CZ12405U1 - Preparation for prevention of iodine insufficiency - Google Patents

Abstract

Disclosure of the invention is, a nutritive additive comprising as active ingredient at least one iodide loose or fixed fatty acid according to formula (1): where v has a value 0-2, x has a value 0-14, y has a value 0-13, z has a value 1-5, z1 has a value 1-6. It is suitable, that means to prevent insufficiency of iodine comprises some of the iodided fatty acid from the group, where belong oleic acid, limoliec acid, palmiting acid, erucic acid, or comprises any mixture of mentioned acids, or comprises mixture of any other fatty acids, that meet formula (1) listed above.

Description

Technical field

The invention relates to a food preparation for the prevention of iodine deficiency.

BACKGROUND OF THE INVENTION

In most developed countries of the world, iodine deficiency treatment is dealt with by iodized salt. The disadvantage of this is that the added potassium iodide is insufficiently stable and its content varies by relative redistribution and also by a steady decrease. The relative redistribution consists in dissolving the potassium iodide crystals in the molecular layer of water which covers the less soluble sodium chloride crystals. Potassium iodide dissolved in this way is soaked in soft paper bags, which causes an absolute reduction in its salt content. Also, due to gravity, it falls downwards, reducing its content in the upper salt layers and increasing the content in the lower layers. At the same time, due to moisture, heat and light, the iodide is oxidized to elemental iodine, which is lost by sublimation. Inadequate salt storage results in 30 to 50% iodine loss per year. Therefore, potassium iodide is gradually replaced by potassium iodate (KJO3), which is much more stable but also more expensive. In addition, the World Health Organization recommends reducing salt consumption to prevent cardiovascular disease.

A drawback of the prior art is that iodine compounds are also used in the treatment of arteriosclerosis. The preparation currently used is a mixture of potassium salts, iodo-benzoic acid and other iodized fatty acids. It contains 24% iodine and 4% potassium. However, it is counterindicated in decompensation of the cardiovascular system, liver, kidney disease, bassed's disease, and idiosinkrase of iodine. It also has no corrective effect on thyroid gland activity, immunomodulatory effect and others.

Data published in scientific literature (published in NN Kevorkov, BA Bachmetev: Possible contribution of tireoid hormones to the alteration of immune system function under stress // Stress and immunity: See also World Conference Conference - Leningrad, 1989 - pp. 72-73) on immunomodulatory effect thyroid hormones and their adaptogenic properties. However, they are not used as a means of regulating the function of the immune system and adaptogens in humans.

The prior art iodine deficiency prevention compositions comprise a mixture of fatty acids from vegetable and / or animal oils and iodine and are described in the publications. CA 985167 A, published March 9, 1976 and ref. CN 1133124 A, published on 16.10.1996 and further in file no. WO 91 18 593 A, WO 95 35 038 A, WO 95 35 03 8 and DE 2 9 710 124 U.

So far, preparations are not known which contain chemically modified fatty acids in which iodine is added to the multiple bonds and the iodine-containing component is directly a fatty acid in a vegetable or animal oil which is itself part of the preparation.

The essence of the technical solution

It has been shown that effective prevention of iodine loss, adjustment of thyroid function, stimulation of growth and development of children, increase of the organism's immune response, reduction of xenobiotics and other adverse environmental effects, antiarteriogenic effect can be achieved with dietary supplement containing iodine in saturated iodine, iodized fatty acids. The essence of the invention is that the food supplement contains at least one iodinated free or bound fatty acid according to the general formula I as one of the active ingredients

CH ₃ - (CH ₂ ) _x - [CH = CH - (CH ₂ ) _v ] _z - [CH - CH - (CH ₂ ) _v ] _{Z 1} - (CH ₂ ) _y - COOH

I I (I), j

-1 CZ 12405 Ul where:

v - is from 0 to 2, x - from 0 to 14, y - from 0 to 13, z - from 1 to 5,

Z 1 - from 1 to 6, and the iodine content of the composition is from 0.02 wt. up to 0.45% by weight, wherein the iodine atoms are attached to the carbon atoms of the fatty acids at the site of the originally double bonds.

It is preferred that the iodine deficiency prevention composition comprises some of the iodinated fatty acids selected from the group consisting of oleic, linoleic, linolenic, palmitic, erucic acid, any mixture thereof, or any mixture with other fatty acids which, by composition, fall within formula (I).

Suitably, a mixture of iodized free or bound fatty acids of the formula I, which are iodinated as part of natural vegetable or animal fats, is used as the active ingredient of the invention.

According to the invention, one of the active components of the preparation can be formed by directly binding a certain amount of iodine with free or bound fatty acids, or mixtures thereof. In this reaction, the iodine atoms bind to the carbon atoms of the acids at the double bond sites. Di-, terta-, hexa-, octa-, decyodidized fatty acids are formed which have a characteristic coloration of the vegetable oil or fat used. It is important that the fatty acids that make up the active ingredient of the dietary supplement be iodized at least partially or completely.

For practical use in production, it is suitable that the active ingredient of a food supplement according to the invention is prepared by a method of combining a given amount of iodine with fatty acids found in vegetable and animal fats. Here we can use industrially produced vegetable oils or animal fats. From animal fats we can use pork, fish and other fats.

From 1 to 100 mg of crystalline iodine per 100 ml of vegetable or animal fat may be used to prepare the active ingredient.

The dietary supplement is suitable for use in accordance with the invention in the form of capsules of various sizes, which may contain, if necessary, an all-day amount of iodine of from 20 to 400 pg.

Examples

Example 1

A preparation made from 100 ml of sunflower oil containing selected fatty acids:

- palmitic acid - 6%,

- oleic acid - 25%,

- linoleic acid - 55%,

- linolenic acid - 2%,

- erucic acid - 1%, and 400 mg of iodine administered to patients for psoriasis for two weeks at a dose of 1 ml daily.

After two weeks, an increase in the immunological perception of the organism was observed in the patients, which was confirmed by laboratory examination of the immune state of blood clotting and accompanied by an improvement in the patient's condition.

-2EN 12405 Ul

Example 2

The preparation, prepared from 100 ml of sunflower oil and 20 mg of iodine, was administered to patients with 1 ml of hyperthermia daily for 3 months (2 weeks intake - 2 weeks pause).

After three months a laboratory examination of the thyroid hormone function was performed. Normalization of hypophizeal-pneumoid system parameters (T3, T4, TTG) as well as improvement of the overall condition of the patients was found.

Example 3

Prepared from 100 ml rapeseed oil containing selected fatty acids:

- palmitic acid - 5%, io - oleic acid - 60%,

- linoleic acid - 20%,

- linolenic acid -10%,

- erucic acid - 1%, and 80 mg of iodine were administered to patients with severe bleeding symptoms after arterio15 sclerosis for 1 month in doses of 0.5 ml daily. Within 2 weeks, almost complete disappearance of capillary bleeding was observed.

Example 4

Prepared from 100 g of lard containing selected fatty acids:

- palmitic acid - 28%,

- stearic acid -13%,

oleic acid - 46%, and 40 mg of iodine at a daily dose of 0.5 g was administered to patients suffering from diabetes and trophic ulcers in the lower limbs for 2 weeks. After this time, a reduction in inflammatory processes and improvement in the lower extremities was observed.

Industrial applicability

The dietary supplement of the proposed solution is an effective means to combat iodine deficiency. It regulates the function of the thyroid gland, stimulates the growth and development of children, increases the immunological susceptibility of the organism, reduces the influence of xenobiotics and other adverse effects of the surrounding environment and also has anti-arterial properties.

Claims (2)

30 PROTECTION REQUIREMENTS A composition for the prevention of iodine deficiency comprising vegetable or animal fats and iodine, characterized in that the vegetable and animal fats contain as one of the active ingredients at least one iodized free or bound fatty acid of the general formula I CH ₃ - (CH ₂ ) _x - [CH = CH - (CH ₂ ) _v ] _z - [CH - CH - (CH ₂ ) _v ] _{Z [} - (CH ₂ ) _y - COOH 35 I (I), J J where: v - has a variable value from 0 to 2, x - from 0 to 14, From 0 to 13, z - from 0 to 5, zi - from 1 to 6, and the iodine content of the composition is from 0.02% to 0.45% by weight, with 5 iodine atoms being bonded with fatty acid carbon atoms at the site of the originally double bonds. A composition for preventing iodine deficiency according to claim 1, wherein the fatty acids are selected from the group consisting of palmitic, oleic, linoleic, linolenic, erucic and any mixtures thereof with other fatty acids in free or bound form, which are included in their content. Formula I.