DE102013210269B8 - Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit - Google Patents

Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit Download PDF

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Publication number
DE102013210269B8
DE102013210269B8 DE102013210269.0A DE102013210269A DE102013210269B8 DE 102013210269 B8 DE102013210269 B8 DE 102013210269B8 DE 102013210269 A DE102013210269 A DE 102013210269A DE 102013210269 B8 DE102013210269 B8 DE 102013210269B8
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DE
Germany
Prior art keywords
liquid
assaying samples
assaying
samples
Prior art date
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Active
Application number
DE102013210269.0A
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English (en)
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DE102013210269B3 (de
Inventor
Marko Heidrich
Heinrich Spiecker
Raoul-Amadeus Lorbeer
Heiko Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LZH Laser Zentrum Hannover eV
Lavision Biotec GmbH
Original Assignee
LZH Laser Zentrum Hannover eV
Lavision Biotec GmbH
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Publication date
Application filed by LZH Laser Zentrum Hannover eV, Lavision Biotec GmbH filed Critical LZH Laser Zentrum Hannover eV
Priority to DE102013210269.0A priority Critical patent/DE102013210269B8/de
Priority to US14/895,107 priority patent/US10126230B2/en
Priority to PCT/EP2014/001482 priority patent/WO2014195005A1/de
Application granted granted Critical
Publication of DE102013210269B3 publication Critical patent/DE102013210269B3/de
Publication of DE102013210269B8 publication Critical patent/DE102013210269B8/de
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/11—Filling or emptying of cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0342—Solid sample being immersed, e.g. equiindex fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/33—Immersion oils, or microscope systems or objectives for use with immersion fluids

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  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optical Measuring Cells (AREA)
DE102013210269.0A 2013-06-03 2013-06-03 Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit Active DE102013210269B8 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE102013210269.0A DE102013210269B8 (de) 2013-06-03 2013-06-03 Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit
US14/895,107 US10126230B2 (en) 2013-06-03 2014-06-03 Device and method for examining samples in a liquid
PCT/EP2014/001482 WO2014195005A1 (de) 2013-06-03 2014-06-03 Vorrichtung und verfahren zur untersuchung von proben in einer flüssigkeit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102013210269.0A DE102013210269B8 (de) 2013-06-03 2013-06-03 Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit

Publications (2)

Publication Number Publication Date
DE102013210269B3 DE102013210269B3 (de) 2014-11-06
DE102013210269B8 true DE102013210269B8 (de) 2015-01-29

Family

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Family Applications (1)

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DE102013210269.0A Active DE102013210269B8 (de) 2013-06-03 2013-06-03 Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit

Country Status (3)

Country Link
US (1) US10126230B2 (de)
DE (1) DE102013210269B8 (de)
WO (1) WO2014195005A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013210269B8 (de) 2013-06-03 2015-01-29 Laser Zentrum Hannover E.V. Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit
JP6144419B2 (ja) * 2014-05-29 2017-06-07 株式会社日立ハイテクノロジーズ 顕微鏡観察容器および観察装置
EP3274695A4 (de) 2015-06-29 2018-09-19 Hewlett-Packard Development Company, L.P. Analytdetektionsgehäuse mit integrierter linse
GB201602557D0 (en) * 2016-02-12 2016-03-30 Imp Innovations Ltd Specimen mounting device and method for live microscopy
US10310248B2 (en) * 2016-08-18 2019-06-04 Olympus Corporation Microscope including a medium container containing an immersion medium in which a specimen container containing an immersion medium and a sample is immersed
JP2018096703A (ja) * 2016-12-08 2018-06-21 オリンパス株式会社 マイクロプレートおよび顕微鏡システム
EP3376021B1 (de) * 2017-03-16 2022-05-04 Ricoh Company, Ltd. Laservorrichtung und verbrennungsmotor
ES2695798B2 (es) * 2017-07-04 2019-12-04 Univ Madrid Carlos Iii Dispositivo rotativo de cambio de objetivo para microscopio de haz láser plano
US11209638B2 (en) * 2017-07-05 2021-12-28 West Virginia University Systems and methods for supporting and positioning body tissue samples in a microscope
EP3662258B1 (de) * 2017-07-31 2023-11-01 Siemens Healthcare Diagnostics Inc. Verfahren und vorrichtung zur bildgebung von proben und/oder probenbehältern
US10585270B2 (en) * 2017-10-25 2020-03-10 University Of Vermont And State Agricultural College Reflected image macroscopy system
CN110389057A (zh) * 2018-04-23 2019-10-29 上海伯顿医疗设备有限公司 一体化多功能生物样品处理器
CN108801752B (zh) * 2018-08-02 2023-11-28 佛山科学技术学院 一种样品装载装置以及样品驱动装置
US10823662B1 (en) * 2020-02-18 2020-11-03 Horiba Instruments, Incorporated Special purpose cuvette assembly and method for optical microscopy of nanoparticle colloids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5870223A (en) 1996-07-22 1999-02-09 Nikon Corporation Microscope system for liquid immersion observation
WO2004048970A1 (en) 2002-11-27 2004-06-10 Medical Research Council Uses of optical projection tomography methods and apparatus
US20050157386A1 (en) 1999-02-17 2005-07-21 Greenwald Roger J. Tissue specimen holder
EP1530073B1 (de) 2001-05-22 2007-11-21 Medical Research Council Optisches Projektions-Tomografie-Gerät mit drehbarem Probenhalter zur Abbildung einer Probe
DE102007020577A1 (de) 2007-04-26 2008-10-30 Carl Zeiss Microimaging Gmbh Probenhalterung für ein Mikroskop
WO2012080478A1 (de) 2010-12-17 2012-06-21 Laser Zentrum Hannover E.V. Technik zur tomographischen bilderfassung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE528659T1 (de) * 2004-10-29 2011-10-15 Green Imaging Technologies Inc Verfahren und gerät zum messen des kapillardrucks in einer probe
DE102013210269B8 (de) 2013-06-03 2015-01-29 Laser Zentrum Hannover E.V. Vorrichtung und Verfahren zur Untersuchung von Proben in einer Flüssigkeit

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5870223A (en) 1996-07-22 1999-02-09 Nikon Corporation Microscope system for liquid immersion observation
US20050157386A1 (en) 1999-02-17 2005-07-21 Greenwald Roger J. Tissue specimen holder
EP1530073B1 (de) 2001-05-22 2007-11-21 Medical Research Council Optisches Projektions-Tomografie-Gerät mit drehbarem Probenhalter zur Abbildung einer Probe
WO2004048970A1 (en) 2002-11-27 2004-06-10 Medical Research Council Uses of optical projection tomography methods and apparatus
DE102007020577A1 (de) 2007-04-26 2008-10-30 Carl Zeiss Microimaging Gmbh Probenhalterung für ein Mikroskop
WO2012080478A1 (de) 2010-12-17 2012-06-21 Laser Zentrum Hannover E.V. Technik zur tomographischen bilderfassung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUISKEN, J. et al: Selective plane illumination microscopy techniques in developmental biology; Development 136, 1963-1975 (2009) doi:10.1242/dev.022426.
KELLER, P. J. et al: Quantitative in vivo imaging of entire embryos with Digital Scanned Laser Light Sheet Fluorescence Microscopy; Current Opinion in Neurobiology 2008, 18:624–632.
SHARPE, J. et al: Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies; Science 19 April 2002: Vol. 296 no. 5567 pp. 541-545, DOI: 10.1126/science.1068206.

Also Published As

Publication number Publication date
WO2014195005A1 (de) 2014-12-11
DE102013210269B3 (de) 2014-11-06
US20160109357A1 (en) 2016-04-21
US10126230B2 (en) 2018-11-13

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