DE1492425A1 - Method of sterilizing surgical sutures - Google Patents
Method of sterilizing surgical suturesInfo
- Publication number
- DE1492425A1 DE1492425A1 DE19631492425 DE1492425A DE1492425A1 DE 1492425 A1 DE1492425 A1 DE 1492425A1 DE 19631492425 DE19631492425 DE 19631492425 DE 1492425 A DE1492425 A DE 1492425A DE 1492425 A1 DE1492425 A1 DE 1492425A1
- Authority
- DE
- Germany
- Prior art keywords
- acids
- alcoholic solution
- surgical sutures
- acid
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 10
- 230000001954 sterilising effect Effects 0.000 title claims description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
- -1 aromatic mono- Chemical class 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 150000001991 dicarboxylic acids Chemical class 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 239000001384 succinic acid Substances 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 2
- 150000003973 alkyl amines Chemical class 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 239000002729 catgut Substances 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 150000007529 inorganic bases Chemical class 0.000 claims description 2
- 150000002763 monocarboxylic acids Chemical class 0.000 claims description 2
- 150000007530 organic bases Chemical class 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- 235000009048 phenolic acids Nutrition 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 229960000583 acetic acid Drugs 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- 229960004365 benzoic acid Drugs 0.000 claims 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 229960005137 succinic acid Drugs 0.000 claims 1
- 235000011044 succinic acid Nutrition 0.000 claims 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000003356 suture material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/20—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom three- or four-membered rings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Description
"Verfahren zum Sterilisieren von chirurgischen Nähmitteln11 "Methods for Sterilizing Surgical Sutures 11
Die Erfindung betrifft ein Verfahren zum Sterilisieren von chirurgischen Nähmitteln insbesondere Catgut oder synthetischen chirurgischen Nähfäden mit oder ohne Nadeln mittels Äthylenoxyd oder Propylenoxyd in alkoholischer Lösung.The invention relates to a method for sterilization of surgical sutures, in particular catgut or synthetic surgical sutures with or without Needles using ethylene oxide or propylene oxide in an alcoholic solution.
Es ist bekannt, der alkoholischen Lösung aliphatische Oxysäuren wie Milchsäure und Ammoniak beizugeben.It is known to add aliphatic oxyacids such as lactic acid and ammonia to the alcoholic solution.
Gemäß der Erfindung werden aliphatische gesättigte oder ungesättigte Mono- oder Dikarbonsäuren oder aromatische Mono- oder Dikarbonsäuren oder aromatische Phenolkarbonsäuren und organische Basen wie Alkylolaminen oder Alkylaminen oder anorganische Basen wie Alkalihydroxyde der alko-r holischen Lösung beigegeben.According to the invention, aliphatic, saturated or unsaturated mono- or dicarboxylic acids or aromatic Mono- or dicarboxylic acids or aromatic phenolic acids and organic bases such as alkylolamines or alkylamines or inorganic bases such as alkali metal hydroxides of the alko-r added holic solution.
Bei der Ausübung des Verfahrens können auch Gemische der aufgeführten Säuren und Basen verwendet werden. Mixtures of the acids and bases listed can also be used in carrying out the process .
909849/1098909849/1098
U92425U92425
Die Erfindung ist auch anwendbar auf Sterilisierverfahren, bei welchen die mit der Säure-Basen-Mi se hung behandelten chirurgischen Nähmittel nachträglich mit Äthylen— oxyd oder anderen üipoxyden begast werden.The invention is also applicable to sterilization processes, in which those treated with the acid-base mixture surgical sutures are subsequently fumigated with ethylene oxide or other lipoxides.
Sei der Ausübung der Erfindung ist beispielsweiseBe the practice of the invention is for example
folgendermaßen zu verfahren:proceed as follows:
130 ml einer Lösung bestehend aus 90 Gew»>' Isopropylalkohol
10 Gew.?i v/asser
1,3 Gew,?S Äthylenoxyd
0,8 Gew.fo Bernsteinsäure130 ml of a solution consisting of 90% by weight isopropyl alcohol
10 wt.? Iv / water
1.3% by weight of ethylene oxide
0.8 wt% succinic acid
mit Triäthanolamin auf pH 7,2 eingestelltadjusted to pH 7.2 with triethanolamine
werden in eine Flasche gegeben, welche das zu sterilisierende Nahtmaterial enthält. Die Mischung wird etwa 14 Tage bei 250C stehengelassen.are placed in a bottle containing the suture to be sterilized. The mixture is left to stand at 25 ° C. for about 14 days.
130 ml einer lösung bestehend aus
90 Gew.$ Isopropylalkohol
10 Gew."fo V/asser
1,2 Jew.^ Äthylenoxyd130 ml of a solution consisting of 90% by weight isopropyl alcohol
10 wt. "Fo V / ater
1,2 Jew. ^ Ethylene Oxide
0,5 Gew.$ Benzoesäure (bzw. 0,5 Gev./i Salizylsäure) mit NaOH auf pH 6,5 gebracht0.5% by weight of benzoic acid (or 0.5% by weight of salicylic acid) brought to pH 6.5 with NaOH
werden in eine Flasche gegeben, welche das zu sterilisierende Nahtmaterial enthält, und 14 'Tage bei 250O belassen.are placed in a bottle containing the suture to be sterilized and left at 25 0 O for 14 days.
BAU QHiGiNAL 9098 4 9/1098BAU QHiGiNAL 9098 4 9/1098
130 ml einer Lösung bestehend aus 90 Gew.?S Isopropylalkohol 10 Gew.^ Wasser 1,2 Gew.jfi Äthylenoxyd 0,5 Gew.?» Sorbinsäure130 ml of a solution consisting of 90 wt.? S isopropyl alcohol 10 wt. ^ Water 1.2% by weight of ethylene oxide 0.5% by weight? » Sorbic acid
mit Triäthanolamin auf pH 6,8 eingestelltadjusted to pH 6.8 with triethanolamine
werden in eine Flasche gegeben, welche das zu sterilisierende Rathmaterlal enthält, und 7 Tage bei 300C belassen.are placed in a bottle containing the sterilized Rathmaterlal, and left for 7 days at 30 0 C.
Hahtmaterial der Stärke 1 wird etwa 1 Tag mit einer' Lösung bestehend aus 95 Gew·^ IsopropylalkoholSuture material of strength 1 is treated with a ' Solution consisting of 95% by weight isopropyl alcohol
5 jew.it «faseer 0,5 Gew.# Bernsteinsäure mit Triäthanolamin auf pH 6,8 gebracht behandelt* Anschließend wird der so behandelte Faden in eine Folyäthylenfolie eingeschweißt und mit Ithylenoxyd durch Begasung sterilisiert«5 jew.it «faseer 0.5 wt. # Succinic acid brought to pH 6.8 with triethanolamine treated * Then the thread treated in this way is welded into a polyethylene film and coated with ethylene oxide sterilized by fumigation "
Claims (5)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP0031035 | 1963-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1492425A1 true DE1492425A1 (en) | 1969-12-04 |
Family
ID=7372135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19631492425 Withdrawn DE1492425A1 (en) | 1963-01-31 | 1963-01-31 | Method of sterilizing surgical sutures |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US3414370A (en) |
| DE (1) | DE1492425A1 (en) |
| NL (1) | NL6400695A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6681184B2 (en) * | 2001-05-15 | 2004-01-20 | Input/Output, Inc. | System for estimating azimuthal variations in seismic data |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2817437A (en) * | 1957-01-15 | 1957-12-24 | Johnson & Johnson | Sterilization of collagenous sutures with epoxides |
| US3097996A (en) * | 1959-05-02 | 1963-07-16 | Bayer Ag | Preservatives consisting of mixed anhydrides of alkylcarbonic acids |
| US2983750A (en) * | 1959-07-03 | 1961-05-09 | Bristol Myers Co | Tris methylammonium salicylate salts |
| US3234268A (en) * | 1964-03-05 | 1966-02-08 | Dow Chemical Co | Alkanolamine salts of salicylic acid and uses thereof |
-
1963
- 1963-01-31 DE DE19631492425 patent/DE1492425A1/en not_active Withdrawn
-
1964
- 1964-01-29 US US341115A patent/US3414370A/en not_active Expired - Lifetime
- 1964-01-29 NL NL6400695A patent/NL6400695A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3414370A (en) | 1968-12-03 |
| NL6400695A (en) | 1964-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E77 | Valid patent as to the heymanns-index 1977 | ||
| EHJ | Ceased/non-payment of the annual fee |