CZ2006143A3 - Industrially produced mixture for preparing peroral rehydrating solution - Google Patents

Abstract

The industrially produced mixture of salts, carrier / filler, sweetener / flavorant and plant extract is restored by dissolution in drinking water and contains components beneficial to the dehydrated organism. It serves as a progression for diarrhea and other conditions accompanied by dehydration. It is administered orally and is intended for immediate use in the hospital, in the field and in the home after drinking water is restored.

Description

(54) Title of the invention:

Factory made mixture for preparation of oral rehydration solution (57)

An industrially produced mixture of salts, carrier / filler, sweetener / flavor and plant extract is recovered by dissolution in drinking water and contains components beneficial to the dehydrated organism. It is used for dietary treatment of diarrheal diseases and other conditions accompanied by dehydration. It is administered orally and is intended for immediate administration in the hospital, in the field and in the home environment.

CZ 2006- 143 A3 · '- <pl / 2οο6-453

An industrially manufactured mixture for the preparation of an oral rehydration solution.

Technical field

BACKGROUND OF THE INVENTION The present invention relates to the industrial preparation of a powdered and / or granulated composition (hereinafter referred to as a composition) which upon reconstitution with potable water forms a solution suitable for oral rehydration of a dehydrated organism in diarrhea. diseases associated with fever and / or vomiting.

BACKGROUND OF THE INVENTION

At present, there are three basic methods of rehydration procedure: The first method uses intravenous administration of solutions for the rehydration of a dehydrated organism to modify the internal environment. However, these solutions are intended solely for administration in a healthcare facility. From the technical point of view, the disadvantage is not only their cost (they must be sterile), but also the cost of consuming medical supplies (needles, cannulas, infusion sets) and the need for medical staff. In addition, entering the venous bed is always associated with the risk of infection being introduced into the body.

The second method uses the preparation of mixtures in pharmacies. These compositions are administered orally after recovery with potable water. Not all of the existing facilities are authorized and equipped to prepare mixtures. The technical disadvantage is that the required raw materials are not always in stock in the required quantity and the required spectrum, as well as a short expiration time of the prepared mixture. The availability of pharmacy services is also limited. Also, the use of prescriptions that are no longer in line with current medical science is technically obsolete.

A third way is to administer an industrially prepared composition for oral administration after recovery by drinking water. This patent application filed by both the applicant and the originator handles this case. The industrially prepared mixture is easy to dissolve, has a long shelf life even at home, complies with current requirements for effective and safe rehydration and is always available. At present, based on this recipe, two preparations are produced in the Czech Republic - Kulíšek and Iontia.

2. Summary of the Invention

The disadvantages of intravenous administration of rehydration solutions as well as pharmaceutical preparation of bulk compositions for the preparation of an oral rehydration solution are eliminated by the industrial preparation of a mixture of salts and filler / carrier, which upon reconstitution with potable water forms a solution for immediate administration in hospital and field medical practice as well as for home use. Said recipe contains components beneficial to the dehydrated organism.

The essence of the composition for preparing an oral rehydration solution is that it contains an appropriate amount of ions needed to compensate for their loss in dehydration. These ions are present in the form of salts, in addition a filler / carrier may be present to facilitate ion absorption, to thicken stool, optionally to protect the intestinal epithelium. In preparing the composition, an artificial sweetener and flavor may be added to the salts to improve the taste of the solution, and a plant extract to improve the taste and effect of the composition.

The optimum mixture is based on salts and fillers / carriers, with salts making up 3-50% by weight of the mixture and fillers / carriers making up 50-97% by weight of the mixture. The filler / carrier is comprised of sugars selected from the group of simple sugars such as glucose, and / or compound sugars such as starch. The use of fillers / carriers - especially glucose - ensures optimal transport of ions into the body. Glucose and ions are transported together into cells. The composition for preparing an oral rehydration solution preferably contains 1-97% by weight of glucose to allow cotransport. The cotransport effect of glucose may be potentiated by compound sugars (0-96%). A sweetener / flavor (0-80%) may be used to improve the taste. The addition of plant extract (0-50%) can contribute to improving the effects of the mixture in addition to the taste effect.

A simple rehydration mixture consists of salts up to 100% by weight, and a variable amount of sweetener / flavor (0-80%) or plant extract (0-50%). It is an economically advantageous recipe with low production costs.

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-3 Exemplary embodiments

Composition of the oral rehydration mixture:

sample recipe: 6,5 g Natrii citrici dihydrati Natrii chlorati Kalii chlorati Glucosae 11,22% 6.65% 5.69% 76.39% sample recipe: Natrii citrici trihydrati 5.63% 13.04 g Natrii chlorati 3.45% Kalii chlorati 2.86% Glucosae 11.50% Amylum oryzae 76.66% sample recipe: Natrii citrici trihydrati 35,00% 2,0 g Natrii chlorati 25,50% Kalii chlorati 18,50% Acesulfam K 5,00% Aspartame 5,00% blueberry extract 14,00% sample recipe: Natrii citrici trihydrati 35,00% 200 g Natrii chlorati 25,50% Kalii chlorati 18,50% Acesulfam K 5,00% Aspartame 5,00% blueberry extract 14,00%

Mixtures according to sample recipes 1-3 are dosed in quantities of 1 individually packed bag per 250 ml of drinking water, mixture according to sample recipe 4 one measuring cup (8 g) into 1 liter of drinking water.

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-4Industrial applicability

The salt / filler / carrier mixture prepared according to the process of the present invention is a suitable product for immediate oral administration for rehydration of the dehydrated organism upon recovery with potable water. It is intended for dietary treatment of diarrheal diseases as well as for administration in other conditions accompanied by dehydration of the organism. It can be used both in hospital and especially in field practice and for home use. Diarrheal diseases bring, in addition to medical, ethical and social problems, a considerable economic burden on the health system. Early administration of the oral rehydration solution shortens the duration of the diarrhea episode, thereby reducing health care costs.

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PATENT CLAIMS

Claims (4)

Φ φ • · · · · · · · • φ φ φ φ φ φ φ φ φ φ φ φ φ φ φ · · φ φ Features necessary for determining the subject matter of the invention: A mixture of salts and other substances comprising components which, upon recovery by drinking water, will enable the successful replacement of lost ions and water by the oral route. (1) An industrial preparation for the preparation of an oral rehydration solution, characterized in that it consists of salts and fillers / carriers in a proportion of 3-50% by weight of salts and 50-97% by weight of fillers / carriers, with an additive content by which are, for example, sweeteners / flavors (0-80%) and plant extracts (0-50%). An industrial preparation for preparing an oral rehydration solution according to claim 1, characterized in that it contains 1-97% by weight of glucose as sodium co-transporter. An industrially manufactured composition for preparing an oral rehydration solution according to claim 2, wherein the cotransporting effect of glucose is potentiated by supplementing the composition with polysaccharide / polysaccharides (0-96%). (4) An industrial preparation for the preparation of an oral rehydration solution, characterized in that it consists of salts of up to 100% by weight with additives such as sweeteners / flavors (0-80%) and plant extracts (0-50). %). for immediate administration in the hospital, in the field and at home.