DE19820466C2 - Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen - Google Patents

Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen

Info

Publication number
DE19820466C2
DE19820466C2 DE19820466A DE19820466A DE19820466C2 DE 19820466 C2 DE19820466 C2 DE 19820466C2 DE 19820466 A DE19820466 A DE 19820466A DE 19820466 A DE19820466 A DE 19820466A DE 19820466 C2 DE19820466 C2 DE 19820466C2
Authority
DE
Germany
Prior art keywords
sample
sample vessel
sound waves
electroacoustic transducer
sound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19820466A
Other languages
German (de)
English (en)
Other versions
DE19820466A1 (de
Inventor
Thomas Hahn
Bernhard Kleffner
Hans Ruf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority to DE19820466A priority Critical patent/DE19820466C2/de
Priority to US09/674,813 priority patent/US6699711B1/en
Priority to PCT/DE1999/001233 priority patent/WO1999058637A2/fr
Priority to EP99927719A priority patent/EP1075507A2/fr
Publication of DE19820466A1 publication Critical patent/DE19820466A1/de
Application granted granted Critical
Publication of DE19820466C2 publication Critical patent/DE19820466C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
DE19820466A 1998-05-07 1998-05-07 Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen Expired - Fee Related DE19820466C2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE19820466A DE19820466C2 (de) 1998-05-07 1998-05-07 Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen
US09/674,813 US6699711B1 (en) 1998-05-07 1999-04-23 Device and method for selective exposure of a biological sample to sound waves
PCT/DE1999/001233 WO1999058637A2 (fr) 1998-05-07 1999-04-23 Dispositif et procede pour exposer de maniere ciblee un echantillon biologique a des ondes acoustiques
EP99927719A EP1075507A2 (fr) 1998-05-07 1999-04-23 Dispositif et procede pour exposer de maniere ciblee un echantillon biologique a des ondes acoustiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19820466A DE19820466C2 (de) 1998-05-07 1998-05-07 Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen

Publications (2)

Publication Number Publication Date
DE19820466A1 DE19820466A1 (de) 1999-11-18
DE19820466C2 true DE19820466C2 (de) 2002-06-13

Family

ID=7866999

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19820466A Expired - Fee Related DE19820466C2 (de) 1998-05-07 1998-05-07 Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen

Country Status (4)

Country Link
US (1) US6699711B1 (fr)
EP (1) EP1075507A2 (fr)
DE (1) DE19820466C2 (fr)
WO (1) WO1999058637A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022505B2 (en) 2000-04-28 2006-04-04 Battelle Memorial Institute Apparatus and method for ultrasonic treatment of a liquid
US7811525B2 (en) 1998-10-28 2010-10-12 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
US8702836B2 (en) 2006-11-22 2014-04-22 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates

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US6948843B2 (en) 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
AU1600000A (en) 1998-10-28 2000-05-15 Covaris, Inc. Apparatus and methods for controlling sonic treatment
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
JP2003533974A (ja) * 1999-12-23 2003-11-18 ドルニエル メドテック システムズ ゲーエムベーハー 細胞内に分子を導入する装置
DE19962904A1 (de) * 1999-12-23 2001-08-09 Dornier Medizintechnik Verfahren zum Transfer von Molekülen in Zellen und Vorrichtung zur Durchführung des Verfahrens
AU2001279645A1 (en) * 2000-06-09 2001-12-17 Syngenta Participations Ag System and method for high throughput tissue disruption
DE10148916A1 (de) * 2001-10-04 2003-04-17 Beatrix Christa Meier Ultraschallvorrichtung
DE10223196B4 (de) * 2002-05-24 2004-05-13 Dornier Medtech Systems Gmbh Verfahren und Einrichtung zum Transferieren von Molekülen in Zellen
WO2005056748A1 (fr) 2003-12-08 2005-06-23 Covaris, Inc. Appareil et procedes de preparation d'echantillon
DE102004016804A1 (de) * 2004-04-06 2005-10-27 Daimlerchrysler Ag Vorrichtung zur Körperschallmessung
US7611840B2 (en) * 2004-08-03 2009-11-03 Agency For Science, Technology And Research Method and device for the treatment of biological samples
EP1846176B1 (fr) * 2005-02-03 2008-09-10 GE Inspection Technologies, LP Procede pour plaquer un composite piezoelectrique
WO2007016605A2 (fr) * 2005-08-01 2007-02-08 Covaris, Inc. Dispositif et procede de traitement d'echantillon par energie acoustique
US8353619B2 (en) 2006-08-01 2013-01-15 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
EP1965190A1 (fr) * 2007-02-27 2008-09-03 Qiagen GmbH Fixation d'un échantillon biologique
EP2027922A1 (fr) 2007-08-02 2009-02-25 Qiagen GmbH Procédé et dispositif de fixation/stabilisation d'un échantillon
DE102008005265B4 (de) * 2008-01-20 2013-06-27 Medite Gmbh Gewebe-Einbettautomat
DE102008021000A1 (de) * 2008-04-25 2009-10-29 Qiagen Gmbh Verfahren und Vorrichtung zum Aufschluss von biologischem Material
JP5655232B2 (ja) * 2008-12-05 2015-01-21 ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ 搬送ヒータを有する熱サイクルシステム
CA2752715C (fr) * 2009-04-14 2018-05-01 Arie R. Van Doorn Cavitation induite par hifu, avec seuil de puissance reduit
EP3809113A1 (fr) * 2009-04-14 2021-04-21 Biocartis NV Traitement d'un échantillon par une énergie acoustique focalisée
ES2677010T3 (es) 2009-04-15 2018-07-27 Biocartis Nv Protección de cámaras de muestras bioanalíticas
CN102341710B (zh) 2009-04-15 2015-04-01 比奥卡尔齐什股份有限公司 用于监视rtPCR反应的光学检测系统
EP2427270B1 (fr) 2009-05-06 2015-04-01 Biocartis NV Dispositif de coupe d'un porte-échantillon
US8691145B2 (en) 2009-11-16 2014-04-08 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for water purification
FR2957532B1 (fr) * 2010-03-19 2012-09-28 Commissariat Energie Atomique Agitateur d'un echantillon liquide
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
EP2701850B1 (fr) 2011-04-27 2018-08-15 Becton Dickinson and Company Dispositifs et procédés de séparation de fragments marqués magnétiquement dans un échantillon
EP2634246A1 (fr) * 2012-03-02 2013-09-04 Justus-Liebig-Universität Giessen Dispositif et procédé d'identification, de séparation et/ou de manipulation spécifique au type de cellule d'au moins une cellule d'un système cellulaire ainsi que de micro-organismes
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10370635B2 (en) 2012-03-15 2019-08-06 Flodesign Sonics, Inc. Acoustic separation of T cells
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
CN110595987A (zh) 2012-10-26 2019-12-20 贝克顿·迪金森公司 用于操纵流体样品中的组分的装置和方法
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
CA2935960C (fr) 2014-01-08 2023-01-10 Bart Lipkens Dispositif d'acoustophorese avec double chambre acoustophoretique
CA2948355A1 (fr) * 2014-05-08 2015-11-12 Bart Lipkens Dispositif d'acoustophorese comprenant un ensemble de transducteurs piezoelectriques
CN104004656B (zh) * 2014-05-27 2015-10-28 华南理工大学 多角度超声波加载的体外细胞学实验装置及方法
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
EP3169451B1 (fr) * 2014-07-17 2020-04-01 University of Washington Système à ultrasons pour cisailler un matériau cellulaire
JP6244296B2 (ja) * 2014-12-15 2017-12-06 オリンパス株式会社 付着物の塗布方法
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US10640760B2 (en) 2016-05-03 2020-05-05 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
CA2984492A1 (fr) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Dispositif acoustophoretique pour deviation de particules a onde angulaire
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
RU2708048C2 (ru) 2015-05-20 2019-12-03 Флодизайн Соникс, Инк. Способ акустического манипулирования частицами в полях стоячих волн
US10161926B2 (en) 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
CN112044720B (zh) 2015-07-09 2023-07-04 弗洛设计声能学公司 非平面和非对称压电晶体及反射器
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US10710006B2 (en) 2016-04-25 2020-07-14 Flodesign Sonics, Inc. Piezoelectric transducer for generation of an acoustic standing wave
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
EP3529347A1 (fr) 2016-10-19 2019-08-28 Flodesign Sonics, Inc. Extraction par affinité de cellules par un procédé acoustique
US10809166B2 (en) 2017-01-20 2020-10-20 Matchstick Technologies, Inc. Ultrasound system for shearing cellular material in a microplate
BR112020009889A2 (pt) 2017-12-14 2020-11-03 Flodesign Sonics, Inc. acionador e controlador de transdutor acústico
WO2019126920A1 (fr) * 2017-12-25 2019-07-04 深圳先进技术研究院 Dispositif de stimulation cellulaire et procédé de stimulation cellulaire

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811525B2 (en) 1998-10-28 2010-10-12 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
US7022505B2 (en) 2000-04-28 2006-04-04 Battelle Memorial Institute Apparatus and method for ultrasonic treatment of a liquid
US8702836B2 (en) 2006-11-22 2014-04-22 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates

Also Published As

Publication number Publication date
WO1999058637A2 (fr) 1999-11-18
DE19820466A1 (de) 1999-11-18
US6699711B1 (en) 2004-03-02
WO1999058637A3 (fr) 2000-01-27
EP1075507A2 (fr) 2001-02-14

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