CY1123160T1 - Αποκαρβοξυλαση γλουταμικου οξεος (gad) για χρηση στην αγωγη αυτοανοσης παθησης - Google Patents
Αποκαρβοξυλαση γλουταμικου οξεος (gad) για χρηση στην αγωγη αυτοανοσης παθησηςInfo
- Publication number
- CY1123160T1 CY1123160T1 CY20201100694T CY201100694T CY1123160T1 CY 1123160 T1 CY1123160 T1 CY 1123160T1 CY 20201100694 T CY20201100694 T CY 20201100694T CY 201100694 T CY201100694 T CY 201100694T CY 1123160 T1 CY1123160 T1 CY 1123160T1
- Authority
- CY
- Cyprus
- Prior art keywords
- composition
- beta cell
- antigen
- vitamin
- cell autoantigen
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 title 1
- 235000013922 glutamic acid Nutrition 0.000 title 1
- 239000004220 glutamic acid Substances 0.000 title 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 4
- 229930003316 Vitamin D Natural products 0.000 abstract 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 235000019166 vitamin D Nutrition 0.000 abstract 3
- 239000011710 vitamin D Substances 0.000 abstract 3
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 3
- 229940046008 vitamin d Drugs 0.000 abstract 3
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 abstract 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 abstract 1
- 229940045513 CTLA4 antagonist Drugs 0.000 abstract 1
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000001165 lymph node Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000003614 tolerogenic effect Effects 0.000 abstract 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 abstract 1
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01005—Acetolactate decarboxylase (4.1.1.5)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Η παρούσα εφεύρεση σχετίζεται με μέθοδο για πρόληψη και/ή αγωγή αυτοάνοσης πάθησης, περιλαμβάνουσα χορήγηση διατιθέμενης σύνθεσης, με την εν λόγω σύνθεση να περιλαμβάνει έστω ένα αυτοαντιγόνο βήτα κυττάρων, σε υποκείμενο. Το υποκείμενο είναι δυνατόν να έχει επίπεδο βιταμίνης-D ορού πάνω από 50 nanomole/λίτρο ή η σύνθεση είναι δυνατόν να χορηγηθεί μέσω ενδολεμφικής ένεσης ή ένεσης απευθείας σε λεμφαδένα, ή στην περίοδο εβδομάδων, μηνών ή ετών. Η εφεύρεση επίσης σχετίζεται με σύνθεση περιλαμβάνουσα πλήθος σωματιδίων, με έκαστο να φέρει ακινητοποιημένο πάνω στην επιφάνεια του τουλάχιστον ένα πρώτο και τουλάχιστον ένα δεύτερο αντιγόνο, όπου το πρώτο αντιγόνο είναι αυτοαντιγόνο βήτα κυττάρων, και το δεύτερο αντιγόνο είναι είτε ανεκτικογόνο ή αυτοαντιγόνο βήτα κυττάρων, και με σύνθεση περιλαμβάνουσα i) τουλάχιστον ένα αυτοαντιγόνο βήτα κυττάρων, και τουλάχιστον ένα από iia) IL-10 επάγουσα ένωση επιλεγόμενη από την ομάδα που αποτελείται από βιταμίνη-D, ανάλογα βιταμίνης-D, αναστολείς τυροσινοκινάσης, γαμμα-αμινοβουτυρικό οξύ, και ανάλογα γαμμα-αμινο βουτυρικού οξέος• και iib) ένωση η οποία μειώνει την ικανότητα των δενδριτικών κυττάρων να ενεργοποιούν αδαή CD4+ Τ κύτταρα, όπως αναστολέα κυκλοοξυγονάσης, CTLA-4 ένωση ή αναστολέα TNF άλφα. Η εφεύρεση επίσης σχετίζεται με φαρμακευτικά κιτ και με την ιατρική χρήση αυτοαντιγόνων βήτα κυττάρων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450678 | 2014-06-04 | ||
| SE1451315 | 2014-11-04 | ||
| PCT/SE2015/050651 WO2015187087A2 (en) | 2014-06-04 | 2015-06-04 | Novel combinations for antigen based therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123160T1 true CY1123160T1 (el) | 2021-10-29 |
Family
ID=54767532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100694T CY1123160T1 (el) | 2014-06-04 | 2020-07-28 | Αποκαρβοξυλαση γλουταμικου οξεος (gad) για χρηση στην αγωγη αυτοανοσης παθησης |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20170196949A1 (el) |
| EP (2) | EP3760224A3 (el) |
| JP (2) | JP6686007B2 (el) |
| CN (2) | CN106535926B (el) |
| AU (3) | AU2015268960B2 (el) |
| CA (2) | CA3210184A1 (el) |
| CY (1) | CY1123160T1 (el) |
| DK (1) | DK3151853T3 (el) |
| ES (1) | ES2807787T3 (el) |
| HU (1) | HUE051151T2 (el) |
| IL (3) | IL300130B1 (el) |
| LT (1) | LT3151853T (el) |
| PL (1) | PL3151853T3 (el) |
| PT (1) | PT3151853T (el) |
| RS (1) | RS60581B1 (el) |
| RU (2) | RU2702632C2 (el) |
| SI (1) | SI3151853T1 (el) |
| WO (1) | WO2015187087A2 (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018133139A1 (zh) | 2017-01-21 | 2018-07-26 | 宁波知明生物科技有限公司 | 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用 |
| EP4300102A3 (en) | 2017-09-08 | 2024-01-24 | Diamyd Medical AB | Improved immunotherapy |
| US20210077587A1 (en) * | 2017-09-08 | 2021-03-18 | Diamyd Medical Ab | Genotype stratification in diabetes treatment and prevention |
| US20200360496A1 (en) * | 2018-02-05 | 2020-11-19 | Diamyd Medical Ab | Novel composition and use thereof |
| WO2019173533A1 (en) * | 2018-03-07 | 2019-09-12 | Athenex HK Innovative Limited | Compositions and methods for treating hyperproliferative skin disorders |
| US10500217B2 (en) | 2018-04-30 | 2019-12-10 | Leslie Ray Matthews, M.D., Llc | Vitamin D3, heat shock proteins, and glutathione for the treatment of chronic inflammation and chronic diseases |
| WO2020210798A1 (en) * | 2019-04-12 | 2020-10-15 | Loma Linda University | Methods for treatment of niemann-pick disease type c |
| WO2022155188A1 (en) * | 2021-01-13 | 2022-07-21 | University Of Maryland, College Park | Methods and platforms for promoting antigen-specific tolerance in the treatment of type 1 diabetes and graft rejection and compositions relating thereto |
| TW202315884A (zh) * | 2021-06-17 | 2023-04-16 | 英商法姆製藥責任有限公司 | 使用衍生自患者之抗原特異性調節ｔ細胞的個體化細胞療法 |
| WO2023066881A1 (en) * | 2021-10-18 | 2023-04-27 | Astrazeneca Ab | Inhibition of map3k15 for treating and preventing diabetes |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674978A (en) * | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
| US5853723A (en) * | 1995-09-21 | 1998-12-29 | University Of Utah Research Foundation | Targeting of peg antibody conjugates to islet cells |
| SE9503379D0 (sv) * | 1995-09-29 | 1995-09-29 | Synectics Medical Ab | A modified GAD, a method for producing a modified GAD, a method for supplying a modified GAD, a peptide and the use of an ordinary and/or a modified GAD |
| US6884785B2 (en) * | 1999-06-17 | 2005-04-26 | The Scripps Research Institute | Compositions and methods for the treatment or prevention of autoimmune diabetes |
| CA2435758C (en) * | 2001-11-21 | 2016-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Polynucleotide therapy against autoantigens for treating insulin dependent diabetes mellitus |
| US20050152914A1 (en) * | 2003-06-13 | 2005-07-14 | Diamyd, Inc. | Formulation of antigen |
| AU2005213449A1 (en) * | 2004-02-04 | 2005-08-25 | The La Jolla Institute For Allergy And Immunology | Anti-CD3 and antigen-specific immunotherapy to treat autoimmunity |
| EP1755631A2 (en) * | 2004-03-03 | 2007-02-28 | Diamyd Medical AB | Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes |
| CN101365494A (zh) * | 2005-10-05 | 2009-02-11 | 贝希尔治疗学股份有限公司 | 治疗自身免疫性疾病的组合物和方法 |
| JP5694668B2 (ja) * | 2006-12-29 | 2015-04-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 自己免疫疾患の診断上および治療上の標的ならびにその用途 |
| KR20100022022A (ko) * | 2007-04-24 | 2010-02-26 | 다이아미드 쎄라퓨틱스 아베 | 자가면역 질환 및 암을 치료하기 위한 의약 및 방법 |
| EP2630967A1 (en) * | 2007-10-12 | 2013-08-28 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| EP2219669A4 (en) * | 2007-12-19 | 2011-03-09 | Mivac Dev Aktiebolag | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE AND ALLERGIC DISEASES |
| EP3753410A3 (en) * | 2010-09-28 | 2021-04-28 | The Regents Of The University Of California | Combinations comprising gaba agonists in treatment of hyperglycemia |
| WO2012062697A1 (en) * | 2010-11-08 | 2012-05-18 | Novartis Ag | Combination therapy for type 1 diabetes |
| US8735359B2 (en) * | 2012-05-24 | 2014-05-27 | Orban Biotech Llc | Combinations of modalities for the treatment of diabetes |
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2015
- 2015-06-04 DK DK15802815.9T patent/DK3151853T3/da active
- 2015-06-04 ES ES15802815T patent/ES2807787T3/es active Active
- 2015-06-04 JP JP2017516633A patent/JP6686007B2/ja active Active
- 2015-06-04 LT LTEP15802815.9T patent/LT3151853T/lt unknown
- 2015-06-04 AU AU2015268960A patent/AU2015268960B2/en active Active
- 2015-06-04 EP EP20172919.1A patent/EP3760224A3/en active Pending
- 2015-06-04 CN CN201580040912.4A patent/CN106535926B/zh active Active
- 2015-06-04 PL PL15802815T patent/PL3151853T3/pl unknown
- 2015-06-04 SI SI201531269T patent/SI3151853T1/sl unknown
- 2015-06-04 RU RU2016150656A patent/RU2702632C2/ru active
- 2015-06-04 WO PCT/SE2015/050651 patent/WO2015187087A2/en active Application Filing
- 2015-06-04 HU HUE15802815A patent/HUE051151T2/hu unknown
- 2015-06-04 PT PT158028159T patent/PT3151853T/pt unknown
- 2015-06-04 US US15/315,557 patent/US20170196949A1/en not_active Abandoned
- 2015-06-04 IL IL300130A patent/IL300130B1/en unknown
- 2015-06-04 EP EP15802815.9A patent/EP3151853B1/en active Active
- 2015-06-04 CN CN202210193065.7A patent/CN114504639A/zh active Pending
- 2015-06-04 RS RS20200789A patent/RS60581B1/sr unknown
- 2015-06-04 CA CA3210184A patent/CA3210184A1/en active Pending
- 2015-06-04 RU RU2019129803A patent/RU2019129803A/ru unknown
- 2015-06-04 CA CA2950893A patent/CA2950893C/en active Active
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