virus - 4 Species 0.000 claims description 3
- 230000010799 Receptor Interactions Effects 0.000 claims description 3
- 108010001857 Cell Surface Receptors Proteins 0.000 claims description 2
- 102000003886 Glycoproteins Human genes 0.000 claims description 2
- 108090000288 Glycoproteins Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 230000001506 immunosuppresive effect Effects 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 description 10
- 239000013598 vector Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000013607 AAV vector Substances 0.000 description 5
- 241000701931 Canine parvovirus Species 0.000 description 5
- 108090000565 Capsid Proteins Proteins 0.000 description 5
- 108010085895 Laminin Proteins 0.000 description 5
- 102100023321 Ceruloplasmin Human genes 0.000 description 4
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- 239000013612 plasmid Substances 0.000 description 4
- 241000701161 unidentified adenovirus Species 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 108010029697 CD40 Ligand Proteins 0.000 description 2
- 102100032937 CD40 ligand Human genes 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 102100025907 Dyslexia-associated protein KIAA0319-like protein Human genes 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 101001076904 Homo sapiens Dyslexia-associated protein KIAA0319-like protein Proteins 0.000 description 2
- 241000702617 Human parvovirus B19 Species 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 241000125945 Protoparvovirus Species 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
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- 108010018737 laminin P1 Proteins 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 241001655883 Adeno-associated virus - 1 Species 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 101150044789 Cap gene Proteins 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 102000002297 Laminin Receptors Human genes 0.000 description 1
- 108010000851 Laminin Receptors Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000015336 Nerve Growth Factor Human genes 0.000 description 1
- 108010025020 Nerve Growth Factor Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 101150024766 VP1 gene Proteins 0.000 description 1
- 101150093578 VP2 gene Proteins 0.000 description 1
- 101150036700 VP3 gene Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
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- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
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- 230000028993 immune response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 238000007169 ligase reaction Methods 0.000 description 1
- 230000000998 lymphohematopoietic effect Effects 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108020001580 protein domains Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000013608 rAAV vector Substances 0.000 description 1
- 101150066583 rep gene Proteins 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
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- 210000004881 tumor cell Anatomy 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19827457A DE19827457C1 (de) | 1998-06-19 | 1998-06-19 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| DE59913833T DE59913833D1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
| DK06018532.9T DK1783225T3 (da) | 1998-06-19 | 1999-06-21 | Strukturprotein fra AAV, dets fremstilling og anvendelse |
| EP06018533A EP1783226A1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| EP06018532A EP1783225B1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| ES99929292T ES2273498T3 (es) | 1998-06-19 | 1999-06-21 | Proteina estructural de vaa, produccion y uso de la misma. |
| AU46141/99A AU765330B2 (en) | 1998-06-19 | 1999-06-21 | AAV scleroprotein, production and use thereof |
| EP99929292A EP1088075B1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
| JP2000556035A JP4652570B2 (ja) | 1998-06-19 | 1999-06-21 | Ａａｖの構造タンパク質、その製造及び用途 |
| ES06018532T ES2352666T3 (es) | 1998-06-19 | 1999-06-21 | Proteína estructural de vaa, producción y uso de la misma. |
| DE59915205T DE59915205D1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| AT99929292T ATE338821T1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
| CA2332115A CA2332115C (en) | 1998-06-19 | 1999-06-21 | Aav structural protein, its preparation and use |
| PCT/EP1999/004288 WO1999067393A2 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
| AT06018532T ATE481490T1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
| US11/647,687 US20070238684A1 (en) | 1998-06-19 | 2006-12-28 | AAV scleroprotein, production and use thereof |
| US12/628,867 US20110052617A1 (en) | 1998-06-19 | 2009-12-01 | Aav scleroprotein, production and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19827457A DE19827457C1 (de) | 1998-06-19 | 1998-06-19 | Strukturprotein von AAV, seine Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19827457C1 true DE19827457C1 (de) | 2000-03-02 |
Family
ID=7871464
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19827457A Expired - Fee Related DE19827457C1 (de) | 1998-06-19 | 1998-06-19 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| DE59915205T Expired - Lifetime DE59915205D1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| DE59913833T Expired - Lifetime DE59913833D1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59915205T Expired - Lifetime DE59915205D1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von AAV, seine Herstellung und Verwendung |
| DE59913833T Expired - Lifetime DE59913833D1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20070238684A1 (https=) |
| EP (3) | EP1783226A1 (https=) |
| JP (1) | JP4652570B2 (https=) |
| AT (2) | ATE481490T1 (https=) |
| AU (1) | AU765330B2 (https=) |
| CA (1) | CA2332115C (https=) |
| DE (3) | DE19827457C1 (https=) |
| DK (1) | DK1783225T3 (https=) |
| ES (2) | ES2273498T3 (https=) |
| WO (1) | WO1999067393A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| ATE314095T1 (de) | 1998-10-21 | 2006-01-15 | Us Health | Virusähnliche partikel zur induktion von autoantikörpern |
| DE19849643A1 (de) * | 1998-10-29 | 2000-05-04 | Deutsches Krebsforsch | An das AAV-Kapsid bindender, den Zelltropismus verändernder Antikörper und Verfahren zum gerichteten Gentransfer |
| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| ES2340230T3 (es) | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
| US7314912B1 (en) | 1999-06-21 | 2008-01-01 | Medigene Aktiengesellschaft | AAv scleroprotein, production and use thereof |
| DE19933288A1 (de) | 1999-07-15 | 2001-01-18 | Medigene Ag | Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung |
| DE19933719A1 (de) | 1999-07-19 | 2001-01-25 | Medigene Ag | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| EP1828390B1 (en) | 2004-12-15 | 2012-06-13 | The University Of North Carolina At Chapel Hill | Chimeric vectors |
| EP2012122A1 (en) * | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| HRP20171334T1 (hr) | 2011-04-22 | 2017-11-17 | The Regents Of The University Of California | Virioni adeno-povezanog virusa s kapsid varijantom i postupci njihove upotrebe |
| US11136557B2 (en) | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| KR102537394B1 (ko) | 2014-03-17 | 2023-05-30 | 애드베룸 바이오테크놀로지스, 인코포레이티드 | 원추세포에서 증강된 유전자 발현을 위한 조성물 및 방법 |
| MY187898A (en) | 2015-03-02 | 2021-10-27 | Adverum Biotechnologies Inc | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | アデノ随伴ウイルス変異体及びその使用方法 |
| EP3827812B1 (en) | 2016-07-29 | 2025-10-29 | The Regents of the University of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| CA3040179A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| WO2019006182A1 (en) | 2017-06-30 | 2019-01-03 | The Regents Of The University Of California | VIRIONS OF ADENO-ASSOCIATED VIRUSES OF CAPSID VARIANTS AND METHODS OF USE THEREOF |
| JP2020534788A (ja) | 2017-08-28 | 2020-12-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アデノ随伴ウイルスカプシド変異体及びその使用方法 |
| JP7406253B2 (ja) * | 2018-01-11 | 2023-12-27 | カメレオン バイオサイエンシーズ， インコーポレイテッド | 免疫回避性ベクターおよび遺伝子療法のための使用 |
| US11821009B2 (en) | 2018-05-15 | 2023-11-21 | Cornell University | Genetic modification of the AAV capsid resulting in altered tropism and enhanced vector delivery |
| US11718834B2 (en) | 2019-02-15 | 2023-08-08 | Sangamo Therapeutics, Inc. | Compositions and methods for producing recombinant AAV |
| AU2020263757B2 (en) | 2019-04-24 | 2025-08-28 | Takara Bio Inc. | AAV mutant having brain-targeting property |
| JP7581264B2 (ja) * | 2019-07-02 | 2024-11-12 | トラスティーズ オブ タフツ カレッジ | 細胞および組織への薬剤の送達のための新規ペプチド、組成物および方法 |
| RU2751592C2 (ru) * | 2019-08-22 | 2021-07-15 | Общество С Ограниченной Ответственностью "Анабион" | Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе |
| AR126840A1 (es) * | 2021-08-20 | 2023-11-22 | Llc «Anabion» | Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 5 (aav5), cápside y vector basado en esta |
| AR126839A1 (es) * | 2021-08-20 | 2023-11-22 | Llc «Anabion» | Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 9 (aav9), cápside y vector basado en esta |
| CN118480097B (zh) * | 2023-09-20 | 2024-11-05 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
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| WO1992012727A1 (en) * | 1991-01-25 | 1992-08-06 | Regents Of The University Of Minnesota | Laminin a chain domain vi polypeptides |
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| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| CA2251738A1 (en) * | 1996-04-16 | 1997-10-23 | Immusol Incorporated | Targeted viral vectors |
| US20010031463A1 (en) * | 1997-09-02 | 2001-10-18 | Jurgen Kleinschmidt | Method for purifying and concentrating AAV-2 and antigen portions thereof |
| DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| ES2340230T3 (es) * | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
| AU2002248297A1 (en) * | 2001-01-05 | 2002-07-16 | Children's Hospital, Inc. | Aav2 vectors and methods |
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| US20050106558A1 (en) * | 2001-12-21 | 2005-05-19 | Luca Perabo | Library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism |
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- 1999-06-21 DE DE59915205T patent/DE59915205D1/de not_active Expired - Lifetime
- 1999-06-21 ES ES99929292T patent/ES2273498T3/es not_active Expired - Lifetime
- 1999-06-21 AU AU46141/99A patent/AU765330B2/en not_active Ceased
- 1999-06-21 DK DK06018532.9T patent/DK1783225T3/da active
- 1999-06-21 WO PCT/EP1999/004288 patent/WO1999067393A2/de not_active Ceased
- 1999-06-21 DE DE59913833T patent/DE59913833D1/de not_active Expired - Lifetime
- 1999-06-21 CA CA2332115A patent/CA2332115C/en not_active Expired - Fee Related
- 1999-06-21 JP JP2000556035A patent/JP4652570B2/ja not_active Expired - Fee Related
- 1999-06-21 EP EP06018533A patent/EP1783226A1/de not_active Withdrawn
- 1999-06-21 ES ES06018532T patent/ES2352666T3/es not_active Expired - Lifetime
- 1999-06-21 AT AT06018532T patent/ATE481490T1/de active
- 1999-06-21 AT AT99929292T patent/ATE338821T1/de not_active IP Right Cessation
- 1999-06-21 EP EP06018532A patent/EP1783225B1/de not_active Expired - Lifetime
- 1999-06-21 EP EP99929292A patent/EP1088075B1/de not_active Expired - Lifetime
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2006
- 2006-12-28 US US11/647,687 patent/US20070238684A1/en not_active Abandoned
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- 2009-12-01 US US12/628,867 patent/US20110052617A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1783225B1 (de) | 2010-09-15 |
| DK1783225T3 (da) | 2011-01-03 |
| AU4614199A (en) | 2000-01-10 |
| EP1088075B1 (de) | 2006-09-06 |
| AU765330B2 (en) | 2003-09-18 |
| US20070238684A1 (en) | 2007-10-11 |
| EP1088075A2 (de) | 2001-04-04 |
| US20110052617A1 (en) | 2011-03-03 |
| CA2332115A1 (en) | 1999-12-29 |
| EP1783225A1 (de) | 2007-05-09 |
| CA2332115C (en) | 2011-08-09 |
| ES2273498T3 (es) | 2007-05-01 |
| ATE481490T1 (de) | 2010-10-15 |
| DE59913833D1 (de) | 2006-10-19 |
| WO1999067393A2 (de) | 1999-12-29 |
| JP4652570B2 (ja) | 2011-03-16 |
| ATE338821T1 (de) | 2006-09-15 |
| EP1783226A1 (de) | 2007-05-09 |
| JP2002518050A (ja) | 2002-06-25 |
| DE59915205D1 (de) | 2010-10-28 |
| ES2352666T3 (es) | 2011-02-22 |
| WO1999067393A3 (de) | 2000-03-30 |
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