CZ305436B6 - Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice - Google Patents

Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice Download PDF

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Publication number
CZ305436B6
CZ305436B6 CZ2014-478A CZ2014478A CZ305436B6 CZ 305436 B6 CZ305436 B6 CZ 305436B6 CZ 2014478 A CZ2014478 A CZ 2014478A CZ 305436 B6 CZ305436 B6 CZ 305436B6
Authority
CZ
Czechia
Prior art keywords
mandelic acid
crystal
ivabradine hydrochloride
ivabradine
hydrochloride
Prior art date
Application number
CZ2014-478A
Other languages
Czech (cs)
English (en)
Other versions
CZ2014478A3 (cs
Inventor
Ondřej Dammer
Veronika Sládková
Eliška Skořepová
Gregor Sedmak
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Priority to CZ2014-478A priority Critical patent/CZ305436B6/cs
Priority to PCT/CZ2015/000076 priority patent/WO2016004911A1/fr
Publication of CZ2014478A3 publication Critical patent/CZ2014478A3/cs
Publication of CZ305436B6 publication Critical patent/CZ305436B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ2014-478A 2014-07-10 2014-07-10 Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice CZ305436B6 (cs)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CZ2014-478A CZ305436B6 (cs) 2014-07-10 2014-07-10 Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
PCT/CZ2015/000076 WO2016004911A1 (fr) 2014-07-10 2015-07-10 Cocristal de chlorhydrate d'ivabradine et d'acide (r)-mandélique et sa composition pharmaceutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2014-478A CZ305436B6 (cs) 2014-07-10 2014-07-10 Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice

Publications (2)

Publication Number Publication Date
CZ2014478A3 CZ2014478A3 (cs) 2015-09-16
CZ305436B6 true CZ305436B6 (cs) 2015-09-16

Family

ID=53765011

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2014-478A CZ305436B6 (cs) 2014-07-10 2014-07-10 Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice

Country Status (2)

Country Link
CZ (1) CZ305436B6 (fr)
WO (1) WO2016004911A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220024924A1 (en) * 2018-11-27 2022-01-27 Teva Czech Industries S.R.O Solid state forms of lumateperone salts and processes for preparation of lumateperone and salts thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008146308A2 (fr) * 2007-05-30 2008-12-04 Ind-Swift Laboratories Limited Procédé de préparation de chlorhydrate d'ivabradine et polymorphe correspondant
WO2011104723A2 (fr) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Sels d'addition d'acide de l'ivabradine et leur préparation
WO2011157720A2 (fr) * 2010-06-14 2011-12-22 Ratiopharm Gmbh Composition pharmaceutique contenant de l'ivabradine à libération modifiée

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882554B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
WO2008065681A2 (fr) 2006-11-30 2008-06-05 Cadila Healthcare Limited Procédé de préparation d'hydrochlorure d'ivabradine
CN101774969B (zh) 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
SI2902384T1 (en) 2010-02-12 2018-03-30 Krka, D.D., Novo Mesto The form of ivabradine hydrochloride
US9440924B2 (en) * 2011-08-02 2016-09-13 Sandoz Ag Acetone solvate of ivabradine hydrochloride
EP2589594A1 (fr) 2011-11-04 2013-05-08 Urquima S.A. Forme IV d'hydrochlorure d'ivabridine
CZ2013767A3 (cs) * 2013-10-02 2015-04-29 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008146308A2 (fr) * 2007-05-30 2008-12-04 Ind-Swift Laboratories Limited Procédé de préparation de chlorhydrate d'ivabradine et polymorphe correspondant
WO2011104723A2 (fr) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Sels d'addition d'acide de l'ivabradine et leur préparation
WO2011157720A2 (fr) * 2010-06-14 2011-12-22 Ratiopharm Gmbh Composition pharmaceutique contenant de l'ivabradine à libération modifiée

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Masciocchi, N., et al: Powder Diff. 2013 (28), 3, 200 - 206 *

Also Published As

Publication number Publication date
CZ2014478A3 (cs) 2015-09-16
WO2016004911A1 (fr) 2016-01-14
WO2016004911A8 (fr) 2016-05-19

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MM4A Patent lapsed due to non-payment of fee

Effective date: 20190710