IL111186A - Process for the preparation of microspheres and microspheres made thereby - Google Patents

Process for the preparation of microspheres and microspheres made thereby

Info

Publication number
IL111186A
IL111186A IL11118694A IL11118694A IL111186A IL 111186 A IL111186 A IL 111186A IL 11118694 A IL11118694 A IL 11118694A IL 11118694 A IL11118694 A IL 11118694A IL 111186 A IL111186 A IL 111186A
Authority
IL
Israel
Prior art keywords
microspheres
preparation
microspheres made
Prior art date
Application number
IL11118694A
Other languages
English (en)
Other versions
IL111186A0 (en
Inventor
Margel Shlomo
Bamnolker Hanna
Original Assignee
Univ Bar Ilan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bar Ilan filed Critical Univ Bar Ilan
Priority to IL11118694A priority Critical patent/IL111186A/xx
Publication of IL111186A0 publication Critical patent/IL111186A0/xx
Priority to AU41934/96A priority patent/AU4193496A/en
Priority to DE19581787T priority patent/DE19581787T1/de
Priority to US08/809,957 priority patent/US6103379A/en
Priority to PCT/US1995/012988 priority patent/WO1996011054A2/en
Publication of IL111186A publication Critical patent/IL111186A/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/10—Magnetic particle immunoreagent carriers the magnetic material being used to coat a pre-existing polymer particle but not being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/86—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids the coating being pre-functionalised for attaching immunoreagents, e.g. aminodextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
IL11118694A 1994-10-06 1994-10-06 Process for the preparation of microspheres and microspheres made thereby IL111186A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL11118694A IL111186A (en) 1994-10-06 1994-10-06 Process for the preparation of microspheres and microspheres made thereby
AU41934/96A AU4193496A (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby
DE19581787T DE19581787T1 (de) 1994-10-06 1995-10-05 Verfahren zur Herstellung von Mikrokügelchen und dadurch hergestellte Mikrokügelchen
US08/809,957 US6103379A (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby
PCT/US1995/012988 WO1996011054A2 (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11118694A IL111186A (en) 1994-10-06 1994-10-06 Process for the preparation of microspheres and microspheres made thereby

Publications (2)

Publication Number Publication Date
IL111186A0 IL111186A0 (en) 1994-12-29
IL111186A true IL111186A (en) 1999-09-22

Family

ID=11066612

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11118694A IL111186A (en) 1994-10-06 1994-10-06 Process for the preparation of microspheres and microspheres made thereby

Country Status (4)

Country Link
AU (1) AU4193496A (xx)
DE (1) DE19581787T1 (xx)
IL (1) IL111186A (xx)
WO (1) WO1996011054A2 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2747669B1 (fr) * 1996-04-22 1998-05-22 Rhone Poulenc Chimie Procede de preparation de particules creuses de silice
CZ297990B6 (cs) 1997-01-21 2007-05-16 W. R. Grace & Co.-Conn. Cásticový adsorbent a zpusob jeho výroby
JP4092070B2 (ja) * 2000-11-27 2008-05-28 独立行政法人科学技術振興機構 糖誘導体を用いる有機無機複合体および金属酸化物の製造方法
GB0107563D0 (en) 2001-03-27 2001-05-16 Amersham Pharm Biotech Uk Ltd NO synthase assay particles and method
US6890703B2 (en) 2002-03-06 2005-05-10 International Business Machines Corporation Preparation of crosslinked particles from polymers having activatible crosslinking groups
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
DE10355409A1 (de) 2003-11-25 2005-06-30 Magnamedics Gmbh Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren
US9278866B2 (en) 2005-08-10 2016-03-08 The Procter & Gamble Company Hollow silica particles, compositions comprising them, and methods for making same
KR101457287B1 (ko) * 2010-04-20 2014-11-04 바스프 에스이 활성 성분을 포함하는 캡슐
WO2014077645A1 (ko) * 2012-11-16 2014-05-22 서울대학교산학협력단 코드화된 고분자 미세입자
DE202016008770U1 (de) * 2016-03-18 2019-08-06 Bundesrepublik Deutschland, vertreten durch den Bundesminister für Wirtschaft und Energie, dieser vertreten durch den Präsidenten der Bundesanstalt für Materialforschung und –prüfung (BAM) Hybride Kern-Schale-Mikropartikel umfassend einen Polymerkern und eine Siliziumdioxidschale mit kontrollierter Struktur und Oberfläche
CN110508222B (zh) * 2019-08-02 2022-03-18 复旦大学 具有介孔二氧化硅壳层的单分散核壳微球及其制备方法
CN113578214B (zh) * 2021-08-11 2023-08-11 天津博蕴纯化装备材料科技有限公司 微米级多孔磁性微球及其制备方法和应用
CN115893980B (zh) * 2022-09-30 2023-08-11 安徽华仕新材有限公司 一种利用球化剂微粉制备多孔支撑体陶瓷的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564336A1 (fr) * 1984-05-16 1985-11-22 Ohayon Hanania Dispositif de separation du sang et d'obtention de serum
FR2624873B1 (fr) * 1987-12-18 1992-01-10 Rhone Poulenc Chimie Particules composites magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie
WO1992016838A1 (en) * 1991-03-20 1992-10-01 Gec-Marconi Limited Separation method
GB9211822D0 (en) * 1992-06-04 1992-07-15 Tioxide Group Services Ltd Composite pigmentary material

Also Published As

Publication number Publication date
DE19581787T1 (de) 1997-11-27
WO1996011054A3 (en) 1996-05-23
WO1996011054A2 (en) 1996-04-18
IL111186A0 (en) 1994-12-29
AU4193496A (en) 1996-05-02

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees