DE10352535A1 - Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit - Google Patents

Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit Download PDF

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Publication number
DE10352535A1
DE10352535A1 DE10352535A DE10352535A DE10352535A1 DE 10352535 A1 DE10352535 A1 DE 10352535A1 DE 10352535 A DE10352535 A DE 10352535A DE 10352535 A DE10352535 A DE 10352535A DE 10352535 A1 DE10352535 A1 DE 10352535A1
Authority
DE
Germany
Prior art keywords
particles
section
complexes
separating
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10352535A
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German (de)
English (en)
Inventor
Gert Dr. Blankenstein
Claus Dipl.-Ing. Marquordt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Steag Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steag Microparts GmbH filed Critical Steag Microparts GmbH
Priority to DE10352535A priority Critical patent/DE10352535A1/de
Priority to EP04025985.5A priority patent/EP1531003B1/de
Priority to US10/983,096 priority patent/US20050106756A1/en
Priority to JP2004324376A priority patent/JP2005140790A/ja
Priority to CNB2004100923056A priority patent/CN100453182C/zh
Publication of DE10352535A1 publication Critical patent/DE10352535A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4316—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor the baffles being flat pieces of material, e.g. intermeshing, fixed to the wall or fixed on a central rod
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE10352535A 2003-11-07 2003-11-07 Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit Withdrawn DE10352535A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE10352535A DE10352535A1 (de) 2003-11-07 2003-11-07 Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
EP04025985.5A EP1531003B1 (de) 2003-11-07 2004-11-02 Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
US10/983,096 US20050106756A1 (en) 2003-11-07 2004-11-08 Microstructured separation device, and method for separating liquid components from a liquid containing particles
JP2004324376A JP2005140790A (ja) 2003-11-07 2004-11-08 粒子を含む液体から液状成分を分離するための微細構造型分離装置および分離方法
CNB2004100923056A CN100453182C (zh) 2003-11-07 2004-11-08 用于从含有微粒的液体中分离液体组分的微结构的分离装置和方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10352535A DE10352535A1 (de) 2003-11-07 2003-11-07 Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit

Publications (1)

Publication Number Publication Date
DE10352535A1 true DE10352535A1 (de) 2005-06-16

Family

ID=34428663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10352535A Withdrawn DE10352535A1 (de) 2003-11-07 2003-11-07 Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit

Country Status (5)

Country Link
US (1) US20050106756A1 (enExample)
EP (1) EP1531003B1 (enExample)
JP (1) JP2005140790A (enExample)
CN (1) CN100453182C (enExample)
DE (1) DE10352535A1 (enExample)

Cited By (3)

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DE102011122579A1 (de) * 2011-12-29 2013-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Trennen von Suspensions- oder Kolloidbestandteilen und Vorrichtung zum Trennen von Suspensions- oder Kolloidbestandteilen
CN114950220A (zh) * 2013-03-13 2022-08-30 雅培制药有限公司 减轻液体中的气泡形成的方法和设备
USD1099356S1 (en) 2013-03-13 2025-10-21 Abbott Laboratories Reagent container

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BRPI0907148B1 (pt) * 2008-02-27 2021-01-12 Boehringer Ingelheim Microparts Gmbh dispositivo para a separação do plasma
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WO2010041231A2 (en) * 2008-10-10 2010-04-15 Cnrs-Dae Cell sorting device
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WO2011078115A1 (ja) * 2009-12-25 2011-06-30 学校法人常翔学園 固液分離機能を有する装置、μ－ＴＡＳデバイス及び固液分離方法
AU2011223512B2 (en) * 2010-03-05 2016-07-21 Garrett Thermal Systems Limited Filter bypass
ES2715828T3 (es) * 2010-04-15 2019-06-06 Cytogen Co Ltd Dispositivo microfluídico y métodos para aislar dianas
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US20130143197A1 (en) * 2010-08-15 2013-06-06 Gpb Scientific, Llc Microfluidic Cell Separation in the Assay of Blood
KR101768123B1 (ko) * 2010-12-03 2017-08-16 삼성전자주식회사 수력학 필터, 이를 구비한 필터링 장치 및 이에 의한 필터링 방법
CN116179323A (zh) 2011-05-27 2023-05-30 不列颠哥伦比亚大学 用于高通量分析的微流控细胞捕获和分析设备
KR101911435B1 (ko) 2011-09-26 2018-10-25 삼성전자주식회사 유체 제어 장치, 이를 포함하는 필터 및 바이오칩
KR101890743B1 (ko) * 2011-10-05 2018-08-23 삼성전자주식회사 유체 제어 장치 및 이를 사용하는 유체 제어 방법
KR101517091B1 (ko) 2012-05-10 2015-05-04 단국대학교 산학협력단 미세입자 분리장치 및 미세입자 분리수거방법
USD962471S1 (en) 2013-03-13 2022-08-30 Abbott Laboratories Reagent container
US9535082B2 (en) 2013-03-13 2017-01-03 Abbott Laboratories Methods and apparatus to agitate a liquid
CN107966576B (zh) 2013-03-15 2021-08-03 雅培制药有限公司 具有后面可进入轨道系统的自动化诊断分析仪及相关方法
US9958429B2 (en) * 2013-11-06 2018-05-01 Japan Science And Technology Agency Substrate for controlling movement direction of animal cells, and cell identification method and cell separation method using the same
EP3226003A4 (en) * 2014-11-28 2018-06-20 Toyo Seikan Group Holdings, Ltd. Micro liquid transfer structure and analysis device
KR102360072B1 (ko) * 2014-12-08 2022-02-08 삼성전자주식회사 미세입자 분리 장치
KR101850852B1 (ko) 2016-01-08 2018-04-23 재단법인차세대융합기술연구원 미세유체채널장치 및 이의 사용방법
KR102593919B1 (ko) * 2016-03-21 2023-10-27 주식회사 지노바이오 세포 포획 카트리지
WO2017217563A1 (ko) 2016-06-13 2017-12-21 엘지전자 주식회사 디스플레이 장치 및 그를 포함하는 디스플레이 시스템
CN106311368B (zh) * 2016-07-29 2018-06-15 大连理工大学 一种用于微量进样器的液滴无损脱离装置
GB2578187B (en) * 2018-09-28 2022-10-05 Guangdong Acxel Micro & Nano Tech Co Ltd Droplet actuation
US11850583B2 (en) * 2019-06-12 2023-12-26 Siemens Healthcare Diagnostics Inc. Plasma separation and sample metering device and kits and methods of use related thereto
DE102020004660B4 (de) * 2020-07-31 2022-06-15 Evorion Biotechnologies Gmbh Vorrichtung zur sequentiellen Positionierung von Partikeln
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WO2023144192A1 (de) * 2022-01-25 2023-08-03 Evorion Biotechnologies Gmbh Vorrichtung zur sequentiellen positionierung von partikeln
CN118922704A (zh) * 2022-03-28 2024-11-08 国立大学法人茨城大学 白血球捕捉设备
US20250325986A1 (en) * 2022-06-23 2025-10-23 Solventum Intellectual Properties Company Methods and devices for removing particles from fluids
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US6451264B1 (en) * 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels

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Publication number Priority date Publication date Assignee Title
DE102011122579A1 (de) * 2011-12-29 2013-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Trennen von Suspensions- oder Kolloidbestandteilen und Vorrichtung zum Trennen von Suspensions- oder Kolloidbestandteilen
WO2013098256A1 (de) 2011-12-29 2013-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum trennen von suspensions- oder kolloidbestandteilen und vorrichtung zum trennen von suspensions- oder kolloidbestandteilen
CN114950220A (zh) * 2013-03-13 2022-08-30 雅培制药有限公司 减轻液体中的气泡形成的方法和设备
USD1099356S1 (en) 2013-03-13 2025-10-21 Abbott Laboratories Reagent container

Also Published As

Publication number Publication date
JP2005140790A (ja) 2005-06-02
EP1531003A1 (de) 2005-05-18
EP1531003B1 (de) 2016-08-17
CN100453182C (zh) 2009-01-21
US20050106756A1 (en) 2005-05-19
CN1628907A (zh) 2005-06-22

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