DE19532006A1 - Sun protection agents contg. betulinic acid - Google Patents
Sun protection agents contg. betulinic acidInfo
- Publication number
- DE19532006A1 DE19532006A1 DE1995132006 DE19532006A DE19532006A1 DE 19532006 A1 DE19532006 A1 DE 19532006A1 DE 1995132006 DE1995132006 DE 1995132006 DE 19532006 A DE19532006 A DE 19532006A DE 19532006 A1 DE19532006 A1 DE 19532006A1
- Authority
- DE
- Germany
- Prior art keywords
- betulinic acid
- sun protection
- protection agents
- skin
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 title claims abstract description 6
- CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 title claims abstract description 6
- DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 title claims abstract description 6
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title claims abstract description 6
- PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 title claims abstract description 6
- MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 title claims abstract description 6
- 230000037072 sun protection Effects 0.000 title abstract 2
- 239000011814 protection agent Substances 0.000 title 1
- 239000002537 cosmetic Substances 0.000 claims abstract 2
- 230000000475 sunscreen effect Effects 0.000 claims description 8
- 239000000516 sunscreening agent Substances 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 4
- 235000018185 Betula X alpestris Nutrition 0.000 claims description 3
- 235000018212 Betula X uliginosa Nutrition 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 240000000731 Fagus sylvatica Species 0.000 abstract 1
- 235000010099 Fagus sylvatica Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 5
- 201000000849 skin cancer Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 description 1
- MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Description
Sonnenschutzmittel reduzieren den Einfall von UV-Strahlung in die Haut. Sie können die UV-Absorption in der Haut jedoch nicht vollständig verhindern. Das wird auch gar nicht angestrebt. Seit kurzem (vgl. hierzu "Blick durch die Wirtschaft" vom 6. Juni 1995) ist bekannt, daß der Birken-Wirkstoff Betulin säure Hautkrebs zumindest in Tierversuchen nicht nur an der Entstehung hindert, sondern sogar abbaut. Da diese Substanz hautverträglich ist, wird vorgeschlagen, sie äußerlich prä ventiv in Verbindung mit Sonnenschutzmitteln anzuwenden.Sunscreens reduce the incidence of UV radiation in the skin. However, they cannot absorb UV in the skin completely prevent. That is not the goal at all. Recently (cf. "Blick durch die Wirtschaft" from June 6, 1995) it is known that the birch active ingredient betulin acid skin cancer, at least in animal experiments, not only at the Prevents development, but even degrades. Because this substance is skin-friendly, it is suggested that it be externally pre to be used ventilatively in connection with sunscreens.
Der Erfindung liegt das Problem zugrunde, daß trotz guter Sonnenschutzmittel bisher nicht vermieden werden kann, daß sich Hautkrebs entwickelt.The invention is based on the problem that despite good Sunscreen so far can not be avoided that skin cancer develops.
Dieses Problem wird durch die Beigabe des Birken-Wirkstoffes Betulinsäure zu Sonnenschutzmitteln gelöst. Denn dieser Wirk stoff hindert voraussichtlich den Hautkrebs an seiner Entste hung und baut bereits entstandene kleinere Melanome, die unter Umständen noch gar nicht diagnostiziert wurden, ab.This problem is caused by the addition of the birch active ingredient Betulinic acid dissolved in sunscreens. Because this effect Substance is likely to prevent skin cancer from developing hung and builds smaller melanomas that have already developed, the under Under certain circumstances have not yet been diagnosed.
Der große Vorteil dieser "Anwendung" sind nicht nur die geringen Kosten, sowie die präventive Anwendung, sondern ganz besonders die Kombination von Sonnenschutzmittel und Anti-Hautkrebs Wirk stoff Betulinsäure. Denn der Hautkrebs entsteht in erster Linie bei Sonnen-Exposition und dann verwendet man gewöhnlich Sonnen schutzpräparate. Darüber hinaus ist der Wirkstoff nicht sehr teuer, geringe Konzentrationen von 100 mg/g genügen und die gute Hautverträglichkeit gewährleistet eine problemlose äußere An wendung.The big advantage of this "application" is not only the small ones Costs, as well as preventive use, but very special the combination of sunscreen and anti-skin cancer active substance betulinic acid. Because skin cancer primarily arises in sun exposure and then you usually use suns protective preparations. In addition, the active ingredient is not very expensive, low concentrations of 100 mg / g are sufficient and the good one Skin compatibility ensures problem-free external appearance turn.
Je nach Anwendung der Sonnencreme kann die Konzentration der Betulinsäure pro Sonnenschutzmittel von 50 mg/g für Säuglinge bis 500 mg/g für besonders gefährdete Menschen variieren, ohne daß die Wirkung oder die Hautverträglichkeit beeinträchtigt wäre. Empfohlen wird für ein universelles Präparat eine Konzen tration von 100 mg/g.Depending on the application of the sunscreen, the concentration of the Betulinic acid per sunscreen of 50 mg / g for infants vary to 500 mg / g for particularly vulnerable people without that the effect or skin tolerance impaired would. A concentrate is recommended for a universal preparation tration of 100 mg / g.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1995132006 DE19532006A1 (en) | 1995-08-31 | 1995-08-31 | Sun protection agents contg. betulinic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1995132006 DE19532006A1 (en) | 1995-08-31 | 1995-08-31 | Sun protection agents contg. betulinic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19532006A1 true DE19532006A1 (en) | 1997-03-06 |
Family
ID=7770817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1995132006 Ceased DE19532006A1 (en) | 1995-08-31 | 1995-08-31 | Sun protection agents contg. betulinic acid |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE19532006A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998051293A1 (en) * | 1997-05-16 | 1998-11-19 | The Board Of Trustees Of The University Of Illinois | Use of betulinic acid derivatives for the treatment and prevention of melanoma |
| WO1998051294A3 (en) * | 1997-05-16 | 1999-04-01 | Univ Illinois | Method and composition for treating cancers |
| WO2000003748A3 (en) * | 1998-07-17 | 2000-06-15 | Procter & Gamble | Compositions which contain triterpenes for regulating hair growth |
| US6124362A (en) * | 1998-07-17 | 2000-09-26 | The Procter & Gamble Company | Method for regulating hair growth |
| US6482857B1 (en) | 1998-07-17 | 2002-11-19 | The University Of Texas Southwestern Medical Center | Compositions which contain triterpenes for regulating hair growth |
| EP2037872A4 (en) * | 2006-06-07 | 2012-10-10 | Valtion Teknillinen | COMPOSITIONS WITH BETULONIC ACID |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0717983A1 (en) * | 1994-12-20 | 1996-06-26 | Unilever Plc | Cosmetic compositions containing betulinic acid |
-
1995
- 1995-08-31 DE DE1995132006 patent/DE19532006A1/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0717983A1 (en) * | 1994-12-20 | 1996-06-26 | Unilever Plc | Cosmetic compositions containing betulinic acid |
Non-Patent Citations (3)
| Title |
|---|
| Blick durch die Wirtschaft 6.Juni 1995 * |
| K.Yasukawa et al., Oncology 48 (1991) S.72-76 * |
| K.Yasukawa et al., Phytomedicine 4 (1995) S.309- 313 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7414042B2 (en) | 1995-03-21 | 2008-08-19 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| WO1998051293A1 (en) * | 1997-05-16 | 1998-11-19 | The Board Of Trustees Of The University Of Illinois | Use of betulinic acid derivatives for the treatment and prevention of melanoma |
| WO1998051294A3 (en) * | 1997-05-16 | 1999-04-01 | Univ Illinois | Method and composition for treating cancers |
| EP1266658A3 (en) * | 1997-05-16 | 2004-05-26 | The Board Of Trustees Of The University Of Illinois | Use of betulinic acid derivatives for the treatment and prevention of melanoma |
| WO2000003748A3 (en) * | 1998-07-17 | 2000-06-15 | Procter & Gamble | Compositions which contain triterpenes for regulating hair growth |
| US6124362A (en) * | 1998-07-17 | 2000-09-26 | The Procter & Gamble Company | Method for regulating hair growth |
| US6451777B1 (en) | 1998-07-17 | 2002-09-17 | The University Of Texas Southwestern Medical Center | Method for regulating hair growth |
| US6482857B1 (en) | 1998-07-17 | 2002-11-19 | The University Of Texas Southwestern Medical Center | Compositions which contain triterpenes for regulating hair growth |
| EP2037872A4 (en) * | 2006-06-07 | 2012-10-10 | Valtion Teknillinen | COMPOSITIONS WITH BETULONIC ACID |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8122 | Nonbinding interest in granting licenses declared | ||
| 8125 | Change of the main classification |
Ipc: A61K 7/42 |
|
| 8131 | Rejection |