DE102018124672A1 - Medicines for the treatment of dermatophytosis and its manufacturing process - Google Patents

Abstract

The present invention discloses a medicament for the treatment of dermatophytosis and its manufacturing method. The medicinal product for the treatment of dermatophytosis comprises, in parts by weight, the following raw materials: Ephedra 5 - 13, dark plum fruit 11 - 17, Anemarrena asphodeloides 6 - 12, Sichuan pepper 2-7, Scutellaria baicalensis 3 - 7, water 300 - 700, alum 3-7, Scutellaria baicalensis Georgi 5-12 and Radix Saposhnikoviae 6-9.

Description

TECHNICAL AREA

The present invention relates to the field of medical health care, and more particularly to a medicament for the treatment of dermatophytosis and its manufacturing method.

BACKGROUND

Dermatophytosis is a very common condition. Many people suffer from dermatophytosis, but there is a lack of medicines and methods to effectively treat dermatophytosis.

Dermatophytosis is a skin disease caused by pathogenic fungi and is highly contagious. There is no sebaceous gland at the position of the human foot sole and at the positions between human toes, so fatty acids are missing, which inhibit filamentous fungi on the skin and whose physiological defense function is poor; whereas the skin sweat glands are rich in these positions, so that sweating often occurs which, in combination with poor air circulation as well as local moisture and warmth, facilitates the growth of filamentous fungi. There is also a thick layer of cornea (stratum corneum) at the sole of the foot, and the keratins in the stratum corneum provide rich nutrients for the fungi, which facilitates the growth of fungi.

Most of the existing agents for treating dermatophytosis use raw materials containing salicylic acid. However, these raw materials can seriously damage the patient's skin, do not fully heal the dermatophytosis, and easily cause relapse. In addition, these medicines have an unpleasant smell and irritation can easily irritate the patient's airways and cause side effects.

SUMMARY OF THE INVENTION

The aim of the present invention is to provide a medicament for the treatment of dermatophytosis and its production process in order to overcome the above deficiencies of the prior art.

The present invention discloses a medicament for the treatment of dermatophytosis, which is produced, in parts by weight, from the following raw materials: ephedra 5-13, dark plum fruit 11-17, anemarrena asphodeloides 6-12, sichuan pepper 2-7, scutellaria baicalensis 3- 7 and water 300-700.

• Schritt 1: Reinigen aller Rohstoffe mit klarem Wasser;
• Schritt 2: jeweiliges mechanisches Pulverisieren der Ephedra, dunkle Pflaumenfrucht und Anemarrhena asphodeloides; Trocknen der vorher pulverisierten Rohstoffe unter Infraroterhitzung; jeweiliges Mahlen der vorher getrockneten Rohstoffe; Filtern der vorher gemahlenen Rohstoffe mit einem Filtersieb; und Vermischen, in Gewichtsanteilen, der gefilterten Ephedra 5 -13, der dunklen Pflaumenfrucht 11 -17 und der Anemarrhena asphodeloides 6 -12, um ein Pulver A zu erhalten;
• Schritt 3: jeweiliges mechanisches Pulverisieren des Sichuan-Pfeffers, Scutellaria baicalensis, Alaun, Scutellaria baicalensis Georgi und Radix Saposhnikoviae; Gefriertrocknen der vorher pulverisierten Rohstoffe; jeweiliges Mahlen der vorher getrockneten Rohstoffe; Filtern der vorher gemahlenen Rohstoffe mit einem Filtersieb; und Vermischen, in Gewichtsanteilen, des gefilterten Sichuan-Pfeffers 2 -7, Scutellaria baicalensis 3 -7, Alaun 3 -7, Scutellaria baicalensis Georgi 5-12 und Radix Saposhnikoviae 6 -9, um ein Pulver B zu erhalten; und
• Schritt 4: Mischen des Pulvers A und des Pulvers B, Zugabe von, in Gewichtsanteilen, Wasser 300 - 700, Einweichen für 2 Std, Kochen des resultierenden Produkts, zweimalige Filtration, um eine klare Flüssigkeit zu erhalten, und Kühlen der klaren Flüssigkeit, um das Arzneimittel zur Behandlung von Dermatophytosis zu erhalten.

The present invention also provides a method of manufacturing the medicament for treating dermatophytosis, comprising the following steps:

• Step 1: clean all raw materials with clear water;
• Step 2: mechanical pulverization of the ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials with infrared heating; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, in parts by weight, the filtered ephedra 5 -13, the dark plum fruit 11 -17 and the Anemarrhena asphodeloides 6 -12 to obtain a powder A;
• Step 3: mechanical pulverization of the Sichuan pepper, Scutellaria baicalensis, alum, Scutellaria baicalensis Georgi and Radix Saposhnikoviae; Freeze-drying the raw materials previously pulverized; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, by weight, the filtered Sichuan pepper 2-7, Scutellaria baicalensis 3-7, alum 3-7, Scutellaria baicalensis Georgi 5-12 and Radix Saposhnikoviae 6 -9 to obtain a powder B; and
• Step 4: Mix powder A and powder B, add, in parts by weight, water 300-700, soak for 2 hours, boil the resulting product, filter twice to obtain a clear liquid, and cool the clear liquid to receive the medicine to treat dermatophytosis.

The drug for treating dermatophytosis of the present invention has a quick onset, no side effects, and a low relapse ratio.

DETAILED DESCRIPTION OF THE EMBODIMENTS

Embodiment 1

• Step 1: Clean all raw materials with clear water at 20 ° C;
• Step 2: mechanical pulverization of the ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials under infrared heating at 50 ° C. for 3 hours; respective grinding of the previously dried raw materials; Filter the previously ground raw materials with a filter screen that allows a particle size of 60 mesh; and mixing, in parts by weight, the filtered ephedra 5, dark plum fruit 17 and Anemarrhena asphodeloides 6 to obtain a powder A;
• Step 3: mechanical pulverization of the Sichuan pepper, Scutellaria baicalensis, alum, Scutellaria baicalensis Georgi and Radix Saposhnikoviae; Freeze drying of the previously pulverized raw materials at -10 ° C for 4h; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, in parts by weight, the filtered Sichuan pepper 2, Scutellaria baicalensis 7, Alum 3, Scutellaria baicalensis Georgi 12 and Radix Saposhnikoviae 6 to obtain a powder B; and
• Step 4: Mix powder A and powder B, add, in parts by weight, water 300, soak for 2 hours, boil the resulting product, filter twice to obtain a clear liquid, and cool the clear liquid to a drug to treat dermatophytosis.

Embodiment 2

• Step 1: Clean all raw materials with clear water at 20 ° C;
• Step 2: mechanical pulverization of the ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials under infrared heating at 50 ° C. for 3 hours; respective grinding of the previously dried raw materials; Filter the previously ground raw materials with a filter screen that allows a particle size of 60 mesh; and mixing, in parts by weight, the filtered ephedra 13, dark plum fruit 11 and Anemarrhena asphodeloides 12 to obtain powder A;
• Step 3: mechanical pulverization of the Sichuan pepper, Scutellaria baicalensis, alum, Scutellaria baicalensis Georgi and Radix Saposhnikoviae; Freeze drying of the previously pulverized raw materials at -10 ° C for 4 hours; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, in parts by weight, the filtered Sichuan pepper 7, Scutellaria baicalensis 3, Alum 7, Scutellaria baicalensis Georgi 5 and Radix Saposhnikoviae 9 to obtain a powder B; and
• Step 4: Mix Powder A and Powder B, add, in parts by weight, water 700, soak for 2 hours, boil the resulting product, filter twice to obtain a clear liquid, and cool the clear liquid to the drug to treat dermatophytosis.

Embodiment 3

• Step 1: Clean all raw materials with clear water at 20 ° C;
• Step 2: mechanical pulverization of the ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials under infrared heating at 50 ° C. for 3 hours; respective grinding of the previously dried raw materials; Filter the previously ground raw materials with a filter screen that allows a particle size of 60 mesh; and mixing, in parts by weight, the filtered ephedra 8, dark plum fruit 15 and Anemarrhena asphodeloides 7 to obtain a powder A;
• Step 3: mechanical pulverization of the Sichuan pepper, Scutellaria baicalensis, alum, Scutellaria baicalensis Georgi and Radix Saposhnikoviae; Freeze drying of the previously pulverized raw materials at -10 ° C for 4 hours; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, in parts by weight, the filtered Sichuan pepper 3, Scutellaria baicalensis 6, Alum 4, Scutellaria baicalensis Georgi 10 and Radix Saposhnikoviae 7 to obtain a powder B; and
• Step 4: Mix powder A and powder B, add, in parts by weight, water 400, soak for 2 hours, boil the resulting product, filter twice to obtain a clear liquid, and cool the clear liquid to the drug to treat dermatophytosis.

Embodiment 4

• Step 1: Clean all raw materials with clear water at 20 ° C;
• Step 2: mechanical pulverization of the ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials under infrared heating at 50 ° C. for 3 hours; respective grinding of the previously dried raw materials; Filter the previously ground raw materials with a filter screen that allows a particle size of 60 mesh; and mixing, in parts by weight, the filtered ephedra 11, dark plum fruit 13 and Anemarrhena asphodeloides 10 to obtain a powder A;
• Step 3: mechanically pulverize the Sichuan pepper, Scutellaria baicalensis, alum, Scutellaria baicalensis Genorgi and Radix Saposhnikoviae; Freeze drying of the previously pulverized raw materials at -10 ° C for 4h; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, in parts by weight, the filtered Sichuan pepper 5, Scutellaria baicalensis 4, alum 6, Scutellaria baicalensis Georgi 6 and Radix Saposhnikoviae 9 to obtain a powder B; and
• Step 4: Mix powder A and powder B, add, by weight, water 600, soak for 2 hours, boil the resulting product, filter twice to obtain a clear liquid, and cool the clear liquid to the drug to treat dermatophytosis.

Embodiment 5

• Step 1: Clean all raw materials with clear water at 20 ° C;
• Step 2: mechanical pulverization of the ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials with infrared heating at 50 ° C for 3h; respective grinding of the previously dried raw materials; Filter the previously ground raw materials with a filter screen that allows a particle size of 60 mesh; and mixing, in parts by weight, the filtered ephedra 9, dark plum fruit 14 and Anemarrhena asphodeloides 8 to obtain a powder A;
• Step 3: mechanical pulverization of the Sichuan pepper, Scutellaria baicalensis, alum, Scutellaria baicalensis Georgi and Radix Saposhnikoviae; Freeze drying of the previously pulverized raw materials at -10 ° C for 4 hours; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve; and mixing, in parts by weight, the filtered Sichuan pepper 4, Scutellaria baicalensis 5, Alum 5, Scutellaria baicalensis Georgi 8 and Radix Saposhnikoviae 8 to obtain a powder B; and
• Step 4: Mix powder A and powder B, add, in parts by weight, water 500, soak for 2 hours, boil the resulting product, filter twice to obtain a clear liquid, and cool the clear liquid to the drug to treat dermatophytosis.

Reference example

A dermatophytosis liquid drug is prepared by the following steps according to the formula of Cn1943697A as a reference example: soaking fresh aloe in white wine (with an ethanol content of 53%) for 15 days, adding garlic, soaking the resulting product for another 7 Days, add rice vinegar, stir well, and collect clear liquid to obtain the dermatophytosis liquid drug.

The drugs for treating dermatophytosis prepared in Embodiments 1 to 5 and the liquid dermatophytosis drug prepared in the reference example were administered to 50 mild patients and 50 heavy patients, respectively, and after the administration, the effects observed in the patients were as follows in Table 1 shown: Table 1 The effects of the embodiments 1-5 and the reference example sample Number of mild patients who were cured Number of serious patients who were cured Shortest healing time for mild patients (days) Shortest healing time for heavy patients (days) Embodiment 1 37 26 3rd 6 Embodiment 2 39 28 3rd 5 Embodiment 3 41 31 2nd 5 Embodiment 4 42 32 2nd 4th Embodiment 5 46 37 1.5 3rd Reference example 32 22 5 10th

It can be seen from Table 1 that the dermatophytosis liquid drug in the reference example has a general therapeutic effect and a long healing time. However, the drugs for treating dermatophytosis produced by the present invention have a high healing rate and a short healing time.

Claims (8)

A drug for the treatment of dermatophytosis, comprising, in parts by weight, the following raw materials: Ephedra 5 -13, dark plum fruit 11 -17, Anemarrena asphodeloides 6-12, Sichuan pepper 2 -7, Scutellaria baicalensis 3 -7 and water 300 -700. The medicine used to treat dermatophytosis after Claim 1 , further comprising, in parts by weight, alum 3 -7, Scutellaria baicalensis Georgi 5 -12 and Radix Saposhnikoviae 6 -9. The medicine used to treat dermatophytosis after Claim 2 , comprising, in parts by weight, the following raw materials: Ephedra 8 -11, dark plum fruit 13 -15, Anemarrhena asphodeloides 7 -10, Sichuan pepper 3 -5, Scutellaria baicalensis 4 -6, water 400 -600, alum 4 -6, Scutellaria baicalensis Georgi 6-10 and Radix Saposhnikoviae 7 -9. The medicine used to treat dermatophytosis after Claim 2 , comprising, in parts by weight, the following raw materials: Ephedra 9, dark plum fruit 14, Anemarrena asphodeloides 8, Sichuan pepper 4, Scutellaria baicalensis 5, water 500, alum 5, Scutellaria baicalensis Georgi 8 and Radix Saposhnikoviae 8. A method of manufacturing the drug for the treatment of dermatophytosis after Claim 1 , comprising the following steps: Step 1: Clean all raw materials with clear water; Step 2: mechanical pulverization of ephedra, dark plum fruit and Anemarrhena asphodeloides; Drying the previously pulverized raw materials with infrared heating; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter screen and mixing, in parts by weight, the filtered ephedra 5-13, the dark plum fruit 11-17 and the anemarrhena asphodeloides 6-12 to obtain a powder A; Step 3: mechanical pulverization of the Sichuan pepper and Scutellaria baicalensis; Freeze-drying the raw materials previously pulverized; respective grinding of the previously dried raw materials; Filtering the previously ground raw materials with a filter sieve and mixing, in parts by weight, the filtered Sichuan pepper 2-7 and Scutellaria baicalensis 3-7 to obtain a powder B; and step 4: mixing powder A and powder B, adding, in parts by weight, water 300-700, soaking for 2 hours, boiling the resulting product, filtration twice to obtain a clear liquid, and cooling the clear liquid, to get the medicine to treat dermatophytosis. The process of manufacturing the drug for the treatment of dermatophytosis after Claim 5 , whereby the filter screen in step 2 and step 3 enables a particle size of 60 mesh. The process of manufacturing the drug for the treatment of dermatophytosis after Claim 5 , whereby, drying with infrared heating in step 2 at 50 ° C for 3 hours. The process of manufacturing the drug for the treatment of dermatophytosis after Claim 5 , whereby the freeze drying in step 3 is carried out at -10 ° C. for 4 hours.