CY2605B2 - Νουκλεοτιδικη ακολουθια η οποια κωδικοποιει την φλαβινικη μονοξυγεναση, την αντιστοιχη πρωτεϊνη καθως και τις εφαρμογες τους στους τομεις της διαγνωσης και της θεραπειας - Google Patents

Νουκλεοτιδικη ακολουθια η οποια κωδικοποιει την φλαβινικη μονοξυγεναση, την αντιστοιχη πρωτεϊνη καθως και τις εφαρμογες τους στους τομεις της διαγνωσης και της θεραπειας

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Publication number
CY2605B2
CY2605B2 CY0700006A CY0700006A CY2605B2 CY 2605 B2 CY2605 B2 CY 2605B2 CY 0700006 A CY0700006 A CY 0700006A CY 0700006 A CY0700006 A CY 0700006A CY 2605 B2 CY2605 B2 CY 2605B2
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CY
Cyprus
Prior art keywords
present
containingmonooxygenase
plications
flavin
diagnosis
Prior art date
Application number
CY0700006A
Other languages
English (en)
Inventor
Marta Blumenfeld
Ilia Tchoumakov
Henri-Jean Garchon
Jean-Francois Bach
Original Assignee
Serono Genetics Inst Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Genetics Inst Sa, Inst Nat Sante Rech Med filed Critical Serono Genetics Inst Sa
Publication of CY2605B2 publication Critical patent/CY2605B2/el

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
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  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά κυρίως σε μια ανθρώπινη φλαβινική μονοξυγενάση 2 ( human flavin monooxygenase 2 - hFMO2), καθώς και σε ένα άλλο ανθρώπινο ένζυμο της οικογένειας FMO, hFMOx, των νουκλεοτιδικών και πολυπεπτιδικών ακολουθιών τους. Η παρούσα εφεύρεση αφορά επίσης σε φορείς κλωνοποίησης και / ή έκφρασης που περιέχουν τις λεγόμενες νουκλεοτιδικές ακολουθίες, καθώς και σε κύτταρα που μεταβάλλονται από τους συγκεκριμένους φορείς, αλλά και σε μεθόδους παρασκευής των εν λόγω πολυπεπτιδίων. Επιπλέον, η παρούσα εφεύρεση αφορά σε μεθόδους επιλογής συστατικών και διαγνωστικές μεθόδους πρόληψης παθολογιών και / ή σε ατέλειες που σχετίζονται με τα FMOs, αλλά και σε φαρμακευτικές συνθέσεις που φέρουν τα εν λόγω συστατικά τα οποία προορίζονται για την θεραπεία και / ή την πρόληψη των συγκεκριμένων παθολογιών.
CY0700006A 1996-12-06 2007-03-22 Νουκλεοτιδικη ακολουθια η οποια κωδικοποιει την φλαβινικη μονοξυγεναση, την αντιστοιχη πρωτεϊνη καθως και τις εφαρμογες τους στους τομεις της διαγνωσης και της θεραπειας CY2605B2 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615032A FR2756845B1 (fr) 1996-12-06 1996-12-06 Sequence nucleotidique codant pour une flavine monooxygenase , proteine correspondante et composition destinee au diagnostic et a la therapie du glaucome

Publications (1)

Publication Number Publication Date
CY2605B2 true CY2605B2 (el) 2010-04-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY0700006A CY2605B2 (el) 1996-12-06 2007-03-22 Νουκλεοτιδικη ακολουθια η οποια κωδικοποιει την φλαβινικη μονοξυγεναση, την αντιστοιχη πρωτεϊνη καθως και τις εφαρμογες τους στους τομεις της διαγνωσης και της θεραπειας

Country Status (13)

Country Link
US (3) US6551792B1 (el)
EP (1) EP0941341B1 (el)
JP (1) JP4062638B2 (el)
AT (1) ATE352635T1 (el)
AU (1) AU746293B2 (el)
CA (1) CA2274011A1 (el)
CY (1) CY2605B2 (el)
DE (1) DE69737293T2 (el)
DK (1) DK0941341T3 (el)
ES (1) ES2279552T3 (el)
FR (1) FR2756845B1 (el)
PT (1) PT941341E (el)
WO (1) WO1998024914A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756845B1 (fr) 1996-12-06 1999-02-26 Genset Sa Sequence nucleotidique codant pour une flavine monooxygenase , proteine correspondante et composition destinee au diagnostic et a la therapie du glaucome
AU7500800A (en) * 1999-09-30 2001-04-30 Mcgill University Human fmo3 gene mutations and polymorphisms, and uses thereof
US6902890B1 (en) 1999-11-04 2005-06-07 Diadexus, Inc. Method of diagnosing monitoring, staging, imaging and treating cancer
JP2002142765A (ja) * 2000-07-14 2002-05-21 Tosoh Corp 新規ゲノム解析法
WO2002006452A2 (en) 2000-07-18 2002-01-24 National Research Council Of Canada Cloning, sequencing and expression of a comamonas cyclopentanone 1,2-monooxygenase-encoding gene in escherichia coli
ES2288173T3 (es) * 2000-12-28 2008-01-01 Epidauros Biotechnologie Ag Identificacion de los determinantes geneticos de la expresion del polimorfo cyp3a5.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4305696A1 (de) * 1993-02-25 1994-09-01 Hoechst Ag Nachweisverfahren zur Identifizierung von Inhibitoren
US5712249A (en) * 1994-09-08 1998-01-27 Ciba-Geigy Corporation Use of insulin-like growth factors I and II for inhibition of inflammatory response
JPH08140674A (ja) * 1994-11-18 1996-06-04 Sumitomo Chem Co Ltd ヒトフラビン含有モノオキシゲナーゼ
FR2756845B1 (fr) 1996-12-06 1999-02-26 Genset Sa Sequence nucleotidique codant pour une flavine monooxygenase , proteine correspondante et composition destinee au diagnostic et a la therapie du glaucome

Also Published As

Publication number Publication date
DK0941341T3 (da) 2007-03-19
DE69737293T2 (de) 2007-06-21
ATE352635T1 (de) 2007-02-15
PT941341E (pt) 2007-02-28
AU5327198A (en) 1998-06-29
EP0941341A1 (fr) 1999-09-15
FR2756845B1 (fr) 1999-02-26
ES2279552T3 (es) 2007-08-16
FR2756845A1 (fr) 1998-06-12
US20030203463A1 (en) 2003-10-30
US6551792B1 (en) 2003-04-22
JP4062638B2 (ja) 2008-03-19
JP2001505430A (ja) 2001-04-24
AU746293B2 (en) 2002-04-18
EP0941341B1 (fr) 2007-01-24
CA2274011A1 (fr) 1998-06-11
US7037709B2 (en) 2006-05-02
DE69737293D1 (de) 2007-03-15
US20060154295A1 (en) 2006-07-13
WO1998024914A1 (fr) 1998-06-11

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