DE102007020726A1 - Overlay and case - Google Patents

Abstract

The object of the invention relates to a support and casing of bacterial cellulose and a device for cleaning. In connection with medical devices that emit high-energy radiation and sound waves, the invention enables the development of existing therapeutic and diagnostic methods or extends the application possibilities of these methods. The invention finds application in cosmetic, medical, diagnostic and pharmaceutical methods. The pads and sheaths of a fiber-crosslinked hydro layer are preferably used in or after medical and technical treatment processes and serve for the transfer of substances and for transmission, but also for protection against high-energy rays or waves. By reusing the pads an economical and material saving use is made possible.

Description

Field of the invention

The The present invention relates to a support and casing and their use in conjunction with medical devices and a device for cleaning. It finds the invention Application in cosmetic, medical, pharmaceutical and technical procedures, preferably in the medical and cosmetic Treatment of outer tissue layers.

Background of the invention

The skin is responsible for the regulation of the water balance and serves as a barrier and protective layer against external influences. In order to penetrate deeper tissue regions from the outside, a number of medical procedures have been developed. These methods are used to kill cancer cells, to stimulate tissue cells or to increase the penetration of drugs. Other methods use sound sources to stimulate internal healing processes or for tissue analysis. Such a method and apparatus is in DE 692 146 72 T2 for the emission of sound waves. Here, thermal effects and gravitational effects are generated in the tissue. In EP 1364 624 A1 a polyacylamide gel pad is used to enhance the laser treatment. In the known methods, energy is supplied to the biological tissue via the skin in the form of electromagnetic fields, light, ionizing radiation or ultrasound waves. Difficulties always occur when the protective layer of the skin has already been damaged or allergic reactions occur.

To penetrate deeper tissue layers, z. As water-filtered infrared A-rays (wIRA) or unfiltered infrared light used. As in DE 101 16 763 C1 described, the radiation of a halogen lamp is filtered by a special Hydroküvette, which takes out the skin polluting radiation components. It comes here to an increased depth effect with known main effects of the irradiated tissues, such as a relaxation of the muscles, anti-inflammatory and pain relief.

Other methods use ultrasound to make drugs more effective in the skin or hair, or to stimulate tissue regeneration by pulsed ultrasound. In order for the sound to be transmitted into the tissue, a coupling substance is needed. It usually uses substances such. B. Aquasonic ^® or other commercially available ultrasound gels, for coupling. These gels are necessary for the ultrasound signal to be transmitted. In DE 100 56 062 A1 is described a treatment method for hair, in which by means of ultrasound and with a temperature increase agents are introduced into the hair. It is also known from the prior art that ultrasound medicaments can be incorporated in creams into deeper tissue regions. The method is called ultrasonophoresis. Basically, due to the sound vibrations, especially at higher dosage and a continuous application, there is a warming especially at the boundary layers. This temperature increase of about 40-45 ° C improves the extensibility of the collagen tissue (scars, tendons, ligaments).

Other outer Treatment methods use warm or cold compresses to treat Tissue injury or for the regeneration of the skin. These compresses usually consist of a gel material and are made with a plastic material jacketed.

The known methods have the serious disadvantage that in the immediate environment of the skin no controllable material exchange takes place or, in the case of a wound, insufficient sterility can be guaranteed. Of particular disadvantage is that the energy rays directly hit the skin and it already here comes to a skin and tissue damage. For treatments with high-energy rays that last for several weeks pull out, it is known that the regenerative ability not only affects the skin and internal tissues, but even completely destroyed. such Tissue defects lead to severe wounds or wounds a severe scarring of the treated tissue regions. In the latter In the case of activated fibroblasts, too much collagen is formed. adversely is that medical device, the energy rays or sound waves send out, cause complications and side effects affect the quality of life of patients. For this Skin pigmentation, dandruff, edema in soft tissue, radiodermatitis, eczema, just a few to call. A particular disadvantage is that in the current ultrasound treatments Gel pads are used from artificial materials, which do not have the properties of ultrasound gels. The use of commercial gels, however, is on wounds and inaccessible Spots, such as on the eye, in tight skin folds or in the vagina, not suitable.

The described disadvantages of skin and tissue treatments are transferable to other medical, pharmaceutical and cosmetic sectors as well as biological and technical fields.

Summary of the invention

The The object of the invention relates primarily to a protective, cooling and transfer pad or cover for blasting or sound waves and, secondarily, mass transfer in conjunction with high-energy rays or sound waves. Further the invention already allows further development existing therapeutic and diagnostic procedures or extended the possible uses of these methods. Through the reprocessing the pads or sheaths in a cleaning device an economic and material-saving use is made possible. The pads and cases are used in combination with medical devices and after medical and technical treatment procedures. Through the use of a hydro tissue in the field of medical Irradiation and ultrasound procedures, when introducing pharmaceutical Substances as well as in the cosmetic treatment are these for safer for humans and additionally allow a substance transfer and after the treatment. For this purpose, in particular a substance transfer and mass transfer through the skin are supported, for example, with the aim of the biological regeneration processes activate the skin and internal tissues. Especially advantageous The invention can be in the field of ultrasound diagnostics and use ultrasound treatment, since the invention is the use This technology expands and thereby the economic use and Hygiene is improved by the treatment.

These Task is inventively by a requirement or sheath according to claim 1 and by a device according to Claim 17 solved. The dependent claims relate to advantageous embodiments of the invention.

It was found to be a tight-fitting and absorbent Hydrocellulose of bacterial cellulose with a high water or Liquid content is suitable to protect the three properties, cool and transfer "to each other. The preferred material has a pronounced Cooling and protective function by an evaporable high liquid or water content with a soft and smooth surface. It became more surprising Way discovered that the transmission of radiation, light and sound waves or of substances, in particular by a high movable water content in a network of thin fibers or a fiber-crosslinked hydro layer is favored. was surprising in particular, that the bacterial cellulose fiber network transmission of ultrasound waves are not or only slightly influenced.

The Task is preferably solved by a support and shell in the field of medical, pharmaceutical, cosmetic and technical Applications, characterized in that these from a hydro tissue from bacterial cellulose fibers or a fiber composite with a mobile Water content or liquid content of at least 60% by weight and a fiber-crosslinked hydro layer in conjunction with a self-trained water film a transmission medium for sound waves or decelerates radiation, scatters or filters out and while or after for cooling and for Mass transfer from the skin or tissue contributes.

By the mobile water fraction is meant an extrudable contiguous aqueous portion which can be extruded and / or mechanically agitated from the fine mesh fine fiber network of bacterial cellulose fibers or a composite of these fibers with microfibers or gel bodies of another fabric. It has been unexpectedly found that straight cellulosic nonwoven webs form a coherent water layer and film of water which are particularly well suited for the transmission of sound waves and for the scattering and filtering of rays. By contact with a skin or a tissue or by slight pressure from the outside, a water film of a few μm up to the nm-range forms by itself. This film is in contact with the inner water layer and thus constitutes a suitable medium for the coupling of sound waves and the scattering and filtering of radiation. It has been found that the invention can be applied in the form of a support or a cover to all bacterial celluloses , However, a prerequisite is that at least one mobile water content or liquid content of at least 60 wt.% Is present. In particular, the formation of its own ever rebuilding water film improves the coupling of ultrasound. This property of the hydro tissue has the advantage over known gel pads or gels that the ultrasonic probe slides particularly well on the overlay or in conjunction with a sleeve, without losing the coupling contact. Accordingly, this applies when the hydro tissue surrounds the ultrasound probe. Here is a water film, z. B. on the skin, and thus supports the sliding. A suspended water layer of thicknesses of z. B. 2-10 mm in the hydro tissue forms a suitable flow and scattering path or a filter section for high-energy radiation or a coupling medium for sound waves. Already layer thicknesses in the hydro tissue between 0.2-2 mm, allow the coupling of sound waves. Greater thicknesses of up to 20 mm and more are more suitable for the therapeutic application of high-energy radiation or for targeted coupling of highly focused ultrasound (FUS). It was found that in the novel use particularly fle xible and absorbent Hydrogewebe on uneven ground have advantages over conventional ultrasound gels in Ulraschall imaging.

Preferably the hydro tissue has a tissue content of bacterial cellulose fibers between 60-100%. By doing that, this proportion is even and distributed in the material in a network, the special features arise the bacterial cellulose. A conventional sponge possesses these properties not, but here has partitions or dividing surfaces. The proportion by weight of water or aqueous Solution in the bacterial cellulose can be up to 99% and is primarily due to physical forces and / or held firmly by hydrogen bonds without dripping from the fabric by itself. It showed Be that bacterial cellulose with a smooth surface in nm area and a continuously networked structure especially good for ultrasonic transmission to uneven Areas is suitable because the bacterial cellulose without technical Aid sucks on a biological surface and a contact layer formed. The use is more hygienic compared to known Ultrasound gels.

The in the bacterial cellulose-containing water or the liquid is not bound like in a gel. By z. B. pressing the ultrasound head will turn off water or liquid the bacteria cellulose is squeezed out and it forms thin aqueous film, at least on the smooth cellulose surface. It also displaces aqueous medium to the outside and depending on the pressure will be a direct contact with the inner moving and made out of pressable water or solvent content. The deformable structure of the hydro tissue additionally provides that the shape of the ultrasound head optimally can cling to. Direct contact with the mobile aqueous Share also improves the material transport, z. B. in the material in or out of this. It has been shown that a hydro tissue Bacterial cellulose is good for ultrasonic coupling suitable. Since the release of water caused by evaporation can be added, it comes in addition to an effective cooling the skin without drying it out. It was found that one Bacterial cellulose with a high water content of over 70% by weight with a smooth surface not only the formation a separate water film for ultrasonic coupling allows but also an effective, fast evaporation and thus one Substance exchange with the environment. Gels or highly networked hydrogel pads however, these properties do not possess. Our observations prove, however, that it is precisely this water mobility in the bacterial cellulose tissue, which consists of the finest fiber nets, not only benefits for the coupling of an ultrasound provides, but also the effect meaningfully changed by high-energy rays.

According to the Invention finds the material application during an ultrasound diagnosis (echo-pulse method) or treatment in the way that the pad or sheath is used for coupling of ultrasound. The ultrasound probes can be applied to the hydro tissue without gel and through the soft, Moist and smooth surface, the sound is on the skin or transmit a biological tissue. The hydro tissue forms It also supports and supports uneven surfaces the application by that aqueous molecules can be transported in and out of the material and thus making a close contact with biological surfaces becomes. The support or shell of bacterial cellulose with Layer thicknesses of 0.2-20 mm behave like one stable layer of water without them flowing apart can. The water layer serves as a kind of preliminary route for rays and waves for transmission to the skin, on fabric or another material. The used bacterial cellulose has a DPw value between 4000 to 9000 (degree of polymerization), wherein the synthesis direction is preferably in the plane. Due to the soft surface with a surface roughness In the nm range, the smallest bumps can be separated from one another Shaping the surface. However, the material, in particular in the medical field, to use, are longer Bacterial cellulose molecular chains, a continuous one Hydronic network and a smooth surface of advantage. Out hygienic reasons, the material can be alcoholic or contain other antiseptic solutions. Because the material forms a sterile barrier, it is possible over to apply a wound area ultrasound. Especially advantageous is that such requirements used to cover the surgical field can be. This can be about the edition in immediate vicinity and without gel the surgical field with an ultrasound diagnostics are observed. In particular, the Pads made in different thicknesses and shapes can be here, the ultrasound probe can be here flat surface, although the ground deformations, z. B. elevations or depressions possesses. The sound signal is passed on so well compared to gel. What kind of the ultrasound is important, for. B. a smooth flat surface on uneven ground, is also for the introduction of high-energy radiation of importance. The treatment procedure in deeper tissue regions can be optimally adjusted and standardized become.

According to the invention it has also been found that the overlay in an infrared light treatment behaves like a water filter. In this case, the bacterial cellulose is on the skin to be irradiated. Depending on the thickness of the edition will be part of filtered out harmful radiation, at the same time the relevant tissue areas cooled and even allows a temperature-driven mass transfer. The inventive requirement can also be used in the field of radiological radiotherapy (eg gamma irradiation) for generating stray radiation and used to combat skin cancer. Stray radiation is actually undesirable in deeper tissue. Alternatively, the material could be usefully used in intensity modulated radiation therapy (IMRT). In the case of skin treatment, it may be desirable that the intensity of the radiation, e.g. As the ionizing radiation, can be adjusted at the site of action and beyond substances are additionally exchanged with the environment or with the tissue. It goes without saying that the hydraulic material is also used in the field of wet wound care. The special properties of the cooling coupled with a mass transfer allows that z. B. the treatment of a thorax irradiated after the irradiation is continued. The aim is that substances that are produced during cell death and activated tissue cells are removed from the upper tissue or the upper skin layers or thinned out here.

According to the Another aspect of the invention replaces the hydro-tissue as a sheath for ultrasound probes the usual ultrasound gel as coupling medium or transmission medium. The advantage is that the material as a protective cover in the form of a hollow body or as a kind of protective cap enveloping the probe and itself flexible also on uneven surfaces creates and sucks to thereby additionally the air between the interfaces to displace. Because of that, wet contact surfaces or a liquid film is present, the sound can be transmitted optimally. This protective cover makes it possible that the ultrasound probe in inaccessible places in the body, such as B. in the vagina, can be introduced. Another application is the eyeball. Here, for example, an edition of the Hydro tissue used. Alternatively, the material may include extremities, like fingers or toes completely or only in the front part, envelop, to protect them or handle them safely. This also applies to other parts of the body. Application of high-frequency probes (up to 50 MHz), but also pulsed Frequencies of different areas can with combined with the hydro tissue.

According to the Purpose of the invention has been found that in particular by the treatment produced increased heat energy in a biological tissue to increased mass transfer leads. At the same time, the tissue or the skin becomes excessive Energy entry protected. The high solution and Water content, which in a suitable case over 90 wt.% Hydro tissue is a prerequisite to the said functions in conjunction with ionizing radiation, laser light or sound waves during or after the treatment of a biological material to enable. In this case, the edition or the shell from bacterial cellulose solutions with or without active ingredients contained and in the further embodiment of the invention, a transmission These agents are provided over the skin. Thereby, that the water in the bacterial cellulose is reversibly bound, supports the material in conjunction with energetic Rays or sound waves preferably a temperature-driven Mass transfer with a biological tissue. This is done by an increase in the evaporation of substances that arises because of energy supplied from outside or was.

Further it was found that bacterial cellulose has a hydrobalance, a substance transfer and a purification of the biological tissue during, but even after treatment with energetic rays or sound waves allows. This can be done in the way that substances and Germs from the upper regions of an adjacent biological surface, such as the z. As a skin, reinforced in the material or in the protective layer migrate or germs to the lower material surface attach without damaging the skin or the biological tissue. The invention supports the cellular balance in the way that is naturally associated with a solution exchange supports tissue regeneration becomes. This in turn has an influence on the fibroblast activation as well as other cellular processes. this shows also in the way that skin dandruff and skin pigmentation, for example, after radiotherapy, by the inventive Edition is reduced. The formation of a Radidermatitis is thus diminished in the area of irradiated skin areas.

Since the material is a biocompatible and preferably native wet material, the field of application is not limited to intact skin. The material may also be used for wounds in conjunction with additional radiation therapy. In doing so, the energetic radiation or the sound waves in the overlay or in the shell itself will also generate heat. The heat development in the overlay and over the biological tissue is used as an additional driving force for the mass transfer. This compatible effect shortens the mass transfer times and improves the acceptance in the application and economic use. Another advantage is that high energy infrared or ionizing radiation, laser light or ultrasonic waves damage the skin and the inner tissue less severely due to the high proportion of protection of the water in the overlay. Darue In addition, less heat is generated in the biological tissue and temperatures above 45 ° C are largely avoided.

According to one Another aspect of the invention is that the hydro tissue from bacterial cellulose in water vapor or after another Sterilize and clean the procedure. The nature of Cleaning can be done by washing, but also by suitable solution and cleaning agents. To the hydro tissue, which will always be wet must, on an ultrasound probe or the ultrasound probe itself to clean, a specially designed cleaning and storage device with a spray nozzle for Use come. There are currently no suitable and specific cleaning devices For ultrasonic probes exist, this device also wash out the commercial gel. The used Bacterial cellulose is stable against alcoholic solutions, but also to alkalis. This can appropriate detergents be used to ensure hygiene. It is also conceivable that the hydro tissue also works as a sponge, fleece or as a gel pad formed or connected or partially or completely encased. For sheathing or as additional cover are suitable Latexes, silicones, polyurethanes and other films or casings with or without pores, the outward water molecules let through to allow a water film.

According to the Invention is preferably a hydro tissue made of bacterial cellulose or in conjunction with a plastic material or a combination from these materials in the form of a gel-like film, fabric or Fleece or a spongy structure used. These are bacterial celluloses suitable, the no thin also delimited layer structure, similar a puff pastry or like the pages in a book, have. A uniform and consistently high material strength with thicknesses between 0.2-20 mm transmits the sound better as an inconsistent construction. It does not matter how the bacterial cellulose is made, but only important that this cellulose has its own liquid or water film manufactures. Here it was found that a uniformly structured and synthetically produced bacterial cellulose having a surface roughness between 10-500 nm and over 60% by weight extrudable water or a liquid is, for. B. a 1-200 microns thick water layer or to allow a water film. By pressing out or slight mechanical pressure from the top can put more water on the top Surface and thus increase the film thickness. Thicker film thicknesses arises only where z. B. from above a pressure is generated. The bacterial cellulose has an average degree of polymerization with a DPw value between 4000-9000. This bacterial cellulose others may be firmly crosslinked with the cellulose and / or only stored Contain substances or fillers. This is then required if the material is to be freeze dried or the hydro tissue must meet certain mechanical requirements. The freeze-dried bacterial cellulose must be before use soaked in a solution tailored to the application become.

at The present invention is the water or the liquid containing physically movable and can, for example, evaporate. By the evaporation effect and the low surface roughness in the nm range, a direct contact with the adjacent surface generated. A flat contact improved and enlarged doing the mass transfer with a biological surface. It was further found that the preferred bacterially synthesized Cellulose also in small quantities additional plastic fibers may contain with thicknesses in the micron range. A mixed fabric from foreign fibers and biological fibers is produced by the biological Activity of Acetobacter xylinum bacteria containing the foreign fibers interweave with bacterial cellulose. In the interstices of the Network are water and solution molecules preferably over Hydrogen bridging and OH groups on the cellulose threads connected. In a simple embodiment, a pure and native bacterial cellulose or a mixed material with others Hydrogels, such as Kol lidon or other substances, such as. B. hyaluronic acid, be used. The known manufacturing process ensures that the bacterial cellulose has an average degree of polymerization (DPw value) of at least 4000. According to the desired properties can be 0.1-10% PVA, CMC or MC or other additives in the form of hydrogels Be added to nutrient medium.

Bacterial cellulose in the form of pads or shells are inoculated by known manufacturing processes with cellulose-forming bacteria, for example, with a stable cellulosic layer producing strain of the microorganism Acetobacter Xylinum and cultured at a temperature of about 28 ° C (see Preparation WO01061026 . DE 100 2275C2 ). The nutrient solution contains in a known manner D-glucose, disodium hydrogenphosphate, citric acid and standard extracts. The stability and internal structure of the bacterial cellulose can be improved in the production by additional additions of water-soluble polymers or tissue fibers or nets. These additives can z. As polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) or methyl cellulose (MC) or similar additives. These additives are added in concentration between 0.1-10% to the culture medium. The total water content ei A suitable hydroenthesis is between 80-99% by weight and may, however, be 70% by weight by way of additives or by removal of water, the proportion which can be pressed out being at least 60%. Through the tissue, the bacterial cellulose, especially at thicknesses below 5 mm, has good semitransparent properties. At thicknesses above 10 mm, the hydro tissue is no longer transparent. In a further development of a known production method, for the first time a matrix, impression or a shaped substrate or base was introduced into the production container, it was observed that the bacteria reproduce this shaped substrate. The result is a pad but also shell with different thicknesses or with a suitable impression for resting on the eyes, noses, extremities, breast and Pobereich or other designed areas of the human body.

Of the Structure of the pads and shells can be designed in such a way that a perforated film or a film with visible pores for expansion the usability of the material during the Manufacturing process is introduced. The connection takes place not by sewing, but by Auflagerung the film on an already existing cellulose layer. Subsequently the structure is wetted with inoculated nutrient solution and the process of wetting repeats.

The Hydro tissue pad has high ductility and flexibility and can be used on uneven skin areas, for example in the knee joint, Face or shoulder area, lying on. This is what the editions offer Overall, good properties for the application z. B. in the form of a plaster, as a wound dressing, as an envelope or as Pad.

The Strength and structure of the hydro tissue has the advantage that the pads or sheaths from the hydro tissue by simple Cleaning and / or sterilizing are preparable. A simple one Cleaning is done in the form that the material used in cooking Water is cleaned. The procedure is as follows: Used Hydro pads, are placed in a container with lid introduced and poured over with sufficient boiling water. Subsequently, salt or a salt mixture is added, to a physiological saline solution, for. B. Ringer or saline solution, manufacture. As an alternative to boiling water, the hydro tissue becomes inserted in a physiological solution and the solution brought to a boil by a microwave oven. After this Cooling is the hydro tissue as good as sterile and can be used. Of advantage are cleaning methods in which in addition a spray used for cleaning to remove particulate buildup on the material.

The Cleaning can also be done automatically with a cleaning device take place, which has a spray nozzle in the ground. This can be useful if the material is used in conjunction with an ultrasound probe is used and not in every application should be removed from this probe. The device serves at the same time as a storage device to the bacterial cellulose to keep moist. It may alternatively be further provided that in the device by means of heating rods the cleaning or storage solution is boiled to sterilization to reach. A device for cleaning ultrasound probes improves hygiene in the field of ultrasound diagnostics overall even without the connection with hydromaterials. In this case, the device on its own, but also in conjunction with an ultrasound device Find application.

Fields of application and embodiments

• a) Gewebe wird im ersten Schritt mit Infrarotlicht, Laserlicht, ionisierende Strahlen oder mit Ultraschallwellen behandelt. Nach Stunden oder unmittelbar nach der Behandlung kommt es zu einer erhöhten Wärmeentwicklung im Gewebe. Dies ist beispielsweise dann der Fall, wenn Weichteilgewebe, wie die Brust, radiologischer Strahlung ausgesetzt wurde. In einem zweiten Schritt wird die Auflage auf die Brust aufgelegt. Es kommt zu einer Kühlung des Gewebes und gleichzeitig zu einem effektiven Stoff austausch aus dem Gewebe über die Haut in das Material hinein. Dabei wird die Haut entschlackt.
• b) Die Auflage wird im ersten Schritt als eine Schutzschicht, Sperrschicht oder Transferschicht auf eine biologische Gewebeoberfläche aufgelegt. Dabei treffen z. B. Infrarotstrahlen oder Ultraschallwellen auf diese Schutzschicht und werden auf die biologische Gewebeoberfläche übertragen. Die Strahlung wird durch den Wasseranteil und Stoffanteil gefiltert und Schallwellen weitergeleitet. Die Wärmeentwicklung oder der Schalleintrag erfolgt somit nicht direkt an der Gewebeoberfläche. Gewebeschädigungen werden so vermieden. Nach der Behandlung verbleibt das Material für eine bestimmte Zeit auf dem Gewebe und tauscht weiter Stoffe mit der anliegenden Fläche aus.

According to the invention, the cooling, protection and transfer pad or sheath can be used as follows:

• a) Tissue is treated in the first step with infrared light, laser light, ionizing radiation or ultrasonic waves. After hours or immediately after treatment there is an increased heat development in the tissue. This is the case, for example, when soft tissue, such as the breast, has been exposed to radiological radiation. In a second step, the pad is placed on the chest. It comes to a cooling of the tissue and at the same time to an effective substance exchange from the tissue through the skin into the material. The skin is detoxified.
• b) The overlay is applied in the first step as a protective layer, barrier layer or transfer layer on a biological tissue surface. Here meet z. As infrared rays or ultrasonic waves on this protective layer and are transmitted to the biological tissue surface. The radiation is filtered by the water content and substance content and sound waves forwarded. The heat development or the sound input is thus not directly on the tissue surface. Tissue damage is avoided. After treatment, the material remains on the fabric for a certain time and continues to exchange fabrics with the adjacent surface.

• 1. Kleine Auflagen in runder oder ovaler Form für Anwendungen am Auge.
• 2. Größere Auflagen in runder oder rechteckiger Form zum Abdecken von Bestrahlungsfeldern.
• 3. Kleine Auflagen mit Dicken bis 1–2 cm für therapeutische Ultraschallbehandlungen.
• 4. Längliche Hülsen bzw. Kappen mit einer Öffnung für Ultraschallsonden zum Einbringen in Körperöffnungen.
• 5. Hülle als Ummantelungen für sonstige Ultraschallsonden.
• 6. Streifenförmige Auflagen für den Halsbereich oder für Extremitäten.
• 7. Abdeckungen mit Durchbrüchen zur Abdeckung von Operationsbereichen für mikrochirurgische Eingriffe.
• 8. Abdeckungen mit geeigneten Aussparungen oder Ausformungen als passende Auflage für Brust, Po, Mund, Nase, Augen oder Gesicht.

Embodiments of the pads, sheaths and sleeves of bacterial cellulose result from the applications. These may include the following embodiments:

• 1. Small pads in round or oval shape for eye applications.
• 2. Larger editions in round or rectangular Form for covering radiation fields.
• 3. Small pads with thicknesses up to 1-2 cm for therapeutic ultrasound treatments.
• 4. Elongated sleeves or caps with an opening for ultrasonic probes for insertion into body orifices.
• 5. Shell as sheaths for other ultrasound probes.
• 6. Strip-shaped pads for the neck area or for extremities.
• 7. Covers with apertures to cover surgical areas for microsurgical procedures.
• 8. Covers with suitable recesses or formations as a suitable support for the chest, buttocks, mouth, nose, eyes or face.

• • Ultraschalldiagnostik der Schilddrüse
• • Pädiatrische Ultraschalldiagnose
• • Ultraschalldiagnose in der Gastroenterologie
• • Kardioechographie
• • Ultraschalldiagnose in der Dermatologie
• • Ultraschalldiagnose in der Traumatologie (z. B. Tiefe einer Nekrose)
• • Ultraschalltherapie in der Sportphysiotherapie
• • Ultraschalltherapie bei schlecht heilenden Wunden
• • Fokussierte Ultraschalltherapie
• • Ultrasonophorese

In the field of ultrasound diagnosis and treatment, bacterial cellulose or the inventive hydro tissue is suitable for the following fields of application:

• • Ultrasonic diagnosis of the thyroid gland
• • Pediatric ultrasound diagnosis
• • Ultrasound diagnosis in gastroenterology
• • cardioechography
• • Ultrasound diagnosis in dermatology
• • Ultrasound diagnosis in traumatology (eg depth of necrosis)
• • Ultrasound therapy in sports physiotherapy
• • Ultrasound therapy for poorly healing wounds
• • Focused ultrasound therapy
• • Ultrasonophoresis

at an embodiment in the form of a flat Edition, the hydro tissue contains an alcoholic or antibacterial solution and is used as a contact surface placed on the skin to allow a picture diagnostics. In the field of another ultrasound diagnosis is a rod-shaped Ultrasound probe with a cap of hydro tissue clothed. In the reusable form, this cap is additionally with slipped over a latex tube and for example introduced into the vaginal opening. Advantage is that no contamination or contamination on the ultrasound probe occurs and also the cleaning of the probe from the gel is unnecessary. Alternatively, the latex tube is omitted if the product to be used as a disposable product and / or sterile.

One Practical use of the invention is the treatment of body regions with infrared light. Here are two-dimensional editions with a Thickness between z. B. 1-6 mm placed on the skin and at a defined distance with a conventional infrared source irradiated. For smaller areas and a higher one Radiation dose are also larger thicknesses used. The high-energy infrared light hits the hydro tissue support and produces an elevated temperature here. The harmless one Light content is filtered out by the water contained. In spite of the increased temperature is due to the cooling effect the condition to no skin damage. The temperature increase in the irradiated area allows a faster uptake from the upper skin layers and thus leads to purification.

at Cosmetic designs can be the hydro tissue substances like Hyaluronic acid, soluble collagen, growth substances, Tannin, vitamins, herbal extracts, oils etc. or others contain cosmetically relevant active ingredients or by incubation with a solution containing these substances introduced become. Here are bacterial cellulose pads for the treatment of Scar tissue or after a peeling of the skin in combination with Laser or ultrasound probes used. The goal is the introduction of cosmetic substances and water in the upper layers of the skin. This can be useful if an injection with Hyaluronic acid has occurred.

The Invention can be applied to all walks of life as well as commercial or commercial applications where a protective, Cooling and transfer pad or cover with an exchange of substances, liquids, media or particles is desired.

Especially everywhere where it applies, an economical cosmetic and medical To ensure treatment.

Further Advantages of the invention result from the choice of the field of application, the treatment forms and applications as well as by an economic Use of the materials used and from the description and the attached drawing.

It It is understood that the foregoing and the following yet to be explained features not only in each case specified combination, but also in other combinations or can be used in isolation, without the scope of the present To leave invention.

embodiments

embodiments The invention are illustrated in the drawings and in the explained in more detail below description. It demonstrate:

1 Use and function of the invention in ultrasound diagnosis or treatment as a support or shell in contact with a surface.

2a Formation of a water film in conjunction with an ultrasound head.

2 B , Support for producing a flat surface on an uneven surface.

3 , Use and function of the invention in the infrared treatment of tissue.

4 , Use and function of the invention in radiation treatment with ionizing radiation.

5 , Use and function of the invention in examination in body cavities.

6 , Detail of a jacketed bag with a media feed.

7 , Processing and holding device for sound probes.

1 , shows the use and function of the invention in ultrasound diagnosis or treatment as an overlay or wrapper in contact with a surface. Figure A. shows a hydro tissue 1 or a hydro layer which is on a surface 12 a skin or a material 5 rests. By the pressure (arrow e.) Of the probe 4 from the top is at least on the surface 3 pushed out further water and formed a thin film of water (not shown). This movie can also be between the surface 12 and the outer surface of the bacterial cellulose. The outer surface 3 also allows evaporation of the water. In the case of a skin patch, the hydro tissue 1 Absorb substances (arrow d.) From the skin or, if necessary, also offer substances for replacement. To determine an ultrasound image, the ultrasound probe is located 4 directly on the surface 3 the edition 1 at. The ultrasound 9 is about the edition 1 , z. B. on the surface 3 , in the material 5 (eg skin). With 10 the echo is shown, which takes its way back to the probe. In Figure B, is an ultrasound probe 4 , at least in the front part of a hydro-tissue sleeve 2 sheathed and z. B. with a silicone ring 6 fixed on this. The pressure from above (arrow e) also creates a film of water between the surface 3 and the probe exterior. The depressed water content, however, can not drain. In Figure C is also a sleeve 2 shown in section, the one ultrasound head 4 jacketed. Here, however, the ultrasound head is not directly on the hydro tissue, but inside the sleeve 2 there is a room 8th in which a solution or a gel can be introduced. This solution is used for sound transmission and the water film between the bacterial cellulose and the skin or material improves the sound transmission. Through the use of bacterial cellulose, the sound signal is optimally forwarded. The sleeve 2 is with a cuff 7 fixed so that the inner solution or material can not escape. The latter embodiment can preferably be used in material testing, but also for the introduction of active ingredients into the skin.

2a , shows the formation of a water film in conjunction with an ultrasound head. Shown is, as by pressing from above (arrow e) additional water or aqueous medium (arrow g.) From a hydro tissue 1 or a hydro layer is pushed out and between ultrasound head 4 and the surface 3 to a visible aqueous film 33 accumulates. The film 33 is only a few microns thick and the aqueous medium is by the pressure from the top to the outside 34 pushed. Although the thickness of the film is reduced, the contact with the inner movable liquid layer remains. This layer 33 in the form of a glossy skin already forms by the weight of the material. In this layer thickness it is hardly visible on the surface of the material. A water film also forms between a biological tissue and the overlay, but this film is affected by the evaporation through the hydrocloth.

Furthermore, this creates a direct contact and exchange with the mobile medium in the support (arrow g.). Depending on the pressure, density and structure of the hydro tissue 1 can be between the lower side of the hydro tissue 1 and the surface 12 form a permanent aqueous film. By evaporation (arrow f) liquid is discharged to the outside and this in turn sucks liquid (arrow d) z. B. from the skin 5 on. Due to the soft and deformable surface 3 of the hydro tissue 1 The film continues to form with the movement of the ultrasound head, thus enabling an optimal coupling for the ultrasound signal.

2 B , shows a support for producing a flat surface on an uneven surface. Shown is an edition 1 that is a shaping or shaping 35 has. Due to this shape 35 the overlay optimally covers an uneven surface 12 , z. B. an uneven body region 5 to be able to perform a treatment here. It will be a plane or even outer surface 3 made to an uneven surface. Next is an ultrathin, liquid layer 33 which is particularly typical of thicker bacterial cellulose pads. Due to the flat surface with a soft deformable surface 3 Here, the ultrasound probe can rest smoothly and the sound can be coupled in. The transmission 9 and received signal 10 is optimally introduced. Thus, the edition improves the use of the echo-pulse method. Alternatively, a sheath may have ab- or formations.

3 , shows the use and function of the invention in the infrared treatment of tissue. On the skin 5 a patient has a flat hydro-tissue support 1 , About a spaced light source 14 becomes ultra-red light 11 emitted different intensity. The emitted light 11 is due to the pad, which is directly related to the skin surface 12 Contact has filtered and only let through the longer rippled light. In the skin 5 The penetrated red light component generates heating. This in turn drives the evaporation over the surface 3 (see arrow a.) and allows cooling, despite the energy supply to the skin. At the boundary layer 12 can also be a water film 33 form, as the entry of the tissue water in the pad 1 is controlled by the evaporation with and over the skin more liquid can be offered than is evaporated.

4 , shows use and function of the invention in radiation treatment with ionizing radiation. According to the 3 is here via an X-ray or other radiation source 15 emitted ionizing or electromagnetic radiation. Spaced here is a circulation 1 on a skin surface 12 on. The radiation 13 penetrates the surface 3 first into the hydro tissue 1 and generates a scattered radiation 16 which are typically (arrows a) in the skin or in an adjacent tissue 5 penetrates. Due to the thickness of the flow path of the support 1 a suitable dose of effect is introduced into the upper tissue region. As the material cools continuously and material exchange takes place, combined treatments can be made possible. Due to the heat development as a secondary effect or with a time delay and concomitant increased transpiration of the skin may occur. In this case, an aqueous film may also be present in the skin / overlay contact area 33 form.

5 , shows the use and function of the invention in examination in body cavities. A rod-shaped ultrasound probe is completely or only in the front region with a hydro tissue 2 surround. With a silicone ring 6 or a cuff 7 the shell is connected to the headboard. The Hydrostoffbehülle 2 is doing to ultrasound transmission in a body cavity 17 used. At the interface body tissue and bacterial cellulose 12 a water film is created 33 by mechanical pressure of the ultrasound probe. This is also possible because the tissue itself can give off fluid. Will not be an additional cover for protection and only a sterile shell 2 used from bacterial cellulose, can also take place a mass transfer. Alternatively, the device may additionally be surrounded by a thin latex sheath which serves as protection against infections. This additional plastic shell can be discarded. Shown is the application of an echo pulse method. Alternatively, a therapeutic ultrasound for the treatment of the tissue can also be used here. Also conceivable would be the destruction of kidney stones. Here, the bacterial cellulose would serve as a transmission medium for shockwaves.

6 , shows a detailed view of a jacketed bag with a media feeder. The sectional view shows a bag 18 that of a hydro tissue 2 is sheathed. The bag 18 is over a hose 19 supplied with solution. With 20 It is shown to have channels in the bag 18 Fabrics over the wall of the shell 2 can penetrate. Alternatively, the interior 8th of the bag 18 also be impermeable to solutions. In this case, radioactive rays 13 , z. As technetium introduced. Due to the high aqueous content of the bacterial cellulose shell 2 becomes a suitable scattered radiation 16 allows. The latter in turn can destroy cancer cells inside a body. Instead of a bag, a catheter may be embedded or sheathed with the hydro tissue here. This device has the advantage that the inner patient tissue can be specifically irradiated.

7 , shows a processing and holding device for sound probes. Shown is an ultrasonic probe cleaning device 40 consisting of a container 29 and a holder 28 for probes 4 , To the ultrasound probe 4 to be able to clean in the lower area, there is a spraying or flushing device at least in the ground 21 , Alternatively, this can also be attached laterally. As additional protection for the ultrasound probe, silicone bands may be used 25 be provided in a mounting frame 31 are introduced. The frame 31 is z. B. removable and has for outdoor recordings 32 for these rings 25 , So a silicone mesh made of silicone rings is possible. With the arrow D, it becomes clear that here is a solution directly on an ultrasound probe 4 is blasted. The probe 4 can do this with a hydro tissue 2 be sheathed. The case 2 is preferably via rings 6 or cuffs 7 fixed. So that the cleaning solution does not splash out, is a two-piece or similar lid 27 with a strap 36 intended. As shown by arrow C (unfold) or arrow A (push), the lid can be removed. Arrow B represents the insertion of the probe into the holder 28 dar. To allow a mechanically controllable cleaning process, are supply lines 22 and derivatives 23 intended. In the upper container part can also be an overflow 26 be provided. The device shown here 40 simultaneously serves to support a probe in conjunction with a hydro tissue. The shape and size of the device depends on the particular type of probe. It goes without saying that so too several Probes can be cleaned at the same time. Alternatively, the device may be provided with a heating coil to heat the solution contained therein and kill germs. Preferably, the device is part of an ultrasonic device and the rinsing of the probe is controlled thereby. Alternatively, this can also be used on its own.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - DE 69214672 T2 [0002]
• EP 1364624 A1 [0002]
• - DE 10116763 C1 [0003]
• DE 10056062 A1 [0004]
• WO 01061026 [0024]
• - DE 1002275 C2 [0024]

Claims (21)

Support and casing in the field of medical, pharmaceutical, cosmetic and technical applications, characterized in that they consist of a hydro tissue ( 1 . 2 ) consists of bacterial cellulose fibers or a fiber composite with a mobile water or aqueous solution content of at least 60% by weight and a fiber-crosslinked hydro layer in conjunction with a self-formed water film ( 33 ) a transmission medium for sound waves ( 9 . 10 ) or radiation ( 11 . 13 ) decelerates, scatters or filters out and thereby or afterwards contributes to the cooling and mass transfer from the skin or tissue. Pad and sheath according to claim 1, characterized in that the hydro ( 1 . 2 ) forms on a biological or technical material a delay line for ionizing radiation, laser and infrared light or by pressure from above on the hydro tissue ( 1 . 2 ) at least one aqueous film ( 33 ) provides for the coupling of ultrasonic waves. Pad and sheath according to claim 1, characterized in that the hydro tissue ( 1 . 2 ) consists of 100% bacterial cellulose fibers or contains additional fibers or nets or gel bodies and has a mechanically mobile aqueous solution fraction. Support and casing according to claims 1 to 3, characterized in that the shell or support itself sucks on biological or technical surfaces or tight here. Pad and sheath according to claim 1 to 4, characterized in that the hydro tissue ( 1 . 2 ) has an increased mass transfer by externally supplied sound waves, shock waves or radiation energies. Pad and sheath according to one of claims 1 to 5, characterized in that the hydro tissue ( 1 . 2 ) a scattered radiation ( 16 ) or filters out shortwave light. Case according to one of claims 1 to 6, characterized in that it comprises an ultrasonic probe ( 4 ), a bag ( 18 ), a catheter, an extremity completely or in the front area wrapped. Case according to claim 7, characterized in that between the ultrasonic probe ( 4 ) and a surface ( 3 ) a room ( 8th ) is formed, in which there is solution, gel or water. Case according to claim 7, characterized in that it is protected by a silicone ring ( 6 ) or a cuff ( 7 ) is fixed. Case according to one of claims 1 to 9, characterized in that this bag ( 18 ) or catheter wrapped and the bag through a hose ( 19 ) is supplied with solution. Support according to one of claims 1 to 10, characterized in that this as a protective or transfer pad is used. An overlay according to claim 11, characterized that this is a wound or an operating field or an area to be irradiated Skin surface covers. Support and casing according to one of claims 1 to 12, characterized in that these are made of bacterial cellulose exists and has a surface roughness of 10-500 nm and a DPw value of 4000-9000. Pad and shell according to one of claims 1 to 13, characterized in that a support or shell at least on one side of formations, impressions or mold structures ( 35 ) having. Pad and sheath according to one of claims 1 to 14, characterized in that the hydro tissue ( 1 . 2 ) is internally combined with a film or with other material structures in different shapes and thicknesses or directly crosslinked with each other. Support and casing according to one of claims 1 to 15, characterized in that these by cleaning and / or Cooking or sterilizing are preparable. Device for cleaning ultrasonic probes, characterized in that at least one probe in a container ( 29 ) with an aqueous or disinfect the cleaning solution at least from below with a flushing device ( 21 ) is cleaned. Apparatus according to claim 17, characterized in that a sheath of a hydro tissue ( 1 . 2 ) together with the ultrasound probe in a device ( 40 ) and the coated ultrasound probe is stored here. Device according to one of claims 17 to 18, characterized in that the device ( 40 ) a multi-part lid ( 27 ) having. Device according to one of claims 17 to 19, characterized in that heating elements are present, to heat the introduced medium. Device according to one of claims 17 to 20, characterized in that the holders for probes ( 28 ) and / or access ( 22 ) and processes ( 23 . 24 ) are present for media.