DE1149857B - Process for the preparation of an agent effective against diseases of the oral cavity - Google Patents

Process for the preparation of an agent effective against diseases of the oral cavity

Info

Publication number
DE1149857B
DE1149857B DEB62958A DEB0062958A DE1149857B DE 1149857 B DE1149857 B DE 1149857B DE B62958 A DEB62958 A DE B62958A DE B0062958 A DEB0062958 A DE B0062958A DE 1149857 B DE1149857 B DE 1149857B
Authority
DE
Germany
Prior art keywords
oral cavity
preparation
effective against
against diseases
agent effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEB62958A
Other languages
German (de)
Inventor
Dr Willi Doerr
Hubertus Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOCHEMISCHES LAB HUBERTUS SCH
Original Assignee
BIOCHEMISCHES LAB HUBERTUS SCH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOCHEMISCHES LAB HUBERTUS SCH filed Critical BIOCHEMISCHES LAB HUBERTUS SCH
Priority to DEB62958A priority Critical patent/DE1149857B/en
Priority to CH591462A priority patent/CH413236A/en
Priority to BE618110A priority patent/BE618110A/en
Priority to DK251662AA priority patent/DK107573C/en
Priority to LU41888D priority patent/LU41888A1/xx
Priority to GB23534/62A priority patent/GB984897A/en
Publication of DE1149857B publication Critical patent/DE1149857B/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Virology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Tea And Coffee (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung eines gegen Erkrankungen der Mundhöhle wirkenden Mittels Gegenstand der Erfindung ist ein mikrobiologisches Verfahren zur Herstellung eines gegen Erkrankungen der Mundhöhle besonders gegen Aphthen wirkenden Mittels. Process for the preparation of an anti-diseases of the oral cavity acting agent The invention is a microbiological method for Production of an anti-diseases of the oral cavity, especially against aphthae Means.

Das erfindungsgemäße Verfahren besteht darin, daß man mit bei Paradontose, Gingivitis, Stomatitis und Aphthen vorhandenen Mundbakterien, die in Form eines Abstriches oder auf andere Weise aus der Mundhöhle entnommen wurden, und Speichel ein pulverisierten Rohkaffee, Kohlehydrate, Stickstoffquellen und Spurenelemente enthaltendes Nährmedium beimpft und die Bakterien unter nichtsterilen Bedingungen in einer Oberflächen- oder Submerskultur fermentiert. Nach entsprechend langem Wachstum bei etwa 18 bis 240 C, gewöhnlich nach etwa 3 Wochen, ist genügend Perkolat erzeugt, worauf das Kulturmedium direkt oder nach dem Filtrieren in übliche flüssige oder feste Verarbeitungsformen übergeführt wird. Das beim Filtrieren zurückbleibende Mycel kann zu einer Salbe verarbeitet werden. The method according to the invention consists in that with periodontal disease, Gingivitis, stomatitis and canker sores present oral bacteria in the form of a Swab or otherwise taken from the oral cavity, and saliva a powdered green coffee, carbohydrates, nitrogen sources and trace elements containing nutrient medium is inoculated and the bacteria under non-sterile conditions fermented in a surface or submerged culture. After a correspondingly long growth at about 18 to 240 C, usually after about 3 weeks, sufficient percolate is produced whereupon the culture medium directly or after filtering into usual liquid or solid processing forms is transferred. What is left after filtering Mycelium can be made into an ointment.

Ein besonders vorteilhaftes Verfahren besteht darin, daß man Wasser mit pulverisiertem Rohkaffee und danach mit Haferflocken versetzt. Zum besseren Aufschluß dieser Rohstoffe, insbesondere des Rohkaffees sollte während der Zugabe dieser Stoffe das Wasser auf einer Temperatur von bis etwa 1000 C gehalten werden. Darauf stellt man den pH-Wert, z. B. mit Weinsäure, auf 5 bis 7 ein und beimpft das so hergestellte Nährmedium nach dem Abkühlen auf etwa 700 C oder darunter mit den Bakterien. A particularly advantageous method is that you have water with powdered green coffee and then mixed with oat flakes. For the better Digestion of these raw materials, especially the green coffee, should be carried out during the addition of these substances the water can be kept at a temperature of up to about 1000 C. The pH value is then set, e.g. B. with tartaric acid, on 5 to 7 and inoculated the nutrient medium produced in this way after cooling to about 700 ° C. or below the bacteria.

Zur Durchführung des erfindungsgemäßen Verfahrens können die angegebenen Stoffe in etwa den folgenden Mengenverhältnissen verwendet werden: 2 1 Wasser, 250 g Haferflocken 100 g Rohkaffee, 15 g Weinsäure. To carry out the process according to the invention, the specified Substances are used in approximately the following proportions: 2 1 water, 250 g oat flakes, 100 g green coffee, 15 g tartaric acid.

Der so hergestellte, physiologisch einwandfreie, d. h. keine unerwünschten Nebenwirkungen hervorrufende Wirkstoff stellt ein ausgezeichnetes Mittel zur Bekämpfung von Krankheiten der Mundhöhle, insbesondere von Aphthen, Paradontose, Gingivitis, Stomatitis und jeglichen Arten von Ulcerationen dar. Er besitzt gleichzeitig analgetische Eigenschaften und kann intern oder extern angewandt werden. The physiologically perfect, d. H. no unwanted Active ingredient causing side effects is an excellent means of combating it diseases of the oral cavity, especially aphthae, periodontal disease, gingivitis, Stomatitis and all kinds of ulcerations. He has analgesic at the same time Properties and can be applied internally or externally.

Klinische Untersuchungen haben gezeigt, daß sich der erfindungsgemäße Wirkstoff zur Behandlung aller entzündlichen Prozesse an der Mundschleimhaut einschließiich sämtlicher Zahnfleischentzündungen, insbesondere der Gingivitis ulcerosa und bei dem fast allen Paradontosen vorhandenen Entzündungszustand der marginalen Gingiva eignet. Die Behandlung mit dem erfindungsgemäßen Wirkstoff führt bei den genannten entzündlichen Zuständen zu einer weitestgehenden Besserung bzw., falls eine Wiederherstellung überhaupt möglich ist, zu einer völligen Heilung. Clinical studies have shown that the inventive Active ingredient for the treatment of all inflammatory processes on the oral mucosa, including all inflammation of the gums, especially ulcerative gingivitis and in the inflammation of the marginal gingiva, which is present in almost all periodontoses suitable. Treatment with the active ingredient according to the invention leads to the above inflammatory conditions to an as far as possible improvement or, if a recovery at all possible to a complete cure.

Ganz hervorragend aber bewährte sich seine Anwendung zur Bekämpfung aller Fälle von Aphthen.However, its use for combating has proven to be very good all cases of aphthous ulcers.

Der erfindungsgemäße Wirkstoff zeigt außerdem überraschende desodorierende Eigenschaften gegenüber den verschiedenartigsten, als unangenehm empfundenen Gerüchen, z. B. Mundgerüchen. Falls die desodorierende Wirkung gesteigert werden soll, gibt man dem Nährmedium vor der Fermentation noch Chlorophyll oder Chlorophyll enthaltende Substanzen zu. The active ingredient according to the invention also shows surprising deodorizing properties Properties in relation to the most varied of odors that are perceived as unpleasant, z. B. Bad breath. If the deodorizing effect is to be increased, there is the nutrient medium contains chlorophyll or chlorophyll before fermentation Substances too.

Man hat schon ein Rohkaffee und Stärke enthaltendes Medium einer Fermentation unter nichtsterilen Bedingungen ausgesetzt. Dieses enthielt jedoch außerdem Schwefel und war vor der Einwirkung der von außen spontan zutretenden Mikroorganismen nicht mit Bakterien beimpft worden. Als Fermentationsprodukt wurde dementsprechend ein völlig anderer, nämlich rheumaspezifischer Wirkstoff mit pharmakologischem Histamingehalt erhalten, der mit dem erfindungsgemäßen Wirkstoff nicht vergleichbar ist. You already have a medium containing green coffee and starch Fermentation suspended under non-sterile conditions. However, this contained also sulfur and was before the action of the spontaneously occurring microorganisms from outside has not been inoculated with bacteria. As a fermentation product was accordingly a completely different, namely rheumatoid-specific active ingredient with pharmacological histamine content obtained, which is not comparable with the active ingredient according to the invention.

Seine Herstellung konnte im Hinblick auf das differenzierte Verhalten von Mikroorganismen unter wechselnden Bedingungen auch nicht aus dem bekannten Verfahren abgeleitet werden.Its production could with regard to the differentiated behavior of microorganisms under changing conditions also not from the known method be derived.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines gegen Erkrankungen der Mundhöhle, besonders gegen Aphthen wirkenden Mittels, dadurch gekennzeidhnet, daß man die bei Paradontose, Gingivitis, Stomatitis und Aphthen vorhandenen Mundbakterien bei p, 5 bis 7 in einem pulverisierten Rohkaffee, Kohlenhydrate und Stickstoffquellen enthaltenden Nährmedium unter nichtsterilen Bedingungen durch Oberflächen- oder Submerskultur fermentiert, das Kulturmedium filtriert und das Filtrat und gegebenenfalls auch das Mycel aufarbeitet. PATENT CLAIM: Process for the production of an anti-diseases the oral cavity, especially against aphthous ulcers, thereby marked, that the oral bacteria present in periodontal disease, gingivitis, stomatitis and aphthae at p, 5 to 7 in a powdered green coffee, carbohydrates and nitrogen sources containing nutrient medium under non-sterile conditions by surface or Fermented submerged culture, the culture medium filtered and the filtrate and optionally also works up the mycelium.
DEB62958A 1961-06-20 1961-06-20 Process for the preparation of an agent effective against diseases of the oral cavity Pending DE1149857B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DEB62958A DE1149857B (en) 1961-06-20 1961-06-20 Process for the preparation of an agent effective against diseases of the oral cavity
CH591462A CH413236A (en) 1961-06-20 1962-05-16 Process for the preparation of an agent effective against diseases of the oral cavity
BE618110A BE618110A (en) 1961-06-20 1962-05-25 Process for obtaining a preparation based on microorganisms, having therapeutic activity and simultaneously deodorant
DK251662AA DK107573C (en) 1961-06-20 1962-06-06 Process for the preparation of a therapeutically effective microorganism preparation which at the same time has a deodorizing effect.
LU41888D LU41888A1 (en) 1961-06-20 1962-06-15
GB23534/62A GB984897A (en) 1961-06-20 1962-06-19 Manufacture of a preparation which in effective in combating diseases of the mouth cavity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB62958A DE1149857B (en) 1961-06-20 1961-06-20 Process for the preparation of an agent effective against diseases of the oral cavity

Publications (1)

Publication Number Publication Date
DE1149857B true DE1149857B (en) 1963-06-06

Family

ID=6973790

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB62958A Pending DE1149857B (en) 1961-06-20 1961-06-20 Process for the preparation of an agent effective against diseases of the oral cavity

Country Status (6)

Country Link
BE (1) BE618110A (en)
CH (1) CH413236A (en)
DE (1) DE1149857B (en)
DK (1) DK107573C (en)
GB (1) GB984897A (en)
LU (1) LU41888A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000038A1 (en) * 1993-06-23 1995-01-05 Wm. Wrigley Jr. Company Improved chewing gum and candy products
FR2779345B1 (en) * 1998-06-03 2003-02-14 Fabre Pierre Dermo Cosmetique USE OF MICROORGANISM EXTRACTS IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BODY ODORS

Also Published As

Publication number Publication date
GB984897A (en) 1965-03-03
BE618110A (en) 1962-09-17
LU41888A1 (en) 1962-08-16
DK107573C (en) 1967-06-12
CH413236A (en) 1966-05-15

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