DE102008017590A1 - Glucopyranosidderivate - Google Patents
Glucopyranosidderivate Download PDFInfo
- Publication number
- DE102008017590A1 DE102008017590A1 DE102008017590A DE102008017590A DE102008017590A1 DE 102008017590 A1 DE102008017590 A1 DE 102008017590A1 DE 102008017590 A DE102008017590 A DE 102008017590A DE 102008017590 A DE102008017590 A DE 102008017590A DE 102008017590 A1 DE102008017590 A1 DE 102008017590A1
- Authority
- DE
- Germany
- Prior art keywords
- salts
- phenyl
- formula
- solvates
- glucopyranos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *[C@@]([C@@]([C@@]1O)O)O[C@](CO)[C@@]1O Chemical compound *[C@@]([C@@]([C@@]1O)O)O[C@](CO)[C@@]1O 0.000 description 4
- QFFKEODDMBLQMI-UHFFFAOYSA-N COc(cc1)ccc1-c(c1c2)c[o]c1ccc2Br Chemical compound COc(cc1)ccc1-c(c1c2)c[o]c1ccc2Br QFFKEODDMBLQMI-UHFFFAOYSA-N 0.000 description 1
- JLFABBWARXFYLA-UHFFFAOYSA-N COc1ccc(C2c3cc(Br)ccc3OC2)cc1 Chemical compound COc1ccc(C2c3cc(Br)ccc3OC2)cc1 JLFABBWARXFYLA-UHFFFAOYSA-N 0.000 description 1
- VWBBZIIDWDBZQN-GGWAWNLDSA-N COc1ccc(C2c3cc([C@@H]([C@@H]([C@H]4O)O)O[C@H](CO)[C@H]4O)ccc3OC2)cc1 Chemical compound COc1ccc(C2c3cc([C@@H]([C@@H]([C@H]4O)O)O[C@H](CO)[C@H]4O)ccc3OC2)cc1 VWBBZIIDWDBZQN-GGWAWNLDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008017590A DE102008017590A1 (de) | 2008-04-07 | 2008-04-07 | Glucopyranosidderivate |
PCT/EP2009/001946 WO2009124638A1 (de) | 2008-04-07 | 2009-03-17 | Glucopyranosidderivate |
ES09729525T ES2394240T3 (es) | 2008-04-07 | 2009-03-17 | Derivados de glucopiranósido |
JP2011503354A JP5485979B2 (ja) | 2008-04-07 | 2009-03-17 | グルコピラノシド誘導体 |
US12/936,539 US8399509B2 (en) | 2008-04-07 | 2009-03-17 | Glucopyranoside derivatives |
EP09729525A EP2260051B1 (de) | 2008-04-07 | 2009-03-17 | Glucopyranosidderivate |
CA2720586A CA2720586C (en) | 2008-04-07 | 2009-03-17 | Glucopyranoside derivatives |
AU2009235786A AU2009235786B2 (en) | 2008-04-07 | 2009-03-17 | Glucopyranoside derivatives |
IL208065A IL208065A (en) | 2008-04-07 | 2010-09-07 | Glucopyrnoside derivatives, process for preparation, use and medications containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008017590A DE102008017590A1 (de) | 2008-04-07 | 2008-04-07 | Glucopyranosidderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102008017590A1 true DE102008017590A1 (de) | 2009-10-08 |
Family
ID=41051529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102008017590A Withdrawn DE102008017590A1 (de) | 2008-04-07 | 2008-04-07 | Glucopyranosidderivate |
Country Status (9)
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010128152A1 (en) * | 2009-05-07 | 2010-11-11 | Novartis Ag | Fused heterocyclic c-glycosides for the treatment of diabetes |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
KR101576589B1 (ko) * | 2011-06-01 | 2015-12-10 | 주식회사 녹십자 | Sglt2 억제제로서의 신규한 다이페닐메탄 유도체 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9340521B2 (en) * | 2013-03-18 | 2016-05-17 | Green Cross Corporation | Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives |
WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
Citations (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0462884A1 (fr) | 1990-06-18 | 1991-12-27 | Adir Et Compagnie | Dérivés de TRH, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
WO1995023780A2 (en) | 1994-03-04 | 1995-09-08 | The Procter & Gamble Company | Skin lightening compositions |
WO1997026265A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
WO1997041097A2 (en) | 1996-12-31 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
WO1998008871A1 (en) | 1996-08-30 | 1998-03-05 | Novo Nordisk A/S | Glp-1 derivatives |
EP0850948A1 (en) | 1996-12-26 | 1998-07-01 | Tanabe Seiyaku Co., Ltd. | Propiophenone derivatives and process for preparing the same |
WO1999003861A1 (en) | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO1999015525A1 (fr) | 1997-09-19 | 1999-04-01 | Sanofi-Synthelabo | Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant |
EP0953357A1 (en) | 1997-01-17 | 1999-11-03 | Drug Delivery System Institute, Ltd. | Nephrotropic drugs |
JP2000080041A (ja) | 1998-03-09 | 2000-03-21 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
WO2000040569A1 (en) | 1999-01-08 | 2000-07-13 | Alizyme Therapeutics Limited | 2-amino-benzoxazinone derivatives for the treatment of obesity |
WO2000063208A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000064888A1 (en) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
WO2000064876A1 (en) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
WO2000066585A1 (en) | 1999-04-30 | 2000-11-09 | Neurogen Corporation | 9H-PYRIMIDO[4,5-b]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS |
WO2000071549A1 (en) | 1999-05-21 | 2000-11-30 | Knoll Gmbh | Thiazoloderivatives and pharmaceutical compositions containing them |
WO2000078312A1 (en) | 1999-06-18 | 2000-12-28 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
WO2001009111A1 (en) | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists |
WO2001016147A1 (fr) | 1999-08-31 | 2001-03-08 | Kissei Pharmaceutical Co., Ltd. | Derives de glucopyranosyloxypyrazole, compositions medicinales renfermant lesdits derives et produits intermediaires obtenus au cours de leur production |
WO2001027128A1 (en) | 1999-10-12 | 2001-04-19 | Bristol-Myers Squibb Company | C-aryl glucoside sglt2 inhibitors |
US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
US6221633B1 (en) | 1997-06-20 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Insulin derivatives having a rapid onset of action |
US6245744B1 (en) | 1998-10-02 | 2001-06-12 | Aventis Pharma Deutschland Gmbh | Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use |
WO2001068660A1 (fr) | 2000-03-17 | 2001-09-20 | Kissei Pharmaceutical Co., Ltd. | Derives glucopyranosyloxybenzylbenzene, preparations medicinales les contenant et intermediaires pour la preparation desdits derives |
WO2001074835A1 (en) | 2000-03-30 | 2001-10-11 | Bristol-Myers Squibb Company | O-glucosylated benzamide sglt2 inhibitors and method |
WO2001074834A1 (en) | 2000-03-30 | 2001-10-11 | Bristol-Myers Squibb Company | O-aryl glucoside sglt2 inhibitors and method |
WO2001083451A1 (fr) | 2000-04-28 | 2001-11-08 | Asahi Kasei Kabushiki Kaisha | Nouveaux composés bicycliques |
WO2001085695A1 (en) | 2000-05-11 | 2001-11-15 | Bristol-Myers Squibb Co. | Tetrahydroisoquinoline analogs useful as growth hormone secretagogues |
WO2001091752A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Melanocortin receptor agonists |
US6342512B1 (en) | 1999-09-01 | 2002-01-29 | Aventis Pharma Deutschland Gmbh | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals |
WO2002028872A1 (fr) | 2000-09-29 | 2002-04-11 | Kissei Pharmaceutical Co., Ltd. | Derives de glucopyranosiloxybenzylbenzene et compositions therapeutiques contenant ces composes |
WO2002036602A1 (fr) | 2000-11-02 | 2002-05-10 | Ajinomoto Co., Inc. | Nouveaux derives du pyrazole et remedes au diabete contenant ces derniers |
WO2002044192A1 (fr) | 2000-11-30 | 2002-06-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glucopyranosyloxybenzylbenzene, compositions medicinales contenant ces derives et produits intermediaires obtenus lors de l'elaboration de ces compositions |
WO2002068439A1 (fr) | 2001-02-26 | 2002-09-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci |
WO2002068440A1 (fr) | 2001-02-27 | 2002-09-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci |
US20020132807A1 (en) | 2000-06-29 | 2002-09-19 | Wang Gary T. | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
US20020137903A1 (en) | 1999-10-12 | 2002-09-26 | Bruce Ellsworth | C-aryl glucoside SGLT2 inhibitors and method |
WO2002080936A1 (en) | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and ppar modulators |
WO2002080935A1 (en) | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators |
WO2003020269A1 (de) | 2001-08-31 | 2003-03-13 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren |
WO2004052902A1 (de) | 2002-12-12 | 2004-06-24 | Aventis Pharma Deutschland Gmbh | Neue aromatische fluorglycosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2004052903A1 (de) | 2002-12-12 | 2004-06-24 | Aventis Pharma Deutschland Gmbh | Neue heterocyclische fluorglykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1980560T3 (pl) * | 2003-03-14 | 2011-11-30 | Astellas Pharma Inc | Pochodne C-glikozydowe do leczenia cukrzycy |
AR048376A1 (es) * | 2003-08-01 | 2006-04-26 | Janssen Pharmaceutica Nv | C- glicosidos heterociclos fusionados sustituidos |
CN1934103B (zh) * | 2004-03-04 | 2011-06-01 | 橘生药品工业株式会社 | 稠杂环衍生物,包含稠杂环衍生物的药物组合物及其医药用途 |
SE533267C2 (sv) | 2008-12-16 | 2010-08-03 | Sandvik Intellectual Property | Skärkit, förfarande för tillverkning av skär, samt ett ur ett skärkit avskilt skär |
-
2008
- 2008-04-07 DE DE102008017590A patent/DE102008017590A1/de not_active Withdrawn
-
2009
- 2009-03-17 JP JP2011503354A patent/JP5485979B2/ja not_active Expired - Fee Related
- 2009-03-17 CA CA2720586A patent/CA2720586C/en active Active
- 2009-03-17 EP EP09729525A patent/EP2260051B1/de not_active Not-in-force
- 2009-03-17 US US12/936,539 patent/US8399509B2/en active Active
- 2009-03-17 WO PCT/EP2009/001946 patent/WO2009124638A1/de active Application Filing
- 2009-03-17 ES ES09729525T patent/ES2394240T3/es active Active
- 2009-03-17 AU AU2009235786A patent/AU2009235786B2/en not_active Ceased
-
2010
- 2010-09-07 IL IL208065A patent/IL208065A/en active IP Right Grant
Patent Citations (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0462884A1 (fr) | 1990-06-18 | 1991-12-27 | Adir Et Compagnie | Dérivés de TRH, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
WO1995023780A2 (en) | 1994-03-04 | 1995-09-08 | The Procter & Gamble Company | Skin lightening compositions |
WO1997026265A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
WO1998008871A1 (en) | 1996-08-30 | 1998-03-05 | Novo Nordisk A/S | Glp-1 derivatives |
EP0850948A1 (en) | 1996-12-26 | 1998-07-01 | Tanabe Seiyaku Co., Ltd. | Propiophenone derivatives and process for preparing the same |
WO1997041097A2 (en) | 1996-12-31 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
EP0953357A1 (en) | 1997-01-17 | 1999-11-03 | Drug Delivery System Institute, Ltd. | Nephrotropic drugs |
US6221633B1 (en) | 1997-06-20 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Insulin derivatives having a rapid onset of action |
WO1999003861A1 (en) | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO1999015525A1 (fr) | 1997-09-19 | 1999-04-01 | Sanofi-Synthelabo | Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant |
JP2000080041A (ja) | 1998-03-09 | 2000-03-21 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
US6245744B1 (en) | 1998-10-02 | 2001-06-12 | Aventis Pharma Deutschland Gmbh | Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use |
WO2000040569A1 (en) | 1999-01-08 | 2000-07-13 | Alizyme Therapeutics Limited | 2-amino-benzoxazinone derivatives for the treatment of obesity |
WO2000063208A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000064888A1 (en) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
WO2000064876A1 (en) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
WO2000066585A1 (en) | 1999-04-30 | 2000-11-09 | Neurogen Corporation | 9H-PYRIMIDO[4,5-b]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS |
WO2000071549A1 (en) | 1999-05-21 | 2000-11-30 | Knoll Gmbh | Thiazoloderivatives and pharmaceutical compositions containing them |
WO2000078312A1 (en) | 1999-06-18 | 2000-12-28 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
WO2001009111A1 (en) | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists |
WO2001016147A1 (fr) | 1999-08-31 | 2001-03-08 | Kissei Pharmaceutical Co., Ltd. | Derives de glucopyranosyloxypyrazole, compositions medicinales renfermant lesdits derives et produits intermediaires obtenus au cours de leur production |
US6342512B1 (en) | 1999-09-01 | 2002-01-29 | Aventis Pharma Deutschland Gmbh | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals |
WO2001027128A1 (en) | 1999-10-12 | 2001-04-19 | Bristol-Myers Squibb Company | C-aryl glucoside sglt2 inhibitors |
US20020137903A1 (en) | 1999-10-12 | 2002-09-26 | Bruce Ellsworth | C-aryl glucoside SGLT2 inhibitors and method |
WO2001068660A1 (fr) | 2000-03-17 | 2001-09-20 | Kissei Pharmaceutical Co., Ltd. | Derives glucopyranosyloxybenzylbenzene, preparations medicinales les contenant et intermediaires pour la preparation desdits derives |
WO2001074835A1 (en) | 2000-03-30 | 2001-10-11 | Bristol-Myers Squibb Company | O-glucosylated benzamide sglt2 inhibitors and method |
WO2001074834A1 (en) | 2000-03-30 | 2001-10-11 | Bristol-Myers Squibb Company | O-aryl glucoside sglt2 inhibitors and method |
WO2001083451A1 (fr) | 2000-04-28 | 2001-11-08 | Asahi Kasei Kabushiki Kaisha | Nouveaux composés bicycliques |
WO2001085695A1 (en) | 2000-05-11 | 2001-11-15 | Bristol-Myers Squibb Co. | Tetrahydroisoquinoline analogs useful as growth hormone secretagogues |
WO2001091752A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Melanocortin receptor agonists |
US20020132807A1 (en) | 2000-06-29 | 2002-09-19 | Wang Gary T. | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
WO2002028872A1 (fr) | 2000-09-29 | 2002-04-11 | Kissei Pharmaceutical Co., Ltd. | Derives de glucopyranosiloxybenzylbenzene et compositions therapeutiques contenant ces composes |
WO2002036602A1 (fr) | 2000-11-02 | 2002-05-10 | Ajinomoto Co., Inc. | Nouveaux derives du pyrazole et remedes au diabete contenant ces derniers |
WO2002044192A1 (fr) | 2000-11-30 | 2002-06-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glucopyranosyloxybenzylbenzene, compositions medicinales contenant ces derives et produits intermediaires obtenus lors de l'elaboration de ces compositions |
WO2002068439A1 (fr) | 2001-02-26 | 2002-09-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci |
WO2002068440A1 (fr) | 2001-02-27 | 2002-09-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci |
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CA2720586A1 (en) | 2009-10-15 |
US20110028414A1 (en) | 2011-02-03 |
CA2720586C (en) | 2016-06-21 |
JP5485979B2 (ja) | 2014-05-07 |
JP2011516511A (ja) | 2011-05-26 |
IL208065A (en) | 2014-03-31 |
AU2009235786B2 (en) | 2013-09-26 |
IL208065A0 (en) | 2010-12-30 |
WO2009124638A1 (de) | 2009-10-15 |
AU2009235786A1 (en) | 2009-10-15 |
EP2260051B1 (de) | 2012-10-17 |
US8399509B2 (en) | 2013-03-19 |
ES2394240T3 (es) | 2013-01-23 |
EP2260051A1 (de) | 2010-12-15 |
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