DE102006025317A1 - Isoindolin-1-on-,Isoindolin-3-on und Isoindolin-1,3-dion-Derivate und ihre Verwendung - Google Patents
Isoindolin-1-on-,Isoindolin-3-on und Isoindolin-1,3-dion-Derivate und ihre Verwendung Download PDFInfo
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- DE102006025317A1 DE102006025317A1 DE102006025317A DE102006025317A DE102006025317A1 DE 102006025317 A1 DE102006025317 A1 DE 102006025317A1 DE 102006025317 A DE102006025317 A DE 102006025317A DE 102006025317 A DE102006025317 A DE 102006025317A DE 102006025317 A1 DE102006025317 A1 DE 102006025317A1
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- hydrogen
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- carbon atom
- carbonyl group
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- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title abstract description 6
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical class C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 title abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 94
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 24
- 238000011282 treatment Methods 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 21
- 238000011321 prophylaxis Methods 0.000 claims abstract description 20
- 201000010099 disease Diseases 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 13
- 230000009424 thromboembolic effect Effects 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 188
- 239000001257 hydrogen Substances 0.000 claims description 89
- 229910052739 hydrogen Inorganic materials 0.000 claims description 88
- -1 Cyano, hydroxy Chemical group 0.000 claims description 77
- 150000002431 hydrogen Chemical class 0.000 claims description 76
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 54
- 229910052799 carbon Inorganic materials 0.000 claims description 46
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 45
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 37
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 36
- 239000000460 chlorine Substances 0.000 claims description 36
- 229910052801 chlorine Inorganic materials 0.000 claims description 36
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 33
- 229910052731 fluorine Inorganic materials 0.000 claims description 33
- 239000011737 fluorine Substances 0.000 claims description 33
- 239000012442 inert solvent Substances 0.000 claims description 30
- 239000012453 solvate Substances 0.000 claims description 29
- 125000004432 carbon atom Chemical group C* 0.000 claims description 26
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 16
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical group C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 claims description 16
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
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- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 9
- 230000023555 blood coagulation Effects 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
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- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 7
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- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 229940019333 vitamin k antagonists Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006025317A DE102006025317A1 (de) | 2006-05-31 | 2006-05-31 | Isoindolin-1-on-,Isoindolin-3-on und Isoindolin-1,3-dion-Derivate und ihre Verwendung |
| PCT/EP2007/004706 WO2007137800A1 (de) | 2006-05-31 | 2007-05-26 | Isoindolin-1-on-, isoindolin-3-on- und isoindolin-1,3-dion-derivate und ihre verwendung |
| JP2009512477A JP2009538850A (ja) | 2006-05-31 | 2007-05-26 | イソインドリン−１−オン、イソインドリン−３−オンおよびイソインドリン−１，３−ジオン誘導体およびそれらの使用 |
| ES07725602T ES2355765T3 (es) | 2006-05-31 | 2007-05-26 | Derivados de isoindolin-1-ona, isoindolin-3-ona e isoindolin-1,3-diona y su uso. |
| AT07725602T ATE489383T1 (de) | 2006-05-31 | 2007-05-26 | Isoindolin-1-on-, isoindolin-3-on- und isoindolin-1,3-dion-derivate und ihre verwendung |
| DE502007005766T DE502007005766D1 (de) | 2006-05-31 | 2007-05-26 | Isoindolin-1-on-, isoindolin-3-on- und isoindolin-1,3-dion-derivate und ihre verwendung |
| CA002653673A CA2653673A1 (en) | 2006-05-31 | 2007-05-26 | Isoindolin-1-one, isoindolin-3-one and isoindoline-1,3-dione derivatives and their use |
| EP07725602A EP2029586B1 (de) | 2006-05-31 | 2007-05-26 | Isoindolin-1-on-, isoindolin-3-on- und isoindolin-1,3-dion-derivate und ihre verwendung |
| US12/301,759 US20100010060A1 (en) | 2006-05-31 | 2007-05-26 | Isoindolin-1-One-, Isoindolin-3-One- and Isoindolin-1,3-Dione-Derivatives and Use Thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006025317A DE102006025317A1 (de) | 2006-05-31 | 2006-05-31 | Isoindolin-1-on-,Isoindolin-3-on und Isoindolin-1,3-dion-Derivate und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102006025317A1 true DE102006025317A1 (de) | 2007-12-06 |
Family
ID=38330737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006025317A Withdrawn DE102006025317A1 (de) | 2006-05-31 | 2006-05-31 | Isoindolin-1-on-,Isoindolin-3-on und Isoindolin-1,3-dion-Derivate und ihre Verwendung |
| DE502007005766T Active DE502007005766D1 (de) | 2006-05-31 | 2007-05-26 | Isoindolin-1-on-, isoindolin-3-on- und isoindolin-1,3-dion-derivate und ihre verwendung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE502007005766T Active DE502007005766D1 (de) | 2006-05-31 | 2007-05-26 | Isoindolin-1-on-, isoindolin-3-on- und isoindolin-1,3-dion-derivate und ihre verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100010060A1 (enExample) |
| EP (1) | EP2029586B1 (enExample) |
| JP (1) | JP2009538850A (enExample) |
| AT (1) | ATE489383T1 (enExample) |
| CA (1) | CA2653673A1 (enExample) |
| DE (2) | DE102006025317A1 (enExample) |
| ES (1) | ES2355765T3 (enExample) |
| WO (1) | WO2007137800A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102307871A (zh) * | 2008-12-08 | 2012-01-04 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的异吲哚啉酮和相关的类似物 |
| LV14985B (lv) | 2013-10-14 | 2015-06-20 | Latvijas Organiskās Sintēzes Institūts | Lenalidomīda iegūšanas process |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10134482A1 (de) * | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| DE10137163A1 (de) * | 2001-07-30 | 2003-02-13 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
-
2006
- 2006-05-31 DE DE102006025317A patent/DE102006025317A1/de not_active Withdrawn
-
2007
- 2007-05-26 ES ES07725602T patent/ES2355765T3/es active Active
- 2007-05-26 EP EP07725602A patent/EP2029586B1/de not_active Not-in-force
- 2007-05-26 CA CA002653673A patent/CA2653673A1/en not_active Abandoned
- 2007-05-26 US US12/301,759 patent/US20100010060A1/en not_active Abandoned
- 2007-05-26 JP JP2009512477A patent/JP2009538850A/ja not_active Withdrawn
- 2007-05-26 DE DE502007005766T patent/DE502007005766D1/de active Active
- 2007-05-26 AT AT07725602T patent/ATE489383T1/de active
- 2007-05-26 WO PCT/EP2007/004706 patent/WO2007137800A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE502007005766D1 (de) | 2011-01-05 |
| ATE489383T1 (de) | 2010-12-15 |
| CA2653673A1 (en) | 2007-12-06 |
| JP2009538850A (ja) | 2009-11-12 |
| EP2029586B1 (de) | 2010-11-24 |
| EP2029586A1 (de) | 2009-03-04 |
| US20100010060A1 (en) | 2010-01-14 |
| WO2007137800A1 (de) | 2007-12-06 |
| ES2355765T3 (es) | 2011-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |