DE112017000292A5 - α6-Integrin bindendes DNA-Aptamer - Google Patents

α6-Integrin bindendes DNA-Aptamer Download PDF

Info

Publication number
DE112017000292A5
DE112017000292A5 DE112017000292.3T DE112017000292T DE112017000292A5 DE 112017000292 A5 DE112017000292 A5 DE 112017000292A5 DE 112017000292 T DE112017000292 T DE 112017000292T DE 112017000292 A5 DE112017000292 A5 DE 112017000292A5
Authority
DE
Germany
Prior art keywords
integrin
dna aptamer
binding dna
binding
aptamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE112017000292.3T
Other languages
English (en)
Inventor
Udo Schumacher
Tobias Lange
Daniel Wicklein
Ulrich Hahn
Katharina Redder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitatsklinikum Hamburg Eppendorf
Universitaet Hamburg
Original Assignee
Universitatsklinikum Hamburg Eppendorf
Universitaet Hamburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatsklinikum Hamburg Eppendorf, Universitaet Hamburg filed Critical Universitatsklinikum Hamburg Eppendorf
Publication of DE112017000292A5 publication Critical patent/DE112017000292A5/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
DE112017000292.3T 2016-01-04 2017-01-03 α6-Integrin bindendes DNA-Aptamer Withdrawn DE112017000292A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102016100039.6A DE102016100039A1 (de) 2016-01-04 2016-01-04 α6-Integrin bindendes DNA-Aptamer
DE102016100039.6 2016-01-04
PCT/DE2017/200000 WO2017118458A1 (de) 2016-01-04 2017-01-03 α6-INTEGRIN BINDENDES DNA-APTAMER

Publications (1)

Publication Number Publication Date
DE112017000292A5 true DE112017000292A5 (de) 2018-09-13

Family

ID=58056937

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102016100039.6A Withdrawn DE102016100039A1 (de) 2016-01-04 2016-01-04 α6-Integrin bindendes DNA-Aptamer
DE112017000292.3T Withdrawn DE112017000292A5 (de) 2016-01-04 2017-01-03 α6-Integrin bindendes DNA-Aptamer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE102016100039.6A Withdrawn DE102016100039A1 (de) 2016-01-04 2016-01-04 α6-Integrin bindendes DNA-Aptamer

Country Status (2)

Country Link
DE (2) DE102016100039A1 (de)
WO (1) WO2017118458A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115820650A (zh) * 2022-11-11 2023-03-21 湖南大学 一种特异性识别并结合整合素α4的核酸适体及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2259800T3 (es) 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
AU2001296846B2 (en) * 2000-10-12 2007-07-05 University Of Rochester Compositions that inhibit proliferation of cancer cells
WO2005052122A2 (en) 2003-11-22 2005-06-09 Sloan-Kettering Institute For Cancer Research METHODS FOR CONTROLLING PATHOLOGICAL ANGIOGENESIS BY INHIBITION OF α6β4 INTEGRIN
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
US20060030535A1 (en) 2004-03-05 2006-02-09 Healy Judith M Controlled modulation of the pharmacokinetics and biodistribution of aptamer therapeutics
CN104412135B (zh) 2012-06-27 2018-04-20 英派尔科技开发有限公司 光照可控薄膜
EP2703005A1 (de) * 2012-09-04 2014-03-05 Università Degli Studi Di Torino Hemmer des Alpha-6-Integrin/E-Cadherinkomplexes
BR112015009138A2 (pt) * 2012-10-23 2020-10-20 Caris Life Sciences Switzerland Holdings, S.A.R.L. métodos para caracterizar um câncer
DE102013112915A1 (de) 2013-11-22 2015-05-28 Universitätsklinikum Hamburg-Eppendorf (UKE) DNA-Aptamere, die E- und P-Selektine spezifisch binden

Also Published As

Publication number Publication date
DE102016100039A1 (de) 2017-07-06
WO2017118458A1 (de) 2017-07-13

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Legal Events

Date Code Title Description
R082 Change of representative

Representative=s name: POHL & PARTNER PATENTANWAELTE MBB, DE

Representative=s name: RGTH RICHTER GERBAULET THIELEMANN HOFMANN PATE, DE

Representative=s name: POHL & PARTNER PATENTANWAELTE, DE

R083 Amendment of/additions to inventor(s)
R082 Change of representative

Representative=s name: RGTH RICHTER GERBAULET THIELEMANN HOFMANN PATE, DE

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee