CZ287415B6 - Adapted milk for infantile nutrition - Google Patents

Abstract

The invented adapted milk for infantile nutrition based on animal milk, water, a mixture of fats and a mixture of sugars, fortified vitamins, mineral substances including trace elements and amino acids contains a mixture of animal milk and water in which the ratio of milk to water is adapted so that 100 ml of the mixture contain 1.1 to 2.55 g of native milk proteins, further 3.0 to 6.0 g of fats formed particularly by milk fat and vegetable oils, whereby the content of the milk fat is in the range 2.0 to 2.8 g and the content of the vegetable oil ranges within 0.8 to 2.5 g, further 6 to 12 g sugars formed particularly by lactose and maltodextrins, whereby the lactose content is in the range of 3 to 9 g and the content of maltodextrins ranges from 2 to 6 g.

Description

Technical field

The invention relates to adapted cow, goat and sheep milk or mixtures thereof for infant formulas.

BACKGROUND OF THE INVENTION

Adapted milk for infant formulas is still mostly used in the dried state. Depending on its purpose, it has a different composition, eg the most widespread baby milk powder contains 100 g:

fats 25,3 g proteins 27,3 g lactose 38,3 g water 3,0 g calcium 1.0 g other minerals 5,092 g iron 4,0 mg, vitamin A 0.110 to 0.230 mg vitamin B2 1.5 mg

Sugars are supplemented with sucrose when diluted. The product has a high protein content.

Various adapted milk formulas for infant formulas in the liquid or dried state are known. E.g. AO 261186 discloses a method for producing adapted infant formulas containing useful bifidogenic microflora and lysozyme enzyme.

AO 267 827 is concerned with the production of concentrated milk with maltodextrin suitable for liquid nutrition, wholly or whole milk being mixed with maltodextrin. This formula is suitable for infant formulas because it contains:

in 100 g of product: diluted in 100 ml of drink:

6.20 g milk fat 3.10 g milk fat

6.10 g protein 3.05 g protein

16.3 g carbohydrates 8.15 g carbohydrates

The product according to AO 267 927 has a high protein content.

It is not possible to achieve an optimum protein / fat / sugar ratio by any of these known solutions.

US patent 3649295 discloses a composition of a humanized fat composition and a child formula utilizing the composition. The composition of the fat blend is limited as follows:

up to 45% safflower-sage oil, up to 45% hardened beef fat (tallow), up to 25% vegetable oil from soybean, corn, peanut, sunflower,

Up to 35% of coconut oil and palm kernel oil, up to 2% soy lecithin.

The fat blend does not contain any milk fat that is easily digestible and has a beneficial effect on the development of the central nervous system in particular in the early development of the human body. On the contrary, it contains beef fat, the digestibility of which is problematic for infants.

The protein source in the child formula of US patent 3649295 consists of proteins obtained by electrodialysis and sugars are lactose. In terms of today's level of infant nutrition, the composition of proteins and sugars is surpassed. In the composition method of the protein source, for example, components of the native source such as hormones, enzymes and other biologically active substances are destroyed. The composition of sugars causes a disproportionate burden on the enzyme system in the intestinal mucosa of the infant.

A method according to Patent No. 284510 is known wherein ultrafiltration and diafiltration yield a protein concentrate. The result is a product with a high content especially of proteins and sugars that are not suitable for infant formulas.

Some foreign companies produce dried milk replacer where the casein and whey protein ratio is adjusted to 40/60 by adding demineralized whey (5 to

%).

The European Society for Pediatric Gastroenterology and Nutrition recommends the following values for infants:

fluid (milk) protein energy intake

140 to 160 ml / kg / day

2.0 to 2.5 g / kg

400 to 450 kJ / kg in percentage of calories of protein fats sugars up to 10% ± 5% ± 3%

These values represent the latest findings of world research.

The disadvantage of the above-mentioned and up to now known products is that due to their composition they can hardly meet the requirements for an ideal infant formula, especially due to the high content of salts and proteins, it causes extreme load on the kidneys.

A negative consequence of the higher content and composition of carbohydrates is the inadequate burden on the enzyme system in the intestinal mucosa (sucrose), and also postpradial fluctuations in glycemia. Sucrose is not suitable for younger infants due to enzymatic activity in the digestive tract and interaction in milk sugar fermentation, which has a negative effect on the physiological microflora.

Mostly milk produced in the dried state is adapted, which positively affects the shelf life of the product. On the other hand, the preparation is often damaged by incorrect procedure (dry weight), poor hygiene, poor quality drinking water, which in many regions does not meet hygiene requirements.

-2GB 287415 B6

SUMMARY OF THE INVENTION

These drawbacks are largely overcome by adapted milk for infant formulas based on animal milk, water, fat and sugar mixtures, fortified with vitamins, minerals including trace elements and amino acids, according to the present invention. It consists of a mixture of animal milk and water in which the ratio of milk and water is adjusted such that 100 ml of the mixture contains 1.1 to 2.55 g of native milk protein and further contains 3.0 to 6 g of fats containing mainly milk fat and vegetable oils, the milk fat content being in the range of 0.8 to 2.5 g and the vegetable oil content in the range of 2.0 to 2.5 g in 100 ml of the mixture, further 100 ml of the mixture contains 6 to 12 g of sugars, consisting mainly of lactose and maltodextrins, with a lactose content of 3 to 9 g and a maltodextrin content of 2 to 6 g in the mixture. Preferably, the animal milk is milk of select quality (Q) with nutritional values per 100 g approximately:

proteins3,3 g fats3,8 sugars4,7 with an energy content of 272 kJ.

Preferably, the milk is cow and / or goat and / or sheep.

The fat blend, whose weight content in the milk blend is 3.0 to 6.0 g, consists mainly of milk fat and vegetable oils, with a milk fat content in the milk blend of about 2.0 to 2.8 g and a vegetable oil content of The fat blend may be supplemented with other fats such as fish oil, lard and the like. Milk fat is easily digestible and contains cholesterol necessary for healthy development, especially of the central nervous system, brain and spinal cord, in the early period of human development. The vegetable fat blend is preferably composed of a mixture of sunflower and low-rape rapeseed oil, which ensures an optimal supply of high-skeletal fatty acids in the appropriate ratio of linoleic acid to linolenic acid, as well as the natural vitamin E and vitamin A supply. Naturally, a mixture of vegetable oils in a predetermined amount may also be composed of other oils to provide the desired fatty acid ratio. However, a mixture of sunflower and rapeseed oil is also very economically advantageous. The mixture of animal and vegetable fats provides an analogous fatty acid and cholesterol profile to that of breast milk. Fats are well absorbable, supplying many natural complex fatty substances. Compared to known preparations, the content of short-chain saturated fatty acids has decreased, and vice versa, the concentration of polyunsaturated fatty acids has increased.

The following table shows the ratio of fatty acids in%:

ratio (%): breast milk: A suggested solution: SFA / PUFA 0.30 0.31 SFA / UFA 45/55 49/51 SFA / MUFA / PUFA 45/40/15 49/36/15 CHOLESTEROL about 15 to 20 mg / 100 ml 18 mg / 100 ml

Where:

SFA = saturated fatty acids UFA = unsaturated fatty acids MUFA = monounsaturated fatty acids PUFA = polyunsaturated fatty acids.

-3GB 287415 B6

The table demonstrates a significant adaptation of the fat composition of the present invention to the values contained in breast milk, thereby improving the supply of essential fatty acids.

The formation of a fat blend promotes the very good utility and absorbability of the necessary nutrients and minerals, especially calcium, and delivers the necessary amounts of cholesterol, phospholipids and complex lipids.

The sugar mixture consists mainly of lactose and maltodextrins, the lactose content in 100 ml of the milk mixture being 3 to 9 g and the maltodextrins content 2 to 6 g in the mixture. The sugar mixture can be supplemented with other sugars such as maltose, trehalose, honey, etc. The sugar mixture provides the necessary content of metabolites, which belong to the bifid factor, is very digestible, helps to create own intestinal microflora and stimulates enzyme activity and morphological changes in the intestinal tract, with minimal burden on the enzyme system.

The possible addition of essential, semi-essential and assisting L-forms of amino acids from 0.5 to 2.0 g per 100 ml of milk mixture, in particular taurine 30 to 90 mg, provides nutrition suitable for premature and hypotrophic children. Taurine improves fat absorption and promotes brain development. Fortification with vitamins, minerals and trace elements provides a comprehensive need for a healthy baby.

The advantages of the adapted milk according to the invention are in particular:

- in optimal protein dosing, eliminating the need for energy to feed a protein charge, since 1.0 g of protein needs 145 kJ,

- vegetable oil or a mixture of vegetable oils, preferably sunflower and rapeseed, enriches the supply of essential fatty acids, natural vitamin E and vitamin A,

- maltodextrins do not burden the enzyme system in the intestinal mucosa (sucrose), they reduce post-prandial blood glucose fluctuations,

- a lower salt intake combined with a decrease in protein content will reduce renal excretion burden,

- the native composition ensures the preservation of all natural milk constituents, in particular nucleoids, complex sugars, lipids, non-proteinaceous crude protein, natural vitamins and minerals, enzymes, hormones,

- easier preparation of the dose and simple calculation of the amount of food per day, as well as nutritional coverage of 150 ml / kg / day, the same concentration of each dose will eliminate the possibility of under- and overdose, which often occurs in nutritional diet,

- saving of el. energy, material and working time in dairy kitchens of hospitals and other infant homes,

- the use of defective water shall be avoided.

However, the main component is the native composition of the mixture based on economically advantageous products and a simple production method without the need for a special technological modification of the protein source, which is far more economical than the previously known solutions.

-4GB 287415 B6

DETAILED DESCRIPTION OF THE INVENTION

Example 1:

g of quality cow's milk of Q quality was diluted with drinking water meeting the hygiene standards for infant formulas to a total volume of 100 ml, containing:

proteins 1,55 g fats 1,79 g sugars 2,21 g

and had an average energy content of 128 ± 4 kJ.

Addition:

- fats up to 4,0 g vegetable sunflower oil,

- sugars up to 6,7 to 7,0 g, which was achieved by adding 1 g of lactose and 3,6 g of maltodextrin, the energy value increased by 165 ± 5 kJ.

Subsequently, fortification additions were added:

vitamin A 200 pg / L vitamin D 10 pg / l vitamin K 60 pg / l vitamin C 40 mg / l thiamine 300 pg / L vitamin B6 200 pg / L Folic acid 100 pg / L calcium 200 mg / l zinc 3 mg / l copper 500 pg / L iron up to 15 mg / l osmolality up to 200 mosmol / kg water minerals 265 mg / 100 ml

so as to achieve average values of vitamins and minerals per 1000 ml:

vitamin A 522 pg vitamin D 15.15 pg vitamin K 88 pg vitamin C 47.5 mg thiamine 488 pg vitamin B6 388 pg Folic acid 118 pg calcium 726 mg zinc 4.6 mg copper 594 pg manganese 9.4 mg magnesium 56.4 mg iodine 98 pg

-5GB 287415 B6

sodium 235 mg potassium 705 mg chlorides 446 mg phosphorus 450 mg iron 0.2 to 15.2 mg / L calcium / phosphorus ratio 1.61

The prepared milk is very well received by infants. When administered, very good results were achieved in the health of the infant compared to other breast milk substitutes, with all the advantages mentioned above.

Example 2:

g of quality cow's milk of Q quality was diluted with drinking water meeting the hygiene standards for infant formulas to a total volume of 100 ml, containing:

proteins 1,55 g fats 1,79 g sugars 2,21 g

and had an average energy content of 128 ± 4 kJ.

By adding 1 g of essential, semi-essential and assisting L-forms of amino acids, in particular taurine 60 mg / l, and adding:

- fats up to 4,20 g vegetable sunflower oil,

- sugars up to 8,5 to 9,0 g, which was achieved by adding 0,8 g of lactose and 5,5 g of maltodextrin, the energy value increased by 223 ± 5 kJ.

Subsequently, fortification additions were added:

vitamin A 250 pg / l vitamin D 10 (15) pg / liter vitamin K 60 pg / l vitamin C 50 mg / l thiamine 300 pg / l vitamin B6 200 pg / l Folic acid 200 pg / l calcium 300 mg / l zinc 6 mg / l copper 500 pg / l iron up to 15 mg / l osmolality up to 200 mosmol / kg water minerals 278 mg / 100 ml

so as to achieve average values of vitamins and minerals per 1000 ml:

vitamin A 572 pg vitamin D 10.15 (15.15) pg vitamin K 88 pg

-6GB 287415 B6

vitamin C 57.5 mg thiamine 488 pg vitamin B6 388 pg Folic acid 218 pg calcium 826 mg zinc 7.6 mg copper 594 pg manganese 9.4 mg magnesium 56.4 mg iodine 98 pg sodium 235 mg potassium 705 mg chlorides 446 mg phosphorus 450 mg iron 0.2 to 15.2 mg / L calcium / phosphorus ratio 1.83

The adapted milk of Example 2 is particularly suitable for premature and hypotrophic infants, with the advantages mentioned above.

Example 3:

g of goat's milk of Q quality was diluted with drinking water complying with hygiene standards for infant formulas to a total volume of 100 ml, containing:

proteins 1,55 g fats 2.11 g sugars 2.16 g

and had an average energy content of 139 ± 6 kJ.

Addition:

- fats up to 4,0 g vegetable oil,

- sugars up to 7,0 g, which was achieved by adding 1,5 g lactose and 3,44 g maltodextrin, the energy value increased by 160 ± 5 kJ.

Subsequently, fortification additions were added:

vitamin A 150 pg / L vitamin D 10 (15) pg / liter vitamin E 2 mg / l vitamin K 50 pg / L vitamin B] 400 pg / L vitamin Bg 400 pg / L vitamin Bj2 3 Pg / l vitamin C 35 mg / l biotin 45 pg / l pantothenic acid 4 mg / l niacin 6 mg / l

taurine 50 mg / l L-carnitine 12 mg / l calcium 200 mg / l zinc 4 mg / l copper 500 pg / l iodine 50 pg / l iron 15 mg / l molybdenum 60 pg / l chrome 50 pg / l selenium 15 pg / l fluorine 500 pg / l osmolality up to 200 mosmol / kg water minerals 289 mg / 100 ml.

In addition to the advantages presented in the examples of adapted cow's milk, the advantages of adapted goat's milk consist mainly in:

- different protein composition, including casein,

- easier fat digestibility,

- less harmful substances that occasionally cause cow's milk intolerance.

For this reason, adapted goat milk is particularly suitable after gastrointestinal surgery and for reduced allergogenic potential in cow's milk intolerance.

Example 4:

g of Q quality sheep milk was diluted with drinking water complying with hygiene standards for infant formulas to a total volume of 100 ml and subsequently fortified and fortified according to Example 3.

Adapted sheep's milk showed a significantly reduced allergogenic potential compared to cow's milk.

Industrial applicability

The adapted milk according to the invention can be produced in any dairy whose equipment makes it possible to meet the standards for the production of infant formulas.

Claims (9)

PATENT CLAIMS 1. Adapted infant formula based on animal milk, water, fat and sugar mixtures, fortified with vitamins, minerals including trace elements and amino acids, characterized in that it contains a mixture of animal milk and water in which the milk / water ratio is modified so that 100 ml of the mixture contains 1,1 to 2,55 g of native milk protein, and further contains 3,0 to 6,0 g of fats mainly composed of milk fat and vegetable oils, the milk fat content being in the range of 1,7 to 2.8 g and a vegetable oil content in the range of 0.8 to 2.5 g, further comprising 6 to 12 g of sugars consisting mainly of lactose and maltodextrins, with a lactose content of 3 to 9 g and a maltodextrin content of 2 to 6 g. Adapted milk according to claim 1, characterized in that the animal milk is cow's and / or goat's and / or sheep's. Adapted milk according to claim 1 or 2, characterized in that the vegetable oil is sunflower and / or rapeseed. Adapted milk according to one of claims 1 to 3, characterized in that 100 ml contains traces of up to 3 g of fish oil and / or lard. Adapted milk according to any one of claims 1 to 4, characterized in that 100 ml contains traces of up to 2 g of essential, semi-essential and assisting L-forms of amino acids. The adapted milk according to claim 5, wherein 100 ml contains traces of up to 12 mg taurine. Adapted milk according to one of claims 1 to 6, characterized in that 100 ml contains 10 to 80 pg of vitamin A and / or traces of up to 3 pg of vitamin D and / or 2 to 8 mg of vitamin C and / or 10 to 100 pg of vitamin B | and / or 0.5 to 1 mg of vitamin B2 and / or 0.2 to 1 mg of vitamin B3 and / or 0.2 to 0.8 mg of vitamin B5 and / or 10 to 100 µg of vitamin Bg and / or 3 to 30 pg of vitamin B9 and / or traces of up to 0.6 pg of vitamin B12 and / or traces of up to 20 pg of vitamin K. Adapted milk according to one of claims 1 to 7, characterized in that 100 ml contains traces of up to 100 mg of calcium and / or traces of up to 1 mg of zinc and / or traces of up to 150 µg of copper and / or traces of up to 3 mg of iron and / or traces up to 0.2 mg fluorine and / or traces up to 15 pg iodine and / or traces up to 8 pg chromium and / or traces up to 8 pg selenium and / or traces up to 8 pg molybdenum and / or traces up to 4 pg manganese. Adapted milk according to any one of claims 1 to 8, characterized in that 100 ml contains traces of up to 2 mg of L-carnitine.