CY2391B1 - Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin. - Google Patents
Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin.Info
- Publication number
- CY2391B1 CY2391B1 CY0300086A CY0300086A CY2391B1 CY 2391 B1 CY2391 B1 CY 2391B1 CY 0300086 A CY0300086 A CY 0300086A CY 0300086 A CY0300086 A CY 0300086A CY 2391 B1 CY2391 B1 CY 2391B1
- Authority
- CY
- Cyprus
- Prior art keywords
- rapamycin
- cyclosporin
- treatment
- pharmaceutical compositions
- transplant rejection
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9615942.1A GB9615942D0 (en) | 1996-07-30 | 1996-07-30 | Organic compounds |
GBGB9705684.0A GB9705684D0 (en) | 1997-03-18 | 1997-03-18 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY2391B1 true CY2391B1 (en) | 2004-09-10 |
Family
ID=26309775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY0300086A CY2391B1 (en) | 1996-07-30 | 2003-11-28 | Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin. |
Country Status (15)
Country | Link |
---|---|
US (2) | US6239124B1 (sl) |
EP (2) | EP0956034B1 (sl) |
JP (2) | JP3942641B2 (sl) |
AT (2) | ATE222502T1 (sl) |
AU (1) | AU730781B2 (sl) |
CA (1) | CA2261666C (sl) |
CY (1) | CY2391B1 (sl) |
DE (2) | DE69714861T2 (sl) |
DK (2) | DK1208847T3 (sl) |
ES (2) | ES2182112T3 (sl) |
HK (1) | HK1023720A1 (sl) |
NZ (1) | NZ333657A (sl) |
PT (2) | PT956034E (sl) |
SI (1) | SI1208847T1 (sl) |
WO (1) | WO1998004279A1 (sl) |
Families Citing this family (81)
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ATE398448T1 (de) * | 1993-09-28 | 2008-07-15 | Scherer Gmbh R P | Herstellung von weichgelatinekapseln |
US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
ES2182112T3 (es) * | 1996-07-30 | 2003-03-01 | Novartis Ag | Composiciones farmaceuticas para el tratamiento del rechazo de transplantes y de estados autoinmunes o inflamatorios, que comprenden ciclosporina a y 40-o-(2-hidroxietil)-rapamicina. |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
GB9825632D0 (en) * | 1998-11-23 | 1999-01-13 | Novartis Ag | Organic compounds |
GB9826882D0 (en) * | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
US20020006901A1 (en) * | 1999-02-05 | 2002-01-17 | Aldo T. Iacono | Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease |
JP2002544167A (ja) * | 1999-05-10 | 2002-12-24 | ノバルティス アクチエンゲゼルシャフト | 有機化合物 |
ATE303398T1 (de) * | 2000-11-03 | 2005-09-15 | Univ Manchester | Selektive glucocorticoid rezeptor agonisten |
US20020127263A1 (en) * | 2001-02-27 | 2002-09-12 | Wenda Carlyle | Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device |
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
US6641611B2 (en) * | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
US20080145402A1 (en) * | 2001-09-10 | 2008-06-19 | Abbott Cardiovascular Systems Inc. | Medical Devices Containing Rapamycin Analogs |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
KR100978836B1 (ko) * | 2001-10-19 | 2010-08-30 | 이소테크니카 인코포레이티드 | 신규한 시클로스포린 유사체 미세유화액 예비농축물 |
CN100415227C (zh) * | 2001-10-25 | 2008-09-03 | 阿特罗吉尼克斯公司 | 化合物在制备用于治疗移植排斥的药物中的应用 |
US7682387B2 (en) * | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
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US7109169B2 (en) * | 2002-06-28 | 2006-09-19 | Hobai Ion A | Method for treating heart failure by inhibiting the sarcolemmal sodium/calcium exchange |
EP1521828B1 (en) | 2002-07-16 | 2015-07-01 | Buck Institute for Research on Aging | Production of polyketides |
EP2263709A1 (en) * | 2002-09-06 | 2010-12-22 | Abbott Laboratories | Medical device having hydration inhibitor |
PT1539157E (pt) * | 2002-09-18 | 2013-10-04 | Univ Pennsylvania | Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal |
US8202530B2 (en) * | 2002-09-27 | 2012-06-19 | Advanced Cardiovascular Systems, Inc. | Biocompatible coatings for stents |
AR043504A1 (es) * | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
EP1663216B1 (en) | 2003-08-29 | 2011-11-02 | Veloxis Pharmaceuticals A/S | Modified release compositions comprising tacrolimus |
US7585517B2 (en) | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
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US8709469B2 (en) | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
US8021849B2 (en) * | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
US20060257450A1 (en) * | 2005-03-21 | 2006-11-16 | Sreenivasu Mudumba | Drug delivery systems for treatment of diseases or conditions |
BRPI0608152A2 (pt) * | 2005-02-09 | 2009-11-10 | Macusight Inc | formulações para tratamento ocular |
JP2008530145A (ja) * | 2005-02-15 | 2008-08-07 | ワイス | 経口投与可能なcci−779製剤 |
CA3054535A1 (en) | 2005-02-18 | 2006-08-24 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
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AU2006235478B2 (en) | 2005-04-12 | 2011-07-21 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising cyclosporine |
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US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
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US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
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US20130317053A1 (en) * | 2011-01-31 | 2013-11-28 | Osaka University | Externally-used drug for treating skin disorder and method for producing same |
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MX2016003615A (es) | 2013-09-24 | 2016-10-26 | Giner Inc | Sistema para tratamiento con gas de un implante de celulas. |
US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
EP3371590A4 (en) * | 2015-11-06 | 2019-07-10 | The Trustees of Columbia University in the City of New York | EXOSOMAL PROTEIN PROFILING FOR DETECTION OF CARDIAC GRAFT REJECTION |
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US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
WO2018129364A1 (en) | 2017-01-06 | 2018-07-12 | Palvella Therapeutics Llc | Anhydrous compositions of mtor inhibitors and methods of use |
CN110603038A (zh) | 2017-02-10 | 2019-12-20 | 塔姆山治疗公司 | 雷帕霉素类似物 |
WO2018204867A1 (en) | 2017-05-04 | 2018-11-08 | Giner, Inc. | Robust, implantable gas delivery device and methods, systems and devices including same |
WO2020010073A1 (en) | 2018-07-02 | 2020-01-09 | Palvella Therapeutics, Inc. | ANHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5286731A (en) | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
US5286730A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
DE69302945T2 (de) | 1992-03-27 | 1996-10-10 | American Home Prod | 29-Demethoxyrapamycin zur Induktion der Immunosuppression |
GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
GB2278780B (en) | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
GB9606452D0 (en) | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
ES2182112T3 (es) * | 1996-07-30 | 2003-03-01 | Novartis Ag | Composiciones farmaceuticas para el tratamiento del rechazo de transplantes y de estados autoinmunes o inflamatorios, que comprenden ciclosporina a y 40-o-(2-hidroxietil)-rapamicina. |
JP2002544167A (ja) * | 1999-05-10 | 2002-12-24 | ノバルティス アクチエンゲゼルシャフト | 有機化合物 |
-
1997
- 1997-07-29 ES ES97937526T patent/ES2182112T3/es not_active Expired - Lifetime
- 1997-07-29 EP EP97937526A patent/EP0956034B1/en not_active Expired - Lifetime
- 1997-07-29 SI SI9730756T patent/SI1208847T1/sl unknown
- 1997-07-29 PT PT97937526T patent/PT956034E/pt unknown
- 1997-07-29 DK DK01131018T patent/DK1208847T3/da active
- 1997-07-29 JP JP50851398A patent/JP3942641B2/ja not_active Expired - Lifetime
- 1997-07-29 NZ NZ333657A patent/NZ333657A/xx not_active IP Right Cessation
- 1997-07-29 AU AU40124/97A patent/AU730781B2/en not_active Expired
- 1997-07-29 PT PT01131018T patent/PT1208847E/pt unknown
- 1997-07-29 EP EP01131018A patent/EP1208847B8/en not_active Expired - Lifetime
- 1997-07-29 DE DE69714861T patent/DE69714861T2/de not_active Expired - Lifetime
- 1997-07-29 AT AT97937526T patent/ATE222502T1/de active
- 1997-07-29 DE DE69736750T patent/DE69736750T2/de not_active Expired - Lifetime
- 1997-07-29 WO PCT/EP1997/004123 patent/WO1998004279A1/en active IP Right Grant
- 1997-07-29 AT AT01131018T patent/ATE340586T1/de active
- 1997-07-29 ES ES01131018T patent/ES2270948T3/es not_active Expired - Lifetime
- 1997-07-29 US US09/230,618 patent/US6239124B1/en not_active Expired - Lifetime
- 1997-07-29 CA CA2261666A patent/CA2261666C/en not_active Expired - Lifetime
- 1997-07-29 DK DK97937526T patent/DK0956034T3/da active
-
2000
- 2000-05-15 HK HK00102877A patent/HK1023720A1/xx not_active IP Right Cessation
-
2001
- 2001-01-11 US US09/758,301 patent/US6455518B2/en not_active Expired - Lifetime
-
2003
- 2003-11-28 CY CY0300086A patent/CY2391B1/xx unknown
- 2003-12-08 JP JP2003408898A patent/JP4149905B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0956034A1 (en) | 1999-11-17 |
ES2270948T3 (es) | 2007-04-16 |
WO1998004279A1 (en) | 1998-02-05 |
SI1208847T1 (sl) | 2007-06-30 |
DE69736750T2 (de) | 2007-08-16 |
DE69736750D1 (de) | 2006-11-09 |
JP2000505806A (ja) | 2000-05-16 |
AU4012497A (en) | 1998-02-20 |
HK1023720A1 (en) | 2000-09-22 |
EP0956034B1 (en) | 2002-08-21 |
US6455518B2 (en) | 2002-09-24 |
EP1208847B8 (en) | 2007-02-14 |
ATE340586T1 (de) | 2006-10-15 |
DK0956034T3 (da) | 2002-12-16 |
PT1208847E (pt) | 2007-07-24 |
DE69714861T2 (de) | 2003-05-22 |
CA2261666A1 (en) | 1998-02-05 |
CA2261666C (en) | 2010-09-14 |
EP1208847A2 (en) | 2002-05-29 |
JP4149905B2 (ja) | 2008-09-17 |
NZ333657A (en) | 2000-05-26 |
JP3942641B2 (ja) | 2007-07-11 |
EP1208847B1 (en) | 2006-09-27 |
JP2004210767A (ja) | 2004-07-29 |
AU730781B2 (en) | 2001-03-15 |
EP1208847A3 (en) | 2002-06-12 |
ATE222502T1 (de) | 2002-09-15 |
DE69714861D1 (de) | 2002-09-26 |
US6239124B1 (en) | 2001-05-29 |
PT956034E (pt) | 2002-12-31 |
US20010008888A1 (en) | 2001-07-19 |
ES2182112T3 (es) | 2003-03-01 |
DK1208847T3 (da) | 2007-01-08 |
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