AU653210B2 - Long-acting biodegradable microparticles and a process for their preparation - Google Patents

Long-acting biodegradable microparticles and a process for their preparation

Info

Publication number
AU653210B2
AU653210B2 AU13109/92A AU1310992A AU653210B2 AU 653210 B2 AU653210 B2 AU 653210B2 AU 13109/92 A AU13109/92 A AU 13109/92A AU 1310992 A AU1310992 A AU 1310992A AU 653210 B2 AU653210 B2 AU 653210B2
Authority
AU
Australia
Prior art keywords
long
preparation
biodegradable microparticles
acting
acting biodegradable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU13109/92A
Other versions
AU1310992A (en
Inventor
Norbert Lill
Jurgen Sandow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU1310992A publication Critical patent/AU1310992A/en
Application granted granted Critical
Publication of AU653210B2 publication Critical patent/AU653210B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Long-acting biodegradable microparticles containing therapeutically active peptides as active ingredient and poly(lactide-co-glycolide) as vehicle, which are obtained by spray drying at temperatures below 60 DEG C with a spray flow above 500 l(STP), are described.
AU13109/92A 1991-03-25 1992-03-24 Long-acting biodegradable microparticles and a process for their preparation Expired AU653210B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4109746 1991-03-25
DE4109746 1991-03-25

Publications (2)

Publication Number Publication Date
AU1310992A AU1310992A (en) 1992-10-01
AU653210B2 true AU653210B2 (en) 1994-09-22

Family

ID=6428150

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13109/92A Expired AU653210B2 (en) 1991-03-25 1992-03-24 Long-acting biodegradable microparticles and a process for their preparation

Country Status (20)

Country Link
EP (1) EP0505966B1 (en)
JP (1) JP3346789B2 (en)
KR (1) KR100203253B1 (en)
AT (1) ATE124254T1 (en)
AU (1) AU653210B2 (en)
CA (1) CA2063883C (en)
CY (1) CY2032A (en)
CZ (1) CZ284756B6 (en)
DE (1) DE59202649D1 (en)
DK (1) DK0505966T3 (en)
ES (1) ES2076592T3 (en)
FI (1) FI99084C (en)
HR (1) HRP940838B1 (en)
IE (1) IE67555B1 (en)
IL (1) IL101346A0 (en)
MY (1) MY109719A (en)
NO (1) NO302856B1 (en)
NZ (1) NZ242073A (en)
YU (1) YU48420B (en)
ZA (1) ZA922130B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69220317T2 (en) * 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Microparticle summary for extended release and manufacture of the same
JP2651320B2 (en) * 1992-07-16 1997-09-10 田辺製薬株式会社 Method for producing sustained-release microsphere preparation
AU4198793A (en) * 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
HU221308B1 (en) * 1992-10-26 2002-09-28 Sanol Arznei Schwarz Gmbh Process for producing microcapsules
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
KR100321854B1 (en) * 1998-12-30 2002-08-28 동국제약 주식회사 Long-term sustained-release microspheres containing luteinizing hormone releasing hormone homologues and a method of producing the same
US20040146561A1 (en) 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
WO2002094320A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Therapeutic compositions for repairing chondropathy
EP1532985B1 (en) * 2002-06-25 2016-10-12 Takeda Pharmaceutical Company Limited Process for producing a sustained-release composition
WO2005092301A1 (en) * 2004-03-26 2005-10-06 Universita' Degli Studi Di Parma Insulin highly respirable microparticles
KR100722607B1 (en) 2006-05-11 2007-05-28 주식회사 펩트론 A process of preparing microspheres for sustained release having improved dispersibility and syringeability
FR2934856B1 (en) * 2008-08-05 2010-08-13 Servier Lab NEW PROCESS FOR OBTAINING THE V-CRYSTALLINE FORM OF AGOMELATIN
BR102012011209A2 (en) * 2012-05-11 2014-03-25 Bioactive Biomateriais Ltda BIODEGRADABLE THREE-DIMENSIONAL MATERIAL AND BIODEGRADABLE THREE-DIMENSIONAL MATERIAL PREPARATION PROCESS
CN105963257B (en) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 Preparation method of sustained-release particles
CN105963258B (en) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 Preparation method of sustained-release particles
CN109985585A (en) * 2019-05-13 2019-07-09 苏州岸谷纳米技术有限公司 A kind of fast preparation method of Biodegradable high molecular microballoon

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600089B2 (en) * 1987-02-12 1990-08-02 Hoechst Aktiengesellschaft Multi-component long-acting medicament formulation for implantation
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
AU611944B2 (en) * 1987-09-21 1991-06-27 Debio Recherche Pharmaceutique S.A. Water insoluble polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053549T3 (en) * 1986-08-11 1994-08-01 Innovata Biomed Ltd A PROCESS FOR THE PREPARATION OF AN APPROPRIATE PHARMACEUTICAL FORMULATION FOR INHALATION.
DE3738228A1 (en) * 1987-11-11 1989-05-24 Hoechst Ag METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
AU600089B2 (en) * 1987-02-12 1990-08-02 Hoechst Aktiengesellschaft Multi-component long-acting medicament formulation for implantation
AU611944B2 (en) * 1987-09-21 1991-06-27 Debio Recherche Pharmaceutique S.A. Water insoluble polypeptides

Also Published As

Publication number Publication date
ATE124254T1 (en) 1995-07-15
EP0505966A1 (en) 1992-09-30
NO302856B1 (en) 1998-05-04
NO921147L (en) 1992-09-28
CS88792A3 (en) 1992-10-14
AU1310992A (en) 1992-10-01
KR920017645A (en) 1992-10-21
CA2063883C (en) 2001-12-11
JPH0570363A (en) 1993-03-23
FI99084C (en) 1997-10-10
YU26392A (en) 1994-12-28
HRP940838A2 (en) 1997-06-30
IL101346A0 (en) 1992-11-15
ZA922130B (en) 1992-11-25
KR100203253B1 (en) 1999-06-15
DK0505966T3 (en) 1995-10-30
NO921147D0 (en) 1992-03-24
DE59202649D1 (en) 1995-08-03
JP3346789B2 (en) 2002-11-18
CY2032A (en) 1998-02-20
HRP940838B1 (en) 2000-12-31
NZ242073A (en) 1993-08-26
FI921248A0 (en) 1992-03-23
IE67555B1 (en) 1996-04-17
FI99084B (en) 1997-06-30
YU48420B (en) 1998-07-10
FI921248A (en) 1992-09-26
CZ284756B6 (en) 1999-02-17
MY109719A (en) 1997-05-31
ES2076592T3 (en) 1995-11-01
IE920956A1 (en) 1992-10-07
EP0505966B1 (en) 1995-06-28
CA2063883A1 (en) 1992-09-26

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