DE19629568C1 - Verfahren zur Herstellung von Isopren - Google Patents

Verfahren zur Herstellung von Isopren

Info

Publication number
DE19629568C1
DE19629568C1 DE19629568A DE19629568A DE19629568C1 DE 19629568 C1 DE19629568 C1 DE 19629568C1 DE 19629568 A DE19629568 A DE 19629568A DE 19629568 A DE19629568 A DE 19629568A DE 19629568 C1 DE19629568 C1 DE 19629568C1
Authority
DE
Germany
Prior art keywords
isoprene
gene
micro
organism
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19629568A
Other languages
German (de)
English (en)
Inventor
Wolfgang Zimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Karlsruhe GmbH
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority to DE19629568A priority Critical patent/DE19629568C1/de
Priority to PCT/DE1997/001498 priority patent/WO1998002550A2/fr
Application granted granted Critical
Publication of DE19629568C1 publication Critical patent/DE19629568C1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19629568A 1996-07-15 1996-07-15 Verfahren zur Herstellung von Isopren Expired - Fee Related DE19629568C1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19629568A DE19629568C1 (de) 1996-07-15 1996-07-15 Verfahren zur Herstellung von Isopren
PCT/DE1997/001498 WO1998002550A2 (fr) 1996-07-15 1997-07-11 Production microbienne d'isoprene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19629568A DE19629568C1 (de) 1996-07-15 1996-07-15 Verfahren zur Herstellung von Isopren

Publications (1)

Publication Number Publication Date
DE19629568C1 true DE19629568C1 (de) 1998-01-08

Family

ID=7800518

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19629568A Expired - Fee Related DE19629568C1 (de) 1996-07-15 1996-07-15 Verfahren zur Herstellung von Isopren

Country Status (2)

Country Link
DE (1) DE19629568C1 (fr)
WO (1) WO1998002550A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008137092A2 (fr) * 2007-05-01 2008-11-13 Acidophil, Llc Procédés de conversion directe du dioxyde de carbone en hydrocarbone au moyen d'un microorganisme photosynthétique métaboliquement modifié
WO2010031076A2 (fr) * 2008-09-15 2010-03-18 Danisco Us Inc. Conversion de dérivés de prényle en isoprène
US8173410B2 (en) 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
US8288148B2 (en) 2007-12-13 2012-10-16 Danisco Us Inc. Compositions and methods for producing isoprene
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
US8815548B2 (en) 2008-09-15 2014-08-26 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
RU2563513C2 (ru) * 2008-07-02 2015-09-20 ДАНИСКО ЮЭс ИНК. Композиции и способы получения изопрена, не содержащего с5-углеводородов в условиях нарушения взаимосвязи между продуцированием изопрена и ростом клеток и/или в условиях продуцирования изопрена на безопасных рабочих уровнях
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US9273298B2 (en) 2010-10-27 2016-03-01 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
EP2344629B1 (fr) * 2008-09-15 2018-01-24 Danisco US Inc. Systèmes utilisant une culture de cellules pour la production d isoprène

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
EP2337845A1 (fr) * 2008-09-15 2011-06-29 Danisco US Inc. Production d isoprène augmentée en utilisant la mévalonate kinase et l isoprène synthase
SG169652A1 (en) 2008-09-15 2011-04-29 Danisco Us Inc Reduction of carbon dioxide emission during isoprene production by fermentation
EP2382312A2 (fr) 2008-12-30 2011-11-02 Danisco US Inc. Procédé de fabrication d'isoprène et d'un co-produit
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
EP2516657A1 (fr) 2009-12-22 2012-10-31 Danisco US Inc. Bioréacteur à membrane pour la production accrue d'isoprène gazeux
SG196782A1 (en) 2009-12-23 2014-02-13 Danisco Us Inc Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl)
WO2011160081A1 (fr) 2010-06-17 2011-12-22 Danisco Us Inc. Compositions de carburant contenant des dérivés d'isoprène
US20120045812A1 (en) 2010-08-06 2012-02-23 Danisco Us Inc. PRODUCTION OF ISOPRENE UNDER NEUTRAL pH CONDITIONS
EP2655597A1 (fr) 2010-12-22 2013-10-30 Danisco US Inc. Production biologique de sucres pentoses à l'aide de cellules recombinantes
JP2014504497A (ja) 2010-12-22 2014-02-24 ダニスコ・ユーエス・インク ２種類のｉｓｐｇ酵素を用いてイソプレン生産を向上させる組成物及び方法
CA2834379A1 (fr) 2011-04-29 2012-11-01 The Goodyear Tire & Rubber Company Production de mevalonate, d'isoprene et d'isoprenoides au moyen de genes codant des polypeptides a activite enzymatique thiolase, hmg-coa synthase et hmg-coa reductase
CA2834633A1 (fr) 2011-04-29 2012-11-01 Danisco Us Inc. Micro-organismes recombinants pouvant augmenter la production de mevalonate, d'isoprene et d'isoprenoides
AU2012289886A1 (en) 2011-08-04 2014-02-20 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-CoA synthase
US8951764B2 (en) 2011-08-05 2015-02-10 Danisco Us Inc. Production of isoprenoids under neutral pH conditions
CA2851265A1 (fr) 2011-10-07 2013-05-10 Danisco Us Inc. Utilisation de phosphocetolase dans la production de mevalonate, precurseurs d'isoprenoide, et isoprene
DK2771460T3 (en) 2011-10-27 2017-06-06 Danisco Us Inc ISOPRENE SYNTHASE VARIETIES WITH IMPROVED SOLUBILITY FOR THE PREPARATION OF ISOPRENE
MX2014007623A (es) 2011-12-23 2015-02-04 Danisco Us Inc Produccion mejorada de isopreno con el uso de celulas hospederas que tienen actividad de ispa reducida.
EP2794876A1 (fr) 2011-12-23 2014-10-29 Danisco US Inc. Production d'isoprène sous des niveaux d'entrée d'oxygène réduits
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
WO2013181647A2 (fr) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions et procédés de production d'isoprène et/ou de bioproduits industriels à l'aide de microorganismes anaérobies
EP2935364A2 (fr) 2012-12-21 2015-10-28 Danisco US Inc. Production d'isoprène, d'isoprénoïde et de précurseurs d'isoprénoïdes au moyen d'une variante de la voie du mévalonate inférieur
CN105555952A (zh) 2013-04-10 2016-05-04 丹尼斯科美国公司 用于乙酰辅酶a-衍生代谢物、异戊二烯、类异戊二烯前体和类异戊二烯的改善生产的磷酸解酮酶
ES2728307T3 (es) 2013-06-21 2019-10-23 Danisco Us Inc Composiciones y métodos para la transformación clostridial
US10648004B2 (en) 2014-02-20 2020-05-12 Danisco Us Inc. Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983729A (en) * 1989-10-19 1991-01-08 The Goodyear Tire & Rubber Company DNA fragment encoding a rubber polymerase and its use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Horst Ibelgaufts "Gentechnologie von A bis Z" VCH Verlagsgesellschaft mbH, D-6940 Weinheim, 1993, S.380-384 *
J.Biol. Chem. 1995, 270, S.13010-16 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008137092A2 (fr) * 2007-05-01 2008-11-13 Acidophil, Llc Procédés de conversion directe du dioxyde de carbone en hydrocarbone au moyen d'un microorganisme photosynthétique métaboliquement modifié
WO2008137092A3 (fr) * 2007-05-01 2008-12-31 Acidophil Llc Procédés de conversion directe du dioxyde de carbone en hydrocarbone au moyen d'un microorganisme photosynthétique métaboliquement modifié
US8609385B2 (en) 2007-05-01 2013-12-17 Zuvachem, Inc. Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
US10626420B2 (en) 2007-12-13 2020-04-21 Danisco Us Inc. Compositions and methods for producing isoprene
US9909144B2 (en) 2007-12-13 2018-03-06 Danisco Us Inc. Compositions and methods for producing isoprene
US8288148B2 (en) 2007-12-13 2012-10-16 Danisco Us Inc. Compositions and methods for producing isoprene
US9260727B2 (en) 2007-12-13 2016-02-16 Danisco Us Inc. Compositions and methods for producing isoprene
US8709785B2 (en) 2007-12-13 2014-04-29 Danisco Us Inc. Compositions and methods for producing isoprene
RU2545699C2 (ru) * 2007-12-13 2015-04-10 ДАНИСКО ЮЭс ИНК. Композиции и способы получения изопрена
US8173410B2 (en) 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
US8916370B2 (en) 2008-04-23 2014-12-23 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
RU2563513C2 (ru) * 2008-07-02 2015-09-20 ДАНИСКО ЮЭс ИНК. Композиции и способы получения изопрена, не содержащего с5-углеводородов в условиях нарушения взаимосвязи между продуцированием изопрена и ростом клеток и/или в условиях продуцирования изопрена на безопасных рабочих уровнях
US8945893B2 (en) 2008-09-15 2015-02-03 Danisco Us Inc. Conversion of prenyl derivatives to isoprene
US8815548B2 (en) 2008-09-15 2014-08-26 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
US8476049B2 (en) 2008-09-15 2013-07-02 Danisco Us Inc. Conversion of prenyl derivatives to isoprene
US9464301B2 (en) 2008-09-15 2016-10-11 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
EP2344629B1 (fr) * 2008-09-15 2018-01-24 Danisco US Inc. Systèmes utilisant une culture de cellules pour la production d isoprène
WO2010031076A3 (fr) * 2008-09-15 2010-11-11 Danisco Us Inc. Conversion de dérivés de prényle en isoprène
EP3323881A1 (fr) * 2008-09-15 2018-05-23 Danisco US Inc. Systèmes faisant appel à une culture de cellules pour la production d'isoprène
WO2010031076A2 (fr) * 2008-09-15 2010-03-18 Danisco Us Inc. Conversion de dérivés de prényle en isoprène
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
US9175313B2 (en) 2009-04-23 2015-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
US9273298B2 (en) 2010-10-27 2016-03-01 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene

Also Published As

Publication number Publication date
WO1998002550A3 (fr) 1998-02-19
WO1998002550A2 (fr) 1998-01-22

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Legal Events

Date Code Title Description
8100 Publication of the examined application without publication of unexamined application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: FORSCHUNGSZENTRUM KARLSRUHE GMBH, 76344 EGGENSTEIN

8339 Ceased/non-payment of the annual fee
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20110201