CY2032A - Long-acting biodegradable microparticles and process for preparation - Google Patents

Long-acting biodegradable microparticles and process for preparation

Info

Publication number
CY2032A
CY2032A CY203298A CY203298A CY2032A CY 2032 A CY2032 A CY 2032A CY 203298 A CY203298 A CY 203298A CY 203298 A CY203298 A CY 203298A CY 2032 A CY2032 A CY 2032A
Authority
CY
Cyprus
Prior art keywords
long
preparation
biodegradable microparticles
acting
acting biodegradable
Prior art date
Application number
CY203298A
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CY2032A publication Critical patent/CY2032A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Long-acting biodegradable microparticles containing therapeutically active peptides as active ingredient and poly(lactide-co-glycolide) as vehicle, which are obtained by spray drying at temperatures below 60 DEG C with a spray flow above 500 l(STP), are described.
CY203298A 1991-03-25 1998-02-20 Long-acting biodegradable microparticles and process for preparation CY2032A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4109746 1991-03-25

Publications (1)

Publication Number Publication Date
CY2032A true CY2032A (en) 1998-02-20

Family

ID=6428150

Family Applications (1)

Application Number Title Priority Date Filing Date
CY203298A CY2032A (en) 1991-03-25 1998-02-20 Long-acting biodegradable microparticles and process for preparation

Country Status (20)

Country Link
EP (1) EP0505966B1 (en)
JP (1) JP3346789B2 (en)
KR (1) KR100203253B1 (en)
AT (1) ATE124254T1 (en)
AU (1) AU653210B2 (en)
CA (1) CA2063883C (en)
CY (1) CY2032A (en)
CZ (1) CZ284756B6 (en)
DE (1) DE59202649D1 (en)
DK (1) DK0505966T3 (en)
ES (1) ES2076592T3 (en)
FI (1) FI99084C (en)
HR (1) HRP940838B1 (en)
IE (1) IE67555B1 (en)
IL (1) IL101346A0 (en)
MY (1) MY109719A (en)
NO (1) NO302856B1 (en)
NZ (1) NZ242073A (en)
YU (1) YU48420B (en)
ZA (1) ZA922130B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69220317T2 (en) * 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Microparticle summary for extended release and manufacture of the same
JP2651320B2 (en) * 1992-07-16 1997-09-10 田辺製薬株式会社 Method for producing sustained-release microsphere preparation
AU4198793A (en) * 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
CA2126685C (en) * 1992-10-26 2002-07-23 Bruno Gander Process for the production of microcapsules
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
KR100321854B1 (en) * 1998-12-30 2002-08-28 동국제약 주식회사 Long-term sustained-release microspheres containing luteinizing hormone releasing hormone homologues and a method of producing the same
WO2002094320A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Therapeutic compositions for repairing chondropathy
US20040146561A1 (en) 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
PT1532985T (en) 2002-06-25 2017-01-20 Takeda Pharmaceuticals Co Process for producing a sustained-release composition
JP4792457B2 (en) 2004-03-26 2011-10-12 ユニヴァーシタ’デグリ ステュディ ディ パルマ Highly breathable insulin microparticles
KR100722607B1 (en) * 2006-05-11 2007-05-28 주식회사 펩트론 A process of preparing microspheres for sustained release having improved dispersibility and syringeability
FR2934856B1 (en) * 2008-08-05 2010-08-13 Servier Lab NEW PROCESS FOR OBTAINING THE V-CRYSTALLINE FORM OF AGOMELATIN
BR102012011209A2 (en) * 2012-05-11 2014-03-25 Bioactive Biomateriais Ltda BIODEGRADABLE THREE-DIMENSIONAL MATERIAL AND BIODEGRADABLE THREE-DIMENSIONAL MATERIAL PREPARATION PROCESS
CN105963257B (en) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 Preparation method of sustained-release particles
CN105963258B (en) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 Preparation method of sustained-release particles
CN109985585A (en) * 2019-05-13 2019-07-09 苏州岸谷纳米技术有限公司 A kind of fast preparation method of Biodegradable high molecular microballoon

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
AU612591B2 (en) * 1986-08-11 1991-07-18 Innovata Biomed Limited Pharmaceutical formulations comprising microcapsules
DE3710175A1 (en) * 1987-02-12 1988-08-25 Hoechst Ag MULTI-PIECE IMPLANTABLE MEDICINE PREPARATION WITH LONG-TERM EFFECT
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3738228A1 (en) * 1987-11-11 1989-05-24 Hoechst Ag METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier

Also Published As

Publication number Publication date
IE920956A1 (en) 1992-10-07
HRP940838A2 (en) 1997-06-30
FI99084C (en) 1997-10-10
MY109719A (en) 1997-05-31
YU48420B (en) 1998-07-10
CA2063883C (en) 2001-12-11
IE67555B1 (en) 1996-04-17
FI99084B (en) 1997-06-30
FI921248A (en) 1992-09-26
AU1310992A (en) 1992-10-01
ZA922130B (en) 1992-11-25
NZ242073A (en) 1993-08-26
EP0505966B1 (en) 1995-06-28
AU653210B2 (en) 1994-09-22
JPH0570363A (en) 1993-03-23
CZ284756B6 (en) 1999-02-17
CA2063883A1 (en) 1992-09-26
NO302856B1 (en) 1998-05-04
KR100203253B1 (en) 1999-06-15
CS88792A3 (en) 1992-10-14
JP3346789B2 (en) 2002-11-18
YU26392A (en) 1994-12-28
KR920017645A (en) 1992-10-21
HRP940838B1 (en) 2000-12-31
DE59202649D1 (en) 1995-08-03
ATE124254T1 (en) 1995-07-15
NO921147L (en) 1992-09-28
IL101346A0 (en) 1992-11-15
EP0505966A1 (en) 1992-09-30
NO921147D0 (en) 1992-03-24
DK0505966T3 (en) 1995-10-30
FI921248A0 (en) 1992-03-23
ES2076592T3 (en) 1995-11-01

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