DE112007000683A5 - Vorrichtung zur Durchführung und Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen - Google Patents

Vorrichtung zur Durchführung und Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen Download PDF

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Publication number
DE112007000683A5
DE112007000683A5 DE112007000683T DE112007000683T DE112007000683A5 DE 112007000683 A5 DE112007000683 A5 DE 112007000683A5 DE 112007000683 T DE112007000683 T DE 112007000683T DE 112007000683 T DE112007000683 T DE 112007000683T DE 112007000683 A5 DE112007000683 A5 DE 112007000683A5
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Germany
Prior art keywords
carrying
temperature
controlled
testing
biological
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Granted
Application number
DE112007000683T
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English (en)
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DE112007000683B4 (de
Inventor
Stefan Heydenhauss
Jens GÖHRING
Friedrich Menges
Jürgen Bauer
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Zenteris GmbH
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Zenteris GmbH
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Publication of DE112007000683A5 publication Critical patent/DE112007000683A5/de
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Expired - Fee Related legal-status Critical Current
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
DE112007000683T 2006-11-28 2007-11-27 Vorrichtung zur Durchführung und Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen Expired - Fee Related DE112007000683B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006056540.1 2006-11-28
DE102006056540A DE102006056540A1 (de) 2006-11-28 2006-11-28 Vorrichtung und Verfahren zur Untersuchung von biologischen und medizinischen Proben
PCT/EP2007/010298 WO2008064865A2 (de) 2006-11-28 2007-11-27 Vorrichtung zur durchführung und untersuchung biologischer proben mit temperaturgesteuerten biologischen reaktionen

Publications (2)

Publication Number Publication Date
DE112007000683A5 true DE112007000683A5 (de) 2009-08-13
DE112007000683B4 DE112007000683B4 (de) 2012-11-15

Family

ID=39111031

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102006056540A Withdrawn DE102006056540A1 (de) 2006-11-28 2006-11-28 Vorrichtung und Verfahren zur Untersuchung von biologischen und medizinischen Proben
DE112007000683T Expired - Fee Related DE112007000683B4 (de) 2006-11-28 2007-11-27 Vorrichtung zur Durchführung und Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE102006056540A Withdrawn DE102006056540A1 (de) 2006-11-28 2006-11-28 Vorrichtung und Verfahren zur Untersuchung von biologischen und medizinischen Proben

Country Status (3)

Country Link
US (1) US20100068822A1 (de)
DE (2) DE102006056540A1 (de)
WO (1) WO2008064865A2 (de)

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Publication number Priority date Publication date Assignee Title
DE102007052281A1 (de) * 2007-11-02 2009-05-07 Zenteris Gmbh Einschritt-Multiplex-Immuntest
DE102008054313B4 (de) 2008-11-03 2012-12-13 Zenteris Gmbh Kartusche und Vorrichtung zur Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen
US8840850B2 (en) * 2009-01-15 2014-09-23 Panasonic Corporation Flow channel structure and method of manufacturing same
US8975087B2 (en) 2010-11-24 2015-03-10 Inanovate, Inc. Longitudinal assay
DE102011109338B3 (de) * 2011-08-03 2013-01-31 Dietrich Reichwein Vorrichtung zur Speicherung elektromagnetischer Energie
CA2879729A1 (en) * 2012-08-07 2014-02-13 California Institute Of Technology Ultrafast thermal cycler
US10793820B2 (en) * 2013-04-30 2020-10-06 Lawrence Livermore National Security, Llc Miniaturized, automated in-vitro tissue bioreactor
DE102015002000B3 (de) * 2015-02-20 2016-02-04 Friz Biochem Gesellschaft Für Bioanalytik Mbh Mikrofluidische Vorrichtung zur temperaturgesteuerten Verarbeitung einer Probenlösung
DE102015001998B3 (de) * 2015-02-20 2016-02-04 Friz Biochem Gesellschaft Für Bioanalytik Mbh Mikrofluidische Kartusche für den Nachweis von Biomolekülen
GB201518993D0 (en) * 2015-10-27 2015-12-09 Randox Lab Ltd Improvements relating to analysis of biochips
CN106929388A (zh) * 2015-12-31 2017-07-07 苏州百源基因技术有限公司 一种实时荧光定量pcr仪
EP3301431B1 (de) 2016-09-29 2019-08-28 Roche Diagniostics GmbH Mehrkammer-analysevorrichtung und verfahren zur analyse

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Publication number Priority date Publication date Assignee Title
US4673657A (en) * 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
FR2790686B3 (fr) * 1999-03-09 2001-05-11 Biomerieux Sa Carte d'analyse dont le remplissage est associe a au moins un volume tampon
FR2803225B1 (fr) * 1999-12-29 2002-06-14 Biomerieux Sa Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides
US6313371B1 (en) * 2000-04-12 2001-11-06 Brian J Conant Flatulence deodorizer
US7470533B2 (en) * 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US20040137607A1 (en) * 2003-01-09 2004-07-15 Yokogawa Electric Corporation Biochip cartridge
US7854897B2 (en) * 2003-05-12 2010-12-21 Yokogawa Electric Corporation Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system
US8961900B2 (en) * 2004-04-28 2015-02-24 Yokogawa Electric Corporation Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge
DE102004022263A1 (de) * 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE102005052713A1 (de) * 2005-11-04 2007-05-16 Clondiag Chip Tech Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE112007001597A5 (de) * 2006-06-27 2009-07-16 Zenteris Gmbh Kühleinrichtung für eine Reaktionskammer zum Prozessieren eines Biochips und Verfahren zum Ansteuern einer solchen Kühleinrichtung

Also Published As

Publication number Publication date
DE102006056540A1 (de) 2008-05-29
WO2008064865A3 (de) 2008-09-12
DE112007000683B4 (de) 2012-11-15
WO2008064865A2 (de) 2008-06-05
US20100068822A1 (en) 2010-03-18

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