DE10227507A1 - Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung - Google Patents

Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Download PDF

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Publication number
DE10227507A1
DE10227507A1 DE10227507A DE10227507A DE10227507A1 DE 10227507 A1 DE10227507 A1 DE 10227507A1 DE 10227507 A DE10227507 A DE 10227507A DE 10227507 A DE10227507 A DE 10227507A DE 10227507 A1 DE10227507 A1 DE 10227507A1
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DE
Germany
Prior art keywords
alkyl
phenyl
agonists
compounds
conh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10227507A
Other languages
German (de)
English (en)
Inventor
Gerhard Dr. Jaehne
Wendelin Dr. Frick
Stefanie Dr. Flohr
Andreas Dr. Lindenschmidt
Heiner Dr. Glombik
Werner Prof. Dr. Kramer
Hubert Dr. Heuer
Hans-Ludwig Dr. Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE10227507A priority Critical patent/DE10227507A1/de
Priority to DK03735534T priority patent/DK1517890T3/da
Priority to MXPA04012308A priority patent/MXPA04012308A/es
Priority to PCT/EP2003/005814 priority patent/WO2004000803A1/de
Priority to ES03735534T priority patent/ES2310662T3/es
Priority to HR20041202A priority patent/HRP20041202A2/xx
Priority to KR10-2004-7020518A priority patent/KR20050010061A/ko
Priority to AU2003238209A priority patent/AU2003238209B2/en
Priority to RU2005101088/04A priority patent/RU2315753C2/ru
Priority to PL03372660A priority patent/PL372660A1/xx
Priority to CN038140934A priority patent/CN1662494A/zh
Priority to YUP-1086/04A priority patent/RS108604A/sr
Priority to BR0311984-0A priority patent/BR0311984A/pt
Priority to EP03735534A priority patent/EP1517890B1/de
Priority to AT03735534T priority patent/ATE401304T1/de
Priority to JP2004514659A priority patent/JP2005533071A/ja
Priority to CA002490108A priority patent/CA2490108A1/en
Priority to DE50310161T priority patent/DE50310161D1/de
Priority to PT03735534T priority patent/PT1517890E/pt
Priority to PA20038575601A priority patent/PA8575601A1/es
Priority to SV2003001555A priority patent/SV2004001555A/es
Priority to UY27852A priority patent/UY27852A1/es
Priority to TW092116320A priority patent/TW200406380A/zh
Priority to US10/463,789 priority patent/US7671047B2/en
Publication of DE10227507A1 publication Critical patent/DE10227507A1/de
Priority to ZA200409379A priority patent/ZA200409379B/xx
Priority to MA27989A priority patent/MA27251A1/fr
Priority to IL165790A priority patent/IL165790A/en
Priority to NO20050088A priority patent/NO20050088L/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE10227507A 2002-06-19 2002-06-19 Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Withdrawn DE10227507A1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE10227507A DE10227507A1 (de) 2002-06-19 2002-06-19 Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP03735534A EP1517890B1 (de) 2002-06-19 2003-06-04 Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
JP2004514659A JP2005533071A (ja) 2002-06-19 2003-06-04 カチオン的に置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用
PCT/EP2003/005814 WO2004000803A1 (de) 2002-06-19 2003-06-04 Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ES03735534T ES2310662T3 (es) 2002-06-19 2003-06-04 Difenilazetidinonas cationicamente sustituidas, procedimiento para su preparacion, medicamentos que contienen a estos compuestos y su uso.
HR20041202A HRP20041202A2 (en) 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
KR10-2004-7020518A KR20050010061A (ko) 2002-06-19 2003-06-04 양이온적으로 치환된 디페닐 아제티디논, 이의 제조방법,이들 화합물을 함유하는 약제 및 이의 용도
AU2003238209A AU2003238209B2 (en) 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
RU2005101088/04A RU2315753C2 (ru) 2002-06-19 2003-06-04 Катионозамещенные дифенилазетидиноны, способ их получения, лекарственные средства, содержащие эти соединения, и их применение
PL03372660A PL372660A1 (en) 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
CN038140934A CN1662494A (zh) 2002-06-19 2003-06-04 阳离子取代的二苯基2－吖丁啶酮、它们的制备方法、含有所述化合物的药物及其用途
YUP-1086/04A RS108604A (sr) 2002-06-19 2003-06-04 Katjonski supstituisani difenil- azetidinoni, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena
BR0311984-0A BR0311984A (pt) 2002-06-19 2003-06-04 Difenilazetidinonas substituìdas cationicamente, processo para a sua preparação, medicamentos contendo estes compostos e sua aplicação
DK03735534T DK1517890T3 (da) 2002-06-19 2003-06-04 Kationisk substituerede diphenylazetidinoner, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse
AT03735534T ATE401304T1 (de) 2002-06-19 2003-06-04 Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE50310161T DE50310161D1 (de) 2002-06-19 2003-06-04 Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
MXPA04012308A MXPA04012308A (es) 2002-06-19 2003-06-04 Difenilazetidinonas cationicamente sustituidas, metodo para su preparacion, medicamentos que comprenden estos compuestos y su uso.
CA002490108A CA2490108A1 (en) 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
PT03735534T PT1517890E (pt) 2002-06-19 2003-06-04 Azetidinonas de difenilo substituídas cationicamente, processo para a sua preparação, medicamentos contendo estes compostos e sua utilização
PA20038575601A PA8575601A1 (es) 2002-06-19 2003-06-13 Procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso
SV2003001555A SV2004001555A (es) 2002-06-19 2003-06-16 Difenilazetidinonas cationicamente sustituidas, procesos para su preparacion, medicamentos que contienen estos compuestos y sus usos
UY27852A UY27852A1 (es) 2002-06-19 2003-06-16 Difenilazatidinonas cationicamente sustituidas, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso.
TW092116320A TW200406380A (en) 2002-06-19 2003-06-17 Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
US10/463,789 US7671047B2 (en) 2002-06-19 2003-06-18 Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
ZA200409379A ZA200409379B (en) 2002-06-19 2004-11-22 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
MA27989A MA27251A1 (fr) 2002-06-19 2004-12-08 Diphenylazetidinones substituees par voie cationique, procede pour leur production, medicaments contenants lesdits composes et utilisation de ceux-ci
IL165790A IL165790A (en) 2002-06-19 2004-12-15 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
NO20050088A NO20050088L (no) 2002-06-19 2005-01-06 Kationisk substituerte difenylazefidinoner, fremgangsmate for deres fremstilling, medikamenter inneholdende nevnte forbindelser og anvendelse derav

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10227507A DE10227507A1 (de) 2002-06-19 2002-06-19 Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number Publication Date
DE10227507A1 true DE10227507A1 (de) 2004-01-08

Family

ID=29719282

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10227507A Withdrawn DE10227507A1 (de) 2002-06-19 2002-06-19 Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE50310161T Expired - Lifetime DE50310161D1 (de) 2002-06-19 2003-06-04 Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50310161T Expired - Lifetime DE50310161D1 (de) 2002-06-19 2003-06-04 Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Country Status (26)

Country Link
EP (1) EP1517890B1 (enExample)
JP (1) JP2005533071A (enExample)
KR (1) KR20050010061A (enExample)
CN (1) CN1662494A (enExample)
AT (1) ATE401304T1 (enExample)
AU (1) AU2003238209B2 (enExample)
BR (1) BR0311984A (enExample)
CA (1) CA2490108A1 (enExample)
DE (2) DE10227507A1 (enExample)
DK (1) DK1517890T3 (enExample)
ES (1) ES2310662T3 (enExample)
HR (1) HRP20041202A2 (enExample)
IL (1) IL165790A (enExample)
MA (1) MA27251A1 (enExample)
MX (1) MXPA04012308A (enExample)
NO (1) NO20050088L (enExample)
PA (1) PA8575601A1 (enExample)
PL (1) PL372660A1 (enExample)
PT (1) PT1517890E (enExample)
RS (1) RS108604A (enExample)
RU (1) RU2315753C2 (enExample)
SV (1) SV2004001555A (enExample)
TW (1) TW200406380A (enExample)
UY (1) UY27852A1 (enExample)
WO (1) WO2004000803A1 (enExample)
ZA (1) ZA200409379B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
DE602004029715D1 (de) 2003-12-23 2010-12-02 Astrazeneca Ab Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
JP5254620B2 (ja) 2004-12-03 2013-08-07 メルク・シャープ・アンド・ドーム・コーポレーション Ｃｂ１アンタゴニストとしての置換ピペラジン
US8361999B2 (en) 2005-04-04 2013-01-29 Pontificia Universidad Catolica De Chile Methods of treating cholesterol gallstone disease with ezetimibe
CN101243072A (zh) 2005-06-20 2008-08-13 先灵公司 用作组胺h3拮抗剂的哌啶衍生物
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
BRPI0715160A2 (pt) 2006-08-08 2013-06-11 Sanofi Aventis imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso
DE102007002260A1 (de) 2007-01-16 2008-07-31 Sanofi-Aventis Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US9212175B2 (en) 2009-03-06 2015-12-15 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
ES2443016T3 (es) 2009-08-26 2014-02-17 Sanofi Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) * 2000-08-29 2002-03-28 Aventis Pharma Gmbh Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
EP1345924B1 (de) * 2000-12-21 2006-08-30 Sanofi-Aventis Deutschland GmbH Diphenylazetidinonderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
CA2431983C (en) * 2000-12-21 2010-06-08 Aventis Pharma Deutschland Gmbh Novel 1,2-diphenylazetidinones, processes for their preparation, medicaments comprising these compounds and their use for treating impaired lipid metabolism
IL156552A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use

Also Published As

Publication number Publication date
RU2315753C2 (ru) 2008-01-27
TW200406380A (en) 2004-05-01
PT1517890E (pt) 2008-10-14
JP2005533071A (ja) 2005-11-04
IL165790A0 (en) 2006-01-15
DE50310161D1 (de) 2008-08-28
PA8575601A1 (es) 2004-02-07
NO20050088L (no) 2005-01-06
MXPA04012308A (es) 2005-02-25
EP1517890A1 (de) 2005-03-30
SV2004001555A (es) 2004-03-19
CA2490108A1 (en) 2003-12-31
BR0311984A (pt) 2005-04-26
WO2004000803A1 (de) 2003-12-31
AU2003238209B2 (en) 2009-01-22
AU2003238209A1 (en) 2004-01-06
ZA200409379B (en) 2006-05-31
ES2310662T3 (es) 2009-01-16
UY27852A1 (es) 2003-12-31
PL372660A1 (en) 2005-07-25
ATE401304T1 (de) 2008-08-15
KR20050010061A (ko) 2005-01-26
DK1517890T3 (da) 2008-11-10
EP1517890B1 (de) 2008-07-16
HRP20041202A2 (en) 2005-06-30
CN1662494A (zh) 2005-08-31
RS108604A (sr) 2007-02-05
RU2005101088A (ru) 2005-06-27
MA27251A1 (fr) 2005-03-01
IL165790A (en) 2010-04-15

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8127 New person/name/address of the applicant

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

8130 Withdrawal