CY2069B1 - Xanthine compounds - Google Patents
Xanthine compoundsInfo
- Publication number
- CY2069B1 CY2069B1 CY9802069A CY9802069A CY2069B1 CY 2069 B1 CY2069 B1 CY 2069B1 CY 9802069 A CY9802069 A CY 9802069A CY 9802069 A CY9802069 A CY 9802069A CY 2069 B1 CY2069 B1 CY 2069B1
- Authority
- CY
- Cyprus
- Prior art keywords
- chem
- effect
- independently represents
- renal
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22664289 | 1989-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY2069B1 true CY2069B1 (en) | 1998-09-11 |
Family
ID=16848383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY9802069A CY2069B1 (en) | 1989-09-01 | 1998-09-11 | Xanthine compounds |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0415456B1 (fr) |
JP (1) | JPH06102662B2 (fr) |
AT (1) | ATE139778T1 (fr) |
BR (1) | BR1100762A (fr) |
CA (1) | CA2024381C (fr) |
CY (1) | CY2069B1 (fr) |
DE (1) | DE69027562T2 (fr) |
DK (1) | DK0415456T3 (fr) |
ES (1) | ES2091212T3 (fr) |
GR (1) | GR3020715T3 (fr) |
HK (1) | HK1000600A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE8817122U1 (de) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
CA2061544A1 (fr) * | 1991-02-25 | 1992-08-26 | Fumio Suzuki | Composes de la xanthine |
DE69229257D1 (de) * | 1991-11-08 | 1999-07-01 | Kyowa Hakko Kogyo Kk | Xanthinderivate zur Behandlung der Demenz |
US5336769A (en) * | 1992-02-17 | 1994-08-09 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
US5342841A (en) * | 1992-03-12 | 1994-08-30 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
TW252044B (fr) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
DE4238367A1 (de) * | 1992-11-13 | 1994-05-19 | Boehringer Ingelheim Kg | Diuretisches Mittel |
WO1994016702A1 (fr) * | 1993-01-26 | 1994-08-04 | Kyowa Hakko Kogyo Co., Ltd. | Medicament contre l'elimination irreguliere des matieres fecales |
US5395836A (en) * | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
US6107064A (en) * | 1994-05-17 | 2000-08-22 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing xanthine derivatives with bacteria and fungi |
ATE247655T1 (de) | 1994-12-13 | 2003-09-15 | Euro Celtique Sa | Dreifachsubstituierte thioxanthine |
US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
WO1996018399A1 (fr) * | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Aryle thioxanthines |
US6254889B1 (en) * | 1995-07-26 | 2001-07-03 | Kyowa Hakko Kogyo Co., Ltd. | Solid dispersion dosage form of amorphous xanthine derivative and enteric-coating polymer |
US5864037A (en) | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
AU7675498A (en) * | 1997-06-16 | 1999-01-04 | Kyowa Hakko Kogyo Co. Ltd. | Preventive and remedy for drug-induced nephropathy |
DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP0970696A1 (fr) * | 1998-05-05 | 2000-01-12 | Kyowa Hakko Kogyo Co., Ltd. | Composition comprenant des diurétiques d'anse et des antagonists des recepteurs A1 de l'adenosine |
CA2333947C (fr) * | 1998-06-01 | 2010-09-21 | Fujisawa Pharmaceutical Co., Ltd. | Composes de pyrazolopyridine utilises en tant qu'antagonistes de l'adenosine a1 contre l'infertilite masculine |
US6576619B2 (en) | 1999-05-24 | 2003-06-10 | Cv Therapeutics, Inc. | Orally active A1 adenosine receptor agonists |
GEP20043267B (en) * | 1999-11-12 | 2004-06-25 | Biogen Inc Us | Adenosine Receptor Antagonists, Methods of Making and Using the Same |
PT1230243E (pt) * | 1999-11-12 | 2009-06-12 | Biogen Idec Inc | Policicloalquilpurinas como antagonistas dos receptores da adenosina |
EP1283056B1 (fr) | 2000-04-26 | 2004-12-15 | Eisai Co., Ltd. | Compositions medicinales favorisant les mouvements intestinaux |
DE60133931D1 (de) * | 2000-12-01 | 2008-06-19 | Biogen Idec Inc | Kondensierte purinderivate als a1-adenosinrezeptorantagonisten |
TWI301834B (en) | 2001-10-22 | 2008-10-11 | Eisai R&D Man Co Ltd | Pyrimidone compound and pharmaceutical composition including the same |
BR0312137A (pt) * | 2002-06-12 | 2005-04-05 | Mcw Res Found Inc | Processo de tratamento de dano de reperfusão de isquemia usando antagonistas de receptor de adenosina |
US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
DE60322748D1 (de) * | 2003-05-06 | 2008-09-18 | Cv Therapeutics Inc | Xanthinderivate als a2b-adenosinrezeptorantagonisten |
CN1894250B (zh) * | 2003-08-25 | 2010-06-09 | PGx健康有限责任公司 | 取代的8-杂芳基黄嘌呤 |
WO2007069675A1 (fr) | 2005-12-14 | 2007-06-21 | Kyowa Hakko Kogyo Co., Ltd. | Préparation orale facilement absorbée contenant un dérivé de la xanthine |
GB0708258D0 (en) * | 2007-04-27 | 2007-06-06 | Katholleke Universiteit Leuven | New anti-viral nulceoside analogs |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1245969B (de) * | 1967-08-03 | VEB Arzneimittelwerk Dresden, Radebeul | Verfahren zur Herstellung von Xanthinderivaten | |
GB1201997A (en) * | 1967-08-04 | 1970-08-12 | Yissum Res Dev Co | New substituted purines and purine derivatives |
GB8618931D0 (en) * | 1986-08-02 | 1986-09-10 | Euro Celtique Sa | 6-thioxanthines |
US4783530A (en) * | 1986-11-13 | 1988-11-08 | Marion Laboratories, Inc. | 8-arylxanthines |
DE8817122U1 (de) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
-
1990
- 1990-08-30 JP JP22894190A patent/JPH06102662B2/ja not_active Expired - Lifetime
- 1990-08-31 EP EP90116791A patent/EP0415456B1/fr not_active Expired - Lifetime
- 1990-08-31 ES ES90116791T patent/ES2091212T3/es not_active Expired - Lifetime
- 1990-08-31 CA CA002024381A patent/CA2024381C/fr not_active Expired - Fee Related
- 1990-08-31 DK DK90116791.6T patent/DK0415456T3/da active
- 1990-08-31 AT AT90116791T patent/ATE139778T1/de not_active IP Right Cessation
- 1990-08-31 DE DE69027562T patent/DE69027562T2/de not_active Expired - Lifetime
-
1996
- 1996-08-02 GR GR960402079T patent/GR3020715T3/el unknown
-
1997
- 1997-05-12 BR BR1100762-1A patent/BR1100762A/pt active IP Right Grant
- 1997-11-19 HK HK97102197A patent/HK1000600A1/xx not_active IP Right Cessation
-
1998
- 1998-09-11 CY CY9802069A patent/CY2069B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69027562D1 (de) | 1996-08-01 |
ATE139778T1 (de) | 1996-07-15 |
JPH03173889A (ja) | 1991-07-29 |
EP0415456A2 (fr) | 1991-03-06 |
GR3020715T3 (en) | 1996-11-30 |
DE69027562T2 (de) | 1997-02-20 |
EP0415456B1 (fr) | 1996-06-26 |
CA2024381C (fr) | 1997-01-07 |
HK1000600A1 (en) | 1998-04-09 |
BR1100762A (pt) | 2000-03-14 |
CA2024381A1 (fr) | 1991-03-02 |
EP0415456A3 (en) | 1991-05-29 |
ES2091212T3 (es) | 1996-11-01 |
DK0415456T3 (da) | 1996-07-29 |
JPH06102662B2 (ja) | 1994-12-14 |
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