CY1124934T1 - Πολυνουκλεοτιδια που περιεχουν μια σταθεροποιητικη περιοχη ουρας - Google Patents

Πολυνουκλεοτιδια που περιεχουν μια σταθεροποιητικη περιοχη ουρας

Info

Publication number
CY1124934T1
CY1124934T1 CY20221100072T CY221100072T CY1124934T1 CY 1124934 T1 CY1124934 T1 CY 1124934T1 CY 20221100072 T CY20221100072 T CY 20221100072T CY 221100072 T CY221100072 T CY 221100072T CY 1124934 T1 CY1124934 T1 CY 1124934T1
Authority
CY
Cyprus
Prior art keywords
stabilizing region
polynucleotides containing
tail stabilizing
polynucleotides
tail
Prior art date
Application number
CY20221100072T
Other languages
English (en)
Inventor
Gabor Butora
Andrew W. Fraley
Edward John MIRACCO
Jennifer Nelson
Amy RHODEN-SMITH
Matthew Stanton
Original Assignee
Modernatx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx, Inc. filed Critical Modernatx, Inc.
Publication of CY1124934T1 publication Critical patent/CY1124934T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Η εφεύρεση παρουσιάζει πολυνουκλεοτίδια που κωδικοποιούν ένα πολυπεπτίδιο που περιλαμβάνει μία 3'-σταθεροποιητική περιοχή και που έχουν αυξημένη σταθερότητα σε σύγκριση με πολυνουκλεοτίδια άγριου τύπου.
CY20221100072T 2015-09-17 2022-01-27 Πολυνουκλεοτιδια που περιεχουν μια σταθεροποιητικη περιοχη ουρας CY1124934T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562220050P 2015-09-17 2015-09-17
US201662279466P 2016-01-15 2016-01-15
PCT/US2016/052451 WO2017049275A2 (en) 2015-09-17 2016-09-19 Polynucleotides containing a stabilizing tail region

Publications (1)

Publication Number Publication Date
CY1124934T1 true CY1124934T1 (el) 2023-01-05

Family

ID=58289752

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20221100072T CY1124934T1 (el) 2015-09-17 2022-01-27 Πολυνουκλεοτιδια που περιεχουν μια σταθεροποιητικη περιοχη ουρας

Country Status (13)

Country Link
US (1) US20180256750A1 (el)
EP (2) EP4101930A1 (el)
JP (2) JP2018527003A (el)
AU (2) AU2016324463B2 (el)
CA (1) CA2998370A1 (el)
CY (1) CY1124934T1 (el)
DK (1) DK3350333T3 (el)
ES (1) ES2908449T3 (el)
HK (1) HK1256703A1 (el)
PL (1) PL3350333T3 (el)
PT (1) PT3350333T (el)
SI (1) SI3350333T1 (el)
WO (1) WO2017049275A2 (el)

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Also Published As

Publication number Publication date
HK1256703A1 (zh) 2019-10-04
PT3350333T (pt) 2022-03-02
ES2908449T3 (es) 2022-04-29
AU2023200136A1 (en) 2023-02-09
AU2016324463B2 (en) 2022-10-27
WO2017049275A2 (en) 2017-03-23
JP2018527003A (ja) 2018-09-20
EP3350333B1 (en) 2021-10-27
US20180256750A1 (en) 2018-09-13
EP3350333A4 (en) 2019-09-04
DK3350333T3 (da) 2022-01-31
PL3350333T3 (pl) 2022-03-07
SI3350333T1 (sl) 2022-04-29
EP3350333A2 (en) 2018-07-25
JP2022160454A (ja) 2022-10-19
WO2017049275A3 (en) 2017-05-11
AU2016324463A1 (en) 2018-03-29
CA2998370A1 (en) 2017-03-23
EP4101930A1 (en) 2022-12-14

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