DE19647683A1 - Measurement of, esp. glucose level, using suction cup - Google Patents

Abstract

Measurement of a body parameter is effected by mechanically producing a skin fold through which a cannula is inserted. A probe is also positioned either in or under the skin. The probe is connected to a sensor and measuring device for monitoring alterations in body metabolism or chemical conditions. A drug is injected according to the monitored changes. The probe is secured in contact with the tissue liquid under the skin during the time required for analysis. Also claimed is the appts. for effecting the above diagnosis and therapy.

Description

The invention extends to the field of medical technology. It deals primarily with metabolic control Diabetics and also touches the injection treatment Insulin. In particular, sensor means - bristle, thread or Capillary - without cannula by means of accelerated puncture or Drilled into or under the skin, which is preferred pulled up by suction in a suction cup. The puncture canal preferably runs almost horizontally against the base of the Skin fold.

State of the art

The invention was an additional notification to application P 34 381.7-11, which in application P 195 19 281.8 by internal priority with the Title "Process and device for suction diagnosis and suction jection "has emerged, and continues the large series accordingly own registrations. In particular, DE 37 08 031.8 and Euro 88103775.8 (published under 0 301 165). Application DE 37 30 469.0 also has a special position one in which it was first proposed by means of a pressure jet Inject liquid inside a suction cup. Also supposed to DE 44 45 066.4 are mentioned here, which are given by internal priority in DE 195 19 279 A1 "Method and device for suction Druckinjektion ". From other authors March with DE 25 3898.5 be mentioned, especially Garcia et al. (U.S. Pat. 4,637,403), whose device punctures the fingertip and one Drops of blood directly onto a glucose measuring layer. On too the Mc Kinnon, Ch. n. (Biojectg. Inc, Euro Publ. 0427457 A2) is expressly referred to.  

Task

The manufacture of sensor cannulas, i.e. H. of cannulas, within which a sensor thread is pushed under the skin is relatively complex, especially for exclusive measuring purposes. In addition, the Sen must be kept particularly thin, since the Cannula jacket determines the outer diameter and its already lowered to a diameter of 0.32 mm could be. Pain-free and low-injury sensor introduction remains a main treatment goal.

Solution of the task

A sensor bristle can also be used for measuring tissue sugar or a sensor thread made of absorbable material from Suction cup rim shot out through the skin and then are pushed further into the subcutaneous tissue. (The penetration of the sensor bristle is caused by high initial speed similar to that for liquid flexible material enables). The thread must first edged like a drill in a kind of lining to be fed with the feed lengthways to be able to avoid sideways. Can too the sensor bristles or the sensor thread itself as a drill with screw threads at its front end and by means of (such a drill chuck, for example one through Compressed thick-walled soft rubber tube or hose end with rotation through a skin pore the skin. For further feed lies the thread reserve either within a bellows on a kind of cross disks between the fold valleys stored or on a longitudinal slit from wall segments The plastic sleeve almost starts out in the center hitting support struts. The latter are from a cone  apart in succession with the wall segments of the sleeve derdriven. The cone tip is at the end of the Sen sorfadens connected, while the cone base a bowl to hold the guide pin for the thread has feed. Because when using a sensor bristle the cannula wall is omitted, the former can be a little thicker be made whatever the loading of chemicals for influencing the current and applying a outer protective layer against chemical diffusion comes in the body. (The through the skin stretching may also be done with adhe sive or pinching agents - thinned skin sets anyway, the permanent injury scar is reduced in size). Resorbable materials therefore deserve preference, because breaking a sensor thread before its withdrawal never completely excluded by technical faults that can. There is the use of polymerized Terephthalic acid and polylactic acid are suggested which the measuring active substances (like NAD-GOD-Perid for the active and Sepharose-Convalin-A for the passive elec trical sensor) can be bound. Especially that Polylactic acid has clear hygroscopic properties ten what for the absorption of tissue fluid by Meaning is. The threads of the molecular chains can be screwed before being covered with a protective film (such as polycarbonates) are coated.

It would result in a kind of drill shape. To introduce avoidance of measuring substances in the body, could also be a measurement not doped with such substances thread (for example made of silk, which is briefly mixed with 2-5% Formaldehyde gas is hardened) under the skin be pushed. The thread can after liquid saturation pulled back into the hose end and the contained With the glucose in the bore of the tube end stored measuring layer are brought to reaction. Threads doped with the measuring layer are retracted  into the hose end there with a metal coating in con clock over which the power line to the measuring device via ent speaking lines is carried out. Here are two Guiding zones separated lengthways by an isolation zone, so must the hose end because of the contact assignment against Rota tion (about deviations in diameter from the Circular shape).

The device for the insertion of a sensor bristle can also be operated with a gas pressure capsule. The gas pressure jet drives the sensor thread or the sen sorborste under the skin, the bristle end must ver be widened and narrowed at the end of the camp sleeve to be held. Treat the current measurements after withdrawal of the sensor thread from the skin also outside the (bearing) sleeve between layered plug-in disks be made. (This can also be done here the sleeves with their corresponding metal coating inside with contact lead to the outside.) If a metabolism measurement (any substance, such as glucose, but also cholesterol u. a.) by reflex optics using color transshipment response selected, two winzi small cylinders from two different reaction surfaces from common test strips are punched out. Two each Cylinders are then glued together so that the two color reaction layers on one side each Limit the total cylinder, which is mainly from hygros copied material (such as diatomaceous earth or silica gel) det. Such a reaction cylinder is now solid anchored on a carrier thread or pin and only just stabbed into the skin, leaving the thick support like the plate of a thumbtack. The metabolism measurement takes place after insertion of the carrier thread Laser scanning at both ends; on the carrier side expediently through a bore of the same. The device for the insertion of a sensor bristle  can now suitably with the equipment a nozzle for pressure injection in a suction cup be coupled. The two devices on the suction bell edge can face each other. If the saturation time for tissue fluid in the sensor thread can be kept short enough, when using a Suction cup an additional clamping device - about by means of two mutually resilient sliders under the suction cup rim - can be saved. The pressure injection Otherwise the substance change takes place via a nozzle Sel measurement under renewed skin suction.

Diagnostics with the sensor bristle can also be done in a separate, separate device housing can be installed. At Powder injection of solid medicines (e.g. in crystalline Form), pressurized gas takes the place of "washing out" - or Dilution liquid for the weft channel.

There can also be a measuring cannula under the skin in the liquid keitssee are introduced over the muscular membranes that from a drilled or shot capillary consists. Such a capillary can be outside or inside doped with a measuring layer for metabolic measurements be and also the injection of liquids (after the Measurement). The capillary wall can, however be perforated and the drainage of tissue fluid serve on a measuring zone in the sleeve for the capillary; in addition, of course, the injection of medication.  

In the meantime, the published documents DE 195 19 279 A1 and DE 195 19 281 A1, to which this application expressly relates and relates and the solutions laid down there in particular for Dose programming of the injector is also used here proposes. The task is a handy and as pocket-friendly as possible to create ge and flat facility, especially for Diabetic eliminates the puncture pain and, if possible, glucose combining measurement and insulin injection remains. It is obvious that the introduction of a sensor thread without Cannula creates minor skin scars; the diameter of the Cannula wall in the absence. Even the combination with one Pressure jet injector must light up, because this is the one offers the same advantages, namely the elimination of a complex Cannula and the smaller bullet channel in the skin. It will be here a two-stage procedure for diagnosis and therapy recommended and prepared, namely the insertion of a sensor thread and with renewed skin suction the injection. In this way may need a skin clamp because of the shorter Skin contact for measurement purposes. The sensor thread has changed in seconds saturated with tissue fluid and can be taken into the device for measurement withdrawn. The patient then has time to think about the therapeu table consequences of the measurement available in a few minutes result to worry before he goes to the injection decides which can be done in a nutshell.

It can be used for power generation for the sensor bullet as for the Injection therefore use the same power source. This can be a torsion spring, but preferred because of the flatter shape a kind of leaf or flat spring - also bundled as in a car chassis suspension - be. From the engine one becomes Central rod moved in or next to the spring and its ends  are mutually by grid on this central rod coupled. (The spring could of course work for both main functions can also be stretched in one direction when the functions decrease alternately coupled to it). The advantage of the Wirkrich change is that the thrust also on the Suction cup base advantageously at the opposite point is applied in opposite directions. When transferring the binary Computer logic into a kind of binary motor logic, which has only two poles used circuits for the target functions, the need arose on, a mechanical feature set from the screw for various sliding functions using a push Torsion unit by spring tension in front of a grid horse riding; only the displacement of the central rod for the tension the strong compression spring then triggers that grid.

Improvements also affect the structure of the sensor thread, yes no health hazards if he accidentally should remain under the skin. Since silver is not copper is preferred. Faster than a wire soul molecularly disperse ones are suitable for one of the derivative poles Metal applications (doping), because then the metal is dissolved Form can be more easily absorbed by the body. The central one Wire core is therefore better through the inner coating of a Capillary brought. The latter is first made into a graphite brought dust flow, and then takes place like an electric lytbades the metal doping. Instead of metal can be used in a Sensor capillary also introduced physiological electrolyte solution about 10% saline. For external contact such as through the tip of a pressure tappet, which was previously the Be acceleration of the sensor capillary towards the body is a metal sealing plug necessary. Alternatively, a degree pierced membrane or welded with heat.  

In addition to polymerized lactic acid with good absorption capacity for GOD-Perid mixture for hydrogen ion production or active Power generation under the influence of glucose can also use terephthalate acid and weakly methylated cellulose can be used. Latter can also be carried away by tissue fluid for material carryover a retraction path in the sleeve or loaded with chemicals Carrier hose or a drum bore serve. The chemical Reaction with glucose is then not found on the sensor thread itself instead of. To save space, the automatically exchangeable Sensor threads, except in sleeves as chains, over transport spools be moved, also stored in drums. The pods will then expediently reduced to carrier hoses, which in the Drum clearing compensate for the space that the retreat Sensor threads because of their swelling is required. Always should the firing channel should be kept tight, any compressed air or Liquid surge on the side before opening against the skin be directed. The thread is ejected very advantageously hydraulic because the pressure transmission is so optimal and the ver displacement volume can be precisely determined. The liquid can in the Sleeve or stored in the carrier hose behind a membrane be pressed in by the pressure tappet. But it can also Water from a tank or bellows through a kind of piston pump be introduced into the launcher through a tappet channel. For Opening protective membranes can be inserted into disposable parts serve electrical filament loops or those from the outside be introduced or heated tips. It can be so preferred as valves for gas or liquid inflow or outflow in the sensor thread area can be achieved. The sensor thread can Ejection against the skin can be stabilized in that in the  Space between it and the surrounding sleeve or carrier tube wall water is introduced shortly before use. The thread is then with expelled the water together and can become even at low Do not loop stiffness in the channel. Compressed gas should be in appropriate compression available for the same effect stand. However, the injectors require one for gas pressure capsules relatively complex equipment. A cheaper way out would be a single-use compressed gas capsule described here. Also it uses a "lock valve" (PCT / 85 see above) an internal pressure chamber, which is connected to a filament loop is triggered. The problem is not just the bullet Thread through the skin, but its retrieval for removal and - depending on the method - preferably for evaluation in the Device. This can slow down the sensor thread done that he has a caliber extension at the rear end has that not through the finer outlet opening of the Channel fits to the skin. It is then preferably of a kind Piston connected in a sleeve (or drum bore) into which also engage the plunger of the device and press the thread can hold on like a button. The thread can also by means of a Brake at the end of the channel be held in front of the skin. In addition to one mechanical solution coupled to the slide slide is preferred wise the electromagnetic and that time or light barriers controlled. When the drum is mounted, it can be straight when braking still held in the transport hose and possibly heat there welded thread also radially on one of the drum axis outgoing spokes with him and towering over him like segment of a pusher from its hole pulled out and curved towards the axis line.  

Although drug tracking in liquid form in many More advantageous, it is also the subject of this Invention an improvement in pressure jet injection (with gas or water) of solids. Their dosing ability is increased for small drugs if they are in a kind elongated chopsticks stored in a drum will. On the way to the exit opening, they are through pushed a clear cylinder. It can their length can be determined photometrically. As soon as the there is a corresponding length in the transparent cylinder, will still be in an upstream cylinder segment part of the stick by swiveling the Cylinder segment canceled. One sideways in the back Part of the transparent cylinder introduced weaker Airflow can pass the stick into the launcher behind the valve-secured pipe crossing to the pressure jet source promote.

Sensor threads are also used up for storage Share preferably a second drum and one Instrumentation through the hole in the projection line to the Ejection channel and / or in the neighboring one.

To demonstrate that with respect to US Pat. No. 5,296,023 Haberet et al. the wording, but not the spirit of it Invention is touched, was still the solution of an injector indicated with three injection cylinders. In each of these Cylinder can also use thinner or water (alone) be introduced. But also water and thinner without Piston metering from cartridges as it affects the total volume of the Injection does not arrive as precisely.

Combinations of the solutions given here are also intended be protected.  

Description of the embodiments

The figure shows in horizontal or longitudinal section in natural size with lateral roll-up of the functional parts is a device for shooting a sensor bristle into a skin fold. Left in the scale 2: 1 and from the United tical turned the wedge slide for the sensor sleeve retraction. In addition, in the 2: 1 scale, a special embodiment of the sleeve cap, likewise in the bottom right in the 3: 1 scale. From the motor axis ( 53 ), the movement runs via the transmission gears ( 54 ) for reducing the speed to the square axis ( 627 ), then over the Sliding sleeve ( 125 ) and the edge bar ( 644 ) to the driving plate ( 126 ) for the rotary slide ( 127 ). The gear wheel ( 126 ) is mounted on the edge bar above the driver plate and is constantly meshed with the pinion ( 800 ) by means of projecting connecting washers. The latter is moved on the screw spindle and is in engagement with the gear wheel ( 803 ), which here only has the function of screw rotation in one direction of rotation. The rotation is always transmitted to the intermediate gear ( 129 ) and from there to the nut ( 130 ) via the gear ( 802 ). A guided on the nut in a circular track and ball-bearing bell (131), the sleeve (691) has already been against the conical Boh tion in the suction cup (1) moves and the two strong compression springs (261, 262) against their four support columns ( 854 ) excited. The relaxation of the springs is prevented by the bolt ( 472 ), which roughly corresponds in structure to that behind the Ra sterkuppe ( 270 ). With the lowering of the grooved slide ( 132 ), the slide bar ( 134 ) is also lowered via the fork ( 133 ), which is then held against the tension spring by the grid cap ( 270 ). This is only possible when the tension spring ( 135 ) is relaxed and lowered at the end of its Bowden cable to the grooved slide. (The small pressure spring behind the dome saves the cogging torque). The leaf spring ( 136 ) is actually rotated 90 degrees around the axis of the groove slide and ensures the height stability of the latter. The Bowden cable ( 138 ) between the grooved slide ( 132 ) and the wedge slide ( 137 ) - again with energy saving in a spring - caused the lowering of the latter. (The side view of the wedge slide frame on the left shows the function of a thrust effect on the collar ( 139 ) when it is lowered). The Bowden cable ( 140 ) lifts when the groove slide is lowered through the central bore in the screw bolt ( 352 ) with a spherical end in the hollow of the elastic piston ( 91 ) carrying the sensor bristles, compressing the bellows with highly elastic septa between the fold valleys, in which the sensor bristle is stored.

The enlarged detail at the top left shows that the sensor bristle is surrounded by the rubber hose end ( 92 ), which is surrounded by the sleeve ( 691 ) after an air gap. The sleeve cap ( 111 ) extends with internal extensions through slots in the sleeve ( 691 ) on the rubber hose end and holds a certain pressure when pushing from the sleeve, which is sufficient for the narrowing of the rubber hose end channel around the sensor bristle and the latter at high speed through the skin drawn up in the suction cup ( 1 ). The detail at the bottom right shows the rubber hose end ( 92 ) of the sleeve ( 691 ) directly in contact. The sleeve cap is extended downwards and has knobs on the inside, which also correspond to the outside of the sleeve ( 991 ). The extensions extending through slots at the bottom of the sleeve ( 691 ) onto the rubber hose end ( 92 ) can also be equipped with tongues at the top in order to cover the slots against the compressed rubber.

The ring sleeve ( 571 ) belongs to a thrust-torsion device, which causes an axis rotation of 90 degrees after each lowering with the rotary slide ( 127 ) and which unload the tongues ( 93 ) either with the grooved slide ( 132 ) or the two Grooved slides ( 94 , 95 ) for triggering the strong compression springs via the Bowden cables ( 96 ) - only one of which is shown - make contact (cf. Fig. ).

The thrust-torsion device is described in more detail in FIG .

The sleeve ( 691 ) is inserted into the groove ( 151 ) by hand and removed again after consumption. The invention is of course intended for the equipment with automatic sleeve or stylus change, as has already been described analogously to FIGS . 9 and 36 of the Euro application 0 301 165 (published on February 1, 1989), albeit for a vertical one Stylus or sleeve storage.

Fig. 2 gives in natural size a cross or vertical section through the device according to Fig. 1 at about the height of the two bars ( 472 ). Below is the detail of the mounting of the strong compression spring ( 261 , 262 ) on the support columns ( 854 ).

It is the housing wall ( 16 ) and the space for battery ( 255 ) and electronic control unit ( 80 ) be marked. The trigger for the slide bar ( 134 ) with the tension spring for the rapid retraction of the sensor bristles from the skin lies between the raster tip ( 270 ) and the tension spring ( 235 ). Here too the fork ( 133 ) embraces the Bowden cable ( 138 ) and is moved by the groove slide ( 132 ). The latter is - as in another switching position of the rotary valve ( 127 ) also the Ril lenschieber ( 94 , 95 ) by means of one of the opposite tonges ( 93 ) in both directions via entrainment when tongue engagement between the driver plate ( 126 , Fig. ) And gear ( 128 ) when power is transferred from the electric motor ( 478 ) to the Rit zel ( 800 ) by moving it on the spindle ( 801 , Fig. ). When the pinions ( 802 , 803 ) are reached by the pinion, the screw nut ( 130 ) on the sliding spindle ( 352 ) is actuated in the opposite direction of rotation via the intermediate gear ( 129 ).

The functional sequence between left (= below) and right (= above):

Fig. 3 shows in longitudinal section or horizontal section on a scale of 2: 1, the sleeve ( 571 ) of the torsion thrust device with the hammer ( 121 ) to explain the switching between the individual functional stages AB. At the bottom left in detail a cross or vertical cut through the hammer end along the cutting line AB of the longitudinal cut.

The sleeve ( 571 ) shows the inside of the zigzag groove, into which a small cross pin of the elongated magnet armature engages and causes a quarter turn of the sleeve with each stroke, provided that the magnet armature is secured against rotation. The rotation is communicated via the torsion spring ( 141 ) and articulated flange ( 142 ) of the hammer. The hammer shaft is rectangular on the right side (ie distal) and is prevented from rotating in the fixed bushing ( 143 ).

In the O position of the magnet armature shown, there is a cross-section rounding of the hammer in the bushing ( 143 ) so that the torsional force can take effect. (Incidentally, even without a torsion spring if the connection between the magnetic armature and the joint flange corresponds to the elastic nature).

The hammer area in the two detailed representations below shows a mechanical locking sleeve ( 144 ) which, as a half-groove, stops the rotation of the hammer via a respective working member (AD). For this purpose, there is an elbow parallel to the slide plate with a passage for the locking sleeve ( 144 ) and for the horseshoe-like pin ( 146 ) with end plate for the pressure spring support.

The lower illustration shows how the cam ( 147 ) of the hammer has lifted the sleeve ( 144 ) against its suspension (because it also springs back slightly against the hammer rotation), so that now the axis rotation is immediately caused by the already over the sleeve ( 571 ) Tensioned (and possibly permanently held in a bias) Tor sion spring ( 141 ) is released. The hammer's cam then finds resistance on the closest sleeve (such as 144 ). There are four such locking mechanisms distributed radially (see detail in cross-section at bottom left).

Fig. 4 shows on a scale of 4: 1 in longitudinal section the variant of a sleeve for the cannula bristle for a device according to Fig. 1 and others right as well as extending into the lower left half a breakaway mechanism for the sensor bristle. On the left you can see a length-reduced sleeve during the sensor feed and on the top left a sleeve cross-section.

The sleeve ( 691 ) consists of several through longitudinal gaps under broken tongues ( 152 ), of which only three were shown. A series of supports extend from each of the tongues, which centrally enclose the sensor bristles. The sleeve as a whole is covered against contamination by a highly elastic membrane, which was not shown.

The piston ( 91 ) advanced into the sleeve projects conically outward and therefore spreads the tongues ( 152 ) apart as the sensor bristles advance. The wedge slide ( 137 ) behind the collar ( 139 ) of the sleeve are spread like a vice in a hinge joint (not shown).

The preceding insertion of the sensor thread is actuated by a mechanism as in FIGS . 1, 2, 3. The rubber hose ends ( 92 ), which are pressurized by the collar of the sleeve ( 691 ), are mounted against the support ring ( 153 ). This, in turn, is rotatably connected by means of the supports ( 154 ) - indicated too weakly here - to the frontal slide for the production of skin folds (or the suction cup), as described analogously for the bell in relation to the nut ( 131 , 130 ; FIG. ). The pressure built up on the end of the hose initially narrows the channel around the sensor bristles.

By actuating the electric pull magnet ( 555 ) from the electronic control part via a (not shown) contact, for example, in front of the strong compression spring ( 261 ).

About the lever ( 159 ) the curved wedge slide ( 155 ), which causes a sector rotation of the support ring ( 153 ) counterclockwise, so that the extensions ( 157 ) of the outwardly protruding slots for the rubber hose end over the gaps ( 158 ) of the support ring and can pass through there. Appropriate bevels in the vertical can facilitate the passage of the extensions. (Bottom right is the top view of the bearing washer on the support ring). The sleeve is now pressed against the sleeve cap ( 111 ) and the sensor bristle is shot through the skin. The pull magnet ( 555 ) must be actuated before a new sleeve is removed. The supports ( 120 ), which originate from the skin fold slide (or the suction cup) (and are shown a little too weakly), allow the support ring ( 153 ) to roll behind them. The anchoring between the support ring and supports ( 120 ) was not shown (see 130 , 131 ; Fig. 1).

Inside the rubber hose end ( 82 ) are indicated in white dashed lines, the line coverings, which continue in the electrical lines ( 84 ) on both sides and there have contact with leaf springs for forwarding to the measuring device. In the case of the carryover of tissue fluid through a kind of wick, the white dashed lines correspond to sensor coverings, for example, for the reaction with the glucose from the tissue fluid.

Fig. 5 shows the variant of the introduction of a sensor bristle according to the type of drill in natural size in longitudinal or horizontal section. At the top right, the sleeve structure for sensor bristle conveyance is drawn out on a scale of 2: 1. Including a preferred variant for a simplified sleeve.

The stage shown is that of the sensor bristles drilled under the skin in a suction cup ( 1 ). For this purpose, the electric motor ( 478 ) with the transmission gears ( 54 ) is fixed on the (omitted) housing base; the edge axis for the drive wheel ( 233 ) is displaceable through the latter and connected to one of the two slides ( 236 ), which in turn run on the rails (shown in broken lines). The frictional connection runs from the drive wheel ( 233 ) via the freely rotating gear ( 232 ) to the elongated gear on the screw bolt ( 352 ). The latter can be moved away from the suction bell by rotation within the elongated nut ( 130 ) and takes the sleeve ( 691 ) in a clamped fit with the collar ( 139 ) thereof by means of the clamping sleeve ( 238 ). The rubber mixing tube end ( 92 ) around the sensor bristle is initially pressed together by transverse sleeves ( 691 ). The inner sleeve ( 97 ) around the end of the rubber hose is mounted on balls opposite the sleeve cap ( 111 ) and rotates with it, the screwed end of the sensor bristle piercing the skin. The greatest distance far under the skin, the sensor bar is moved over the threaded rod ( 235 ), namely in the internal thread of a large gearwheel, which is fixed between the nut ( 130 ) and the cross plate ( 251 ), the threaded rod ( 235 ) itself moves with its end through this cross plate. The associated small drive wheel ( 234 ) is driven by a second motor (not shown) or via a manual transmission from the motor ( 478 ). The rapid retraction of the sensor bristles takes place under the action of the two compression springs ( 237 ) between wing plates on the suction bell and a carriage ( 236 ) each moving on a rail, after which the latch ( 472 , see Fig. 2, it is only one shown) was triggered by an electromagnet (the latter if not shown, as the vacuum source was omitted).

The variant of the front end of the sleeve ( 691 ) shows the sleeve cap ( 111 ) firmly integrated around the suction cup opening for the Sen sorborste with a ball bearing for the inner sleeve ( 97 ), which takes up the pressure of the rubber hose end. The rubber hose end sits on the sleeve ( 691 ) with a caliper jump and rotates with the inner sleeve.

At the top right, the detail of a preferred solution of the connection between the sensor sleeve and suction cup on a 2: 1 scale. The end of the rubber hose ( 92 ) is fixed at one end in and on the sleeve ( 691 ). The latter has a fine thread at the end, which acts opposite to that of the screw nut ( 130 ), and if both threads are matched, the pitch is appropriate. The external thread on the sleeve corresponds to an internal thread of the inner sleeve ( 111 ), which is part of the device. The inner sleeve ( 250 ) is sealed in the spout ( 117 ), which starts from the suction cup. There is also a sealing ring between the inner sleeve and sleeve ( 691 ). When the displacement spindle ( 352 ) rotates, the rubber hose end is pressed together and, with the roughened end of its end face, the inner sleeve ( 250 ) is also rotated. The latter is removed from the suction cup as the sleeve ( 691 ) is approached. When using the device, the sensor is pushed a certain distance out of the inner sleeve via the threaded rod ( 235 ). (The problems of the protective cover before use have been omitted: they can be solved by pulling off the cap or glow wire loop against a protective membrane). The skin already lying on the tip of the sensor thread in the perforated disc ( 254 , FIG. ) Can initially dodge the free thread end. The thread end is drilled through the skin by rotation via the screw nut ( 130 ).

Fig. 6 shows in horizontal or longitudinal section in the dimension rod 3: 1 the variant of a device for a shot of the sensor bristles under the skin by means of a pressure gas surge. Above in the vertical or transverse view, individual representations of the plug-in disks on which the sensor bristle is temporarily stored. The device can expediently be operated from a CO ₂ compressed gas capsule and, in doing so, make use of additional devices, such as those shown in FIG . 1, but also in European application No. 0 221 005 ( FIGS. 13, 17, 19 and others). , but especially in the one already mentioned above by Mc Kinnon.

From the compressed gas hose ( 893 ), a gas surge is conducted via a pipe into the channel of the sleeve ( 691 ). The pressure jet pushes the end plate ( 214 , greatly exaggerated) on the sensor bristle and the latter in front of it, whereby the end plate cannot go beyond the constriction ( 215 ) at the sleeve end.

The clamp ( 253 ) inserted conically from above between the collar ( 139 ) of the sleeve and such a tube ensures gas-tight coupling of the conical tube end to the funnel of the sleeve ( 691 ). The sensor bristles are retracted by pulling on the magnet ( 555 ), which affects the bar ( 236 ) on the bar ( 236 ) via the lever ( 159 ). The latter is moved along the rail ( 252 ) and in the same. (The route has been shortened). By pulling the wedge strips ( 99 ) back from the carriage, the strips are moved from these strips against their spring clips ( 85 , above in the vertical view) to the rods ( 355 ) so far that the sensor bristles in the narrowed channel between which is alternately encased from above and, in lined up washers ( 86 ). In this case, a current discharge from the surface of the sensor bristles occurs via the electrical (integrated) lines ( 84 ), which rings are passed on to the measuring device by mutual contact of the line rings. Each of the lines corresponds to the contact on a sensor bristle side. The top disc shown with its Schlit zen ( 98 ) for the wedge bars ( 99 ) shows the individual design device. To the right of this are depictions of two adjacent disks in the stage after the wedge bar retraction and after insertion into the slots ( 98 ).

After taking the metabolism measurement, the magnet ( 555 ) is switched off again, and the slide ( 252 ) returns under the action of the compression spring ( 237 ) back to the position shown. The wedge rods in turn spread the plug washers so that the sleeve can be pushed over the sensor bristle again. (Especially if suction is introduced from the jet pump via the compressed gas hose ( 893 )). Withdrawal of the sleeve again permits its removal for replacement by an unused one.

Between the cone for the sleeve receptacle in the suction cup ( 1 ) and the perforated disc ( 254 ), the chamber ( 354 ) is formed, which is closed in a plate-like manner by the edge of the suction cup. It is shown how the skin bulges somewhat out of the opening of the perforated plate of the sensor bristle in this arrangement. The light beam ( 353 ) can be reflected on this small skin bladder before the sensor bristle is shot in and can be thrown through it and past it onto the corresponding sensor. This makes optical skin control much easier, because surface irregularities can also be better recognized. (A hair follicle, for example, would not be able to pass through the small opening in the perforated plate).

Fig. 7 shows in natural size in horizontal or longitudinal section a device for measuring purposes, in which the sensor bristle has been shortened to a small double or sensor cylinder ( 216 ), the bottom surfaces of which each have color measuring layers with different sensitivity ranges for glucose. The carrier thread (made of any material, if it is detached from the sensor layer for measuring purposes) with the sensor cylinder, which is stuck to the skin, is drawn out on the right in a scale of 2: 1. (The sensor cylinder again very exaggerated in size, because in reality approx. 0.3 mm in diameter).

On the far right in the scale 4: 1 carrier thread or here carrier capillary ( 217 ) within a measuring jug.

The latter consists of the fixed base cylinder ( 219 ) and the cap cylinder ( 218 ) slid onto it, each of which is equipped with laser sources as photoemitter ( 580 ) and photosensor ( 581 ). (Possibly with fiber optic insert with upstream lenses and subsequent coupling to the sensor, as schematically outlined above). The electrical lines ( 6 , each doubled) lead to the measuring device, not shown.

The weft device corresponds approximately to that described in FIG. 1, the sleeve ( 691 ) for storing the carrier capillary or the carrier thread being shortened.

The sleeve ( 691 ) is connected to its collar ( 139 ) by means of the bracket ( 253 ) with the collar of the pressure tube with the compressed gas hose ( 893 ). After saturation of the sensor cylinder with tissue fluid, the latch ( 472 ; Fig. ) Is withdrawn and the tension spring ( 237 ) moves the sleeve ( 691 ) by means of the carriage ( 236 ) on the rails ( 252 ) so that the sensor cylinder contacts the skin leaves and the suction bell is re-aerated. (The source of suction was again known and omitted arbitrarily).

The caliber jump between sensor cylinder and carrier prevents penetration of the skin, binding of the cylinder in the carrier end serves as a safeguard against cylinder tearing.

At the bottom left the round tip of a pen-like shooting device with the carrier capillary ( 217 ) in the central channel. If pressure is applied to any skin area, it is stretched before the shot. Optical skin monitoring can then be dispensed with again for such a simple device.

Fig. 8 shows schematically in a longitudinal section on a scale of 4: 1 (if the sensor capillary is exaggerated) a variant of the device in schematic.

The sensor capillary is often perforated for fluid drainage (especially in the end area). The measuring layer is inside the sleeve ( 691 , crossed), but could also be in the sensor capillary. Via the pump presented as a syringe (pull in the direction of the arrow), the inflow of liquid can be favored via the feed line into the sleeve. After pulling the valve slide, medication can be injected from the lower syringe via the sensor capillary. The end of the sensor capillary to be shot into the skin can be sharpened (like the hard coating compound in the case of the sensor cylinder of the FIG. Lengthened in the manner of a cannula tip, that is to say it can be put on like a spout).

With the invention, the combination of the Darge put parts and solutions and their use under Kombina tion with programming and registration devices to be protected.  

FIG. 9 shows the outline of the device for measurement and injection described in FIG. 10 in a layer from below, below in a frontal view on a scale of 1: 2.

It can be seen that the suction bell ( 7 ) is arranged a little eccentrically pushed in the narrower device part. On the top left you can see the folding handle () for the exchange of the water thinner container, below the adjusting screw () for the total amount of injections. The lid () with the bag for suction generation only occupies the square space to the left of the suction cup. The right square denotes the tub () for the compression spring.

Addendum to Fig. 39:

The sticks for taking the medicine could be removed with the help of Glutamate aldehyde can be made in a nozzle.

Regarding Fig. 41 below: A device for slight axis displacement of the drum and a grid change for rotating the drum allow further rows within the drum to be occupied with sensor threads. The bullet channel is marked by a reinforced black ring.

Fig. 10 shows in a schematic longitudinal section in natural size the left part of the preferred Lösungsbei game of FIG. 9 is shown for the injection function, wherein the housing wall only fragmentarily. In the top middle, a detail of the mechanism for the injection delay for the injection cylinder with the thinner is shown from below. The cutting plane runs through the injection cylinder ( 1 ) for Ver thinner and shows the wedge angle of the injection (cylinder) piston ( 2 ). The protective bellows ( 3 ), which encloses an auxiliary liquid (such as sterile water), is stretched between the injection cylinder and piston. In the slightly tapered Zylin derende the valve disc ( 4 ) is inserted, which covers the nozzle ( 5 ) in the direction of the suction cup ( 7 ) (and can release). The Ven tilscheibe can be rotated by means of the lever ( 6 ) (see. Fig. 12). The generation of suction can only be triggered if the three electrical contact points ( 139 ) of a touch switch in the suction bell edge report skin contact; the interruption of the skin contact before the end of the respective functional cycle causes error messages and functional interruptions via the electronic control center ( 27 ). The four tube segments (x, Fig. 15) serve to accommodate the cover springs. The window ( 9 ) with a perforated diaphragm (see FIG. 16) interrupts the suction bell and is also present on the opposite side instead of the insertion of the measuring thread. The wall of the injection cylinder serves as a sealing seal in the vicinity of the suction bell.

The square pin ( 10 ) is mounted between balls and at the end has the roller ( 11 ) to bevel the injection plunger. The screw bolt ( 13 ) can be adjusted in height on the handwheel ( 12 ). The grid switch ( 15 ) reports the sector rotations according to the lowering of its ball through a channel-shaped profile by contact closure to the electronic control center ( 27 ). (Wiring and hose connections have been omitted in the drawing). The screw bolt is prevented from turning by the tongue tab ( 240 ) on the side, which meets the shoulder ( 241 ) of a lateral cut in the injection plunger (detail at the bottom left in cross and longitudinal section). The fact that a tongue tab of ( 241 ) extends upwards in the rear injection cylinder for medication against a corresponding piston shoulder can also limit the filling quantity of the injection cylinder manually.

The housing wall ( 16 ) is only shown to a certain extent, especially since the components have been pulled apart for clarity. Both cantilever pins ( 10 , 243 ) are moved to the right by the bend at the end of the connecting rod ( 244 ), one in the puncture stage shown. The wedge slide ( 33 ) has a slot guide for a pin along which it is moved. The pin is firmly connected to the bottom of the case. The displacement takes place via the spring-loaded cable pull ( 245 ) via the double roller ( 246 ) by means of the push rod (y, Fig. 11) after the rollers ( 11 , 247 ) acting on the wedge bevels have been pulled back via the cable pull ( 245 ), the on the cross pin ( 248 ) of the square pin ( 10 ) attached tension spring to the slide ( 33 ) is tensioned. The wedge slide lowers the injection piston (behind the plane of the rollers ( 10 , 247 )) by acting on the small roller ( 79 ). For this purpose, the valve disc ( 4 ) must release the liquid inflow to a feed line in the injection piston. The injection pistons are filled according to the piston stroke. Thinner or water who the compressed air from the bag ( 93 , Fig. 15) between the bellows and the cardboard cylinder ( 39 ) under pressure. The pressure is in the example shown on the check valve ( 43 ) even after lowering the device cover and during the expansion phase of the bag in the container housing ( 135 ).

Although a separation of the air spaces is not required for the given functional context, the collar ring of the cardboard cylinder is pressed by the separate jacket sleeve ( 136 ), which is pressed from the cover by means of the folding handle ( 40 ) when rotating in the bayonet lock against the sealing ring ( 137 ). Since in our case a separation into two gas pressure compartments is not necessary, the common air supply hose ( 42 ) bifurcates. The pressure relief valve ( 271 ) opens as soon as the necessary gas back pressure in the container housing ( 135 ) is reached. The medication cartridge ( 138 ) and its emptying by means of the metering device ( 249 ) is described in more detail in FIG. 17. The device is powered by the battery ( 26 ).

FIG. 11 is a longitudinal section of FIG. 10, but has been reduced by a little more than a quarter; it mainly contains the mechanical part of the measuring device, the electronic part of which is combined with the control center ( 27 , FIG. 10). From the electric motor ( 25 ) via the reduction gear ( 98 ) and a sliding gear on a square rod, a screw ( 47 ) is driven, on which the pinion ( 46 ) moves along when the screw rotates. The pinion takes a thrust-torsion unit with it over a slide with fork, which is moved laterally on a push rod (). In the final phase of this side shift, the thrust-torsion unit bumps into a light pressure spring in a separate holder and is actuated as a result. The push rod engages with one end of the angle in the notch of one of three switching rods ( 996 , 273 , 274 ) which also moves them. The shift rods are each assigned to one of the functional phases (a, b, c in Fig. 13). The changeover between them takes place each time one of the two gearwheels ( 802 , 803 ) is approached, each of which is firmly connected to one screw end. The pinion has at least one side knob ( 48 ) on both side surfaces, which engage one of the gearwheels ( 802 , 803 ) in respective side knobs and drive them (both only in one of the two directions) (see FIG. 14). In our example, only the function of the right gear ( 803 ) is used and transferred to the screw sleeve ( 278 ) with internal thread, which moves the screw bolt ( 275 ). The movement of the latter is communicated via the angle rod ( 276 ) to the central rod ( 272 ) in the center of the strong compression spring ( 277 ). This compression spring is laterally displaceable within a fixed frame (not shown) around the spring stroke height within housing troughs ( 279 ). The thrust movement of the central rod is transmitted via one of the two grid pots ( 280 , 281 ), in which the strong compression spring is located at the end of the spring Three eliptoid bodies each serve as a grid, which can snap into the corresponding grooves of the latter, distributed regularly around the radius of the central rod, under the action of an annular slide ( 282 ), the inclined flank of which is pressed against the eliptoid by a compression spring. The grid is triggered by one of the Bowden cables ( 284-286 ) by pressure actuation from one of the shift rods ( 996 , 273 , 274 ) .The push mechanism for the spring-back pin ( 287 ) for the sleeve transport has only been moved up for clarification really comes close to the S screw sleeve ( 278 ) on the crossbar ( 288 ), to which both pins ( 287 , 289 ) are attached with their weak compression spring. With their angled ends, these pins engage in an inner channel backdrop of the transport drums ( 290 , 291 ). Their rotational effect as a thrust-torsion unit is shown in more detail in FIG. 21; the pushing movement to the left is in the oblique groove or turning phase. For clarity, the transport drums have been moved slightly to the left, as the dash-dotted arrow lines indicate. The thrust mechanism is triggered via the tilt lever ( 292 ) by the push rod ( 293 ) with a free path through parallel partial rod guidance through the angle rod ( 276 ) in an almost extreme right position thereof. The stronger compression spring is tensioned on the rod ( 295 ) by means of a cable on the sliding sleeve ( 294 ) via a cable (dash-dotted line, as it is only not shown virtually) in the shift rod (). A wing of the wing cross ( 296 ) shown in detail above in cross section blocks the pushing movement of the rod ( 295 ) until the pushing movement of the rod ( 297 ) guided in the fixed sleeve by means of the rocker arm ( 292 ) of the rod via the spring-backed pushing torsion -Unit (analogous to the switching process for the switching functions ac) turns the turnstile under the rod ( 295 ) away. The double roller ( 298 ) serves to reverse the movement of the previously described cable pull ( 245 , Fig. 10) towards the end of the shift rod (). The pressure trigger ( 299 ) for the functional phase (c) continues in the Bowden cable ( 286 ); the pressure trigger ( 301 ) approximately in the Bowden cable ( 285 ); the Bowden cables run in wide arches, not shown, due to their function. The connecting rod ( 244 , see FIG. 10) for the injection is connected to the angle rod ( 276 ).

The ladder-like adjusting mechanism ( 300 ) for the valve disk ( 4 , Fig. 10, Fig. 17?), Which is moved in one direction via two pull cables, is shown in Fig. 22? described in more detail. The suction cup ( 7 ) is only partially drawn in with two of its release pins ( 8 ); it closes the trough for guiding the sleeve ( 691 ) with the sensor thread in the center (not shown, see Fig. ?).

Fig. 2 gives a side view of a transmission detail (left) in cable connection with the two valve discs of the injection cylinders (right) in natural size. On the left of the injection cylinder connected to the control another valve position is shown, in the middle a 2: 1 scale vertical section through the two ends of the injection cylinders with the valve discs. At the bottom left, the detail of a valve cap with an eccentric nozzle, which rotates around an injection cylinder and can be made to coincide with an opening in the cylinder base. Lateral hose lines are used to supply liquid via holes in the cap, which can be brought into alignment with those in the injection cylinder by rotating the valve cap. (Only one hose and one cylinder bore is shown). The holes can be staggered according to the distance from the cylinder base. The cylinder base can fall if the nozzle is also at an angle to the piston-cylinder axis.

The edge axis of the gearbox with the sliding gear ( 45 ) is set in rotation by the motor gearbox. It is connected to the pinion ( 46 ) in a sliding connection via disks on an axle sleeve. The pinion is displaced as it rotates by the meshing gear along the screw ( 47 ). Both the end plate of the latter to the pinion and the pinion on both sides have side knobs ( 48 ). Another parallel led axis serves the lateral displacement of the slide ( 49 ) with a fork encompassing the pinion. The wire core of the Bowden cable ( 50 ) is fastened to the slide. The other end of the wire rigidly connects the ends of the swivel arms of the two valve disks.

The upper and lower injection cylinders are connected to one another by a wall slot. The edge notch ( 51 ) of the valve discs is rotated by means of the swivel arms and passes through radial holes in the wall of the injection cylinder. One cylinder - in our example the upper one - shows the holes for the (symbolized as lines) feed lines for insulin 1, for thinner (water + table salt), insulin 2 and water. The lower cylinder only shows the discharges for thinner and water. The width of the marginal notch is selected so that it can be used to pass on one type of insulin, but in a middle position between the insulin mouth and the thinner opening, the mixture of insulin-Ver can also flow in. The edge notch can only flow thinner or water into the injection cylinder when the swivel arm is in the appropriate position. In the extreme upper swivel arm position (left figure), the liquid flow is stopped, while the liquid discharge from both cylinders through the nozzle in the lower cylinder via the hollows (hatched) it can follow. The other valve disc position (left) corresponds to the condition during a thinner filling of the cylinders.

The enlarged detail in the middle in vertical section shows the position of two sealing rings ( 52 ) and the passage of the swivel arms by means of an axis ( 54 ) to the valve disks. (Here the cavities were left without hatching). During the water discharge with reduced pressure, the water can possibly enter the space between the valve disc and sealing ring for cleaning.

Fig. 3 shows in cross section along the section line AB of Fig. 1 further functional mechanisms and their mechanical bases in natural size and two stages of func tion.

The threaded spindle ( 23 ) is screwed out of its threaded sleeve ( 55 ).

In the upper illustration, the sliding cover ( 56 ) is pulled out to the right in its rail guide (see FIG. 6), so that it closes off the suction cup ( 7 ). Under the central passage is the bracket ( 62 ) for attaching an absorbent cellulose swab, which can take the water during a cleaning procedure for the cylinder and nozzle. In the slot ( 63 , Fig. 4 above) inside the suction bell wall, a slide is vertically movable, the lower part of which contains the window ( 64 ) with the pinhole, while the upper part has a heat-stable sealing plate with filament, which in the position shown Nozzle seals. The lower part of the slide extends beyond the edge of the suction cup under the influence of the compression spring ( 67 ). The latter is counteracted by the cable pull ( 66 ), which is guided over the deflection rollers ( 68 , 69 ) and fastened at the end of the locking pin ( 70 ). The trigger grid ( 72 ), which is firmly connected to the device housing, is triggered after the cable ( 73 ) has been actuated. The tension of the spring ( 67 ) via retraction of the locking pin until it engages takes place via the shift linkage ( 71 ) between the end of the locking pin and the cover slide when the latter is pushed back on its cross bar ( 57 ) (as shown below). The cross bar can be located on the far left at the end of the sliding cover. Of the electrical lines to the parts of the slider, only one and only parts are shown. The locking pin ( 70 ) is closed to the suction cup by the sealing ring.

The driver wedge ( 78 ) is held by a holder from the end of the threaded spindle ( 23 ) and acts on the curvature of the leaf spring ( 75 ), which in turn is displaceable along the rail ( 74 ). When it moves to the right, the driver circle overtakes the leaf spring ( 75 ), while it takes it back to the left when it returns and actuates the release grid ( 72 ) via the cable. The leaf spring ( 77 ) lowers the angular U-hook ( 59 ), which projects with one end into the hole in the lower drawer slide ( 61 ) and holds it in place. In this device version, each of the three steel springs ( 37 , Fig. 1) is connected with its own bowstring ( 38 ), each with a drawer slide. The U-hook in turn runs within the sleeve segment ( 60 ) which is rotatably connected to the end of the threaded spindle del. If - as in the illustration above - the threaded spindle is turned into the threaded sleeve, only the lower bowstring is tensioned. After locking in tensioned state (see. Fig. 1) the water can be emptied through the nozzle with reduced force and speed.

When the sliding cover is retracted - as in the illustration below - the wedge bevel ( 58 ) has raised the U-hook against the leaf spring ( 77 ) so that all three steel springs can now be tensioned.

Fig. 4 shows the top of a horizontal section in natural size the detail of an injection cylinder with valve disc ( 4 ) and nozzle ( 5 ). The latter is directed (after removal of the slide with the perforated panel and heating coil) against the suction cup ( 7 ), which is closed at the bottom by the sliding cover ( 56 ). In addition, the four release pins ( 8 ) can be seen in their sleeves.

Under the horizontal section, a part of the suction bell ( 7 ) and a trigger pin ( 8 ) is shown in cross-section in dimension along the section line AB of the horizontal section in the scale 2: 1, which protrudes within a bore of the oriel (which here replaces the sleeve) the Druckfe der ( 83 ) is held down. The cable ( 80 ) is attached to the release pin and leads via two rollers in a slot of the bay projection to one of the four grids ( 88 , Fig. 7) for triggering suction.

Fig. 5 shows in a longitudinal section through the slide with the window ( 64 ) and the nozzle ( 5 ) in the injection cylinder wall on a scale of 4: 1 (the nozzle being oversubscribed even further). The dash-dotted line shows the skin that lies against the window and bulges into the pinhole. The beam led from the light source ( 81 ) to the light receiver runs in a window hole (or in optical fibers with lenses for opening into the pinhole) and just touches the small skin blister. (From the light receiver, the cable leads to the photometer within the electronic control center ( 27 , Fig. 1). The liquid jet (dashed) is bundled by the conical nozzle constriction between the pinhole.

Fig. 6 shows in vertical section on a scale of 2: 1 the attachment of the sliding cover ( 56 ) on a Ge housing wall ( 16 ) as a detail.

FIG. 7 gives an approximately natural size of a vertical or cross section through the inventive example of FIG. 1; the cutting plane lies in the depth of the pipe socket ( 85 ) which has an edge ring at the end. The pipe socket are attached to the cover ( 86 ) via a rubber-elastic plate connection ( 779 ). This allows a somewhat uneven lid closure with a slight tilt. (But why then there must be free space between the edge of the device ( 16 ) and the edge of the lid), ie play must be left. A starting from the device wall Käscher bracket certain Ela stitäts or a kind (not shown) auxiliary funnel on the device base ensures that the edge ring of the pipe socket on the grid carriage ( 288 ) can pass. However, this is only possible when the grid carriage on its raised rail ( 89 ) is pulled back from the trigger pin by means of the cable ( 80 ) via the roller ( 92 ). The open position of the cover remains secured beforehand; the cover and pipe socket are drawn in on the left in the raised position and on the right in the lowered position. The dovetail guide of the grid carriage is visible in its rail in a detail at the bottom right. The grid carriage is reset via the tension spring ( 90 ). The four cables must be actuated simultaneously via the release pins in order to release the lid lift. The bag ( 93 ) between the cover ( 86 ) and the cover plate ( 94 ) of the housing is connected to the suction bell ( 7 , FIG. 3) via the connecting hose ( 95 ). Sub-segments of the bag surface put together in pairs show examples (left as dovetails, right as meanders) for a firm connection between the bag surface and the lower lid surface on the one hand and the cover plate on the other. The location of the springs projecting from within the pipe socket on the housing base - for example near the housing corners - was not recorded in FIG. 1.

Fig. 18 shows a plan view above, including in cross section an adjusting mechanism for the valve disc control (see. Fig. 12) on a scale of 2: 1; cut under the cross. Detail of a locking pin on a 4: 1 scale. The slide ( 303 ) runs on the rail ( 302 ) with the resilient wave profile that can be seen in cross section and is still elastically supported by the leaf spring ( 304 ). On the slide ( 303 ), in turn, the cover slide ( 305 ) is slidable ver. (The slide guide in the lateral grooves due to fold projections on the rail and slide were not shown). The locking pin ( 306 ) is set back into the cover slide. The ball catch ( 310 ), which acts against the sliding bar ( 311 ) and is directed there against its wedge projection ( 422 , detail in the center in cross-section), is embedded on the bridge projecting from the cover slide. When the sliding bar is moved, the lid slide is guided over the wave profile due to the harder spring of the ball catch. With each wave crest, the circuit closes between the spring tongues of the locking pin and the springs of the electrical lines ( 307 ). Together with the result of an actuation or non-actuation of the electric pull switch ( 312 ) on a cable pull, the counting pulses directed to the control center can be used to control the sliding movement and thus the position of the valve disc via the wire core ( 313 ) of a Bowden cable. The sliding bar is shifted to the left (straight) via a cable with reversing roller. The carriage ( 303 ) comes to a stop at the stop bars ( 308 , 309 ). By reversing the movement twice in the manner of a movement loop, the desired valve disc position can be achieved from both starting and end positions of the shift rod (). The ball catcher overtakes in the wedge projection ( 422 ) as soon as it is moved past the slide ( 305 ).

FIG. 19 illustrates in a longitudinal section in a natural size approach of the control of shift rods (for example with the operating phases ad) in the switching function in two extreme positions. The figure shows a roll-up of the components of FIG. 10 in a longitudinal section to clarify the function. On the left in frontal view and a small longitudinal section detail, a locking device for the movement of a shift rod. At the bottom right a cross section through the axes with projection of drive and success organs.

From the motor ( 25 ) and the reduction gear ( 98 ), the drive movement runs via the gear ( 45 ) which can be moved on the square axis, the lateral connection plates of the slide book (not shown) extending to the pinion ( 46 ) on the screw ( 47 ), but also with angle brackets ( 314 ) on the thrust-torsion unit ( 180 ), which can be moved briefly against a cross pin on its axis to the end of the angle. If the end of the angle is pressed against one of the two spring buffers ( 315 ), the axis undergoes a quarter turn and engages in the middle wide groove guide of the adjacent shift rod ( 996 , 273 , 274 ) to take it in the opposite direction.

The detailed illustrations on the left show how the angle arm of the axis of the thrust-torsion unit displaces the spring-loaded sliding fork ( 316 ). The bridge angle (cross-section detail on the right) in turn lifts the bridge angle ( 318 ), which is also suspended downwards, and which is mounted in a cylinder ( 317 ) fixed on the housing base. The bridge angle on the sliding fork is part of the piston movement on the shift rod, which is secured against rotation accordingly. The non-angled rod end of the bridge bracket ( 318 ) is lifted out of the groove guide of the shift rod, after which the latter can be moved. At the other end of the shift path, the spring-loaded rod end of the left bridge angle gets into the narrower left groove via the bevel of the piston expansion of the shift rod and holds the shift rod, which is now left by the angle of the rod with the thrust-torsion unit.

Fig. 20 shows the solution of a two-sided switching operation at a shear-torsion unit above in connection motor and the bottom of the Gegenendposition. The representation is in longitudinal section on a scale of 2: 1, for the detail of a thrust torsion unit on the right of it on a scale of 4: 1.

The detail reveals that a pin extending from the shift cylinder ( 321 ) extends into the guide slot ( 320 ) of the envelope cylinder, which permits limited shifting of the shift cylinder against an external spring and the rotation of the shift cylinder within the from the fork to the gear ( 45 , Illustration left) held envelope cylinder prevented. The shift cylinder has a zigzag groove profile far inside, into which the cross pin ( 322 ) of the central axis extends.

Depending on the direction of rotation of the motor, the pinion ( 46 ) on the screw ( 47 ) causes the thrust-torsion unit ( 180 ) to shift laterally. The plunger ( 323 ) on the right is connected at an angle to the push rod ( 324 ) which carries the ball catch ( 325 ). The latter is located between the rack for the gear ( 45 ) on the square drive axis to the motor. A right fork shoulder prevents the ball catch from leaving its seat between the fork legs to the right. If the push-torsion unit pushes against the outer compression spring and the buffer rod ( 326 ) during left-hand movement, the latter prevents the envelope cylinder and the fork from moving to the right, so that the ball catch leaves its seat in the recessed recess of the push-rod ( 324 ). The latter moves the plunger ( 323 ) against the inner shift cylinder and actuates it with partial rotation of the axis. (The outer compression spring leads the shift cylinder back into the vertical distance of the groove guide.) An axis rotation in the same direction is achieved if the thrust-torsion unit is moved all the way to the right. Only now the shift cylinder is prevented from further displacement by the buffer sleeve ( 326 ). On the other hand, the compression spring acts against the envelope cylinder (lower illustration). The tappet ( 323 ) can escape through a gap ( 327 ) in the axle bearing.

FIG. 21 shows a top view of the bottom of the housing ( 16 ) of the release mechanism for the four cover springs (x, FIG. ??) for generating suction.

To shorten the display, the bottom part is interrupted; the width of the floor plan has also been reduced to around half. The shift rod ( 328 ) has two piston-like expansions with grooves for driving by the angle of the axis of the thrust-torsion unit ( 180 ). The latter is only actuated on the left side against the outer spring buffer ( 315 ). The axle can be moved within the axle bushings ( 329 , 330 ) and is rigidly connected to the holding sleeve ( 331 ). The cables ( 80 ), which are guided over deflection rollers ( 332 ) and whose ends attach to the four grid slides ( 88 , FIG. 17?), Are attached to the latter. The cable springs interposed tension springs ( 332 ) allow the sliding movement of the shift rod ( 328 ) to continue even after triggering the strong compression springs in the four pipe sockets ( 85 ), which occurs both when the shift rod is shifted to the left and to the right. During the right shift, the driver pin ( 334 ) is shifted to the right via the cross bar ( 333 ) on the shift rod. The driver pin is based on a square rod that actuates a cable. ?? In the final phase of shifting the shift rod to the right, the pressure switches of the two Bowden cables ( 283 , 285 ?, Fig. 11) are actuated and thus the strong compression spring ( 277 ) is triggered, in which voltage position it is in each case. When the shift rod is shifted to the left, it hits the pressure switch ( 335 ) in the final phase. Using a Bowden cable, this moves a valve cone ( 336 ) against a flat spring and triggers the re-ventilation of the suction bell (of which only one wall segment is shown).

. The 22 shows in longitudinal section on a scale of 4: 1 is a sleeve (691) engaged within the lips as sealing a funnel-shaped Saugglockenöffnung (337). The front elastic piston ( 338 ) inside the sleeve carries the sensor thread ( 341 ), which lies in its front half near the suction cup inside the bore of the guide cylinder ( 340 ). The front piston as well as the rear elastic piston ( 339 ) each have a funnel trough with a bag-like extension towards the rear towards the plunger ( 344 ), into which the expansion punches ( 343 ) can penetrate. Both the rear piston ( 339 ) and the plunger ( 344 ), which, as a component of the device, mediate the pushing movement, have such an expansion stamp. Lateral openings in the sleeve in the vicinity of the guide cylinder - some can be fine-pored for the air outlet and be closed by a special membrane ring with a separate opening mechanism - are closed by the film-like protective membrane ( 346 ). The opening can be brought about by increasing the pressure inside the sleeve or via the electrical glow wire ring ( 347 ) via corresponding electrical lines from the electronic control center. This happens during or before the water trapped between the two elastic pistons by advancing the rear piston - until it is coupled to the front - via a channel in the front elastic piston. Again, the channel is closed before use. An annular welding of the front edge of the piston ( 338 ) can be released by the inserted heating wire spiral ( 348 ) after passage of the water into the front sleeve chamber. A sudden caliber narrowing of the sleeve or internal knobs in front of the front piston rim can also serve the same purpose. (The middle figure shows the functional stage just described). Two sleeve cross-sections can be seen at the top right, in order to represent the interlinking of the sleeves by means of two elastic threads which are led through the bores of the outer knobs ( 345 ). Below is shown the stage in which the plunger ( 344 ) penetrated the sleeve at high speed, drove the two pistons in front of it and expelled the water from the lateral sleeve openings. The sensor thread was driven out of the front neck constriction of the guide cylinder ( 341 ), which lies directly against the skin in the suction cup (not shown). When the plunger is retracted, it also takes back the two pistons due to the adhesion to the expansion plungers, so that the front part of the guide cylinder lies.

This hole has on the surface two mutually insulated metal strips (made of silver, for example), from which measurement currents are tapped or passed and fed to the measuring device in the control center. The line contact can be guaranteed similar to a light bulb socket by continuing the metal strip on the front of the receiving cylinder, from where the current flow via a kind of crescent-shaped spring washers ( 350 ) within the bell jar funnel it follows via lines to the measuring device.

Below is a natural size of a drive variant for the rear elastic piston ( 339 ), in which the protective membrane ( 351 ) is opened by the heating wire loop ( 352 ) on the end of the plunger ( 344 ) after contact. The sealing ring ( 355 ) on the plunger ensures that the interior of the sleeve is sealed after the plunger has been inserted. Via a central channel in the plunger, compressed air is fed into the space behind the pistons ( 339 ) through the central bore in the plunger via the hose ( 356 ) via the heating chamber ( 357 ) from a compressed air reservoir that was created in the bag under the device cover ( 344 ) initiated, whereby this is pushed forward and displaces the water from the intermediate piston space. The plunger is sealed against the sleeve by a sealing ring ( 42 ).

Figs. 23 are, in turn, shows a longitudinal section on a scale of 4: 1, a variant sleeve again including an apparatus for operation thereof. The front end of the plunger ( 344 ) has a dome-shaped extension which has the heating wire loop ( 352 ) around a central channel opening. The dome-shaped extension penetrates into a hollow plastic cap ( 359 ), in which the sensor thread ( 341 ) is inserted centrally towards the front. The tappet channel (the illustration has been shortened due to lack of space) opens on the right into the pump cylinder ( 360 ), the piston of which is only indicated in a very fragmentary manner and is driven by the central rod (, FIG. 11). (The blocking grid ( 361 ) inhibiting the movement of the pump cylinder until after compression of the medium in the pump cylinder by the piston was only hinted at). If the medium is air, it enters the pump cylinder chamber via the check valve ( 362 ) when the piston moves back. Preferably, however, the medium is water, which is taken from the bellows ( 363 ) via the check valve, the compressed air container surrounding it (analogous to FIG. 10) not being shown here.

Inclined channels ( 364 ) are provided in the guide cylinder for discharging air or water from the inner sleeve space, one of which is shown. The protective membrane to the outside air must again be opened before or during use. (Cross section with a heating wire loop at the top). The heating wire loop ( 358 ) for opening the membrane above the outlet opening of the sensor thread (greatly oversized in terms of size) with its electrical lines can also be used for the contact message through the neck of the sleeve - that is, for checking its seating. The lines ( 365 , 366 ) lead from the metal strips for tapping the measuring currents of an electrically active or passive sensor (primarily for glucose) to the measuring device.

The Fig. 24 demonstrates in schematic cross section in natural size above the action of a single pressure transducer in the form of a square pin (10) with the end roller (11) successively to the wedge bevel of the injection cylinder piston (2, 165). The edge knob ( 224 ) of the injection plunger ( 2 ) causes the injection plunger ( 165 ) to begin its downward movement even in the final phase of its lowering. The moment of movement arises under the action of the tensioned steel spring ( 37 ) over the bowstring ( 38 ). In the longitudinal section below, the arrow indicates the direction of movement of the square pin as a pressure sensor. The positional relationship of the injection cylinders ( 1 , 225 ) to the suction cup ( 7 ) can also be seen. The triggering process has been described with reference to FIG. 11.

In detail from the end of a steel spring at the top left it is shown that the bowstring ( 38 ) can be guided in both directions for the two main force functions in the opposite direction in addition to a single steel spring (longitudinal section on the left). The frontal section shows that for this purpose the ends of the steel spring, to which the single bow tendon is attached, are angled.

Other side free.  

FIG. 25 shows the top of the cross section in real size the mechanism for the sleeves transport out of the bush chain in the position for use in the suction cup. About a support on the Ge housing bottom rotates the ellipse ( 376 ) whose extension in the form of a half-groove segment ( 367 ) has a sleeve ( 691 ) with its neck pushed through the seal of the suction cup opening. (A kind of herringbone profile of the sleeve surface can facilitate the attack of the semi-gutter segment.) The traction cable ( 368 ?) Is tensioned in the outermost position via a roller under the action of the square rod with the driving pin ( 334 , Fig. 21). The outermost opposite position of the ellipse under the action of the pulling rope ( 369 ?) Is shown in dashed lines from the rod ( 292 , Fig. 11). The slanted sleeve shown in dashed lines is grasped by the leaf spring ( 370 ) while stretching the (not shown) rubber threads to the neighboring sleeves and pushed forward downwards when the ellipse is turned clockwise. The half-gutter segment is shown on the right as a detail in the frontal section. The pulleys for the cable ( 369 ) are located under the cover plate (see Fig. ??). Only the right side wall of the suction cup is shown. The tension spring ( 371 ) stabilizes both end positions of the ellipse movement. The arch of the bridge ( 372 ) stabilizes the sleeve position after insertion in the seal to the suction cup.

Below this, the trough recess ( 373 ) for receiving the sleeve ( 691 ) is shown in a longitudinal section on the left and in a frontal section on the right. The cable pull over the roller ( 374 ) acts on the U-slide ( 375 ), which has the pin guide ( 376 ), to actuate the sleeve plunger for a sleeve variant for advancing the rear elastic piston or sealing the sleeve end with compressed gas or Influence of liquid pressure by coupling the cable with the strong compression spring (see Fig. ??).

Fig. 26 shows above in a scale of 2: 1 with somewhat oversubscribed sleeve size, the arrangement in a transport chain in frontal section. The sleeve chain runs over the two side spools or transport drums ( 290 , 291 ) over a curved roof rail and below over an inclined link with a deep incision for lowering the sleeve against the edge of the suction cup. In which incision does the ellipse ( 360 ) engage and has a sleeve led downward with the warp threads stretched (as shown in FIG. 25).

The zigzag guide of the pin for drum rotation is shown greatly enlarged as a roll-up on the lower left. To the right of it in natural size, the engagement of the spring-back pin ( 287 , see FIG. 11) in the backdrop profile of the transport drum.

Fig. 27 shows a longitudinal section through a device for delayed execution of a sleeve change after shifting the transport rod for the function row b right, an overrunning pawl for three functions in succession. (These functions correspond to function b! (For example between phase A / B in Fig. 28) for function-free end sections for switching the thrust-torsion unit ( 180 ). Below the wing cross ( 296 , see Fig. 11) the leaf spring louvre ( 379 ) is shown on the left in a frontal section for the stabilization of the wing cross position. To the right shows the detail of a wing, such as the end of the (shortened) rod ( 380 ?) with a ball of an oblique flank with an angle below 45 degrees in order to reduce the frictional forces for the triggering process. After the left displacement of the rod ( 380 ) has been released, the compression spring ( 382 ) becomes effective. The force is transmitted via the cross plate ( 384 ) on the rod ( 380 ) to the cross plate ( 383) ) on the sliding plate, which lies below the rod in the laterally overlapping rail guide ( 385 ). Below this is a profile strip ( 386 ) with angled widening g on the housing base in the rail ( 387 ) can be moved parallel to the tension plate ( 392 ) and is pressed by the compression spring ( 388 ) against the ellipse ( 389 ). This ellipse is only shown in the lower of the three adjacent longitudinal sections (AB, CD, EF) at a stage in which it has transversely displaced the ellipse by the compression spring ( 390 ) after the tension on the rope ( 391 ) has subsided. It displaces the profile bar to the right. Below is a longitudinal section just below half of the tension plate, but only partially and two of the cross section above. The head sleeve ( 393 , top right in detail in 2: 1 scale) protrudes through a hole in the tension plate, the bottom collar of which is pushed along the profile strip. The inner pot ( 394 ), on the other hand, is raised against the base collar by a compression spring, so that its base edge falls from below against the tension plate. When the tension plate is moved, the three parallel head sleeves are taken along. On the profile heights, the head sleeves protrude higher from the tension plate and thus push the respective sliding sleeve ( 395 ) on its square rod with its own bearing in front of it. Various working functions are coupled with the sliding sleeves. At the thinner parts of the profile strip, the head sleeve (with a suitable bevel of the contact surface) detaches from the sliding sleeve and moves under it. If the tension plate is pulled back to the right after the work functions (by rope pull), you must also cross the ellipse 27958 00070 552 001000280000000200012000285912784700040 0002019647683 00004 27839rch rope pull so that gaps in the profile allow the head sleeves to move past under the sliding sleeves. An alternative solution to the problem is given in FIG. 30.

Fig. 28 gives 2: 1 in a longitudinal section details for a power transmission from the right end of the strong compression spring ( 277 ) to the sleeve ( 691 ) to insert them into the bell jar when the strong compression spring is tightened from the right. The same mechanism can be used to keep a pipe joint tight from the device, if pressurized gas or liquid is to be introduced into the sleeve from there. The parts in the space between the trough trough ( 373 , see FIG. 25) and the strong compression spring have been omitted. The bolt ( 275 ) connected to the central rod ( 272 ) via the angled rod ( 276 ) has guided the strong compression spring to the right and tensioned it until the ball engages in the recessed recess of the central rod. The right end of the compression spring now only lies against the strong frame in the housing recess. Previously, she moved the rotary hinge ( 396 ) to the right from the position shown in dashed lines. As can be seen from the cross-sectional detail above, the rope ( 397 ) via the roller ( 374 ) on the perforated ring ( 398 ) takes effect, pushing it to the left. Two or more opposing ropes can be used to reduce friction. The pin guide ( 376 ), the spring back of which has not been shown, is also used for stabilization next to the trough recess ( 373 ). The opening in the perforated ring is chosen so that the ring of the Hülsenwan application but allows a central plunger to pass from the central rod. The rotary hinge ( 396 ) is spring-back.

Fig. 29 shows a circuit diagram for the mechanical functions again when using a thrust-torsion unit under the action of the sliding action of the spindle or screw ( 47 , Fig. 11, ??) with switching in both directions (indicated by arrows).

Of the four switching options (ad, see Fig. 19?) Only three are occupied. (The fourth could automate the adjustment of the total injection quantity to the drug dosage. The screw bolt ( 13 , Fig. 10) would be designed as a screw with a shift lever, the end of which would be actuated by the shift rod with function d via the control center ). L is the grid in the left grid pot ( 280 ), R is the one in the right grid pot ( 281 , Fig. 11). The large rectangle delimits the frame of the sideways movement of the strong compression spring ( 277 , Fig. 11). The hatched squares correspond to the grid pots, the inner circles of which are the grid elliptoid. It is drawn in black when it is snapped into the central pole in the functional stage marked with capital letters. The Li, which is guided by the free guide, never bends to the right indicates the position of the central rod.

During each extreme movement, a switch (not shown) takes place in the thrust-torsion unit. Switching after engagement of the side knobs ( 48 , Fig. 19?) In the gears for the rotation of the screw sleeve ( 278 , Fig. 11) and thus the tension of the strong compression spring ( 277 ) are inevitable. The switching distances themselves are not assigned any other switching functions. The frequent reversals of the motor running direction for switching over to the correct shift rod and the need to lock it can be avoided if the function rod for c is assigned functions as described in FIG. 21. It is particularly important for the injections that the compression spring can take effect immediately after the suction is triggered. In this case, only a single switchover function of the thrust-torsion unit is necessary and the short partial movement in the switch position c between B / C and DIE, as described in the diagram, is eliminated. I always denotes the right-hand movement, II the left-hand movement of the respective shift rod.

FIG. 30 shows an alternative solution to an overrunning pawl according to FIG. 27 for the step-by-step actuation of three functions in succession in the course of a single shift of the function rod (such as for b I FIG. 29). Three sliding sleeves ( 395 ) are adapted to the functional paths and distances on a few square bars and are moved one after the other by the stop angle ( 400 ) which is moved to the left via the shift bar by the engine. They operate their cable pulls to the right, unfolding the adapted tension spring sections ( 399 ). The function is performed with the tension spring section extended. The effort required for the motor is constantly increasing because the stretching continues beyond what is necessary for the individual function, but this can be portable with a spindle drive.

Fig. 31 time in longitudinal section on a 4: 1 scale, a sleeve for the insertion of a sensor thread similar to that in Fig. 23. However, the rear elastic piston ( 339 ) is extended by the pin ( 401 ), the end of which extends to the plunger of the ram ( 344 ) runs thin-walled to penetrate it and allow it to snap together. The perforated ring ( 398 ) conveys the rear piston to the inside to displace water (left), as described in FIG. 28.

Fig. 32 shows in longitudinal section in natural size a detail of the sensor brake according to Fig. 34. It is a frontal section which makes it clear that the cross plate ( 413 ) of the switching cover ( 406 ) against the stop by the tension spring ( 417 ) of the bracket fixed to the device. To rotate the switching pin, the cable ( 414 ) is actuated via the roller ( 419 ) with the result shown in dashed lines.

Fig. 33 gives an electrical circuit diagram on the most important control functions of the electronic control center ( 27 ). Three touch switches ( 139 ) are operated from the edge of the suction cup. The suitability is reported by the respective window ( 64 ) - the second for the injection is on the left opposite. At least the end positions of the shift rods ( 996 , 273 , 274 ) trigger feedback. Metabolism measurement signals reach the measuring device in the control center via the measuring lines ( 501 ). Count signals come from the locking pin ( 310 , Fig. 18) or under a locking device directly under the lever of the valve disc ( 4 ). It is shown above the suction cup ( 7 ). The strong compression spring ( 277 ) is initially slightly tensioned when the motor starts until the inhibition of the rotation of the screw cover ( 275 , Fig. 11) is high enough to initiate the transmission of force to the shift rods. The process is monitored on the sliding contact ( 403 ) on the angle rod ( 276 ). The malfunction of a locking grid on the central rod within the compression spring ( 277 ) can thus be detected. Line connections also run from the battery ( 26 ) via the control center to the motor ( 25 ) and to the magnets ( 554 ) of the dosing device. The list is therefore not complete.

Figs. 34 shows a mechanical braking device for the sensor in connection with a thread Dosierhydraulik in scale 4: 1. Top three functional stages of operation of the brake claws (404) in the frontal section. A longitudinal section in the middle and a cross section below. The brake claws are held by the two hinge segments rotating about a common axis, which arcuate the switching pin ( 406 ). Against the compression springs ( 407 ), the cross pin ( 408 ), which is provided with an end collar, is pressed downwards in the slots of the hinge segments by the switching pin in the direction of the sensor thread between the brake claw ends that almost touch there. The brake claws are brought together on both sides by compression springs on the cross pin.

On the cross section below it can be seen that the axis ( 409 ) is attached to the wall of the suction cup ( 7 ) and that the switching pin in the middle section (shown as cross sections) has an elliptical flattening. The switching pin is rigidly connected to the piston of the plunger ( 344 ) shown in the end section only (as indicated by dash-dotted lines by the length of the drawer to the right leaving the thrust function open). 408 ) in the slot of the switching claws, the ends of which come into the slots ( 410 ) in the sleeve ( 691 ) and, by means of a wedge shape (not shown), also contribute to their insertion into the sealing ring of the suction bell funnel. The brake claw ends lie in the slots of the sleeve directly to the elastic carrier hose ( 411 , made of rubber or plastic) In order to create a pushing space for the switching pin, the spreading mechanism with the cross pin ( 408 ) is shifted to the right according to the dashed arrow and the brake claw pair using connecting rods ( 412 , top in frontal section) brought to the right in the position shown. In stage C on the frontal cut, the axle pin on its cross plate ( 413 ) is rotated by 90 degrees via the rope ( 414 ) fastened in its eyelet via a roller, whereby the brake shoes are spread apart again and with (not shown) springback of the When it is withdrawn, Achsbelzens leave the slots in the sleeve. The rotation mechanism has been described in FIG. 32.

On the cross section below you can see that the cuff ( 415 ) on a cross pin is only moved by the axle bolt ( 406 ) when the piston of the tappet ( 344 ) against the diaphragm ( 416 ) into the funnel-shaped projection supported by a device backdrop of the carrier hose ( 411 ) has penetrated and the water stored there began to displace under thread ejection. The thread end is clamped in the carrier hose before it leaves the carrier hose and is also heat-welded to it by means of the heated brake claw ends (not shown). Below is the detail of a longitudinal section to illustrate the spreading of the brake claw ends by changing the cross-section of the brake bolt moving past. The sealing plug ( 421 ) at the end of the sensor thread prevents water from entering during storage in water-absorbing sensor thread; it is preferably metal or metal-doped if it is used as a lead-off electrode for measuring currents.

Fig. 35 shows a 2: 1 scale. Storage of the sensor threads ( 341 ) by means of their carrier hoses ( 411 ) in bores ( 424 ) of a drum ( 423 ) at the top in a frontal section and at the bottom in a longitudinal section. At the top right in 4: 1 scale, the detail of a sensor thread variant in the carrier tube.

The drum ( 423 ) rotates about the axis with a blind bore ( 425 ), the latching of the sector movement - similar to the metering device Fig. ?, By means of a stepper motor or like the transport drum ( 291 , Fig. 11) - was not shown again . From the axis ( 425 ) goes from a fixed pipe leg ( 426 ) through which the transport medium for the thread weft (compressed air or water through the blind hole in the hole ( 424 ) is introduced, which faces the seal of the opening funnel of the suction bell ( 7 ) The transport sleeve has a collar ring which is pushed forward in a starting part of the bore with further clearing from the drive medium in the event of a slight pressure surge, so that the carrier sleeve is sealed in the seal of the suction cup. The strong pressure wave of the transport medium throws the thread through the The sensor thread is braked by the brake shoes ( 404 ), which are actuated here by an electromagnet in the manner of a slot closure of a camera (cf. FIG. 36). To the right of the drum ( 423 ) a second wider drum ( 427 ) abuts the pipe leg ( 426 ). The holes and larger lights ( 428 ) correspond in number and distance to those of the drum ( 423 ). The sliding pin ( 430 ) can be withdrawn completely from the drums from a guide tube ( 429 ) which is only indicated. The tip of the push pin is heated via the glow wire loop ( 431 ). After firing the sensor thread, the heated tip can be brought up to the collar of the carrier tube and glued to it. (The mechanical principle as for the tappet ( 344 ) in Fig. 23 can also be used.) With the push pin, the carrier sleeve and the sensor thread are withdrawn into the bore ( 428 ) and the carrier sleeve is stripped from the push pin end by the leaf spring ( 432 ). The movement of both drums is ensured by the spring-back coupling pin ( 433 ). The drums are pressed together by the wing nut ( 434 ) and pressed to the left to the suction cup. The channel for the transport medium is sealed in the area of the pipe leg ( 426 ) by sealing rings. The function of the wing nut is advantageously carried out by two or three hooks ( 435 ) distributed around the circumference of the right edge of the wide drum. The latter are operated via a cable train and mechanism analogous to that for the sleeve pressure in FIGS . 25, 28).

The variant of a sensor thread storage at the top right shows a slight piston expansion ( 436 ) at the end of the sensor thread, which can be pressed through the elastic carrier tube ( 411 ) by the pressure of the transport medium. There is also yet another variant in the form of the sensor thread pushed open sliding rings ( 437 ), which are pushed together during the thread extension from the carrier sleeve. The sensor thread is stored in a bore of a drum ( 423 ).

Fig. 36 shows in natural size in cross section at the top left the variation of a drum ( 423 ) like that in Fig. 35 to demonstrate a special metabolic measuring tap. To the right of this is a stage in which the drum has been shifted to the right. Below details of the area around the suction bell funnel in the scale 2: 1, on the far right in the frontal section in the scale 5: 1 the detail of a special measured value recording on the brake claws for the sensor thread. In functional stage A, a sensor thread is inserted in its carrier hose into the suction bell funnel. By means of the cable ( 438 ) in stage B the drum is moved to the right after injection and braking of the sensor thread via the electromagnet ( 439 ), which approaches the upper flat brake claw guided in a rail to the lower fixed brake claw. A second thread brake is actuated by the electromagnet ( 440 ) and takes sensor thread near its tip. Measuring currents can be picked up and fed to the measuring device via lines from both pairs of brake claws. The sensor thread can also be stored in the drum without a sleeve or carrier hose and, after opening the brake shoes, spring back into the magnet and fall into a collecting trough (not shown). The function can also continue in the manner described for FIG. 35. The right detail shows that the clamping jaws around a sensor thread are marked by a crescent-shaped incision, on which various mutually insulated measuring contacts are located. In this arrangement, sensor threads are used which have two electrically insulated strip-shaped metal layers on their surface. Two opposing measuring contacts can be queried in the measuring device and the measurement result can be evaluated if a potential builds up between them or current flows. (The measuring layer is shown as a contour reinforcement at the bottom in frontal section. The drum is reset by thrust from the claw ( 441 ).

Fig. 37 shows the top left of a detail of the end of a carrier tube or sleeve for the sensor filament (341) having an internal bore here, so represents a capillary. This capillary also has a metal doping on the inner surface of the bore or can be filled with an electrolyte (in the case of a metal sealing plug ( 421 , FIG. 34). This plug or the inner capillary coating is contacted by the tip of the plunger ( 344 ) for measurement.

Including first a frontal section, then a longitudinal section of a variant of the drum ( 423 ) for the storage of sensor threads. In longitudinal section, such a sensor thread is inserted into its carrier tube at the bottom. Its end is connected to a radial lamella ( 442 ) that leads to the drum axis. About the obliquely angular push rod ( 443 ) is directed against a tension spring by cable by means of a cuff running on the push rod, a spring-loaded slide with end claw on the protruding end of the radial plate. In the stage shown below, the carrier tube was already pulled out halfway and the sensor thread returns (after the weft) into the hole, where the metabolic substances of interest, when the sensor thread is swollen, can transmit measurement signals to the control center with the reaction layer ( 444 ) via lead wires . The drum is a disposable part. Only three of the radial fins are shown in the frontal section.

Fig. 38 shows approximately natural size two kind of double-acting leaf springs, which is layered on both sides and which can be used as a drive source instead of the torsion spring in Fig. 11. The tension is carried out via the central rod which is passed (or through a central hole).

The left tendon ( 447 ) is connected to the central rod by the left grid pot ( 280 ) with the ball grid (black). It is tensioned when the central rod is moved to the left by the motor and can be released for operation. In the tensioned state, the latching takes place beforehand in the grid ( 448 ), which is connected to the function rod.

Fig. 39 shows in longitudinal section an injection device for crystalline stretched thread-like drugs. The cylinder ( 449 ) for the bullet is firmly installed in the suction cup ( 7 ) at its lower edge. After the sealing ring ( 450 ) there follows the transparent cylinder ( 451 ) with the photoemitter ( 452 ) and photosensor ( 453 ) and again a sealing ring. The cylinder segment ( 455 ) can be folded down against the spring ( 454 ) by means of a pull rope via a hinge joint. The end seal of the cylinder segment is directed after extension by the spring against the mouth of the drum ( 456 ) in which the crystals or medicament threads are stored. The heated sheet metal discs ( 457 ) keep the drum bores clean by intermittent heat application. The crystals are fed via the push pin ( 458 ) by means of the motor spindle. (The representation of the push pin and its guidance is greatly shortened, the drum axis is actually turned steeply from near the ground.) The metal bellows ( 460 ) ensures that the seal closes securely right up to the cylinder ( 449 ) after charging with compressed gas. The valve is shown in a 4: 1 enlarged detail, the spring-loaded ball of which passes the (far oversized) medication rod with a slight "charging flow" from the tube ( 462 ). However, if the injection is made from the direction of the arrow into the tube crossing, the ball seals the insertion channel for the medicine. The dosing takes place according to the optical control in the transparent cylinder ( 451 ). The measured light intensity is weakened with the length of the drug stick that penetrates into the cylinder. The commands corresponding to the dose information provided by the control center are sent to the motor for the push pin movement and to the cable pull in order to break off the corresponding excess portions of the medication stick.

Fig. 40 shows up in a schematic cross-section above the injection nozzle and the bottom of a longitudinal section of the same detail a solution for a jet injector for liquids with three injection cylinders. In cross section, the dashed lines indicate that in the two upper cylinders via valves, not shown here, both from the two medication cartridges ( 463 , 464 ) via metering spindles, quantities of medication are dispensed into one of the cylinders (for one of the medications). For dilution, either water or thinner from each of the bellows ( 465 , 466 ) is added to both upper cylinders, depending on the position of the valve ( 467 ). The lower third cylinder is always only supplied with either water or thinner. The injection via the nozzle in the center takes place via the piston movement, the upper pistons being interconnected with one of the two wedge slopes ( 468 ). (Natural size detail seen from the top right).

Fig. 41 shows a horizontal section of a spherical exchange pressure gas container ( 178 ) - for example for CO ₂ - with inner socket ( 179 ) for the pressure tappet ( 183 ).

The seal before use is made by the press fit of the tappet with its taper ( 189 ) at the end and at the ring edge ( 184 ) by means of a glow wire loop or a limited conductive material zone that is electrically insulated from the environment. The central alignment against the injection plunger ( 2 ) is carried out, for example, by the edge slide ( 135 ) on the edge of the nozzle, which is guided in a guide fork ( 186 ) fixed on the injector base, supplemented by the counter lamella or fin ( 187 ) in a device rail. The height adjustment can be done through the open sliding cover ( 56 , Fig. 1). Melting of the ring edge by direct current releases the movement of the pressure plunger ( 183 ) directed against the injection piston. Such an equipment benefits the miniaturization of the injector. The injection plunger ( 2 ) and the connecting hose ( 170 ) for filling the intermediate plunger chamber are designated by the two-plunger syringe.

The detail at the bottom right shows a variant of greater functional reliability. The plunger is replaced by a cartridge (or a hollow plunger, 196 ). In it, the strong compression spring ( 198 ) is in tension against the cover ( 197 ) with an edge spout against the gas pressure. The latter has an effect on the gas supply opening ( 201 ) in the inner socket ( 179 ), which presses the cover against the sealing ring ( 200 ). The compression spring pushes the lid into the open position shown in dashed lines as soon as after the sealing seal (for example made of wax) has melted in the narrow inlet opening ( 199 ) in the inner socket by pickling the same by means of the heating wire ( 123 ), the gas entry is made possible. At the same time, the ring edge ( 185 ) around the opening of the inner socket for the hollow plunger is melted by further heating wires, so that the latter is shot out of the exchange compressed gas container ( 178 ).

The Fig. 42 shows the solution for the drive of a part of the mechanical control mechanism by a small electric motor (97) from the motor axis of the small electric motor of the power flow passes via a small intermediate gear (98) to reduce rotational speed and then continues through the transmission gears ( 99 ) to the working axis. This can actuate a dosing spindle, in which case two such devices are expediently used for the dosing. It can be injected more quickly.

Fig. 43 shows two for the purpose of a Dosierspindelan drives interconnected solenoids ( 100 , 101 ) in 2: 1 scale. The magnet armature with its rounded end against small spline teeth of a (in roll-up and partially shown) gear. In front of the left magnet ( 100 ), the gear ( 102 ) is rotated in small increments via a ratchet gear, which drives the metering spindle. The work of the magnet ( 101 ) is carried out accordingly, but the rotational effect on the gear ( 102 ) via the intermediate gear ( 98 ) is increased. The ratchet gears arranged against each other together cause the gear ( 102 ) to rotate or at least do not hinder one another. Coarse and fine dosing and thus total dosing can thus quickly follow for one type of medicine.

The leaf spring ( 143 ) stabilizes against the undulating surface of the wheel connected to the intermediate wheel ( 108 ) ( 144 , detail cut vertically to the right) whose sector movement and counts the cans by contact actuation in line connection with the control center.

The gear ( 107 ) on the micrometer screw ( 106 ) is held by the fork ( 134 ) in engagement with the idler gear ( 108 ) and prevented from lateral evasion. When the gear ( 102 ) rotates by means of the magnets ( 100 , 101 ), the micrometer screw is moved to the left and drives the plug ( 140 ).

Claims (26)

1. Device for controlling the metabolism of a living being by means of chemical-physical determination of at least one substance by introducing a carrier for the substance to be determined under the skin of the living being in order to connect the substance to be determined to a measuring device, preferably in connection with an injector with the possibility of program control as a function of the measurement data collected, characterized in that mechanical means are present to introduce the wearer at least through the epidermis into the body of the living being without a sheath through a cannula and to prevent it from penetrating completely over a predeterminable distance or at least in parts of the body, preferably in conjunction with means of introducing medication into the body under pressure without using a cannula. 2. Institutional metabolic control procedure of a living being by means of chemical-physical determination at least one substance by introducing a carrier for the substance to be determined under the skin of the living being in order to determining substance in connection with a measuring device bring, preferably in connection with an injector with the Possibility of program control depending on the collected measurement data, characterized, that this carrier has an extent of at least one and a half Millimeters in length and at most one millimeter in diameter at least within the body and without sheathing through inserted a cannula into the body and then out of it again Will get removed.   3. Device according to claim 1, characterized, that to the means a device for producing a skin fold heard and a mechanical arrangement of functional parts such that the introduction point of the carrier and the drug on the respective skin fold opposite and around one Skin fold width are apart. 4. Device according to claim 1, characterized, that at least one spring as a means for generating the pressure serves to introduce the carrier, which by arrangement of Grids and drive circuits for tensioning and triggering the spring also for generating the pressure for the Drug injection can be used. 5. Device according to claim 1, characterized, that to prevent uncontrolled movement of the wearer for a type of brake shoes are provided for a substance to be determined, preferably using at least one electromagnet for the brake shoe actuation against the carrier. 6. Device according to claim 1, characterized, that function as an electrical conductor for measurement purposes a capillary as a carrier of the substance to be determined metals are introduced, which after the unintentional whereabouts of the Wearer in the body with their molecular cohesion at the latest lose the wearer's dissolution.   7. Device according to claim 1, characterized, that the carrier for the substance to be determined is among others especially in the vicinity of the circumference in the bore of one revolver-like drum is rotated about its axis, preferably surrounded by chemicals relevant to measurement. 8. Device according to claim 1, characterized, that to introduce the wearer this within a coat from one under pressure during insertion into the body set medium is surrounded, this medium is preferably short is liquid introduced before introduction. 9. Device according to claim 1, characterized, that about a power transmission on one against the counter bearing one tensioned spring-facing lever on closing means for the skin-directed channel for carrier ejection. 10. Device according to claim 1, characterized, that medicine brought into rod form in individual holes stored in a transparent pipe segment using shear agents to be spent, and away from the insertion site into the body Pipe segment from the dosing axis after optical length measurement the rod swiveled out of the axis line of the feed channel can be made to bend the stick according to the dose downsize.   11. The device according to claim 1, characterized, that a measured amount of liquid by a pressure sensor Introduction of the wearer during this introduction into the body a space is introduced behind the carrier, preferably at Storage of this liquid in a sleeve surrounding the carrier and enclosed by at least one membrane.   12. The method and device according to claim 1 and 2, characterized, that the thread or the capillary in a hose end is stored that is temporarily pressurized to  to ensure guidance of the thread or the capillary. 13. The method according to claim 1 and 3, characterized, that means the end of the hose as part of the device at least one biased spring quickly against the skin is moved. 14. The method according to claim 1 and 3, characterized, that the hose end rotates and the The thread or the cannula is brought into the skin like a drill will. 15. The method and device according to claim 1 and 2, characterized, that the hose end after penetration of the skin through the End of the thread or capillary relaxed and the latter by means of a guide pin as part of the device pushed a long way under the skin will. 16. The method and device according to claim 1 and 2, characterized, that the thread or the capillary within a Sleeve are stored, which they after loading shoots into the skin with compressed gas. 17. Device according to claim 2, characterized, that the hose end inside two contains electrically isolated metallized strips, which with external contacts signals from after wetting with Tissue fluid withdrawn thread or cannula for Run the measuring device. 18. Device according to claim 2 and 8, characterized in that the metallized Strips of reagents are deposited  which with the tissue fluid from the thread or of the capillary react to generate signals. 19. Device according to claim 2, characterized, that the wall of the capillary for tissue fluid is permeable. 20. The method and device according to claim 1 and 2, characterized, that a thread or a capillary in front Has portion that is placed like a cylinder and at least at one end with a measuring layer Contains reagents whose be by metabolic products The color change is recorded photometrically. 21. Device according to claim 2 and 11, characterized, that both bottom surfaces of a small cylinder with Reagents are loaded, which are evaluated photometrically will. 22. Device according to claim 2 and 11, characterized, that he filled with reagents for a color change Cylinder also contains hygroscopic layers and with one of its ends in the end of a carrier thread is let in. 23. The method and device according to claim 1 and 2, characterized, that the insertion of the thread or the capillary in or under the skin at the base of a mechanically generated one Skin fold occurs as part of the device. 24. Device according to claim 2 and 14, characterized,  that the skin fold by suction inside a suction cup he is witnessed and the mouth of the entry channel for the Thread or the cannula into the suction cup a kind of hole aperture is attached so that the skin through the hole through the thread or the capillary is more closely approached than in the area. 25. Device according to claim 2, characterized in that the thread or the capillary after withdrawal from the skin outside of theirs Storage sleeve inserted between spring washers so be summarized that the washers over conductive parts Cause signal derivation. 26. Device and method according to claim 1 and 2, characterized, that the pin-like narrow end part with the bore for the insertion of the thread or the cannula into the skin is rounded like a dome to oppose at vertical pressure a skin area with compliant subsoil evading the same and thus its dilution with a safe pen to secure fixation for the absorption of the tissue fluid.