CY2142B1 - Trimetazidine derivatives process for their preparation and pharmaceutical compositions containing them - Google Patents

Trimetazidine derivatives process for their preparation and pharmaceutical compositions containing them

Info

Publication number
CY2142B1
CY2142B1 CY9900038A CY9900038A CY2142B1 CY 2142 B1 CY2142 B1 CY 2142B1 CY 9900038 A CY9900038 A CY 9900038A CY 9900038 A CY9900038 A CY 9900038A CY 2142 B1 CY2142 B1 CY 2142B1
Authority
CY
Cyprus
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
trimetazidine
derivatives process
Prior art date
Application number
CY9900038A
Other languages
English (en)
Inventor
Gilbert Regnier
Jean-Paul Vilaine
Nicole Villeneuve
Jean-Pierre Bidouard
Jean-Pierre Iliou
Albert Lenaers
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of CY2142B1 publication Critical patent/CY2142B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CY9900038A 1991-09-18 1999-11-19 Trimetazidine derivatives process for their preparation and pharmaceutical compositions containing them CY2142B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9111469A FR2681324B1 (fr) 1991-09-18 1991-09-18 Nouveaux derives de la trimetazidine, leur procede de preparation et les compositions pharmaceutiques les contenant.

Publications (1)

Publication Number Publication Date
CY2142B1 true CY2142B1 (en) 2002-06-21

Family

ID=9417037

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9900038A CY2142B1 (en) 1991-09-18 1999-11-19 Trimetazidine derivatives process for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US5283246A (ja)
EP (1) EP0533579B1 (ja)
JP (1) JPH0676396B2 (ja)
AT (1) ATE145899T1 (ja)
AU (1) AU647964B2 (ja)
CA (1) CA2078520C (ja)
CY (1) CY2142B1 (ja)
DE (1) DE69215626T2 (ja)
DK (1) DK0533579T3 (ja)
ES (1) ES2097299T3 (ja)
FR (1) FR2681324B1 (ja)
GR (1) GR3022322T3 (ja)
NZ (1) NZ244370A (ja)
ZA (1) ZA927165B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432179A (en) * 1991-07-19 1995-07-11 Zeria Pharmaceutical Co., Ltd. Piperazine derivatives and pharmaceuticals containing the same
FR2703048B1 (fr) * 1993-03-24 1996-01-05 Adir Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
EP0791589B1 (en) * 1994-04-11 2002-03-06 Chugai Seiyaku Kabushiki Kaisha 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
WO1997007109A1 (en) * 1995-08-21 1997-02-27 Takeda Chemical Industries, Ltd. Quinone compound, its production and use
FR2757164B1 (fr) * 1996-12-16 1999-01-22 Adir Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JPH10265386A (ja) * 1997-03-21 1998-10-06 Toshio Sato 抗酸化作用を有する抗アレルギー剤
EP1829535A3 (en) * 1999-10-27 2007-10-24 Tanox, Inc. Tissue factor antagonists and methods of use thereof
US6608066B1 (en) * 1999-10-27 2003-08-19 Sunol Molecular Corporation Tissue factor antagonists and methods of use thereof
FR2802424B1 (fr) * 1999-12-17 2002-02-15 Adir Comprime matriciel permettant la liberation prolongee de trimetazidine apres administration par voie orale
FR2805463B1 (fr) * 2000-02-25 2003-01-24 Adir UTILISATION DE LA TRIMETAZIDINE POUR L'OBTENTION DE COMPOSITIONS PHARMACEUTIQUES DESTINEES A INHIBER L'ACYL-CoA ACETYLTRANSFERASE
FR2827284B1 (fr) * 2001-07-16 2003-10-31 Servier Lab Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2003037323A2 (en) * 2001-10-26 2003-05-08 MEDIGENE AG Gesellschaft für Molekularbiologische Kardiologie und Onkologie Inhibitors of the fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction
WO2007116243A2 (en) * 2006-04-10 2007-10-18 Mintails Limited Method for treating fibromyalgia and related conditions
PL2394644T3 (pl) 2010-05-04 2014-11-28 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Preparat trimetazydyny o różnych profilach uwalniania
CN103554057B (zh) * 2013-11-13 2016-04-20 武汉武药科技有限公司 曲美他嗪衍生物及其制备方法
WO2018093839A1 (en) 2016-11-15 2018-05-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Therapy for mitochondrial fatty acid beta-oxidation and transport disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1187706A (en) * 1968-06-07 1970-04-15 Ciba Ltd 2-Aminomethyl-2,3-Dihydro-Benzofurans
US4100285A (en) * 1976-04-09 1978-07-11 Nippon Shinyaku Co., Ltd. N-substituted trialkoxybenzyl piperazine derivatives
EP0202580B1 (en) * 1985-05-13 1990-03-28 Kuraray Co., Ltd. 3,4-dihydrobenzopyran derivatives
WO1987005020A1 (en) * 1986-02-21 1987-08-27 Kuraray Co., Ltd. 3,4-dihydro-2h-benzopyran derivatives and their medicinal use

Also Published As

Publication number Publication date
US5283246A (en) 1994-02-01
EP0533579A1 (fr) 1993-03-24
NZ244370A (en) 1994-09-27
JPH05194451A (ja) 1993-08-03
DE69215626D1 (de) 1997-01-16
DE69215626T2 (de) 1997-06-12
DK0533579T3 (da) 1997-05-26
FR2681324B1 (fr) 1993-10-29
JPH0676396B2 (ja) 1994-09-28
AU647964B2 (en) 1994-03-31
GR3022322T3 (en) 1997-04-30
ZA927165B (en) 1993-03-24
FR2681324A1 (fr) 1993-03-19
AU2453792A (en) 1993-03-25
EP0533579B1 (fr) 1996-12-04
CA2078520A1 (fr) 1993-03-19
CA2078520C (fr) 2001-04-24
ES2097299T3 (es) 1997-04-01
ATE145899T1 (de) 1996-12-15

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