CZ16841U1 - Industrially manufactured mixture for preparing peroral rehydrating solution - Google Patents

Description

Technical field

The invention relates to the industrial preparation of a powdered and / or granulated mixture (hereinafter referred to as the mixture) which, when reconstituted with potable water, forms a solution suitable for oral rehydration of the dehydrated organism in diarrhea, as well as rehydration or in a disease accompanied by fever and / or vomiting. BACKGROUND OF THE INVENTION

At present, there are three basic methods of rehydration procedure: The first method uses intravenous administration of solutions to rehydrate the dehydrated organism to adjust the internal environment. However, these solutions are intended solely for administration in a healthcare facility. From the technical point of view, the disadvantage is not only their cost (they must be sterile), but also the cost of consuming medical supplies (needles, cannulas, infusion sets) and the need for medical staff. In addition, entering the venous bed is always associated with the risk of infection being introduced into the body.

The second method uses the preparation of mixtures in pharmacies. These compositions are administered orally after recovery with potable water. Not all of the existing facilities are authorized and equipped to prepare mixtures. The technical disadvantage is that the required raw materials are not always in stock in the required quantity and the required spectrum, as well as a short expiration time of the prepared mixture. The availability of pharmacy services is also limited. Recipes are often used that are no longer in line with current medical science.

A third way is to administer an industrially prepared composition for oral administration after recovery by drinking water. This utility model application filed by the applicant and at the same time by the originator handles this case. The industrially prepared mixture simply dissolves, has a long shelf life even at home, meets the current requirements for effective and safe rehydration and is always available. At present, based on this recipe, two products are produced in the Czech Republic - Kulíšek and Iontia.

Description of the technical solution

The disadvantages of intravenous administration of rehydration solutions as well as pharmaceutical preparation of bulk compositions for the preparation of an oral rehydration solution are eliminated by the industrial preparation of a mixture of salts and filler / carrier, which upon reconstitution with potable water forms a solution for immediate administration in hospital and field medical practice as well as for home use. Said recipe contains components beneficial to the dehydrated organism.

The essence of the composition for the preparation of an oral rehydration solution is that it contains a suitable amount of ions needed to compensate for their loss in the dehydration of the organism. These ions are present in the form of salts, further the composition may contain a filler / carrier to facilitate ion absorption, to stool thickening, to protect the intestinal epithelium, and to improve the taste and effects of the composition.

A simple rehydration mixture consists of salts up to 100% by weight, and may also contain variable amounts of filler - in this case, sweeteners / flavorings (0 to 80% by weight) or plant extract (0 to 50% by weight) . It is an economically advantageous recipe with low production costs.

The optimum mixture is based on salts and fillers / carriers, wherein the salts make up 3 to 99% by weight of the mixture and the fillers / carriers make up 1 to 97% by weight of the mixture. The filler / carrier comprises sugars from the group of simple sugars such as glucose and / or compound sugars such as starch. The use of simple sugars - mainly glucose - ensures optimal transport of ions into the body. Glucose and ions are transported together into cells. The oral rehydration solution composition therefore preferably contains 1 to 97 wt. glucose to facilitate cotransport. The co-transport effect of glucose may be potentiated by compound sugars (0 to 96% by weight). A sweetening / flavoring agent (0 to 80 wt%) may be used to improve the taste. The addition of plant extract (0 to 50% by weight) can contribute to improving the effects of the mixture in addition to the taste effect.

Examples

Composition of the oral rehydration mixture:

1. sample recipe, 6.5 g: Natrii citric acid dihydrate 11,22% 10 Natrii chlorati 6.65% Kalii chlorati 5.69% Glucosae 76.39%. 2. Sample recipe, 13.04 g: Natrii citrici trihydrati 5.63% 15 Dec Natrii chlorati 3.45% Kalii chlorati 2.86% Glucosae 11.50% Amylum oiyzae 76.66%. 20 May 3. Sample recipe, 2.0 g: Natrii citrici trihydrati 35,00% Natrii chlorati 25,50% Kalii chlorati 18,50% Acesulfam K 5,00% Aspartame 5,00% 25 blueberry extract 14.00%. 4. Sample recipe, 200 g: Natrii citrici trihydrati 35,00% Natrii chlorati 25,50% Kalii chlorati 18,50% 30 Acesulfam K 5,00% Aspartame 5,00% blueberry extract 14.00%.

Mixtures according to sample recipes 1 to 3 are dosed in quantity of 1 individually packed bag per 250 ml drinking water, mixture according to sample recipe 4 one measuring cup (8 g) into 1 liter of drinking water.

Industrial applicability

The salt / filler / carrier mixture prepared according to the process of the present invention is a suitable product for immediate oral administration for rehydration of the dehydrated organism upon recovery with potable water. It is intended for dietary treatment of diarrheal diseases as well as for administration in other conditions accompanied by dehydration of the organism. It can be used both in hospital and especially in field practice and for home use. Diarrheal diseases bring, in addition to medical, ethical and social problems, a considerable economic burden on the health system. Early administration of the oral rehydration solution shortens the duration of the diarrhea episode, thereby reducing health care costs.

Claims (3)

PROTECTION REQUIREMENTS An industrial preparation for preparing an oral rehydration solution, characterized in that it contains salts and optionally fillers / carriers in a ratio of 3 to 100% by weight. % salts and 0 to 97 wt. fillers / carriers. 5 An industrially manufactured composition for preparing an oral rehydration solution according to claim 1, characterized in that it contains 1 to 97 wt. % glucose as a sodium co-transporter, and 0 to 96 wt. polysaccharide (s) to enhance the cotransport effect of glucose. An industrially prepared composition for preparing an oral rehydration solution according to claims 1 and 2, which contains 5,000 g of glucose per serving to be dissolved in 250 ml of cold water. 10 (glucose), 0.735 g of sodium citrate dihydrate (citric acid dihydrate), 0.438 g of sodium chloride (sodium chlorate) and 0.373 g of potassium chloride (potassium chlorate). End of document