CZ2004335A3 - Peptidy odvozené od kaseinu a jejich použití pro léčení - Google Patents

Info

Publication number

CZ2004335A3

CZ2004335A3 CZ2004335A CZ2004335A CZ2004335A3 CZ 2004335 A3 CZ2004335 A3 CZ 2004335A3 CZ 2004335 A CZ2004335 A CZ 2004335A CZ 2004335 A CZ2004335 A CZ 2004335A CZ 2004335 A3 CZ2004335 A3 CZ 2004335A3

Authority

CZ

Czechia

Prior art keywords

peptide

casein

pharmaceutical composition

terminal portion

pharmaceutically acceptable

Prior art date

2001-08-30

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 964
• 239000005018 casein Substances 0.000 title claims abstract description 229
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 title claims abstract description 229
• 235000021240 caseins Nutrition 0.000 title claims abstract description 229
• 102000004196 processed proteins & peptides Human genes 0.000 title abstract description 214
• 238000002560 therapeutic procedure Methods 0.000 title description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 87
• 201000010099 disease Diseases 0.000 claims abstract description 46
• 230000003612 virological effect Effects 0.000 claims abstract description 27
• 230000011132 hemopoiesis Effects 0.000 claims abstract description 24
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 23
• 208000036142 Viral infection Diseases 0.000 claims abstract description 18
• 230000009385 viral infection Effects 0.000 claims abstract description 18
• 230000002708 enhancing effect Effects 0.000 claims abstract description 15
• 208000014951 hematologic disease Diseases 0.000 claims abstract description 14
• 208000035150 Hypercholesterolemia Diseases 0.000 claims abstract description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims description 380
• 238000000034 method Methods 0.000 claims description 265
• 102100038920 Alpha-S1-casein Human genes 0.000 claims description 259
• 101000741048 Homo sapiens Alpha-S1-casein Proteins 0.000 claims description 259
• 239000004480 active ingredient Substances 0.000 claims description 245
• 239000003937 drug carrier Substances 0.000 claims description 231
• 102000009366 Alpha-s1 casein Human genes 0.000 claims description 173
• 108050000244 Alpha-s1 casein Proteins 0.000 claims description 173
• 238000011282 treatment Methods 0.000 claims description 166
• 108010041111 Thrombopoietin Proteins 0.000 claims description 147
• 102000036693 Thrombopoietin Human genes 0.000 claims description 147
• 230000001939 inductive effect Effects 0.000 claims description 139
• 230000002265 prevention Effects 0.000 claims description 131
• 210000000130 stem cell Anatomy 0.000 claims description 98
• 239000012634 fragment Substances 0.000 claims description 77
• 210000004369 blood Anatomy 0.000 claims description 76
• 239000008280 blood Substances 0.000 claims description 76
• 238000002360 preparation method Methods 0.000 claims description 68
• 239000003814 drug Substances 0.000 claims description 64
• 210000001185 bone marrow Anatomy 0.000 claims description 56
• 230000000694 effects Effects 0.000 claims description 54
• 230000004663 cell proliferation Effects 0.000 claims description 53
• 210000001772 blood platelet Anatomy 0.000 claims description 52
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 49
• 241000282414 Homo sapiens Species 0.000 claims description 48
• 230000035755 proliferation Effects 0.000 claims description 46
• 206010043554 thrombocytopenia Diseases 0.000 claims description 44
• 208000035475 disorder Diseases 0.000 claims description 41
• 230000001400 myeloablative effect Effects 0.000 claims description 36
• 239000000203 mixture Substances 0.000 claims description 33
• 201000010000 Agranulocytosis Diseases 0.000 claims description 32
• 206010018687 Granulocytopenia Diseases 0.000 claims description 32
• 206010033661 Pancytopenia Diseases 0.000 claims description 32
• 210000002540 macrophage Anatomy 0.000 claims description 30
• 230000007812 deficiency Effects 0.000 claims description 29
• 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 26
• 238000010322 bone marrow transplantation Methods 0.000 claims description 26
• 210000005259 peripheral blood Anatomy 0.000 claims description 25
• 239000011886 peripheral blood Substances 0.000 claims description 25
• 208000031886 HIV Infections Diseases 0.000 claims description 24
• 208000023275 Autoimmune disease Diseases 0.000 claims description 23
• 208000030507 AIDS Diseases 0.000 claims description 22
• 206010012601 diabetes mellitus Diseases 0.000 claims description 22
• 206010018473 Glycosuria Diseases 0.000 claims description 21
• 230000035780 glucosuria Effects 0.000 claims description 21
• 208000031226 Hyperlipidaemia Diseases 0.000 claims description 19
• 210000004698 lymphocyte Anatomy 0.000 claims description 19
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
• 230000024245 cell differentiation Effects 0.000 claims description 16
• 238000002512 chemotherapy Methods 0.000 claims description 16
• 210000004443 dendritic cell Anatomy 0.000 claims description 15
• 230000010437 erythropoiesis Effects 0.000 claims description 15
• 230000003394 haemopoietic effect Effects 0.000 claims description 15
• 230000002093 peripheral effect Effects 0.000 claims description 15
• 210000004180 plasmocyte Anatomy 0.000 claims description 15
• 208000037357 HIV infectious disease Diseases 0.000 claims description 14
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 14
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 14
• 210000000440 neutrophil Anatomy 0.000 claims description 14
• 230000002489 hematologic effect Effects 0.000 claims description 13
• 238000011127 radiochemotherapy Methods 0.000 claims description 13
• 108090000394 Erythropoietin Proteins 0.000 claims description 12
• 102000003951 Erythropoietin Human genes 0.000 claims description 12
• 208000021161 Plasma cell disease Diseases 0.000 claims description 12
• 229940105423 erythropoietin Drugs 0.000 claims description 12
• 238000002513 implantation Methods 0.000 claims description 12
• 208000015181 infectious disease Diseases 0.000 claims description 12
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 12
• 208000018706 hematopoietic system disease Diseases 0.000 claims description 11
• 208000018138 dendritic cell deficiency Diseases 0.000 claims description 9
• 208000026278 immune system disease Diseases 0.000 claims description 9
• 238000001959 radiotherapy Methods 0.000 claims description 9
• 235000012000 cholesterol Nutrition 0.000 claims description 8
• 229940079593 drug Drugs 0.000 claims description 8
• 208000032467 Aplastic anaemia Diseases 0.000 claims description 7
• 238000011476 stem cell transplantation Methods 0.000 claims description 7
• 241000725303 Human immunodeficiency virus Species 0.000 claims description 6
• 208000037913 T-cell disorder Diseases 0.000 claims description 6
• 210000002443 helper t lymphocyte Anatomy 0.000 claims description 6
• 201000001421 hyperglycemia Diseases 0.000 claims description 6
• 210000000987 immune system Anatomy 0.000 claims description 6
• 230000036039 immunity Effects 0.000 claims description 6
• 208000035143 Bacterial infection Diseases 0.000 claims description 5
• 208000022362 bacterial infectious disease Diseases 0.000 claims description 5
• 208000007541 Preleukemia Diseases 0.000 claims description 4
• 208000032839 leukemia Diseases 0.000 claims description 4
• 208000023661 Haematological disease Diseases 0.000 claims description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 230000028993 immune response Effects 0.000 abstract description 5
• 231100000252 nontoxic Toxicity 0.000 abstract description 5
• 235000013336 milk Nutrition 0.000 abstract description 4
• 239000008267 milk Substances 0.000 abstract description 4
• 210000004080 milk Anatomy 0.000 abstract description 4
• 230000003000 nontoxic effect Effects 0.000 abstract description 4
• 230000004936 stimulating effect Effects 0.000 abstract description 4
• 230000007170 pathology Effects 0.000 abstract 1
• 102000011632 Caseins Human genes 0.000 description 217
• 108010076119 Caseins Proteins 0.000 description 217
• 210000004027 cell Anatomy 0.000 description 154
• 241000699670 Mus sp. Species 0.000 description 61
• 235000001014 amino acid Nutrition 0.000 description 32
• 229940024606 amino acid Drugs 0.000 description 31
• 150000001413 amino acids Chemical class 0.000 description 30
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 27
• 238000011534 incubation Methods 0.000 description 22
• 230000001965 increasing effect Effects 0.000 description 21
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 19
• 239000000427 antigen Substances 0.000 description 17
• 102000036639 antigens Human genes 0.000 description 17
• 108091007433 antigens Proteins 0.000 description 17
• 239000001963 growth medium Substances 0.000 description 17
• 238000002347 injection Methods 0.000 description 17
• 239000007924 injection Substances 0.000 description 17
• 102100037904 CD9 antigen Human genes 0.000 description 16
• 210000003643 myeloid progenitor cell Anatomy 0.000 description 16
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 15
• 210000003593 megakaryocyte Anatomy 0.000 description 15
• 230000000638 stimulation Effects 0.000 description 15
• 239000004471 Glycine Substances 0.000 description 14
• 241000699666 Mus <mouse, genus> Species 0.000 description 14
• 210000002798 bone marrow cell Anatomy 0.000 description 14
• 239000012636 effector Substances 0.000 description 14
• 102000004127 Cytokines Human genes 0.000 description 13
• 108090000695 Cytokines Proteins 0.000 description 13
• 238000002474 experimental method Methods 0.000 description 13
• 238000004519 manufacturing process Methods 0.000 description 13
• 238000011084 recovery Methods 0.000 description 13
• -1 ketomethylene Chemical group 0.000 description 12
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 11
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 11
• 241001465754 Metazoa Species 0.000 description 11
• 206010028980 Neoplasm Diseases 0.000 description 11
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 11
• 201000011510 cancer Diseases 0.000 description 11
• 210000003743 erythrocyte Anatomy 0.000 description 11
• 229940090044 injection Drugs 0.000 description 11
• 210000000265 leukocyte Anatomy 0.000 description 11
• 210000001744 T-lymphocyte Anatomy 0.000 description 10
• 238000003556 assay Methods 0.000 description 10
• 239000003795 chemical substances by application Substances 0.000 description 10
• 238000010348 incorporation Methods 0.000 description 10
• 238000012360 testing method Methods 0.000 description 10
• 238000002054 transplantation Methods 0.000 description 10
• 230000001225 therapeutic effect Effects 0.000 description 9
• 210000001519 tissue Anatomy 0.000 description 9
• 229940107161 cholesterol Drugs 0.000 description 8
• 235000013365 dairy product Nutrition 0.000 description 8
• 210000003714 granulocyte Anatomy 0.000 description 8
• 239000000243 solution Substances 0.000 description 8
• 239000000725 suspension Substances 0.000 description 8
• 231100000419 toxicity Toxicity 0.000 description 8
• 230000001988 toxicity Effects 0.000 description 8
• NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 7
• 239000012980 RPMI-1640 medium Substances 0.000 description 7
• 210000000601 blood cell Anatomy 0.000 description 7
• 239000012228 culture supernatant Substances 0.000 description 7
• 230000004069 differentiation Effects 0.000 description 7
• 230000000925 erythroid effect Effects 0.000 description 7
• 239000003102 growth factor Substances 0.000 description 7
• 238000004128 high performance liquid chromatography Methods 0.000 description 7
• 210000000822 natural killer cell Anatomy 0.000 description 7
• 239000000546 pharmaceutical excipient Substances 0.000 description 7
• 239000000843 powder Substances 0.000 description 7
• 230000004044 response Effects 0.000 description 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
• 108010010803 Gelatin Proteins 0.000 description 6
• 241000282412 Homo Species 0.000 description 6
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
• 230000004071 biological effect Effects 0.000 description 6
• 230000015572 biosynthetic process Effects 0.000 description 6
• 239000002775 capsule Substances 0.000 description 6
• 238000004113 cell culture Methods 0.000 description 6
• 210000004700 fetal blood Anatomy 0.000 description 6
• 239000008273 gelatin Substances 0.000 description 6
• 229920000159 gelatin Polymers 0.000 description 6
• 235000019322 gelatine Nutrition 0.000 description 6
• 235000011852 gelatine desserts Nutrition 0.000 description 6
• 210000005260 human cell Anatomy 0.000 description 6
• 239000002953 phosphate buffered saline Substances 0.000 description 6
• 239000000047 product Substances 0.000 description 6
• 210000002966 serum Anatomy 0.000 description 6
• 239000000126 substance Substances 0.000 description 6
• 241000283707 Capra Species 0.000 description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
• 102000001554 Hemoglobins Human genes 0.000 description 5
• 108010054147 Hemoglobins Proteins 0.000 description 5
• 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 5
• SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 5
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
• 102000014171 Milk Proteins Human genes 0.000 description 5
• 108010011756 Milk Proteins Proteins 0.000 description 5
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 5
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 5
• 208000007502 anemia Diseases 0.000 description 5
• 238000001516 cell proliferation assay Methods 0.000 description 5
• 238000003776 cleavage reaction Methods 0.000 description 5
• 239000010432 diamond Substances 0.000 description 5
• 235000005911 diet Nutrition 0.000 description 5
• 230000037213 diet Effects 0.000 description 5
• 239000008298 dragée Substances 0.000 description 5
• 235000013305 food Nutrition 0.000 description 5
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 5
• 238000000338 in vitro Methods 0.000 description 5
• 238000001727 in vivo Methods 0.000 description 5
• 230000007774 longterm Effects 0.000 description 5
• 229960001913 mecysteine Drugs 0.000 description 5
• 229920000609 methyl cellulose Polymers 0.000 description 5
• 239000001923 methylcellulose Substances 0.000 description 5
• 235000010981 methylcellulose Nutrition 0.000 description 5
• 229940078547 methylserine Drugs 0.000 description 5
• 230000004048 modification Effects 0.000 description 5
• 238000012986 modification Methods 0.000 description 5
• 229920001223 polyethylene glycol Polymers 0.000 description 5
• 108090000623 proteins and genes Proteins 0.000 description 5
• 230000005855 radiation Effects 0.000 description 5
• 230000007017 scission Effects 0.000 description 5
• 235000000346 sugar Nutrition 0.000 description 5
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 4
• 241000283690 Bos taurus Species 0.000 description 4
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 4
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
• 238000002965 ELISA Methods 0.000 description 4
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
• 108091006905 Human Serum Albumin Proteins 0.000 description 4
• 102000008100 Human Serum Albumin Human genes 0.000 description 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
• 241000283973 Oryctolagus cuniculus Species 0.000 description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 229920002472 Starch Polymers 0.000 description 4
• 241000700605 Viruses Species 0.000 description 4
• 230000000844 anti-bacterial effect Effects 0.000 description 4
• 238000001514 detection method Methods 0.000 description 4
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
• 239000008103 glucose Substances 0.000 description 4
• 230000006872 improvement Effects 0.000 description 4
• 230000005764 inhibitory process Effects 0.000 description 4
• 238000007912 intraperitoneal administration Methods 0.000 description 4
• 231100000518 lethal Toxicity 0.000 description 4
• 230000001665 lethal effect Effects 0.000 description 4
• 239000002609 medium Substances 0.000 description 4
• 235000021239 milk protein Nutrition 0.000 description 4
• 210000003205 muscle Anatomy 0.000 description 4
• 235000016709 nutrition Nutrition 0.000 description 4
• 239000003960 organic solvent Substances 0.000 description 4
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
• 239000002243 precursor Substances 0.000 description 4
• 235000018102 proteins Nutrition 0.000 description 4
• 102000004169 proteins and genes Human genes 0.000 description 4
• 230000006337 proteolytic cleavage Effects 0.000 description 4
• 238000007363 ring formation reaction Methods 0.000 description 4
• FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 4
• 239000011780 sodium chloride Substances 0.000 description 4
• 210000000952 spleen Anatomy 0.000 description 4
• 239000003381 stabilizer Substances 0.000 description 4
• 235000019698 starch Nutrition 0.000 description 4
• 230000004083 survival effect Effects 0.000 description 4
• 239000003826 tablet Substances 0.000 description 4
• 229940104230 thymidine Drugs 0.000 description 4
• 231100000331 toxic Toxicity 0.000 description 4
• 230000002588 toxic effect Effects 0.000 description 4
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 3
• 241000894006 Bacteria Species 0.000 description 3
• 241000700198 Cavia Species 0.000 description 3
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
• 208000034423 Delivery Diseases 0.000 description 3
• 229920001917 Ficoll Polymers 0.000 description 3
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 3
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 3
• 241001494479 Pecora Species 0.000 description 3
• 102000003992 Peroxidases Human genes 0.000 description 3
• 241000283984 Rodentia Species 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 230000002776 aggregation Effects 0.000 description 3
• 238000004220 aggregation Methods 0.000 description 3
• 238000004458 analytical method Methods 0.000 description 3
• 239000003242 anti bacterial agent Substances 0.000 description 3
• 238000004364 calculation method Methods 0.000 description 3
• 244000309466 calf Species 0.000 description 3
• 239000000969 carrier Substances 0.000 description 3
• 239000001913 cellulose Substances 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 235000010980 cellulose Nutrition 0.000 description 3
• 238000005119 centrifugation Methods 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 210000001072 colon Anatomy 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 239000002552 dosage form Substances 0.000 description 3
• 231100000673 dose–response relationship Toxicity 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 239000000499 gel Substances 0.000 description 3
• 238000007446 glucose tolerance test Methods 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 238000002372 labelling Methods 0.000 description 3
• 239000008101 lactose Substances 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 230000014759 maintenance of location Effects 0.000 description 3
• 230000036210 malignancy Effects 0.000 description 3
• 229930182817 methionine Natural products 0.000 description 3
• 210000004940 nucleus Anatomy 0.000 description 3
• 239000003921 oil Substances 0.000 description 3
• 235000019198 oils Nutrition 0.000 description 3
• 238000007911 parenteral administration Methods 0.000 description 3
• 230000001575 pathological effect Effects 0.000 description 3
• 210000002568 pbsc Anatomy 0.000 description 3
• 108040007629 peroxidase activity proteins Proteins 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 230000002062 proliferating effect Effects 0.000 description 3
• 230000001737 promoting effect Effects 0.000 description 3
• 238000011160 research Methods 0.000 description 3
• 239000000600 sorbitol Substances 0.000 description 3
• 238000006467 substitution reaction Methods 0.000 description 3
• 150000008163 sugars Chemical class 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 230000035899 viability Effects 0.000 description 3
• OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
• RSPOGBIHKNKRFJ-MSZQBOFLSA-N (2S)-2-amino-2,3-dimethylpentanoic acid Chemical compound C[C@@](C(=O)O)(C(CC)C)N RSPOGBIHKNKRFJ-MSZQBOFLSA-N 0.000 description 2
• WTDHSXGBDZBWAW-QMMMGPOBSA-N (2s)-2-[cyclohexyl(methyl)azaniumyl]propanoate Chemical compound OC(=O)[C@H](C)N(C)C1CCCCC1 WTDHSXGBDZBWAW-QMMMGPOBSA-N 0.000 description 2
• LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 2
• FOUZISDNESEYLX-UHFFFAOYSA-N 2-(2-hydroxyethylazaniumyl)acetate Chemical compound OCCNCC(O)=O FOUZISDNESEYLX-UHFFFAOYSA-N 0.000 description 2
• IVCQRTJVLJXKKJ-UHFFFAOYSA-N 2-(butan-2-ylazaniumyl)acetate Chemical compound CCC(C)NCC(O)=O IVCQRTJVLJXKKJ-UHFFFAOYSA-N 0.000 description 2
• HEPOIJKOXBKKNJ-UHFFFAOYSA-N 2-(propan-2-ylazaniumyl)acetate Chemical compound CC(C)NCC(O)=O HEPOIJKOXBKKNJ-UHFFFAOYSA-N 0.000 description 2
• QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 2
• FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 description 2
• OYIFNHCXNCRBQI-UHFFFAOYSA-N 2-aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 description 2
• GAUBNQMYYJLWNF-UHFFFAOYSA-N 3-(Carboxymethylamino)propanoic acid Chemical compound OC(=O)CCNCC(O)=O GAUBNQMYYJLWNF-UHFFFAOYSA-N 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• 102100035606 Beta-casein Human genes 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• 206010006187 Breast cancer Diseases 0.000 description 2
• 208000026310 Breast neoplasm Diseases 0.000 description 2
• 108010041397 CD4 Antigens Proteins 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 241000282836 Camelus dromedarius Species 0.000 description 2
• VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 description 2
• 108090000746 Chymosin Proteins 0.000 description 2
• CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 2
• WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 2
• 108090000790 Enzymes Proteins 0.000 description 2
• 102000008946 Fibrinogen Human genes 0.000 description 2
• 108010049003 Fibrinogen Proteins 0.000 description 2
• 102000016359 Fibronectins Human genes 0.000 description 2
• 108010067306 Fibronectins Proteins 0.000 description 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
• 102000015779 HDL Lipoproteins Human genes 0.000 description 2
• 108010010234 HDL Lipoproteins Proteins 0.000 description 2
• 208000032843 Hemorrhage Diseases 0.000 description 2
• 101000947120 Homo sapiens Beta-casein Proteins 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 2
• QWCKQJZIFLGMSD-VKHMYHEASA-N L-alpha-aminobutyric acid Chemical compound CC[C@H](N)C(O)=O QWCKQJZIFLGMSD-VKHMYHEASA-N 0.000 description 2
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
• JTTHKOPSMAVJFE-VIFPVBQESA-N L-homophenylalanine Chemical compound OC(=O)[C@@H](N)CCC1=CC=CC=C1 JTTHKOPSMAVJFE-VIFPVBQESA-N 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• 108010007622 LDL Lipoproteins Proteins 0.000 description 2
• 102000007330 LDL Lipoproteins Human genes 0.000 description 2
• 239000004472 Lysine Substances 0.000 description 2
• WRUZLCLJULHLEY-UHFFFAOYSA-N N-(p-hydroxyphenyl)glycine Chemical compound OC(=O)CNC1=CC=C(O)C=C1 WRUZLCLJULHLEY-UHFFFAOYSA-N 0.000 description 2
• VKZGJEWGVNFKPE-UHFFFAOYSA-N N-Isobutylglycine Chemical compound CC(C)CNCC(O)=O VKZGJEWGVNFKPE-UHFFFAOYSA-N 0.000 description 2
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 2
• 102000019040 Nuclear Antigens Human genes 0.000 description 2
• 108010051791 Nuclear Antigens Proteins 0.000 description 2
• 101710160107 Outer membrane protein A Proteins 0.000 description 2
• 108010033276 Peptide Fragments Proteins 0.000 description 2
• 102000007079 Peptide Fragments Human genes 0.000 description 2
• 208000013544 Platelet disease Diseases 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 108090000783 Renin Proteins 0.000 description 2
• 102100028255 Renin Human genes 0.000 description 2
• 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 2
• 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 description 2
• 108010077895 Sarcosine Proteins 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 241000282898 Sus scrofa Species 0.000 description 2
• 230000006052 T cell proliferation Effects 0.000 description 2
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 2
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
• 206010047700 Vomiting Diseases 0.000 description 2
• 102100023038 WD and tetratricopeptide repeats protein 1 Human genes 0.000 description 2
• NAXKFVIRJICPAO-LHNWDKRHSA-N [(1R,3S,4R,6R,7R,9S,10S,12R,13S,15S,16R,18S,19S,21S,22S,24S,25S,27S,28R,30R,31R,33S,34S,36R,37R,39R,40S,42R,44R,46S,48S,50R,52S,54S,56S)-46,48,50,52,54,56-hexakis(hydroxymethyl)-2,8,14,20,26,32,38,43,45,47,49,51,53,55-tetradecaoxa-5,11,17,23,29,35,41-heptathiapentadecacyclo[37.3.2.23,7.29,13.215,19.221,25.227,31.233,37.04,6.010,12.016,18.022,24.028,30.034,36.040,42]hexapentacontan-44-yl]methanol Chemical compound OC[C@H]1O[C@H]2O[C@H]3[C@H](CO)O[C@H](O[C@H]4[C@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@H]6[C@H](CO)O[C@H](O[C@H]7[C@H](CO)O[C@@H](O[C@H]8[C@H](CO)O[C@@H](O[C@@H]1[C@@H]1S[C@@H]21)[C@@H]1S[C@H]81)[C@H]1S[C@@H]71)[C@H]1S[C@H]61)[C@H]1S[C@@H]51)[C@H]1S[C@@H]41)[C@H]1S[C@H]31 NAXKFVIRJICPAO-LHNWDKRHSA-N 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 230000002411 adverse Effects 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• 235000010419 agar Nutrition 0.000 description 2
• 238000011316 allogeneic transplantation Methods 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• 230000006907 apoptotic process Effects 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 230000000923 atherogenic effect Effects 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 239000011230 binding agent Substances 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 208000034158 bleeding Diseases 0.000 description 2
• 230000000740 bleeding effect Effects 0.000 description 2
• 238000004820 blood count Methods 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910000019 calcium carbonate Inorganic materials 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• 229910000389 calcium phosphate Inorganic materials 0.000 description 2
• 235000011010 calcium phosphates Nutrition 0.000 description 2
• 229910002092 carbon dioxide Inorganic materials 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 230000032823 cell division Effects 0.000 description 2
• 230000003915 cell function Effects 0.000 description 2
• 229940080701 chymosin Drugs 0.000 description 2
• 230000005757 colony formation Effects 0.000 description 2
• 238000004624 confocal microscopy Methods 0.000 description 2
• 238000012258 culturing Methods 0.000 description 2
• 230000009089 cytolysis Effects 0.000 description 2
• 210000000805 cytoplasm Anatomy 0.000 description 2
• 230000034994 death Effects 0.000 description 2
• 230000001066 destructive effect Effects 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 230000029087 digestion Effects 0.000 description 2
• 230000008034 disappearance Effects 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 229940088598 enzyme Drugs 0.000 description 2
• 239000012091 fetal bovine serum Substances 0.000 description 2
• 229940012952 fibrinogen Drugs 0.000 description 2
• 239000000945 filler Substances 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 230000006870 function Effects 0.000 description 2
• 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
• 239000007789 gas Substances 0.000 description 2
• 210000002360 granulocyte-macrophage progenitor cell Anatomy 0.000 description 2
• 238000000227 grinding Methods 0.000 description 2
• 208000003669 immune deficiency disease Diseases 0.000 description 2
• 238000010166 immunofluorescence Methods 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 238000010255 intramuscular injection Methods 0.000 description 2
• 239000007927 intramuscular injection Substances 0.000 description 2
• 238000011835 investigation Methods 0.000 description 2
• POPBCYBNIJKVES-XAFWQQJMSA-N isracidin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C1=CN=CN1 POPBCYBNIJKVES-XAFWQQJMSA-N 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 210000004185 liver Anatomy 0.000 description 2
• 230000005923 long-lasting effect Effects 0.000 description 2
• 239000007937 lozenge Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 229940049920 malate Drugs 0.000 description 2
• BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
• 238000004949 mass spectrometry Methods 0.000 description 2
• 210000001616 monocyte Anatomy 0.000 description 2
• GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 2
• 210000004898 n-terminal fragment Anatomy 0.000 description 2
• 229910052760 oxygen Inorganic materials 0.000 description 2
• 230000035515 penetration Effects 0.000 description 2
• 229960001639 penicillamine Drugs 0.000 description 2
• 239000012071 phase Substances 0.000 description 2
• 238000002616 plasmapheresis Methods 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 239000008107 starch Substances 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 229960005322 streptomycin Drugs 0.000 description 2
• 230000003319 supportive effect Effects 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 208000011580 syndromic disease Diseases 0.000 description 2
• 239000000454 talc Substances 0.000 description 2
• 229910052623 talc Inorganic materials 0.000 description 2
• 235000012222 talc Nutrition 0.000 description 2
• 231100000378 teratogenic Toxicity 0.000 description 2
• 230000003390 teratogenic effect Effects 0.000 description 2
• 238000011191 terminal modification Methods 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• 231100000820 toxicity test Toxicity 0.000 description 2
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
• 230000002747 voluntary effect Effects 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 230000003442 weekly effect Effects 0.000 description 2
• SCIFESDRCALIIM-SECBINFHSA-N (2r)-2-(methylazaniumyl)-3-phenylpropanoate Chemical compound CN[C@@H](C(O)=O)CC1=CC=CC=C1 SCIFESDRCALIIM-SECBINFHSA-N 0.000 description 1
• OCLLVJCYGMCLJG-CYBMUJFWSA-N (2r)-2-azaniumyl-2-naphthalen-1-ylpropanoate Chemical compound C1=CC=C2C([C@@](N)(C(O)=O)C)=CC=CC2=C1 OCLLVJCYGMCLJG-CYBMUJFWSA-N 0.000 description 1
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
• BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 description 1
• LDUWTIUXPVCEQF-LURJTMIESA-N (2s)-2-(cyclopentylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC1CCCC1 LDUWTIUXPVCEQF-LURJTMIESA-N 0.000 description 1
• IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 description 1
• IUYZJPXOXGRNNE-ZETCQYMHSA-N (2s)-2-[cyclopentyl(methyl)amino]propanoic acid Chemical compound OC(=O)[C@H](C)N(C)C1CCCC1 IUYZJPXOXGRNNE-ZETCQYMHSA-N 0.000 description 1
• DFVGBNVFYCYLDR-JTQLQIEISA-N (2s)-2-[methyl(naphthalen-1-yl)amino]propanoic acid Chemical compound C1=CC=C2C(N(C)[C@@H](C)C(O)=O)=CC=CC2=C1 DFVGBNVFYCYLDR-JTQLQIEISA-N 0.000 description 1
• XKZCXMNMUMGDJG-AWEZNQCLSA-N (2s)-3-[(6-acetylnaphthalen-2-yl)amino]-2-aminopropanoic acid Chemical compound C1=C(NC[C@H](N)C(O)=O)C=CC2=CC(C(=O)C)=CC=C21 XKZCXMNMUMGDJG-AWEZNQCLSA-N 0.000 description 1
• RHMALYOXPBRJBG-WXHCCQJTSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s,3r)-2-[[(2s)-2-[[2-[[2-[[(2r)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]- Chemical compound C([C@@H](C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 RHMALYOXPBRJBG-WXHCCQJTSA-N 0.000 description 1
• FMNQRUKVXAQEAZ-JNRFBPFXSA-N (5z,8s,9r,10e,12s)-9,12-dihydroxy-8-[(1s)-1-hydroxy-3-oxopropyl]heptadeca-5,10-dienoic acid Chemical compound CCCCC[C@H](O)\C=C\[C@@H](O)[C@H]([C@@H](O)CC=O)C\C=C/CCCC(O)=O FMNQRUKVXAQEAZ-JNRFBPFXSA-N 0.000 description 1
• DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
• QITDFMFPFGJWJY-UHFFFAOYSA-N 1-(2,2-diphenylethylamino)cyclopropane-1-carboxylic acid Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CNC1(C(=O)O)CC1 QITDFMFPFGJWJY-UHFFFAOYSA-N 0.000 description 1
• 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 description 1
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
• BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 description 1
• UEQSFWNXRZJTKB-UHFFFAOYSA-N 2-(2,2-diphenylethylamino)acetic acid Chemical compound C=1C=CC=CC=1C(CNCC(=O)O)C1=CC=CC=C1 UEQSFWNXRZJTKB-UHFFFAOYSA-N 0.000 description 1
• PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical compound NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 description 1
• XCDGCRLSSSSBIA-UHFFFAOYSA-N 2-(2-methylsulfanylethylamino)acetic acid Chemical compound CSCCNCC(O)=O XCDGCRLSSSSBIA-UHFFFAOYSA-N 0.000 description 1
• DHGYLUFLENKZHH-UHFFFAOYSA-N 2-(3-aminopropylamino)acetic acid Chemical compound NCCCNCC(O)=O DHGYLUFLENKZHH-UHFFFAOYSA-N 0.000 description 1
• OGAULEBSQQMUKP-UHFFFAOYSA-N 2-(4-aminobutylamino)acetic acid Chemical compound NCCCCNCC(O)=O OGAULEBSQQMUKP-UHFFFAOYSA-N 0.000 description 1
• KGSVNOLLROCJQM-UHFFFAOYSA-N 2-(benzylamino)acetic acid Chemical compound OC(=O)CNCC1=CC=CC=C1 KGSVNOLLROCJQM-UHFFFAOYSA-N 0.000 description 1
• KQLGGQARRCMYGD-UHFFFAOYSA-N 2-(cyclobutylamino)acetic acid Chemical compound OC(=O)CNC1CCC1 KQLGGQARRCMYGD-UHFFFAOYSA-N 0.000 description 1
• DICMQVOBSKLBBN-UHFFFAOYSA-N 2-(cyclodecylamino)acetic acid Chemical compound OC(=O)CNC1CCCCCCCCC1 DICMQVOBSKLBBN-UHFFFAOYSA-N 0.000 description 1
• NPLBBQAAYSJEMO-UHFFFAOYSA-N 2-(cycloheptylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCCCC1 NPLBBQAAYSJEMO-UHFFFAOYSA-N 0.000 description 1
• CTVIWLLGUFGSLY-UHFFFAOYSA-N 2-(cyclohexylazaniumyl)-2-methylpropanoate Chemical compound OC(=O)C(C)(C)NC1CCCCC1 CTVIWLLGUFGSLY-UHFFFAOYSA-N 0.000 description 1
• OQMYZVWIXPPDDE-UHFFFAOYSA-N 2-(cyclohexylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCCC1 OQMYZVWIXPPDDE-UHFFFAOYSA-N 0.000 description 1
• PNKNDNFLQNMQJL-UHFFFAOYSA-N 2-(cyclooctylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCCCCC1 PNKNDNFLQNMQJL-UHFFFAOYSA-N 0.000 description 1
• DFTZSHZOTLFTJU-UHFFFAOYSA-N 2-(cyclopentylamino)-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)NC1CCCC1 DFTZSHZOTLFTJU-UHFFFAOYSA-N 0.000 description 1
• DXQCCQKRNWMECV-UHFFFAOYSA-N 2-(cyclopropylazaniumyl)acetate Chemical compound OC(=O)CNC1CC1 DXQCCQKRNWMECV-UHFFFAOYSA-N 0.000 description 1
• JRSNLSRAJONDMV-UHFFFAOYSA-N 2-[(2-amino-2-oxoethyl)-(2,2-diphenylethyl)amino]acetic acid Chemical compound C=1C=CC=CC=1C(CN(CC(=O)N)CC(O)=O)C1=CC=CC=C1 JRSNLSRAJONDMV-UHFFFAOYSA-N 0.000 description 1
• HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
• WBXOONOXOHMGQW-UHFFFAOYSA-N 3-aminobicyclo[2.2.1]heptane-4-carboxylic acid Chemical compound C1CC2(C(O)=O)C(N)CC1C2 WBXOONOXOHMGQW-UHFFFAOYSA-N 0.000 description 1
• 101800000535 3C-like proteinase Proteins 0.000 description 1
• 101800002396 3C-like proteinase nsp5 Proteins 0.000 description 1
• AOKCDAVWJLOAHG-UHFFFAOYSA-N 4-(methylamino)butyric acid Chemical compound C[NH2+]CCCC([O-])=O AOKCDAVWJLOAHG-UHFFFAOYSA-N 0.000 description 1
• UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 1
• FVBZXNSRIDVYJS-UHFFFAOYSA-N 6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid Chemical compound NCCCCC(C(O)=O)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N FVBZXNSRIDVYJS-UHFFFAOYSA-N 0.000 description 1
• RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 208000033399 Anaphylactic responses Diseases 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
• 206010065553 Bone marrow failure Diseases 0.000 description 1
• 206010006002 Bone pain Diseases 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
• 238000011749 CBA mouse Methods 0.000 description 1
• 101100422770 Caenorhabditis elegans sup-1 gene Proteins 0.000 description 1
• 241000282826 Camelus Species 0.000 description 1
• 241000283705 Capra hircus Species 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 241000282994 Cervidae Species 0.000 description 1
• 241000283153 Cetacea Species 0.000 description 1
• 238000008620 Cholesterol Assay Methods 0.000 description 1
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 206010009944 Colon cancer Diseases 0.000 description 1
• 206010010356 Congenital anomaly Diseases 0.000 description 1
• 108010069514 Cyclic Peptides Proteins 0.000 description 1
• 102000001189 Cyclic Peptides Human genes 0.000 description 1
• XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 description 1
• AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 description 1
• ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 description 1
• MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 description 1
• 229930195711 D-Serine Natural products 0.000 description 1
• QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
• 150000008574 D-amino acids Chemical class 0.000 description 1
• ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 description 1
• 229930028154 D-arginine Natural products 0.000 description 1
• 229930182847 D-glutamic acid Natural products 0.000 description 1
• HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 description 1
• 229930195721 D-histidine Natural products 0.000 description 1
• 229930182845 D-isoleucine Natural products 0.000 description 1
• ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 description 1
• 229930182819 D-leucine Natural products 0.000 description 1
• KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
• FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 description 1
• 229930182818 D-methionine Natural products 0.000 description 1
• 229930182820 D-proline Natural products 0.000 description 1
• AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 description 1
• 229930182822 D-threonine Natural products 0.000 description 1
• 229930182827 D-tryptophan Natural products 0.000 description 1
• QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 1
• OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 description 1
• KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 description 1
• 229930182831 D-valine Natural products 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
• 241000792859 Enema Species 0.000 description 1
• IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
• 102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 description 1
• 108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 206010019663 Hepatic failure Diseases 0.000 description 1
• 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
• 101001033279 Homo sapiens Interleukin-3 Proteins 0.000 description 1
• 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 description 1
• 101000946053 Homo sapiens Lysosomal-associated transmembrane protein 4A Proteins 0.000 description 1
• 101000799461 Homo sapiens Thrombopoietin Proteins 0.000 description 1
• 101000694103 Homo sapiens Thyroid peroxidase Proteins 0.000 description 1
• LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• 208000001911 Idiopathic aplastic anemia Diseases 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 102000000646 Interleukin-3 Human genes 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 101800002036 Kidney-derived growth factor Proteins 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102000004895 Lipoproteins Human genes 0.000 description 1
• 108090001030 Lipoproteins Proteins 0.000 description 1
• 102000008072 Lymphokines Human genes 0.000 description 1
• 108010074338 Lymphokines Proteins 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 102100034728 Lysosomal-associated transmembrane protein 4A Human genes 0.000 description 1
• 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 229920000877 Melamine resin Polymers 0.000 description 1
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
• HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
• 206010067482 No adverse event Diseases 0.000 description 1
• BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
• AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
• UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
• 240000007594 Oryza sativa Species 0.000 description 1
• 235000007164 Oryza sativa Nutrition 0.000 description 1
• 238000006610 Payne rearrangement reaction Methods 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108010043958 Peptoids Proteins 0.000 description 1
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 229920002125 Sokalan® Polymers 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 206010042971 T-cell lymphoma Diseases 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 206010043275 Teratogenicity Diseases 0.000 description 1
• 244000299461 Theobroma cacao Species 0.000 description 1
• 235000009470 Theobroma cacao Nutrition 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• XNRNNGPBEPRNAR-UHFFFAOYSA-N Thromboxane B2 Natural products CCCCCC(O)C=CC1OC(O)CC(O)C1CC=CCCCC(O)=O XNRNNGPBEPRNAR-UHFFFAOYSA-N 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 244000098338 Triticum aestivum Species 0.000 description 1
• 229920004890 Triton X-100 Polymers 0.000 description 1
• 239000013504 Triton X-100 Substances 0.000 description 1
• 102000004142 Trypsin Human genes 0.000 description 1
• 108090000631 Trypsin Proteins 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
• TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 230000005856 abnormality Effects 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• PMZXXNPJQYDFJX-UHFFFAOYSA-N acetonitrile;2,2,2-trifluoroacetic acid Chemical compound CC#N.OC(=O)C(F)(F)F PMZXXNPJQYDFJX-UHFFFAOYSA-N 0.000 description 1
• 238000003916 acid precipitation Methods 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 201000004208 acquired thrombocytopenia Diseases 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 229940040563 agaric acid Drugs 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 125000000217 alkyl group Chemical group 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• DLAMVQGYEVKIRE-UHFFFAOYSA-N alpha-(methylamino)isobutyric acid Chemical compound CNC(C)(C)C(O)=O DLAMVQGYEVKIRE-UHFFFAOYSA-N 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 125000000539 amino acid group Chemical group 0.000 description 1
• UGJQDKYTAYNNBH-UHFFFAOYSA-N amino cyclopropanecarboxylate Chemical compound NOC(=O)C1CC1 UGJQDKYTAYNNBH-UHFFFAOYSA-N 0.000 description 1
• 230000036783 anaphylactic response Effects 0.000 description 1
• 230000002744 anti-aggregatory effect Effects 0.000 description 1
• 230000003276 anti-hypertensive effect Effects 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 239000003443 antiviral agent Substances 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 238000003149 assay kit Methods 0.000 description 1
• 239000012298 atmosphere Substances 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000002238 attenuated effect Effects 0.000 description 1
• 230000003190 augmentative effect Effects 0.000 description 1
• 238000013475 authorization Methods 0.000 description 1
• 238000011888 autopsy Methods 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 210000002960 bfu-e Anatomy 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 239000010836 blood and blood product Substances 0.000 description 1
• 238000009640 blood culture Methods 0.000 description 1
• 229940125691 blood product Drugs 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 238000009583 bone marrow aspiration Methods 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 244000309464 bull Species 0.000 description 1
• 229960005069 calcium Drugs 0.000 description 1
• 235000001465 calcium Nutrition 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229960004424 carbon dioxide Drugs 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 229940071162 caseinate Drugs 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 210000004970 cd4 cell Anatomy 0.000 description 1
• 230000007910 cell fusion Effects 0.000 description 1
• 230000006037 cell lysis Effects 0.000 description 1
• 108091092356 cellular DNA Proteins 0.000 description 1
• 229940099352 cholate Drugs 0.000 description 1
• BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
• 238000011278 co-treatment Methods 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 235000021277 colostrum Nutrition 0.000 description 1
• 210000003022 colostrum Anatomy 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 235000020247 cow milk Nutrition 0.000 description 1
• 210000004748 cultured cell Anatomy 0.000 description 1
• 230000001351 cycling effect Effects 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 230000000120 cytopathologic effect Effects 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 230000002354 daily effect Effects 0.000 description 1
• 230000002498 deadly effect Effects 0.000 description 1
• 230000007123 defense Effects 0.000 description 1
• 239000007857 degradation product Substances 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 229950006137 dexfosfoserine Drugs 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 210000002249 digestive system Anatomy 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 238000002224 dissection Methods 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
• 238000009510 drug design Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 235000013399 edible fruits Nutrition 0.000 description 1
• 239000003792 electrolyte Substances 0.000 description 1
• 239000007920 enema Substances 0.000 description 1
• 229940079360 enema for constipation Drugs 0.000 description 1
• YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
• 210000000267 erythroid cell Anatomy 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 description 1
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
• 229940093471 ethyl oleate Drugs 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 239000010685 fatty oil Substances 0.000 description 1
• 230000002550 fecal effect Effects 0.000 description 1
• 239000012894 fetal calf serum Substances 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 238000000684 flow cytometry Methods 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical class O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 238000000799 fluorescence microscopy Methods 0.000 description 1
• 230000037406 food intake Effects 0.000 description 1
• 238000013467 fragmentation Methods 0.000 description 1
• 238000006062 fragmentation reaction Methods 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 230000002538 fungal effect Effects 0.000 description 1
• 239000003365 glass fiber Substances 0.000 description 1
• 229940093181 glucose injection Drugs 0.000 description 1
• 230000004153 glucose metabolism Effects 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 230000002641 glycemic effect Effects 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 230000010005 growth-factor like effect Effects 0.000 description 1
• 230000035876 healing Effects 0.000 description 1
• 230000002008 hemorrhagic effect Effects 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 102000053400 human TPO Human genes 0.000 description 1
• 229940116886 human interleukin-6 Drugs 0.000 description 1
• 235000020256 human milk Nutrition 0.000 description 1
• 210000004251 human milk Anatomy 0.000 description 1
• QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
• 229960002591 hydroxyproline Drugs 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• 230000009610 hypersensitivity Effects 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 238000003125 immunofluorescent labeling Methods 0.000 description 1
• 102000018358 immunoglobulin Human genes 0.000 description 1
• 229940072221 immunoglobulins Drugs 0.000 description 1
• 230000004957 immunoregulator effect Effects 0.000 description 1
• 238000002650 immunosuppressive therapy Methods 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 238000011081 inoculation Methods 0.000 description 1
• 230000031891 intestinal absorption Effects 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• RGXCTRIQQODGIZ-UHFFFAOYSA-O isodesmosine Chemical compound OC(=O)C(N)CCCC[N+]1=CC(CCC(N)C(O)=O)=CC(CCC(N)C(O)=O)=C1CCCC(N)C(O)=O RGXCTRIQQODGIZ-UHFFFAOYSA-O 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
• GCHPUFAZSONQIV-UHFFFAOYSA-N isovaline Chemical compound CCC(C)(N)C(O)=O GCHPUFAZSONQIV-UHFFFAOYSA-N 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 231100000636 lethal dose Toxicity 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 238000009630 liquid culture Methods 0.000 description 1
• 229940057995 liquid paraffin Drugs 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 208000007903 liver failure Diseases 0.000 description 1
• 231100000835 liver failure Toxicity 0.000 description 1
• 210000003141 lower extremity Anatomy 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 238000012792 lyophilization process Methods 0.000 description 1
• 239000008176 lyophilized powder Substances 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 210000004379 membrane Anatomy 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 230000000051 modifying effect Effects 0.000 description 1
• 210000005087 mononuclear cell Anatomy 0.000 description 1
• PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
• 210000004877 mucosa Anatomy 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• 230000003472 neutralizing effect Effects 0.000 description 1
• 239000002547 new drug Substances 0.000 description 1
• 235000021590 normal diet Nutrition 0.000 description 1
• 229940127240 opiate Drugs 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 239000003791 organic solvent mixture Substances 0.000 description 1
• 229960003104 ornithine Drugs 0.000 description 1
• 150000002926 oxygen Chemical class 0.000 description 1
• 230000020477 pH reduction Effects 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• LQRJAEQXMSMEDP-XCHBZYMASA-N peptide a Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C/C=1C=CC=CC=1)C(N)=O)C(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C\C1=CC=CC=C1 LQRJAEQXMSMEDP-XCHBZYMASA-N 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• 208000008494 pericarditis Diseases 0.000 description 1
• 210000004976 peripheral blood cell Anatomy 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000008196 pharmacological composition Substances 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
• USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 description 1
• 230000035790 physiological processes and functions Effects 0.000 description 1
• 239000003075 phytoestrogen Substances 0.000 description 1
• 108010086662 phytohemagglutinin-M Proteins 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 239000002985 plastic film Substances 0.000 description 1
• 229920006255 plastic film Polymers 0.000 description 1
• 239000004014 plasticizer Substances 0.000 description 1
• 210000004224 pleura Anatomy 0.000 description 1
• 229920001184 polypeptide Polymers 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 230000001376 precipitating effect Effects 0.000 description 1
• 230000035935 pregnancy Effects 0.000 description 1
• 230000002028 premature Effects 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 239000002510 pyrogen Substances 0.000 description 1
• 238000003908 quality control method Methods 0.000 description 1
• 230000002285 radioactive effect Effects 0.000 description 1
• 238000000163 radioactive labelling Methods 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 230000000405 serological effect Effects 0.000 description 1
• 229940076279 serotonin Drugs 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 239000002002 slurry Substances 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 235000015424 sodium Nutrition 0.000 description 1
• 235000010413 sodium alginate Nutrition 0.000 description 1
• 239000000661 sodium alginate Substances 0.000 description 1
• 229940005550 sodium alginate Drugs 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000007901 soft capsule Substances 0.000 description 1
• 239000012439 solid excipient Substances 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
• 238000005507 spraying Methods 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 239000012134 supernatant fraction Substances 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000002511 suppository base Substances 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 231100000211 teratogenicity Toxicity 0.000 description 1
• 231100001274 therapeutic index Toxicity 0.000 description 1
• 229940035024 thioglycerol Drugs 0.000 description 1
• 230000002537 thrombolytic effect Effects 0.000 description 1
• 230000035921 thrombopoiesis Effects 0.000 description 1
• 230000001361 thrombopoietic effect Effects 0.000 description 1
• 239000003104 tissue culture media Substances 0.000 description 1
• 239000004408 titanium dioxide Substances 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
• KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1
• YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
• 229940029284 trichlorofluoromethane Drugs 0.000 description 1
• 238000003211 trypan blue cell staining Methods 0.000 description 1
• 239000012588 trypsin Substances 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 229940045136 urea Drugs 0.000 description 1
• 229940116269 uric acid Drugs 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 210000001835 viscera Anatomy 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 230000003313 weakening effect Effects 0.000 description 1
• 235000008939 whole milk Nutrition 0.000 description 1
• 235000021249 α-casein Nutrition 0.000 description 1
• 235000021247 β-casein Nutrition 0.000 description 1
• 235000021246 κ-casein Nutrition 0.000 description 1