DE1117993T1 - Pneumatisch-gestützte elektrospray-vorrichtung mit alternierenden druckgradienten für die massenspektrometrie - Google Patents

Pneumatisch-gestützte elektrospray-vorrichtung mit alternierenden druckgradienten für die massenspektrometrie

Info

Publication number
DE1117993T1
DE1117993T1 DE1117993T DE99956493T DE1117993T1 DE 1117993 T1 DE1117993 T1 DE 1117993T1 DE 1117993 T DE1117993 T DE 1117993T DE 99956493 T DE99956493 T DE 99956493T DE 1117993 T1 DE1117993 T1 DE 1117993T1
Authority
DE
Germany
Prior art keywords
pneumatic
supported
mass spectrometry
pressure gradients
alternating pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1117993T
Other languages
English (en)
Inventor
J Wells
C Tong
P Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Varian Inc
Original Assignee
Varian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varian Inc filed Critical Varian Inc
Publication of DE1117993T1 publication Critical patent/DE1117993T1/de
Pending legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H01J49/045—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol with means for using a nebulising gas, i.e. pneumatically assisted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE1117993T 1998-09-28 1999-09-27 Pneumatisch-gestützte elektrospray-vorrichtung mit alternierenden druckgradienten für die massenspektrometrie Pending DE1117993T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/162,261 US6207955B1 (en) 1998-09-28 1998-09-28 Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry
PCT/US1999/022322 WO2000019192A1 (en) 1998-09-28 1999-09-27 Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry

Publications (1)

Publication Number Publication Date
DE1117993T1 true DE1117993T1 (de) 2001-12-20

Family

ID=22584874

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1117993T Pending DE1117993T1 (de) 1998-09-28 1999-09-27 Pneumatisch-gestützte elektrospray-vorrichtung mit alternierenden druckgradienten für die massenspektrometrie

Country Status (6)

Country Link
US (1) US6207955B1 (de)
EP (1) EP1117993A1 (de)
JP (1) JP2003517576A (de)
CA (1) CA2345430C (de)
DE (1) DE1117993T1 (de)
WO (1) WO2000019192A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040902B2 (en) 2011-10-17 2015-05-26 Shimadzu Corporation Atmospheric pressure ionization mass spectrometer

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US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
US6359275B1 (en) * 1999-07-14 2002-03-19 Agilent Technologies, Inc. Dielectric conduit with end electrodes
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
JP3581604B2 (ja) * 1999-09-13 2004-10-27 株式会社日立製作所 大気圧イオン化質量分析装置
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US6841774B1 (en) * 2000-11-28 2005-01-11 Mds Inc. Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams
CA2444731C (en) * 2001-04-20 2010-09-14 David D. Y. Chen High throughput ion source with multiple ion sprayers and ion lenses
US6690006B2 (en) 2001-05-24 2004-02-10 New Objective, Inc. Method and apparatus for multiple electrospray sample introduction
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
CN100340856C (zh) * 2004-02-03 2007-10-03 复旦大学 一种纳升喷雾装置
JP4151592B2 (ja) 2004-03-10 2008-09-17 株式会社島津製作所 質量分析装置
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
GB0608024D0 (en) 2006-04-24 2006-05-31 Micromass Ltd Mass spectrometer
US20110049348A1 (en) * 2009-08-25 2011-03-03 Wells Gregory J Multiple inlet atmospheric pressure ionization apparatus and related methods
JP5254915B2 (ja) * 2009-09-11 2013-08-07 紀本電子工業株式会社 浮遊粒子状物質発生装置
JP5589750B2 (ja) * 2010-10-15 2014-09-17 株式会社島津製作所 質量分析装置用イオン化装置及び該イオン化装置を備える質量分析装置
JP7032286B2 (ja) * 2018-11-08 2022-03-08 株式会社日立ハイテク イオン源
GB2572671B (en) 2019-02-01 2021-09-22 Agilent Technologies Inc Interface device between sample separation device and mass spectrometer having multiple sample capillaries
CN111569750B (zh) * 2020-04-22 2022-03-22 江苏大学 一种基于电场诱导的液滴微混合蒸发调控装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861988A (en) * 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
US5170053A (en) * 1990-08-30 1992-12-08 Finnigan Corporation Electrospray ion source and interface apparatus and method
US5115131A (en) * 1991-05-15 1992-05-19 The University Of North Carolina At Chapel Hill Microelectrospray method and apparatus
AU2170392A (en) * 1991-05-21 1992-12-30 Analytica Of Branford, Inc. Method and apparatus for improving electrospray ionization of solute species
US5349186A (en) * 1993-06-25 1994-09-20 The Governors Of The University Of Alberta Electrospray interface for mass spectrometer and method of supplying analyte to a mass spectrometer
US5868322A (en) 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
DE19882421T1 (de) 1997-03-15 2001-07-26 Analytica Of Brandford Inc Eimalsonde mit mikrofeiner Spitze für den Einsatz bei der Elektroversprühung von Stoffen mit geringer Durchflußmenge

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040902B2 (en) 2011-10-17 2015-05-26 Shimadzu Corporation Atmospheric pressure ionization mass spectrometer

Also Published As

Publication number Publication date
WO2000019192A1 (en) 2000-04-06
US6207955B1 (en) 2001-03-27
CA2345430A1 (en) 2000-04-06
EP1117993A1 (de) 2001-07-25
JP2003517576A (ja) 2003-05-27
CA2345430C (en) 2006-02-07

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