DE187019T1 - Dobutaminesalze. - Google Patents

Dobutaminesalze.

Info

Publication number
DE187019T1
DE187019T1 DE198585309216T DE85309216T DE187019T1 DE 187019 T1 DE187019 T1 DE 187019T1 DE 198585309216 T DE198585309216 T DE 198585309216T DE 85309216 T DE85309216 T DE 85309216T DE 187019 T1 DE187019 T1 DE 187019T1
Authority
DE
Germany
Prior art keywords
dobutamine
acid
formula
salt
tartrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198585309216T
Other languages
English (en)
Inventor
Eddie Herman Indianapolis Indiana 46227 Massey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE187019T1 publication Critical patent/DE187019T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/06—Glycolic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Seasonings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Claims (9)

X-6107 Europäische Patentanmeldung : 85 309 216.1 Europäische Veröffentlichung: 0 187 019 Anmelder : Eli Lilly and Company Patentansprüche
1. Salz von N-[3-(4-Hydroxyphenyl)-1-methylpropyl]-2-(3,4-dihydroxyphenyl) ethylamin mit einer Säure der Formel I
(OHC2-C1 ^Alkyl-H-COOH) 1 _2 .
2. Dobutamxntartrat.
3.Dobutamin-(+)-tartrat.
4. Feste kristalline filtrierbare freie Base von Dobutamin.
5. Pharmazeutische Formulierung, dadurch gekennzeichnet, daß es sich hierbei um eine wäßrige Lösung eines Dobutaminsalzes nach irgendeinem der Ansprüche 1 bis 3 in Verbindung mit einem Antioxidans handelt.
6. Pharmazeutische Formulierung, dadurch gekennzeichnet, daß es sich hierbei um eine wäßrige Lösung von Dobutamin-(+)-tartrat und Natriumbisulfit handelt.
7. Verfahren zur Herstellung eines Salzes von Dobutamin und einer Säure der Formel
(OHC2-C11 -Alkyl-HCOOH) 1 _2 (D,
dadurch gekennzeichnet, daß man
(a) Dobutamin als freie Base mit der Säure der Formel (I) neutralisiert oder
(b) ein Säureadditionssalz von Dobutamin einer metathetischen Reaktion mit einem Salz der Säure der Formel (I) unterzieht.
8. Verfahren nach Anspruch 7, dadurch gekennzeichnet, daß man als Säure der Formel (I) Weinsäure verwendet.
5
9. Verfahren nach Anspruch 8, dadurch gekennzeichnet, daß man als Säure der Formel (I) (+)-Weinsäure verwendet.
20 25 30 35
DE198585309216T 1984-12-20 1985-12-18 Dobutaminesalze. Pending DE187019T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68440484A 1984-12-20 1984-12-20

Publications (1)

Publication Number Publication Date
DE187019T1 true DE187019T1 (de) 1987-11-26

Family

ID=24747892

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585309216T Expired - Lifetime DE3580575D1 (en) 1984-12-20 1985-12-18 Dobutaminesalze.
DE198585309216T Pending DE187019T1 (de) 1984-12-20 1985-12-18 Dobutaminesalze.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8585309216T Expired - Lifetime DE3580575D1 (en) 1984-12-20 1985-12-18 Dobutaminesalze.

Country Status (24)

Country Link
EP (1) EP0187019B1 (de)
JP (1) JPS61155355A (de)
KR (1) KR870000803B1 (de)
CN (1) CN1009922B (de)
AT (1) ATE58370T1 (de)
AU (1) AU589929B2 (de)
CA (1) CA1254909A (de)
CS (1) CS253734B2 (de)
DD (1) DD241071A5 (de)
DE (2) DE3580575D1 (de)
DK (1) DK589385A (de)
EG (1) EG17889A (de)
ES (2) ES8705841A1 (de)
FI (1) FI855018A7 (de)
GR (1) GR853027B (de)
HU (1) HU194805B (de)
MY (1) MY104814A (de)
NZ (1) NZ214583A (de)
PH (1) PH22547A (de)
PL (1) PL148296B1 (de)
PT (1) PT81705B (de)
RO (1) RO93391B (de)
SU (1) SU1480761A3 (de)
ZA (1) ZA859629B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA881076B (en) * 1987-02-24 1989-10-25 Lilly Co Eli Dobutamine salts
FR2740337B1 (fr) * 1995-10-27 1997-11-21 Rhone Poulenc Rorer Sa Compositions pharmaceutiques stabilisees contenant un derive ayant une activite adrenergique
FR2740338B1 (fr) * 1995-12-01 1997-12-05 Rhone Poulenc Rorer Sa Compositions pharmaceutiques stabilisees contenant de la dobutamine
FR2809619B1 (fr) * 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
CN105906515B (zh) * 2015-12-10 2018-03-13 菏泽市方明制药有限公司 一种盐酸多巴酚丁胺脱色工艺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987200A (en) * 1972-04-12 1976-10-19 Eli Lilly And Company Method for increasing cardiac contractility
FR2333499A1 (fr) * 1975-12-01 1977-07-01 Roussel Uclaf Nouveau derive de la phenethylamine et ses sels, procede de preparation et application a titre de medicament

Also Published As

Publication number Publication date
RO93391B (ro) 1988-03-31
DE3580575D1 (en) 1990-12-20
DD241071A5 (de) 1986-11-26
ES557426A0 (es) 1988-08-01
ES550151A0 (es) 1987-05-16
ZA859629B (en) 1987-07-29
FI855018A0 (fi) 1985-12-17
CA1254909A (en) 1989-05-30
DK589385D0 (da) 1985-12-18
JPS61155355A (ja) 1986-07-15
FI855018L (fi) 1986-06-21
AU589929B2 (en) 1989-10-26
EG17889A (en) 1991-03-30
PL256848A1 (en) 1986-10-21
PT81705A (en) 1986-01-01
HUT40069A (en) 1986-11-28
GR853027B (de) 1986-04-18
EP0187019A3 (en) 1987-09-30
PH22547A (en) 1988-10-17
PL148296B1 (en) 1989-10-31
CN85109229A (zh) 1986-10-01
DK589385A (da) 1986-06-21
ES8802570A1 (es) 1988-08-01
RO93391A (ro) 1988-03-30
CN1009922B (zh) 1990-10-10
NZ214583A (en) 1989-04-26
EP0187019B1 (de) 1990-11-14
PT81705B (pt) 1988-04-21
SU1480761A3 (ru) 1989-05-15
EP0187019A2 (de) 1986-07-09
HU194805B (en) 1988-03-28
ATE58370T1 (de) 1990-11-15
FI855018A7 (fi) 1986-06-21
JPH0327544B2 (de) 1991-04-16
KR870000803B1 (ko) 1987-04-20
MY104814A (en) 1994-04-30
AU5141585A (en) 1986-06-26
CS253734B2 (en) 1987-12-17
KR860004834A (ko) 1986-07-14
ES8705841A1 (es) 1987-05-16

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