JP2005533071A - カチオン的に置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用 - Google Patents
カチオン的に置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用 Download PDFInfo
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- JP2005533071A JP2005533071A JP2004514659A JP2004514659A JP2005533071A JP 2005533071 A JP2005533071 A JP 2005533071A JP 2004514659 A JP2004514659 A JP 2004514659A JP 2004514659 A JP2004514659 A JP 2004514659A JP 2005533071 A JP2005533071 A JP 2005533071A
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- Prior art keywords
- alkyl
- phenyl
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- conh
- compounds
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- Abandoned
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 131
- 239000003814 drug Substances 0.000 title claims description 15
- 238000000034 method Methods 0.000 title description 8
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- 238000002360 preparation method Methods 0.000 title description 4
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 125
- 239000000203 mixture Substances 0.000 claims description 32
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
- 229910052731 fluorine Inorganic materials 0.000 claims description 24
- -1 (phenyl) - Chemical class 0.000 claims description 19
- 229910052794 bromium Inorganic materials 0.000 claims description 18
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10227507A DE10227507A1 (de) | 2002-06-19 | 2002-06-19 | Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| PCT/EP2003/005814 WO2004000803A1 (de) | 2002-06-19 | 2003-06-04 | Kationisch substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
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| JP2005533071A true JP2005533071A (ja) | 2005-11-04 |
| JP2005533071A5 JP2005533071A5 (enExample) | 2006-07-06 |
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| JP2004514659A Abandoned JP2005533071A (ja) | 2002-06-19 | 2003-06-04 | カチオン的に置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用 |
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| JP (1) | JP2005533071A (enExample) |
| KR (1) | KR20050010061A (enExample) |
| CN (1) | CN1662494A (enExample) |
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| BR (1) | BR0311984A (enExample) |
| CA (1) | CA2490108A1 (enExample) |
| DE (2) | DE10227507A1 (enExample) |
| DK (1) | DK1517890T3 (enExample) |
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| HR (1) | HRP20041202A2 (enExample) |
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| SV (1) | SV2004001555A (enExample) |
| TW (1) | TW200406380A (enExample) |
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| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| ATE485267T1 (de) | 2003-12-23 | 2010-11-15 | Astrazeneca Ab | Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung |
| WO2006060461A1 (en) | 2004-12-03 | 2006-06-08 | Schering Corporation | Substituted piperazines as cb1 antagonists |
| EP1865947A1 (en) | 2005-04-04 | 2007-12-19 | Pontificia Universidad Catolica de Chile | The use of ezetimibe in the prevention and treatment of cholesterol gallstones |
| ATE450526T1 (de) | 2005-06-20 | 2009-12-15 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
| DE102007002260A1 (de) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| CN102482312A (zh) | 2009-08-26 | 2012-05-30 | 赛诺菲 | 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途 |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| DE10042447A1 (de) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports |
| ES2277890T3 (es) * | 2000-12-21 | 2007-08-01 | Sanofi-Aventis Deutschland Gmbh | Nuevas difenilazetidinonas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para el tratamiento de trastornos del metabolismo de lipidos. |
| IL156552A0 (en) * | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
| HUP0401073A2 (hu) * | 2000-12-21 | 2004-09-28 | Aventis Pharma Deutschland Gmbh. | Difenilazetidinon-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
-
2002
- 2002-06-19 DE DE10227507A patent/DE10227507A1/de not_active Withdrawn
-
2003
- 2003-06-04 KR KR10-2004-7020518A patent/KR20050010061A/ko not_active Ceased
- 2003-06-04 ES ES03735534T patent/ES2310662T3/es not_active Expired - Lifetime
- 2003-06-04 CA CA002490108A patent/CA2490108A1/en not_active Abandoned
- 2003-06-04 PT PT03735534T patent/PT1517890E/pt unknown
- 2003-06-04 MX MXPA04012308A patent/MXPA04012308A/es active IP Right Grant
- 2003-06-04 WO PCT/EP2003/005814 patent/WO2004000803A1/de not_active Ceased
- 2003-06-04 DE DE50310161T patent/DE50310161D1/de not_active Expired - Lifetime
- 2003-06-04 PL PL03372660A patent/PL372660A1/xx not_active Application Discontinuation
- 2003-06-04 HR HR20041202A patent/HRP20041202A2/xx not_active Application Discontinuation
- 2003-06-04 RS YUP-1086/04A patent/RS108604A/sr unknown
- 2003-06-04 DK DK03735534T patent/DK1517890T3/da active
- 2003-06-04 AT AT03735534T patent/ATE401304T1/de not_active IP Right Cessation
- 2003-06-04 AU AU2003238209A patent/AU2003238209B2/en not_active Ceased
- 2003-06-04 BR BR0311984-0A patent/BR0311984A/pt not_active IP Right Cessation
- 2003-06-04 EP EP03735534A patent/EP1517890B1/de not_active Expired - Lifetime
- 2003-06-04 JP JP2004514659A patent/JP2005533071A/ja not_active Abandoned
- 2003-06-04 RU RU2005101088/04A patent/RU2315753C2/ru not_active IP Right Cessation
- 2003-06-04 CN CN038140934A patent/CN1662494A/zh active Pending
- 2003-06-13 PA PA20038575601A patent/PA8575601A1/es unknown
- 2003-06-16 UY UY27852A patent/UY27852A1/es unknown
- 2003-06-16 SV SV2003001555A patent/SV2004001555A/es unknown
- 2003-06-17 TW TW092116320A patent/TW200406380A/zh unknown
-
2004
- 2004-11-22 ZA ZA200409379A patent/ZA200409379B/xx unknown
- 2004-12-08 MA MA27989A patent/MA27251A1/fr unknown
- 2004-12-15 IL IL165790A patent/IL165790A/en not_active IP Right Cessation
-
2005
- 2005-01-06 NO NO20050088A patent/NO20050088L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL372660A1 (en) | 2005-07-25 |
| CA2490108A1 (en) | 2003-12-31 |
| DE50310161D1 (de) | 2008-08-28 |
| ATE401304T1 (de) | 2008-08-15 |
| KR20050010061A (ko) | 2005-01-26 |
| HRP20041202A2 (en) | 2005-06-30 |
| MXPA04012308A (es) | 2005-02-25 |
| NO20050088L (no) | 2005-01-06 |
| DK1517890T3 (da) | 2008-11-10 |
| CN1662494A (zh) | 2005-08-31 |
| TW200406380A (en) | 2004-05-01 |
| SV2004001555A (es) | 2004-03-19 |
| RU2315753C2 (ru) | 2008-01-27 |
| BR0311984A (pt) | 2005-04-26 |
| RU2005101088A (ru) | 2005-06-27 |
| EP1517890A1 (de) | 2005-03-30 |
| MA27251A1 (fr) | 2005-03-01 |
| UY27852A1 (es) | 2003-12-31 |
| DE10227507A1 (de) | 2004-01-08 |
| IL165790A (en) | 2010-04-15 |
| WO2004000803A1 (de) | 2003-12-31 |
| AU2003238209B2 (en) | 2009-01-22 |
| RS108604A (sr) | 2007-02-05 |
| IL165790A0 (en) | 2006-01-15 |
| AU2003238209A1 (en) | 2004-01-06 |
| EP1517890B1 (de) | 2008-07-16 |
| PT1517890E (pt) | 2008-10-14 |
| PA8575601A1 (es) | 2004-02-07 |
| ES2310662T3 (es) | 2009-01-16 |
| ZA200409379B (en) | 2006-05-31 |
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