CY1124677T1 - (1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου - Google Patents

(1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου

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Publication number
CY1124677T1
CY1124677T1 CY20211100932T CY211100932T CY1124677T1 CY 1124677 T1 CY1124677 T1 CY 1124677T1 CY 20211100932 T CY20211100932 T CY 20211100932T CY 211100932 T CY211100932 T CY 211100932T CY 1124677 T1 CY1124677 T1 CY 1124677T1
Authority
CY
Cyprus
Prior art keywords
carboxamide
methods
methylocyclohexane
purine
amino
Prior art date
Application number
CY20211100932T
Other languages
English (en)
Inventor
Paul F. FERNANDEZ
Tracy L. GAEBELE
Lianfeng Huang
Matthew J. JACKSON
Matthew M. KREILEIN
Xiaoling Lu
Wenju Wu
Jean Xu
Zheng Chen
Original Assignee
Signal Pharmaceuticals, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharmaceuticals, Llc filed Critical Signal Pharmaceuticals, Llc
Publication of CY1124677T1 publication Critical patent/CY1124677T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχονται στο παρόν σκευάσματα, στερεές μορφές και μέθοδοι χρήσης που σχετίζονται με (1s,4s)-4-(2-(((3S,4R)-3-φθοροτετραϋδρο-2Η-πυραν-4-υλ)αμινο)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9Η-πουριν-9-υλ)-1-μεθυλκυκλοεξανο-1-καρβοξαμίδιο.
CY20211100932T 2016-04-01 2021-10-27 (1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου CY1124677T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317468P 2016-04-01 2016-04-01
PCT/US2017/025289 WO2017173218A1 (en) 2016-04-01 2017-03-31 Solid forms of (1s,4s)-4-(2-(((3s4r)-3-fluorotetrahydro-2h-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9h-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use

Publications (1)

Publication Number Publication Date
CY1124677T1 true CY1124677T1 (el) 2022-07-22

Family

ID=59960229

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100932T CY1124677T1 (el) 2016-04-01 2021-10-27 (1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου

Country Status (18)

Country Link
US (2) US10047090B2 (el)
EP (2) EP3845536A1 (el)
JP (1) JP6995058B2 (el)
CN (1) CN109819649B (el)
AU (1) AU2017240050B2 (el)
CA (1) CA3019105A1 (el)
CY (1) CY1124677T1 (el)
DK (1) DK3436019T3 (el)
ES (1) ES2895419T3 (el)
HR (1) HRP20211546T1 (el)
HU (1) HUE056631T2 (el)
LT (1) LT3436019T (el)
MX (1) MX2018011970A (el)
PL (1) PL3436019T3 (el)
PT (1) PT3436019T (el)
RS (1) RS62496B1 (el)
SI (1) SI3436019T1 (el)
WO (1) WO2017173218A1 (el)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201629063A (zh) 2014-10-06 2016-08-16 標誌製藥公司 經取代胺基嘌呤化合物、其組合物及用其之治療方法
BR112018070163A2 (pt) * 2016-04-01 2019-01-29 Signal Pharm Llc compostos de aminopurina substituída, composições e métodos de tratamento
US10604537B2 (en) * 2016-06-21 2020-03-31 Teva Pharmaceuticals International Gmbh Solid state forms of ixazomib citrate
US10543214B2 (en) 2017-10-04 2020-01-28 Celgene Corporation Compositions and methods of use of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide
EP3692041A1 (en) * 2017-10-04 2020-08-12 Celgene Corporation Processes for the preparation of cis-4 [2-{(3s.4r)-3-fluorooxan-4-yl]amino)-8-(2,4,6-trichloroanilino)-9h-purin-9-yl]-1-methylcyclohexane-1-carboxamide

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US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
FI109088B (fi) 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
US7723340B2 (en) 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
JP2009516707A (ja) 2005-11-18 2009-04-23 アストラゼネカ・アクチエボラーグ 固形製剤
JO3235B1 (ar) 2006-05-26 2018-03-08 Astex Therapeutics Ltd مركبات بيررولوبيريميدين و استعمالاتها
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BR112018070163A2 (pt) 2016-04-01 2019-01-29 Signal Pharm Llc compostos de aminopurina substituída, composições e métodos de tratamento

Also Published As

Publication number Publication date
EP3436019B1 (en) 2021-07-28
EP3845536A1 (en) 2021-07-07
EP3436019A1 (en) 2019-02-06
JP2019515889A (ja) 2019-06-13
CN109819649A (zh) 2019-05-28
AU2017240050B2 (en) 2021-12-16
CA3019105A1 (en) 2017-10-05
US20180362529A1 (en) 2018-12-20
AU2017240050A1 (en) 2018-10-11
US10047090B2 (en) 2018-08-14
CN109819649B (zh) 2023-02-28
PT3436019T (pt) 2021-11-04
EP3436019A4 (en) 2019-08-28
DK3436019T3 (da) 2021-10-11
LT3436019T (lt) 2021-10-25
HRP20211546T1 (hr) 2022-01-07
HUE056631T2 (hu) 2022-02-28
WO2017173218A1 (en) 2017-10-05
PL3436019T3 (pl) 2022-01-10
US20170283418A1 (en) 2017-10-05
SI3436019T1 (sl) 2021-12-31
ES2895419T3 (es) 2022-02-21
RS62496B1 (sr) 2021-11-30
JP6995058B2 (ja) 2022-02-21
US10513519B2 (en) 2019-12-24
MX2018011970A (es) 2019-05-20

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