DE1134478B - Skin protection ointment containing silicone - Google Patents

Description

Skin protection ointment containing silicone. The invention relates to a Ointment with combined therapeutic and cosmetic, usefulness. In particular the invention relates to a protective ointment in the form of creams and ointments that an extremely long-lasting protection of the skin against water and the influence from irritants, such as those in the home, in hospitals, laboratories, industrial Plants and the like, as well as in the open air.

It has been both clinically and specially elaborated Laboratory tests demonstrated that virtually all of the commonly available in stores Protective ointments of this kind located in one direction or another are an actual one Protection against the multitude of irritants encountered during actual use will not offer. Since the requirements in the use of such a product are so varied that it has not yet been possible to find a universal composition To create utility one has a large number of special formulations elaborated which specific tasks in skin protection should fulfill.

For example, from a chemical point of view, such a product must be be absolutely non-toxic and without affecting the skin. Chemical substances on the Skin may be present, such as sweat, urine in children, cosmetics, soaps and perfumes, facial tonics, and the like, must not be affected. Farther Such a product must have a large number of polar solvents, which as such irritants or those used as solvents or carriers of skin irritants act, reject. Finally, the ointment must not have any local effect on the Reduce therapeutic substances applied to the skin.

From a physical standpoint, the ointment must be proportionate let it spread easily at normal temperature. You must be firmly on the at the same time Skin adheres and remains stable over a wide temperature range. Farther the product should be able to at least one mild wash with water and But it should also be easily removable if desired to survive soap will.

From a medical point of view, the protective substance should also be the most special Do not irritate sensitive skin areas, and it should preferably have at least one have limited sedative effects. It is particularly important that the ointment die normal activity under conditions such as: B. in the usual industrial Dermatoses occur, not impaired or prevented. The protective ointment should in be able to be used against irritations such as those for Colostomy or stomatic fistulas or intertrigo and the like occur without there is a risk of infection. Furthermore, the ointment should have a protective effect against Poison ivy and similar irritations caused by pollen possess as well as against a large number of active ingredients, such as those found in households or in industry.

The invention is based on the observation that a formulation, those from a certain ratio of a paraffinic ointment base, a Silicone liquid or oil and zinc stearate result in a protective ointment that meets the above requirements. The protective effect is that according to the invention Ointment apparently largely selective, and the components potentiate the normal Protective effect expected from each individual can be insofar as than the properties of the composition according to the invention are completely different of those who combine two of the three individual ingredients be attained. They also outperform the properties with all three ingredients in various proportions or combinations other than those mentioned below differ, be obtained.

The silicone oils consist of linear or cyclic polymers of the repeating group in which R usually denotes methyl or phenyl radicals and the end groups of the chains of the linear polymers contain the same radicals in triple substitution. The silicone polymers are generally water-clear, odorless, inert liquids of exceptional thermal stability. Their viscosity changes little with temperature fluctuations. The pour points of the liquids are around -40 ° C and their flash points around 300 ° C with viscosity indices of over 100 cSt at 25 ° C. Oils with viscosities of 10 cSt and higher have boiling points of over 200 ° C and are not addictive at normal temperatures .

The special properties of silicone oils, such as the ability to water to repel. Heat resistance, chemical and physiological ineffectiveness, They have non-toxicity, odorlessness and good adhesion to the skin as protective agents Made particularly suitable for the skin. Their complete non-toxicity in the Use on the skin is known to have been proven.

According to the invention, a silicone oil with a viscosity index between 150 to 350 cSt (25 ° C) used because it has been found that such Viscosities and the associated repellent properties of the silicones for the Skin protection ointment of the present invention is particularly suitable. On the other hand make it more difficult higher viscosities the introduction of the powdered zinc stearate, so that the quantities not sufficient to achieve a sufficient protective effect. On the other hand, leave behind Low viscosity silicones leave a greasy film on the skin and are therefore dated cosmetic point of view undesirable.

That used as a further component of the protective ointment according to the invention Zinc stearate has a dual purpose, namely, to be completely resilient to effect the ointment towards solvents; also avoids the addition of Zinc stearate removes the unsightly greasy sheen caused by the paraffinic ointment base as well as caused by the silicone oil. The zinc stearate is preferred Manufactured according to the regulations of the Pharmacopoeia and should be free of granular components be. Furthermore, it should not be less than 13% and not more than 15.5% zinc oxide contain. Its density should be around 1.68 g / ccm.

Paraffinic ointment bases can have various properties in terms of viscosity, consistency and melting point. liür the invention Ointment is preferred that has a Saybolt melting point of 45 to 49 ° C, a Saybolt viscosity of 50 to 60 at 100 ° C and an ASTM consistency from 200 to 300.

In terms of weight, the ointment according to the invention should be 25% of the paraffinic Ointment base, 45 to 60% of a dimethyl and / or diphenyl polysiloxane of 150 to 350 cSt at 25 ° C and 15 to 30% zinc stearate.

The ointment according to the invention is widely used in vitro according to the Glass plate immersion test from Suskind (»Industrial and Laboratory Evaluation of a Silicone Protective Cream "; AMA Arch. Ind. And Occ. Med. 9, 101, 1954) been. In this test, the ointment is applied in an even thin film on one Applied to the side of a normal microscope slide. The coated one Page is then inserted vertically into a flask containing the liquid to be examined contains so that the lower half of the slide is immersed while the upper half remains above the liquid level. Det unchanged film on the top Half of the object carrier is used to control the immersed half. This test provides information about whether the film has been immersed after a certain period of time breaks or is destroyed, swells, flakes or completely dissolves. For weight determination is the slide before the test and after each 5 minutes, 20 minutes, 1 hour, Weighed 3 hours, 6 hours and 24 hours after immersion. To this end the solvent is air-dried before each weighing.

This test gives a good approximation of the results that are expected can be applied when the protective film is applied to human skin and for a immersed in the solvent for a certain period of time. The results of this test show that the ointment according to the application provides 100% protection against a number caused by polar solvents and other irritants for at least 24 hours. Alcohols, ketones, acids, alkalis, oil fractions, soaps, Detergents, phenol, dichromates, metal polishes and synthetic wetting agents tried.

The ointment according to the invention was compared to all previously on the market the products located there have a much higher protective effect. For example, a product A, which is made from silicone, nitrocellulose and castor oil in an ointment base for vanishing cream insists within 5 minutes through the tested solvents removed by 40 to 100 "/ o, so it shows only a very limited protective effect.

Product B, containing 20 / o silicone in a fat-free ointment base, was peeled off within 5 minutes between 8 and 60, within 1 hour between 35 to 100 ° / o for the same solvents.

Product C, containing 52.5% silicone in an inert ointment base, was removed by 2 to 100 / o from the solvents in 5 minutes and by 4 to 35% within 3 hours. Product D, containing 77D / o silicone with a mineral f üllston, showed some peeling after 5 minutes, and within 3 hours it was completely replaced. Product E, consisting of 30 "/ o silicone in a paraffinic Ointment base, was attacked by solvents after 6 hours. The full Results of these tests are given in the following tables.

Comparative stability figures after the film immersion test. Removal of the film in O / o 1% Line Curd Soap Lubricant Soap Testereme immersion time ethyl alcohol acetone nitric water 1% 1% Silicone oil (48%) ... 5 minutes 0 0 0 0 0 0 Zinc stearate (275). 20 minutes 0 0 0 0 0 0 Petrolatum (25 "/ o). IShourO00000 3 hours 0 0 0 0 0 0 6 hours 0 0 0 0 0 0 24 hours000000 5 minutes 75 100 60 55 60 60 20 minutes 85 60 55 60 60 1 hour 100 60 55 60 60 Product A ... # 3 hours 60 55 60 60 6 hours 60 55 60 60 24 hours 60 60 100 60 | 5 minutes 35 60 50 30 20 20 20 minutes 40 70 80 30 35 25 1 hour 45 80 100 40 35 35 Product B. .. # 3 hours 100 100 100 50 45 35 6 hours (weight- (weight-40 24 hour increase) increase) 45 5 minutes 5 10 5 5 4 4 20minutes7155845 1 hour 7 20 5 8 4 5 Product C. ... # 3 hours 10 30 5 8 4 5 6 hours 10 40 5 8 4 5 24 hours 10 40 5 8 4 5 5 minutes 16 100 4 6 7 0 20 minutes 74 7 6 8 8 1 hour 84 13 6 8 10 Product D. .. # 3 hours 100 15 6 8 10 6 hours 15 6 8 10 24 hours (weight increase) 5 minutes 0 0 0 0 0 0 20 minutes 0 0 0 0 0 0 1 hour 0 0 0 0 0 0 Products . .. # 3 hours 0 1 1 0 0 0 6 hours 4 10 10 (weight- (weight- 2nd 24 hours 8 15 20 increase) increase) 4 Comparative stability figures after the film immersion test. Detachment of the film in ° / o Cresol HCl NaOH HN4OH Phenol H2SO4 K2CR2O7 Spindle disinfect Testereme immersion time H2SO4 oil agent (1%) (10%) (27%) (10%) (30%) (13%) (1%) Silicone oil (48%) 5 minutes 0 0 0 0 0 0 0 0 0 Zinc stearate (27%) 20 minutes 000,000,000 0 Petrolatum (25%) 1 hour 0 0 0 0 0 0 0 0 0 3 hours 0 0 0 0 0 0 0 ao 6 hours 0 0 0 0 0 0 0 0 0 24 hours00000000 0 5 minutes 60 60 50 60 50 40 50 40 100 20 minutes 60 60 50 100 100 45 55 95 1 hour 60 60 50 50 50 60 100 1 hour 60 60 50 50 50 60 100 Product hours 60 60 100 50 50 60 6 hours 60 60 50 60 24 hours 60 60 50 60 (Continuation) Cresol HCl NaOH HN4OH PHenol H2SO4 K2CR2O7 Spindle disinfectant Test cream immersion time H2SO4 oil agent (1%) (10%) (27%) (10%) (30%) (13%) (1%) 5 minutes 25 10 30 8, 0 9, 0 20 22 15 20 20 minutes 25 10 30 65 20 40 40 48 1 hour 30 25 30 100 90 30 40 60 100 Product B .. .. # 3 hours 35 30 30 100 30 40 100 - 6 hours 45 40 100 (weight-40 24 hours 45 50 increase) 40 5minutes652553500 20 minutes 6 5 2 5 6 3 5 0 0 1 hour 7 5 4 5 6 7 5 0 0 Product C .. .. # 3 hours 7 7 7 5 6 7 5 35 0 6 hours 7 7 7 5 6 7 5 85 0 24 hours 7 7 7 5 6 7 5 100 0 5minutes555460210 20 minutes 5 5 67 4 6 0 2 1 0 1 hour 9 7 67 4 6 14 3 6 0 Product D .. .. # 3 hours 9 7 67 4 15 14 4 7 0 6 hours 9 7 67 4 15 16 4 7 0 24 hours 9 7 67 4 15 16 4 7 0 5minutes000000000 20 minutes000000200 1 hour 0 0 0 0 0 0 2 0 0 Products .. .. # 3 hours 0 1 1 0 1 0 2 0 0 6 hours 2 10 3 1 (weight 2 100 0 24 hours 4 15 5 8 increase) 2 In addition to the demonstrable superiority of the ointment according to the invention with regard to its resistance to irritants, a cosmetic superiority in the use of the same can also be recognized. When applied to the skin in the form of a thin film, a pleasant, smooth, silky feeling is achieved on the coated surface.

The film produced is neither sticky nor slippery, both of which are undesirable and is also dangerous when tools or equipment are operated by hand. In addition, the ointment is easy to spread and there are no "knots" when it is rubbed into the skin. This is especially important when using for delicate skin that should only be rubbed a little, such as the Preventing diaper rashes. After all, the film is completely invisible on the skin, which is particularly beneficial from a cosmetic point of view.

In the following examples a skin ointment according to the invention is used described.

Example 1 48 kg of a dimethylpolysiloxane having a viscosity of 200 cSt at 25 ° C are mixed with 25 kg of a white paraffinic ointment base (USA.-Pharmacopeia) mixed and heated to 55 ° C. After that, 27 kg of zinc stearate are passed through added to the heated mixture through a colloid mill. After homogenizing the product is passed through an ointment mill and packaged.

Example 2 48 kg of a dimethylpolysiloxane having a viscosity of 150 cSt at 25 ° C with 25 kg of a white paraffinic ointment base and 27 kg of zinc stearate mixed well at room temperature. The product is supported by a Ointment grinder given until it is soft.

Example 3 60 kg of a diphenylpolysiloxane with a viscosity of 350 cSt at 25 ° C are mixed with 25 kg of a white paraffinic ointment base and 15 kg of zinc stearate (USA.-Pharmacopeia) mixed at 25 ° C.

After homogenization, the mass is passed through an ointment mill.

Example 4 45 kg of a mixture of 5û% and dimethyl polyiloxane 50% diphenylpolysiloxane with a viscosity of almost 200 cSt at 25 ° C with 25 kg of a white paraffinic ointment base and 30 kg of zinc stearate (USA.-Pharmacopeia) mixed. The resulting mixture is warmed to 55 ° C and then passed through a colloid mill given.

After homogenization, the product is passed through an ointment mill and packaged.

Claims (2)

PATENT CLAIMS: 1. Silicone skin protection ointment with paraffinic Basis, characterized in that it contains 45 to 60 percent by weight of a dimethyl and / or Diphenylpolysiloxane with a viscosity of 150 to 350 cSt at 25 ° C, 15 to 30 percent by weight of zinc stearate and 25 percent by weight of a paraffinic ointment base contains. 2. Skin protection ointment according to claim 1, characterized in that it 48 percent by weight of a dimethyl and / or diphenyl polysiloxane with a viscosity of 200 cSt at 25 ° C, 27 weight percent zinc stearate and 25 weight percent one white paraffinic ointment base with a Saybolt viscosity of 50 to 60 at 100 ° C. Documents considered: British Patent Specification No. 803 289, 714 795; U.S. Patent No. 2,698,824.