DE112007003160A5 - Automatischer Mikrofluidik-Prozessor - Google Patents

Automatischer Mikrofluidik-Prozessor Download PDF

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Publication number
DE112007003160A5
DE112007003160A5 DE112007003160T DE112007003160T DE112007003160A5 DE 112007003160 A5 DE112007003160 A5 DE 112007003160A5 DE 112007003160 T DE112007003160 T DE 112007003160T DE 112007003160 T DE112007003160 T DE 112007003160T DE 112007003160 A5 DE112007003160 A5 DE 112007003160A5
Authority
DE
Germany
Prior art keywords
microfluidic processor
automatic microfluidic
automatic
processor
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE112007003160T
Other languages
English (en)
Other versions
DE112007003160B4 (de
Inventor
Andreas Richter
Stephan Klatt
Tobias Wage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dresden
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE112007003160A5 publication Critical patent/DE112007003160A5/de
Application granted granted Critical
Publication of DE112007003160B4 publication Critical patent/DE112007003160B4/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0672—Swellable plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
DE112007003160.3T 2006-10-27 2007-10-23 Automatischer Mikrofluidik-Prozessor Active DE112007003160B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006051535A DE102006051535A1 (de) 2006-10-27 2006-10-27 Automatischer Mikrofluidik-Prozessor
DE102006051535.8 2006-10-27
PCT/DE2007/001905 WO2008049413A2 (de) 2006-10-27 2007-10-23 Automatischer mikrofluidik-prozessor

Publications (2)

Publication Number Publication Date
DE112007003160A5 true DE112007003160A5 (de) 2009-09-24
DE112007003160B4 DE112007003160B4 (de) 2023-02-09

Family

ID=39267935

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102006051535A Withdrawn DE102006051535A1 (de) 2006-10-27 2006-10-27 Automatischer Mikrofluidik-Prozessor
DE112007003160.3T Active DE112007003160B4 (de) 2006-10-27 2007-10-23 Automatischer Mikrofluidik-Prozessor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE102006051535A Withdrawn DE102006051535A1 (de) 2006-10-27 2006-10-27 Automatischer Mikrofluidik-Prozessor

Country Status (4)

Country Link
US (1) US9029131B2 (de)
EP (1) EP2094387A2 (de)
DE (2) DE102006051535A1 (de)
WO (1) WO2008049413A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8551599B2 (en) 2008-09-03 2013-10-08 The Regents Of The University Of Michigan Reconfigurable microactuator and method of configuring same
WO2011124092A1 (en) 2010-04-09 2011-10-13 The Hong Kong University Of Science And Technology Liquid-electronic hybrid divider
DE102010015161B4 (de) 2010-04-16 2014-03-13 Technische Universität Dresden Mikrofluidiksystem und Verfahren zu dessen Betreiben
KR20120091631A (ko) * 2011-02-09 2012-08-20 삼성전자주식회사 미세유동장치
KR101257700B1 (ko) * 2011-12-05 2013-04-24 삼성전자주식회사 미세유동장치 및 이를 포함하는 미세유동시스템
FR2987282B1 (fr) 2012-02-24 2017-12-29 Fonds De L'espci Georges Charpak Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage
DE102012206042B4 (de) 2012-04-13 2013-11-07 Technische Universität Dresden Verfahren und Vorrichtung zur gezielten Prozessführung in einem Mikrofluidik-Prozessor mit integrierten aktiven Elementen
JP2014240065A (ja) * 2013-05-15 2014-12-25 公立大学法人大阪府立大学 流路構造体および流路構造体の製造方法
JP7296210B2 (ja) * 2015-11-23 2023-06-22 バークレー ライツ，インコーポレイテッド インサイチュー生成マイクロ流体分離構造、そのキット、及びその使用方法
CN111420718B (zh) * 2020-04-01 2022-01-14 安徽大学 一种求解最小集合覆盖问题的微流控芯片及其dna计算方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920701670A (ko) 1989-06-14 1992-08-12 원본미기재 개선된 마이크로펌프(micropump).
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
DE19812436A1 (de) 1998-03-22 1999-09-30 Univ Dresden Tech Funktionselement für die Fluid- oder Aerosoltechnik
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6283718B1 (en) 1999-01-28 2001-09-04 John Hopkins University Bubble based micropump
KR100677860B1 (ko) * 1999-07-23 2007-02-05 보드 오브 트러스티스 오브 유니버스티 오브 일리노이즈 미세하게 제조되는 장치 및 그의 제조방법
JP3548858B2 (ja) 2001-01-22 2004-07-28 独立行政法人産業技術総合研究所 流量の制御方法及びそれに用いるマイクロバルブ
WO2003051286A2 (en) 2001-11-01 2003-06-26 Regents Of The University Of Minnesota Hydrogel compositions, devices, and microscale components
DE10157317A1 (de) 2001-11-23 2003-06-05 Gesim Ges Fuer Silizium Mikros Grundelement eines Mikrofluidik-Prozessors
DE10202996A1 (de) 2002-01-26 2003-08-14 Eppendorf Ag Piezoelektrisch steuerbare Mikrofluidaktorik
AU2003285849A1 (en) * 2002-03-20 2004-03-29 Advanced Sensor Technologies, Inc. Personal monitor to detect exposure to toxic agents
US7648619B2 (en) * 2002-06-04 2010-01-19 Industrial Technology Research Hydrogel-driven micropump
DE10300896A1 (de) * 2003-01-13 2004-07-22 Disetronic Licensing Ag Automatische, von Hydrogelen getriebene Fördereinrichtung mit einstellbarer Abgabecharakteristik zum Fördern eines Mediums, insbesondere Insulin
WO2005108571A1 (ja) * 2004-05-07 2005-11-17 Konica Minolta Medical & Graphic, Inc. 検査用マイクロリアクタおよび遺伝子検査装置ならびに遺伝子検査方法
DE102004062893A1 (de) 2004-12-20 2006-06-29 Technische Universität Dresden Elektronisch steuerbare Mikropumpe auf Hydrogelbasis
US8337777B2 (en) * 2006-06-28 2012-12-25 Applied Biosystems, Llc Sample distribution devices and methods

Also Published As

Publication number Publication date
EP2094387A2 (de) 2009-09-02
DE102006051535A1 (de) 2008-12-18
DE112007003160B4 (de) 2023-02-09
WO2008049413A2 (de) 2008-05-02
US9029131B2 (en) 2015-05-12
US20100151561A1 (en) 2010-06-17
WO2008049413A3 (de) 2008-06-19

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R081 Change of applicant/patentee

Owner name: TECHNISCHE UNIVERSITAET DRESDEN, DE

Free format text: FORMER OWNER: RICHTER, ANDREAS, DR., 01219 DRESDEN, DE

Effective date: 20111129

R012 Request for examination validly filed

Effective date: 20120711

R016 Response to examination communication
R016 Response to examination communication
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R018 Grant decision by examination section/examining division
R020 Patent grant now final
R082 Change of representative