CZ20011465A3 - Způsob přípravy 4-arylpiperidin-3-methanolů a příbuzných sloučenin - Google Patents

Způsob přípravy 4-arylpiperidin-3-methanolů a příbuzných sloučenin Download PDF

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Publication number
CZ20011465A3
CZ20011465A3 CZ20011465A CZ20011465A CZ20011465A3 CZ 20011465 A3 CZ20011465 A3 CZ 20011465A3 CZ 20011465 A CZ20011465 A CZ 20011465A CZ 20011465 A CZ20011465 A CZ 20011465A CZ 20011465 A3 CZ20011465 A3 CZ 20011465A3
Authority
CZ
Czechia
Prior art keywords
formula
compound
group
hydrogen
trans
Prior art date
Application number
CZ20011465A
Other languages
Czech (cs)
English (en)
Inventor
Theodorus Hendricus Antonius Peters
Franciscus Bernardus Gemma Benneker
Hans Jan Hoorn
Frantisek Picha
Original Assignee
Synthon B. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon B. V. filed Critical Synthon B. V.
Publication of CZ20011465A3 publication Critical patent/CZ20011465A3/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CZ20011465A 1998-11-02 1999-11-01 Způsob přípravy 4-arylpiperidin-3-methanolů a příbuzných sloučenin CZ20011465A3 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10667398P 1998-11-02 1998-11-02

Publications (1)

Publication Number Publication Date
CZ20011465A3 true CZ20011465A3 (cs) 2001-08-15

Family

ID=22312658

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20011465A CZ20011465A3 (cs) 1998-11-02 1999-11-01 Způsob přípravy 4-arylpiperidin-3-methanolů a příbuzných sloučenin

Country Status (5)

Country Link
EP (1) EP1124802A1 (no)
AU (1) AU6360999A (no)
CZ (1) CZ20011465A3 (no)
NO (1) NO20012099L (no)
WO (1) WO2000026187A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7708998A (en) * 1997-05-29 1998-12-30 Smithkline Beecham Corporation Novel process
JP2002533325A (ja) * 1998-12-22 2002-10-08 ペンテツク・フアーマシユーテイカルズ・インコーポレイテツド アリールピペリジンカルビノール中間体および誘導体の製造方法
US20010053862A1 (en) * 1998-12-22 2001-12-20 Bruce Ronsen Process for preparing arylpiperidine carbinol intermediates and derivatives
AU2000246280A1 (en) * 2000-05-12 2001-11-20 Synthon B.V. Tosylate salts of 4-(p-fluorophenyl)-piperidine-3-carbinols
PT1347960E (pt) 2001-01-04 2005-03-31 Ferrer Int Processo para a preparacao de (+)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperidina
NZ532432A (en) 2001-10-22 2005-02-25 Synthon Bv N-formyl paroxetine compounds and their use in a synthetic route for obtaining paroxetine
WO2007089193A1 (en) * 2006-02-02 2007-08-09 Astrazeneca Ab A process for preparing 2-hydroxy-3- [5- (morpholin-4-ylmethyl)pyridin-2-yl] lh-indole-5-carbonitrile as a free base or salts thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI792076A (fi) * 1978-07-05 1980-01-06 Ciba Geigy Ag Foerfarande foer framstaellning av nya fenylpiperidinderivat
EP0223334B1 (en) * 1985-08-10 1991-07-10 Beecham Group Plc Process for the preparation of aryl-piperidine carbinols
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9526645D0 (en) * 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
JP3446468B2 (ja) * 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
AU7708998A (en) * 1997-05-29 1998-12-30 Smithkline Beecham Corporation Novel process

Also Published As

Publication number Publication date
WO2000026187A1 (en) 2000-05-11
AU6360999A (en) 2000-05-22
NO20012099D0 (no) 2001-04-27
EP1124802A1 (en) 2001-08-22
NO20012099L (no) 2001-07-02

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