CZ289196A3 - Preparation for treating genitals of domestic animals - Google Patents

Abstract

The invented preparation for treating genitals of domestic animals and intended for treating microbial infections of uterus or vagina as well as other inflammatory diseases of genitals contains aqueous-alcoholic extracts of potmarigold calendula, lady's mantle, common St. Johnswort containing 20 to 60 percent alcohol and essential oil of caraway, coriander and chamomile. The preparation contains 1 to 5 percent by weight potmarigold calendula extract containing at least 23 percent by weight ethanol and at least 2.5 percent by weight dry matter, 3 to 9 percent by weight lady's mantle extract containing at least 30 percent by weight ethanol and at least 2 percent by weight dry matter, 6 to 12 percent by weight common St. Johnswort extract containing at least 50 percent by weight ethanol and at least 3.0 percent by weight dry matter, 0.1 to 0.4 percent by weight essential oil of caraway, 0.01 to 0.6 percent by weight essential oil of coriander and 0.02 to 0.4 percent by weight essential oil of chamomile. This combination of natural substances is preferably thickened with a homopolymer of acrylic acid being cross-linked with pentaerythritol allyl ether or saccharose or hydroxyethylether cellulose or a sodium salt thereof or with polyacrylamide in a mixture with isoparaffins having 13 and 14 carbon atoms, further with ethoxylated lauryl alcohol and surface active agents.

Description

The invention relates to a medicament based on plant extracts and essential oils incorporated into a gel base. This preparation is intended especially for treatment of genitalia of livestock, especially cows and sows during microbial infections, during birth injuries, for preventive treatment of birth canal immediately after fetus equipment, for treatment of minor contaminated skin injuries, eventually for treatment of mammary gland inflammation.

BACKGROUND OF THE INVENTION

For the treatment of microbial infections of the uterus (endometritis) or vagina (vagimtid) as well as other inflammatory diseases of the genitalia, topically applied antibiotics are mostly used with antibiotics of the tetracycline series or with chloramphenicol. The disadvantage of antibiotic products is the need for repeated treatments at recommended intervals and especially the transfer of the active ingredients to milk and its withdrawal from food use during the withdrawal period. In practice, these rules are often not respected, which helps the emergence of resistant strains of pathogenic microorganisms, especially to antibiotics of the teracycline series. The iodine preparations do not have these deficiencies, but are not suitable for some pathological conditions and their applicability is limited to postpueiperal time due to adverse effects on the uterine wall and fallopian tubes.

A formulation using medicinal plants for at least approximately the same indication is nowhere described. The bacteriostatic and bactericidal effects of the individual plant extracts and essential oils are described. However, their separate administration does not achieve the desired effect.

SUMMARY OF THE INVENTION

The aforementioned disadvantages are eliminated by a preparation for the treatment of animal genitalia comprising water-alcoholic extracts of marigold, lady's mantle, St. John's wort with an alcohol content of 20 to 60% and essential oil of caraway, coriander and camomile. The preparation contains 1 to 5% by weight of marigold extract containing at least 23% by weight of ethanol and at least 2.5% by weight of dry matter, 3 to 9% by weight of lady's mantle extract containing at least 30% by weight of ethanol and at least 2% by weight of dry matter. % by weight of St. John's wort extract containing at least 50% by weight of ethanol and at least 3,0% by weight of dry matter and 0,1 to 0,4% by weight of caraway seed and 0,1 to 0,6% by weight of coriander and 0,02 to 0% 0,4% by weight of essential oil of camomile. This combination of natural substances is preferably thickened with substances based on carboxyvinyl polymers or cellulose derivatives or polyacrylamides in admixture with isoparaffins and surfactants.

The composition of the preparation is the result of testing a wider selection of plant extracts and essential oils in vitro (for example, on cultures of pathogenic microorganisms of both collection strains and strains isolated from swabs) and the use of literature on tissue effects. In vivo, the various ratios of the most beneficial effects applied in the selected vehicle and some combinations thereof were compared. The effects of the substances used in the preparation can be divided into 3 groups:

a) spasmic and vasoconstructive

(b) bacteriostatic to bacteriocidal

c) proliferative and generally healing

Separate administration of substances with predominant effect of group (a). (marigold, St. John's wort, Lady's mantle) did not have the desired effect, similarly to, for example, the separate application of chamomile containing azulene, which could only be applied after separation of the damaged uterine epithelium. Marigold and lady's mantle extracts containing tannins and St. John's wort containing hypericin have spasm and vasoconstructive effects.

The vasoconstriction of blood vessels that nourish the surface layer of the endometrium infested by microorganisms results in separation and spasmic effects of the extracts as well as expulsion of the pathological content of the endometrium.

The simultaneous treatment of caraway oil with bacteriocidal effects provides an environment for the action of azulene contained in the camomile extract, which promotes the growth of new tissue, so that the inflammatory condition is healed rapidly.

The individual components of the formulation interact synergistically, and due to their simultaneous action, the formulation of the invention is effective, has no side effects, does not promote the emergence of resistant strains, does not require a withdrawal period, has a wider indication area and last but not least significantly reduces the cost of treatment.

The composition according to the invention is also suitable for the treatment of more serious inflammatory conditions (pyometra or grade 3 eudometritis) treated with antibiotics.

The antibiotic product destroys pathogenic microorganisms, but the return of the genitals to the physiological state is slower.

Application of the composition of the invention will accelerate recovery and organ return to function

The composition of the invention containing plant extracts and essential oils can be administered to non-animal animals without a withdrawal period, i.e. milk from treated cows is usable for food purposes immediately after application of the composition containing plant extracts and essential oils as opposed to milk from cows treated with antibiotics. It is used in therapy and prevention, it has antibacterial, anti-inflammatory, healing, astringent and epithelializing effects. Another advantage of the formulation is good compatibility and non-irritability, which is a precondition for preventive use.

The optimum ratio of extracts and essential oils was selected based on monitoring of growth inhibitory effect of pathogenic microorganisms. The gel-forming agent (thickener) has been chosen to ensure stability of the formulation over a wide temperature range, to release the active ingredients well and to allow easy intrauterine application

Examples

He did

Ingredients:

Calendulae 3.00  St John's wort (hyperici) 9.00  lady's mantle (alchemillae) 6.00 Oil of Coriander (Oleum coriandri) 0.30  caraway caraway 0.20  Chamomile (Chamomillae) 0.10 Carbomer 0.30 Triethanolamine 0.30 Methylparaben 0.25 Demineralized water sterilized ad 100.00 g

Preparation process:

The carbomer is swollen in water and neutralized with triethanloamine. Methylparaben is dissolved in the mixture of extracts and sibc and mixed thoroughly with the gel base.

Example 2

Ingredients;

Calendulae 3.00  St John's wort (hyperici) 9.00  lady's mantle (alchemillae) 6.00 Coriander (Oleum coriandri) 0.30  caraway caraway 0.20  Chamomile (Chamomillae) 0.10 Carbomer 0.30 Triethanolamine 0.30 Methylparaben 0.25 Glycerine 5.00 Water demineralized sterilized ad 100.00 g Preparation process: The carbomer is swollen in a mixture of water and glycerin and neutralized with triethanloamine. Methylparaben is dissolved in the mixture of extracts and essential oils and mixed thoroughly with the gel basis. Example 3 Ingredients: Calendulae 3.00  St John's wort (hyperici) 9.00  lady's mantle (alchemillae) 6.00 Coriander (Oleum coriandri) 0.30  caraway caraway 0.20

chamomillae 0,10

Sepigel (a mixture of polyacrylamide, (43 _and 14 isoparaffin and ethoxylated lauryl alcohol) 1.00

Methylparaben 0.25

Water demineralized sterilized ad 100,00 g

Preparation process:

Methylparaben is dissolved in the mixture of extracts and essential oils, water is added and a mixture of polyacrylamide, (43 _and 14 isoparaffin and ethoxylated lauryl alcohol) is added slowly with stirring.

Example 4

Ingredients:

Calendulae extract 3,00 St John's wort (hyperici) 9,00 Lady's mantle (alchemillae) 6,00

Oil of coriander (Oleum coriandri) 0,30 caraway seeds 0,20 chamomillae 0,10

Hydroxyethylcellulose 0.80

Methylparaben 0.25

Water demineralized sterilized ad 100,00 g

Preparation process:

Methylparaben is dissolved in the mixture of extracts and essential oils, hydroxyethylcellulose is dispersed and water is added with stirring.

Example 5

Ingredients:

Calendulae extract 3,00 St John's wort (hyperici) 9,00 Lady's mantle (alchemillae) 6,00

Oil of coriander (Oleum coriandri) 0,30 caraway seeds 0,20 chamomillae 0,01

Hydroxyethylcellulose 0.80

Methylparaben 0.25

Glycerin 5.00

Water demineralized sterilized ad 100,00 g

Preparation process:

Methylparaben is dissolved in the mixture of extracts and essential oils, hydroxyethylcellulose is dispersed and water and glycerin are added with stirring.

Industrial applicability

The preparation is intended for the pharmaceutical industry with application mainly in veterinary gynecology, eventually traumatology and dermatology.

Claims (5)

A preparation for the treatment of livestock genitalia, for the treatment of microbial infections of the uterus or vagina and other inflammatory genital diseases, characterized in that it contains water-alcoholic extracts of marigold, lady's mantle, St. John's wort containing 20 to 60% alcohol and essential caraway oil. , coriander and chamomile in a pharmaceutically acceptable carrier. Composition according to claim 1, characterized in that it contains 1 to 5% by weight of marigold extract containing at least 23% by weight of ethanol and at least 2.5% by weight of dry matter, 3 to 9% by weight of mantle extract having a content of at least 30% by weight ethanol and at least 2% by weight of dry matter and 6 to 12% by weight of St. John's wort extract containing at least 50% by weight of ethanol and at least 3,0% by weight of dry matter and 0,1 to 0,4% by weight of essential caraway seed and 0,1 to 0, 6% by weight of essential coriander oil and 0.02 to 0.4% by weight of camomile essential oil. Composition according to claims 1 and 2, characterized in that it comprises a homopolymer of acrylic acid cross-linked with allyl ether of pentaerythrytol or sucrose. A composition according to claims 1 and 2, characterized in that it comprises hydroxyethyl ether cellulose or its sodium salt. Composition according to claims 1 and 2, characterized in that it contains polyacrylamide in admixture with isoparaffins having a carbon number of 13 and 14, ethoxylated lauryl alcohol and surfactants.