DE19819962A1 - Hochaktive alkalische Phosphatase - Google Patents

Hochaktive alkalische Phosphatase

Info

Publication number
DE19819962A1
DE19819962A1 DE19819962A DE19819962A DE19819962A1 DE 19819962 A1 DE19819962 A1 DE 19819962A1 DE 19819962 A DE19819962 A DE 19819962A DE 19819962 A DE19819962 A DE 19819962A DE 19819962 A1 DE19819962 A1 DE 19819962A1
Authority
DE
Germany
Prior art keywords
biap
seq
alkaline phosphatase
highly active
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19819962A
Other languages
German (de)
English (en)
Inventor
Werner Hoelke
Rainer Mueller
Helmut Burtscher
Jose Luis Millan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Priority to DE19819962A priority Critical patent/DE19819962A1/de
Priority to AT99108502T priority patent/ATE323769T1/de
Priority to DE59913343T priority patent/DE59913343D1/de
Priority to NZ335500A priority patent/NZ335500A/en
Priority to EP99108502A priority patent/EP0955369B1/de
Priority to AU26926/99A priority patent/AU765392B2/en
Priority to ZA9903079A priority patent/ZA993079B/xx
Priority to US09/305,681 priority patent/US6406899B1/en
Priority to JP12649499A priority patent/JP4295386B2/ja
Publication of DE19819962A1 publication Critical patent/DE19819962A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
DE19819962A 1998-05-05 1998-05-05 Hochaktive alkalische Phosphatase Withdrawn DE19819962A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE19819962A DE19819962A1 (de) 1998-05-05 1998-05-05 Hochaktive alkalische Phosphatase
AT99108502T ATE323769T1 (de) 1998-05-05 1999-04-30 Hochaktive alkalische phosphatase
DE59913343T DE59913343D1 (de) 1998-05-05 1999-04-30 Hochaktive alkalische Phosphatase
NZ335500A NZ335500A (en) 1998-05-05 1999-04-30 Highly active eukaryotic alkaline phosphatase and a process for producing it
EP99108502A EP0955369B1 (de) 1998-05-05 1999-04-30 Hochaktive alkalische Phosphatase
AU26926/99A AU765392B2 (en) 1998-05-05 1999-05-04 Highly active alkaline phosphatase
ZA9903079A ZA993079B (en) 1998-05-05 1999-05-04 Highly active alkaline phosphatase.
US09/305,681 US6406899B1 (en) 1998-05-05 1999-05-05 Highly active alkaline phosphatase
JP12649499A JP4295386B2 (ja) 1998-05-05 1999-05-06 高活性アルカリ性ホスファターゼ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19819962A DE19819962A1 (de) 1998-05-05 1998-05-05 Hochaktive alkalische Phosphatase

Publications (1)

Publication Number Publication Date
DE19819962A1 true DE19819962A1 (de) 1999-11-11

Family

ID=7866683

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19819962A Withdrawn DE19819962A1 (de) 1998-05-05 1998-05-05 Hochaktive alkalische Phosphatase
DE59913343T Expired - Lifetime DE59913343D1 (de) 1998-05-05 1999-04-30 Hochaktive alkalische Phosphatase

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59913343T Expired - Lifetime DE59913343D1 (de) 1998-05-05 1999-04-30 Hochaktive alkalische Phosphatase

Country Status (8)

Country Link
US (1) US6406899B1 (https=)
EP (1) EP0955369B1 (https=)
JP (1) JP4295386B2 (https=)
AT (1) ATE323769T1 (https=)
AU (1) AU765392B2 (https=)
DE (2) DE19819962A1 (https=)
NZ (1) NZ335500A (https=)
ZA (1) ZA993079B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10036491A1 (de) * 2000-07-25 2002-02-07 Roche Diagnostics Gmbh Expression von Alkalischer Phosphatase in Hefe
DE10213201A1 (de) * 2002-03-25 2003-10-16 Roche Diagnostics Gmbh Erzeugung von schwach aktiven oder inaktiven Mutanten von Alkalischer Phosphatase und deren Expression in Hefe
EP1460425A1 (en) 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Deglycosylated enzymes for conjugates
US20110142817A1 (en) * 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
CA2554683C (en) 2004-02-04 2014-06-10 Pharmaaware Sepsis B.V. Use of alkaline phosphatase for the detoxification of lps present at mucosal barriers
EP3097188B1 (en) 2014-01-24 2018-08-29 AM-Pharma B.V. Downstream processing of an alkaline phosphatase
US9926544B2 (en) 2014-01-24 2018-03-27 Am-Pharma B.V. Chimeric alkaline phosphatase-like proteins
JP6977301B2 (ja) * 2016-04-13 2021-12-08 東ソー株式会社 変異型アルカリホスファターゼをコードする遺伝子
US11932860B2 (en) * 2017-10-03 2024-03-19 Kikkoman Corporation Method for producing alkaline phosphatase, alkaline phosphatase obtained using said method, and vector and transformant for production thereof
CA3087569A1 (en) 2018-01-09 2019-07-18 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
WO2019183208A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Intestinal alkaline phosphatase formulations
EP4275761A3 (en) 2018-03-20 2024-02-28 Theriva Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
JP7417854B2 (ja) * 2018-09-25 2024-01-19 東レ株式会社 アルカリホスファターゼ組成物並びに脱リン酸化核酸及び標識化核酸の製造方法
KR20220005560A (ko) 2019-05-06 2022-01-13 신세틱 바이오로직스, 인코퍼레이티드 알칼리성 포스페이트-기반 종양학 치료제
JP7510787B2 (ja) 2020-05-28 2024-07-04 シスメックス株式会社 アルカリフォスファターゼ融合抗体及びその製造方法、並びに免疫測定用試薬及び免疫測定方法
JP2024046503A (ja) 2022-09-22 2024-04-03 シスメックス株式会社 細胞外小胞に含まれるアルカリフォスファターゼの活性を測定する方法、キャリブレータ及び結合体
JP2025144440A (ja) 2024-03-19 2025-10-02 シスメックス株式会社 試料中の細胞外小胞に含まれるアルカリホスファターゼの活性又は濃度を測定する方法、ポリペプチド分子及びその製造方法、並びにキャリブレータ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
DE69323131T2 (de) 1992-03-10 1999-09-16 La Jolla Cancer Research Foundation, La Jolla Rekombinierte alkalische phosphatase aus kälberdarm

Also Published As

Publication number Publication date
EP0955369B1 (de) 2006-04-19
US6406899B1 (en) 2002-06-18
JP4295386B2 (ja) 2009-07-15
AU765392B2 (en) 2003-09-18
AU2692699A (en) 1999-11-11
ATE323769T1 (de) 2006-05-15
EP0955369A3 (de) 2002-02-06
ZA993079B (en) 2000-11-06
EP0955369A2 (de) 1999-11-10
DE59913343D1 (de) 2006-05-24
NZ335500A (en) 2000-02-28
JPH11332586A (ja) 1999-12-07

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination