DE19581787T1 - Verfahren zur Herstellung von Mikrokügelchen und dadurch hergestellte Mikrokügelchen - Google Patents

Verfahren zur Herstellung von Mikrokügelchen und dadurch hergestellte Mikrokügelchen

Info

Publication number
DE19581787T1
DE19581787T1 DE19581787T DE19581787T DE19581787T1 DE 19581787 T1 DE19581787 T1 DE 19581787T1 DE 19581787 T DE19581787 T DE 19581787T DE 19581787 T DE19581787 T DE 19581787T DE 19581787 T1 DE19581787 T1 DE 19581787T1
Authority
DE
Germany
Prior art keywords
microspheres
production
produced
microspheres produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19581787T
Other languages
English (en)
Inventor
Shlomo Margel
Hanna Bamnolker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bar Ilan University
Original Assignee
Bar Ilan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bar Ilan University filed Critical Bar Ilan University
Publication of DE19581787T1 publication Critical patent/DE19581787T1/de
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/10—Magnetic particle immunoreagent carriers the magnetic material being used to coat a pre-existing polymer particle but not being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/86—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids the coating being pre-functionalised for attaching immunoreagents, e.g. aminodextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
DE19581787T 1994-10-06 1995-10-05 Verfahren zur Herstellung von Mikrokügelchen und dadurch hergestellte Mikrokügelchen Ceased DE19581787T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11118694A IL111186A (en) 1994-10-06 1994-10-06 Process for the preparation of microspheres and microspheres made thereby
PCT/US1995/012988 WO1996011054A2 (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby

Publications (1)

Publication Number Publication Date
DE19581787T1 true DE19581787T1 (de) 1997-11-27

Family

ID=11066612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19581787T Ceased DE19581787T1 (de) 1994-10-06 1995-10-05 Verfahren zur Herstellung von Mikrokügelchen und dadurch hergestellte Mikrokügelchen

Country Status (4)

Country Link
AU (1) AU4193496A (de)
DE (1) DE19581787T1 (de)
IL (1) IL111186A (de)
WO (1) WO1996011054A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016105122A1 (de) * 2016-03-18 2017-09-21 Bundesrepublik Deutschland, Vertreten Durch Den Bundesminister Für Wirtschaft Und Energie, Dieser Vertreten Durch Den Präsidenten Der Bundesanstalt Für Materialforschung Und -Prüfung (Bam) Verfahren zur Synthese hybrider Kern-Schale-Mikropartikel umfassend einen Polymerkern und eine Siliziumdioxidschale mit kontrollierter Struktur und Oberfläche

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2747669B1 (fr) * 1996-04-22 1998-05-22 Rhone Poulenc Chimie Procede de preparation de particules creuses de silice
DE69810080T2 (de) 1997-01-21 2003-10-09 Grace W R & Co Siliciumdioxidadsorbent auf magnetischem träger
JP4092070B2 (ja) * 2000-11-27 2008-05-28 独立行政法人科学技術振興機構 糖誘導体を用いる有機無機複合体および金属酸化物の製造方法
GB0107563D0 (en) 2001-03-27 2001-05-16 Amersham Pharm Biotech Uk Ltd NO synthase assay particles and method
US6890703B2 (en) 2002-03-06 2005-05-10 International Business Machines Corporation Preparation of crosslinked particles from polymers having activatible crosslinking groups
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
DE10355409A1 (de) 2003-11-25 2005-06-30 Magnamedics Gmbh Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren
US9278866B2 (en) 2005-08-10 2016-03-08 The Procter & Gamble Company Hollow silica particles, compositions comprising them, and methods for making same
KR101457287B1 (ko) * 2010-04-20 2014-11-04 바스프 에스이 활성 성분을 포함하는 캡슐
EP2905304B1 (de) * 2012-11-16 2017-09-13 Quanta Matrix Co., Ltd. Codierte polymermikropartikel
CN110508222B (zh) * 2019-08-02 2022-03-18 复旦大学 具有介孔二氧化硅壳层的单分散核壳微球及其制备方法
CN113578214B (zh) * 2021-08-11 2023-08-11 天津博蕴纯化装备材料科技有限公司 微米级多孔磁性微球及其制备方法和应用
CN115893980B (zh) * 2022-09-30 2023-08-11 安徽华仕新材有限公司 一种利用球化剂微粉制备多孔支撑体陶瓷的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564336A1 (fr) * 1984-05-16 1985-11-22 Ohayon Hanania Dispositif de separation du sang et d'obtention de serum
FR2624873B1 (fr) * 1987-12-18 1992-01-10 Rhone Poulenc Chimie Particules composites magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie
EP0640216B1 (de) * 1991-03-20 2002-10-02 Marconi Optical Components Limited Abtrennungsverfahren
GB9211822D0 (en) * 1992-06-04 1992-07-15 Tioxide Group Services Ltd Composite pigmentary material

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016105122A1 (de) * 2016-03-18 2017-09-21 Bundesrepublik Deutschland, Vertreten Durch Den Bundesminister Für Wirtschaft Und Energie, Dieser Vertreten Durch Den Präsidenten Der Bundesanstalt Für Materialforschung Und -Prüfung (Bam) Verfahren zur Synthese hybrider Kern-Schale-Mikropartikel umfassend einen Polymerkern und eine Siliziumdioxidschale mit kontrollierter Struktur und Oberfläche
DE102016105122B4 (de) * 2016-03-18 2019-07-11 Bundesrepublik Deutschland, Vertreten Durch Den Bundesminister Für Wirtschaft Und Energie, Dieser Vertreten Durch Den Präsidenten Der Bundesanstalt Für Materialforschung Und -Prüfung (Bam) Verfahren zur Synthese hybrider Kern-Schale-Mikropartikel umfassend einen Polymerkern und eine Siliziumdioxidschale mit kontrollierter Struktur und Oberfläche

Also Published As

Publication number Publication date
IL111186A0 (en) 1994-12-29
AU4193496A (en) 1996-05-02
IL111186A (en) 1999-09-22
WO1996011054A2 (en) 1996-04-18
WO1996011054A3 (en) 1996-05-23

Similar Documents

Publication Publication Date Title
DE69506496T2 (de) Verfahren zur Herstellung von modifizierten Harzen und ihre Verwendungen
DE69414315T2 (de) Verfahren zur Herstellung von Kapseln sowie dadurch erhaltene Kapseln
DE69433950D1 (de) Verfahren zur Herstellung von Polyester
DE69403610D1 (de) Verfahren zur Herstellung von Ameisensäure und ihren Derivaten
DE69426166D1 (de) Verfahren zur Herstellung von Polyester
DE69512288D1 (de) Verfahren zur Herstellung von Hexafluorpropan und Perfluorpropan
DE69511571T2 (de) Verfahren zur herstellung von essbaren hüllen und daraus hergestellten zusammensetzungen
DE69510596D1 (de) Verfahren zur Herstellung von Organooxysilane
DE19581787T1 (de) Verfahren zur Herstellung von Mikrokügelchen und dadurch hergestellte Mikrokügelchen
DE59502641D1 (de) Verfahren zur Herstellung von Kieselsäuregranulat und Verwendung des so hergestellten Granulats
DE69611815D1 (de) Verfahren zur Herstellung von Mischungen aus Polydiorganosiloxanen und Silica
DE69531196D1 (de) Vorrichtung und verfahren zur herstellung von transmissionshologrammen
DE69630038D1 (de) Verfahren zur herstellung und aufreinigung von enzymen
DE59606485D1 (de) Verfahren zur Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
DE59606489D1 (de) Verfahren zur Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
DE59509716D1 (de) Verfahren zur Herstellung von Polyestern und Copolyestern
DE69501311T2 (de) Verfahren zur Herstellung von Polymerpartikeln
DE69508151D1 (de) Verfahren zur Herstellung von Verbundfolie und Verbundfolie
DE59606657D1 (de) Verfahren zur Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
DE69431396D1 (de) Verfahren zur herstellung von n-tert-butyl-2-pyrazincarboxamid und n-tert-butyl-2-piperazincarboxamid
DE59606488D1 (de) Verfahren zur Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
DE69419516D1 (de) Verfahren zur herstellung von hexafluorocyclobuten und verfahren zur herstellung von hexafluorocyclobutan
DE59502926D1 (de) Verfahren zur herstellung von alkaliaminoborhydriden und alkaliaminoborhydrid-komplexen
DE69910867D1 (de) Verbessertes Verfahren zur Herstellung von Chloroalkylen und Alkynylaminen
DE59700696D1 (de) Verfahren und zwischenprodukte zur herstellung von pyridyl-4-fluoranilinen

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection