CY1124677T1 - (1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου - Google Patents

(1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου

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Publication number
CY1124677T1
CY1124677T1 CY20211100932T CY211100932T CY1124677T1 CY 1124677 T1 CY1124677 T1 CY 1124677T1 CY 20211100932 T CY20211100932 T CY 20211100932T CY 211100932 T CY211100932 T CY 211100932T CY 1124677 T1 CY1124677 T1 CY 1124677T1
Authority
CY
Cyprus
Prior art keywords
carboxamide
methods
methylocyclohexane
purine
amino
Prior art date
Application number
CY20211100932T
Other languages
English (en)
Inventor
Paul F. FERNANDEZ
Tracy L. GAEBELE
Lianfeng Huang
Matthew J. JACKSON
Matthew M. KREILEIN
Xiaoling Lu
Wenju Wu
Jean Xu
Zheng Chen
Original Assignee
Signal Pharmaceuticals, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharmaceuticals, Llc filed Critical Signal Pharmaceuticals, Llc
Publication of CY1124677T1 publication Critical patent/CY1124677T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχονται στο παρόν σκευάσματα, στερεές μορφές και μέθοδοι χρήσης που σχετίζονται με (1s,4s)-4-(2-(((3S,4R)-3-φθοροτετραϋδρο-2Η-πυραν-4-υλ)αμινο)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9Η-πουριν-9-υλ)-1-μεθυλκυκλοεξανο-1-καρβοξαμίδιο.
CY20211100932T 2016-04-01 2021-10-27 (1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου CY1124677T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317468P 2016-04-01 2016-04-01
PCT/US2017/025289 WO2017173218A1 (en) 2016-04-01 2017-03-31 Solid forms of (1s,4s)-4-(2-(((3s4r)-3-fluorotetrahydro-2h-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9h-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use

Publications (1)

Publication Number Publication Date
CY1124677T1 true CY1124677T1 (el) 2022-07-22

Family

ID=59960229

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100932T CY1124677T1 (el) 2016-04-01 2021-10-27 (1s,4s)-4-(2-(((3s,4r)-3-φθoροtetpaϋδpo-2h-πypan-4-yλ)amino)-8-((2,4,6-τριχλωροφαινυλ)αμινο)-9η-πουριν-9-υλ)-1-μεθυλοκυκλοεξανο-1-καρβοξαμιδιο και μεθοδοι χρησης αυτου

Country Status (18)

Country Link
US (2) US10047090B2 (el)
EP (2) EP3845536A1 (el)
JP (1) JP6995058B2 (el)
CN (1) CN109819649B (el)
AU (1) AU2017240050B2 (el)
CA (1) CA3019105A1 (el)
CY (1) CY1124677T1 (el)
DK (1) DK3436019T3 (el)
ES (1) ES2895419T3 (el)
HR (1) HRP20211546T1 (el)
HU (1) HUE056631T2 (el)
LT (1) LT3436019T (el)
MX (1) MX2018011970A (el)
PL (1) PL3436019T3 (el)
PT (1) PT3436019T (el)
RS (1) RS62496B1 (el)
SI (1) SI3436019T1 (el)
WO (1) WO2017173218A1 (el)

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KR20230035424A (ko) 2014-10-06 2023-03-13 시그날 파마소티칼 엘엘씨 치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법
KR102356433B1 (ko) * 2016-04-01 2022-01-27 시그날 파마소티칼 엘엘씨 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법
US10604537B2 (en) * 2016-06-21 2020-03-31 Teva Pharmaceuticals International Gmbh Solid state forms of ixazomib citrate
CN111417634A (zh) * 2017-10-04 2020-07-14 细胞基因公司 用于制备顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的方法
BR112020006599B1 (pt) 2017-10-04 2024-02-20 Celgene Corporation Cápsulas compreendendo cis-4-[2-{[(3s,4r)-3-fluoro-oxan-4-il]amino}-8-(2,4,6-tricl oroanilino)-9h-purin-9-il]-1-metilciclohexano-1-carb oxamida

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IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
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KR102356433B1 (ko) 2016-04-01 2022-01-27 시그날 파마소티칼 엘엘씨 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법

Also Published As

Publication number Publication date
PL3436019T3 (pl) 2022-01-10
AU2017240050A1 (en) 2018-10-11
EP3436019B1 (en) 2021-07-28
HRP20211546T1 (hr) 2022-01-07
PT3436019T (pt) 2021-11-04
SI3436019T1 (sl) 2021-12-31
EP3845536A1 (en) 2021-07-07
ES2895419T3 (es) 2022-02-21
LT3436019T (lt) 2021-10-25
EP3436019A4 (en) 2019-08-28
JP6995058B2 (ja) 2022-02-21
CN109819649B (zh) 2023-02-28
CN109819649A (zh) 2019-05-28
MX2018011970A (es) 2019-05-20
DK3436019T3 (da) 2021-10-11
JP2019515889A (ja) 2019-06-13
US10513519B2 (en) 2019-12-24
RS62496B1 (sr) 2021-11-30
WO2017173218A1 (en) 2017-10-05
US20180362529A1 (en) 2018-12-20
US10047090B2 (en) 2018-08-14
EP3436019A1 (en) 2019-02-06
US20170283418A1 (en) 2017-10-05
AU2017240050B2 (en) 2021-12-16
CA3019105A1 (en) 2017-10-05
HUE056631T2 (hu) 2022-02-28

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