DE102013220264A1 - Verfahren zum Mischen von Flüssigkeiten und mikrofluidisches Zentrifugalsystem - Google Patents

Verfahren zum Mischen von Flüssigkeiten und mikrofluidisches Zentrifugalsystem Download PDF

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Publication number
DE102013220264A1
DE102013220264A1 DE102013220264.4A DE102013220264A DE102013220264A1 DE 102013220264 A1 DE102013220264 A1 DE 102013220264A1 DE 102013220264 A DE102013220264 A DE 102013220264A DE 102013220264 A1 DE102013220264 A1 DE 102013220264A1
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DE
Germany
Prior art keywords
mixing chamber
mixing
centrifugal system
centrifugal
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102013220264.4A
Other languages
German (de)
English (en)
Inventor
Melanie Hoehl
Arne Kloke
Juergen Steigert
Felix von Stetten
Nils Paust
Jens Liebeskind
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Priority to DE102013220264.4A priority Critical patent/DE102013220264A1/de
Priority to PCT/EP2014/070288 priority patent/WO2015051993A1/fr
Publication of DE102013220264A1 publication Critical patent/DE102013220264A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
    • B01F25/51—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle in which the mixture is circulated through a set of tubes, e.g. with gradual introduction of a component into the circulating flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/403—Mixers using gas or liquid agitation, e.g. with air supply tubes for mixing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/408—Controlling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/409—Parts, e.g. diffusion elements; Accessories
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J7/00—Apparatus for generating gases
    • B01J7/02—Apparatus for generating gases by wet methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
DE102013220264.4A 2013-10-08 2013-10-08 Verfahren zum Mischen von Flüssigkeiten und mikrofluidisches Zentrifugalsystem Withdrawn DE102013220264A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102013220264.4A DE102013220264A1 (de) 2013-10-08 2013-10-08 Verfahren zum Mischen von Flüssigkeiten und mikrofluidisches Zentrifugalsystem
PCT/EP2014/070288 WO2015051993A1 (fr) 2013-10-08 2014-09-24 Procédé pour mélanger des liquides et système microfluidique basé sur la force centrifuge

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102013220264.4A DE102013220264A1 (de) 2013-10-08 2013-10-08 Verfahren zum Mischen von Flüssigkeiten und mikrofluidisches Zentrifugalsystem

Publications (1)

Publication Number Publication Date
DE102013220264A1 true DE102013220264A1 (de) 2015-04-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE102013220264.4A Withdrawn DE102013220264A1 (de) 2013-10-08 2013-10-08 Verfahren zum Mischen von Flüssigkeiten und mikrofluidisches Zentrifugalsystem

Country Status (2)

Country Link
DE (1) DE102013220264A1 (fr)
WO (1) WO2015051993A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018215777A1 (fr) * 2017-05-24 2018-11-29 Heriot-Watt University Mélange microfluidique
CN112481123A (zh) * 2020-11-16 2021-03-12 大连理工大学 一种研究剪切力和生化因子梯度调控细胞划痕修复的微流控系统及方法
EP3882637A4 (fr) * 2018-11-16 2023-02-22 Biofab Limited Système microfluidique permettant le mélange de liquides et procédé
DE102022203875B3 (de) 2022-04-20 2023-06-15 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Handhabung zweier flüssigkeitsvolumina

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5511880A (en) 1994-09-27 1996-04-30 Spacelabs Medical, Inc. Method and apparatus for storing and mixing a plurality of fluids and body fluid sampling cartridge using same
DE102010003223A1 (de) 2010-03-24 2011-09-29 Albert-Ludwigs-Universität Freiburg Vorrichtung zum Einsetzen in einen Rotor einer Zentrifuge, Zentrifuge und Verfahren zum fluidischen Koppeln von Kavitäten
DE102013003223A1 (de) 2013-02-27 2014-08-28 Haver & Boecker Ohg Packmaschine und Verfahren zum Füllen von Offensäcken

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WO2005016532A2 (fr) * 2003-06-13 2005-02-24 Corning Incorporated Systeme automatise de chambre de reaction pour essais biologiques
US20050272144A1 (en) * 2004-06-08 2005-12-08 Konica Minolta Medical & Graphic, Inc. Micro-reactor for improving efficiency of liquid mixing and reaction
KR20080084049A (ko) * 2007-03-14 2008-09-19 삼성전자주식회사 펌프 유닛 및 이를 구비한 원심력 기반의 미세유동 시스템
US20090075801A1 (en) * 2007-09-19 2009-03-19 Dalibor Hodko Counter-centrifugal force device
KR20110046867A (ko) * 2009-10-29 2011-05-06 삼성전자주식회사 기체 제공부를 포함하는 미세 유동 장치, 및 이를 이용한 액체 혼합 방법 및 에멀젼 형성 방법
JP6100234B2 (ja) * 2011-03-28 2017-03-22 バイオサーフィット、 ソシエダッド アノニマ 液体のスイッチング、ドーシングおよびポンピング

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5511880A (en) 1994-09-27 1996-04-30 Spacelabs Medical, Inc. Method and apparatus for storing and mixing a plurality of fluids and body fluid sampling cartridge using same
DE102010003223A1 (de) 2010-03-24 2011-09-29 Albert-Ludwigs-Universität Freiburg Vorrichtung zum Einsetzen in einen Rotor einer Zentrifuge, Zentrifuge und Verfahren zum fluidischen Koppeln von Kavitäten
DE102013003223A1 (de) 2013-02-27 2014-08-28 Haver & Boecker Ohg Packmaschine und Verfahren zum Füllen von Offensäcken

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Garstecki, P. et al. (Mixing with bubbles: a practical technology for use with portable microfluidic devices, Lab on a Chip 6 (2006) 207)
Grumann, M. et al. (Batch-mode mixing on centrifugal microfluidic platforms, Lab on a Chip 5 (2005) 560-565)
Noroozi, Z. et al. (Reciorocation flow-based centrifugal microfluidic mixer. Review of Scientific Instruments 80 (2009) 75102)
Oordt, T. et al. (Miniature stick-packaging - an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems, Lab on a Chip 13 (2013) 288)
Sànchez Miròn, A. et al., Mixing in bubble column and airlift reactors, Chemical Engineering Research and Design 82 (2004) 1367
W. Kaiser, Kunststoffchemie für Ingenieure, Hanser Fachbuchverlag, 2007
Wang, S. S. et al. (Accoustically induced bubbles in a microfluidic channel for mixing enhancement, Mircofluidic Nanofluidic 6 (2009) 847)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018215777A1 (fr) * 2017-05-24 2018-11-29 Heriot-Watt University Mélange microfluidique
US11760625B2 (en) 2017-05-24 2023-09-19 Heriot-Watt University Microfluidic mixing
EP3882637A4 (fr) * 2018-11-16 2023-02-22 Biofab Limited Système microfluidique permettant le mélange de liquides et procédé
CN112481123A (zh) * 2020-11-16 2021-03-12 大连理工大学 一种研究剪切力和生化因子梯度调控细胞划痕修复的微流控系统及方法
CN112481123B (zh) * 2020-11-16 2022-02-15 大连理工大学 一种研究剪切力和生化因子梯度调控细胞划痕修复的微流控系统及方法
DE102022203875B3 (de) 2022-04-20 2023-06-15 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Handhabung zweier flüssigkeitsvolumina

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Publication number Publication date
WO2015051993A1 (fr) 2015-04-16

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