CY1122937T1 - Επιτοποι πρωτεϊνης f αναπνευστικου συγκυτιακου ιου - Google Patents
Επιτοποι πρωτεϊνης f αναπνευστικου συγκυτιακου ιουInfo
- Publication number
- CY1122937T1 CY1122937T1 CY20201100248T CY201100248T CY1122937T1 CY 1122937 T1 CY1122937 T1 CY 1122937T1 CY 20201100248 T CY20201100248 T CY 20201100248T CY 201100248 T CY201100248 T CY 201100248T CY 1122937 T1 CY1122937 T1 CY 1122937T1
- Authority
- CY
- Cyprus
- Prior art keywords
- rsv
- children
- age
- virus
- protein epitopes
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 208000002330 Congenital Heart Defects Diseases 0.000 abstract 1
- 241000709661 Enterovirus Species 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000001010 compromised effect Effects 0.000 abstract 1
- 208000028831 congenital heart disease Diseases 0.000 abstract 1
- 230000034994 death Effects 0.000 abstract 1
- 231100000517 death Toxicity 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Ο Αναπνευστικός Συγκυτιακός Ιός είναι ένας κοινός ιός κρυολογήματος που ανήκει στην οικογένεια του παραμυξοϊού. Ο RSV είναι λοιμογόνος, εύκολα μεταδιδόμενος και η συνηθέστερη αιτία ασθένειας της κατώτερης αναπνευστικής οδού σε παιδιά ηλικίας κάτω των 2 ετών. Μέχρι 98% των παιδιών που ακολουθούν ημερήσια φροντίδα θα μολυνθούν σε μια μόνο εποχή RSV. Μεταξύ 0.5% και 3.2% των παιδιών με λοίμωξη RSV απαιτούν νοσηλεία. Περίπου 90,000 εισαγωγές στο νοσοκομείο και 4500 θάνατοι ετησίως αναφέρθηκαν στις Ηνωμένες Πολιτείες. Οι κύριοι παράγοντες κινδύνου για νοσηλεία λόγω RSV είναι η πρόωρη γέννηση, η χρόνια πνευμονική νόσος, η συγγενής καρδιοπάθεια, η διακυβευμένη ανοσία, και η ηλικία κάτω των 6 εβδομάδων σε υγιή, κατά τα άλλα παιδιά.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759664P | 2013-02-01 | 2013-02-01 | |
| US201361783380P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/014054 WO2014121021A1 (en) | 2013-02-01 | 2014-01-31 | Respiratory syncytial virus f protein epitopes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122937T1 true CY1122937T1 (el) | 2020-10-14 |
Family
ID=51262966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100248T CY1122937T1 (el) | 2013-02-01 | 2020-03-18 | Επιτοποι πρωτεϊνης f αναπνευστικου συγκυτιακου ιου |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10016496B2 (el) |
| EP (1) | EP2950886B1 (el) |
| JP (1) | JP6450688B2 (el) |
| CN (1) | CN105073196B (el) |
| AU (1) | AU2014212268B2 (el) |
| CA (1) | CA2900110A1 (el) |
| CY (1) | CY1122937T1 (el) |
| DK (1) | DK2950886T3 (el) |
| ES (1) | ES2778899T3 (el) |
| HR (1) | HRP20200404T1 (el) |
| LT (1) | LT2950886T (el) |
| PL (1) | PL2950886T3 (el) |
| PT (1) | PT2950886T (el) |
| RS (1) | RS60056B1 (el) |
| SI (1) | SI2950886T1 (el) |
| WO (1) | WO2014121021A1 (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| PL3094353T3 (pl) | 2014-01-15 | 2020-09-07 | Medimmune, Llc | Przeciwciała swoiste pod kątem RSV i ich funkcjonalne części |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| JP7265984B2 (ja) * | 2016-10-21 | 2023-04-27 | アディマブ， エルエルシー | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| WO2018075974A2 (en) * | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| IL303833A (en) | 2016-10-21 | 2023-08-01 | Adimab Llc | Respiratory syncytial virus antibodies and methods for their production and use |
| TWI683826B (zh) * | 2016-11-22 | 2020-02-01 | 國立臺灣大學 | 重組ｒｓｖ抗原 |
| TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| US12024553B2 (en) | 2019-04-30 | 2024-07-02 | Medimmune Limited | Dosage regimens for and compositions including anti-RSV antibodies |
| CN111208307B (zh) * | 2020-04-21 | 2020-07-17 | 上海普铭生物科技有限公司 | 一种与参照分子具有相同或不同的靶蛋白结合的分子的筛选方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US20020018780A1 (en) * | 2000-05-25 | 2002-02-14 | Scott Koenig | Epitope-based vaccine for respiratory syncytial virus F-protein |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| AU2009236585B2 (en) * | 2008-04-18 | 2013-03-07 | Vaxinnate Corporation | Deletion mutants of flagellin and methods of use |
| EP2408477A4 (en) * | 2009-03-16 | 2013-03-27 | Sanofi Pasteur Biologics Llc | REPLICATION DEFECTS FLAVIVIRUS VACCINE VACCINATORS AGAINST RESPIRATORY SYNZYTIAL VIRUS |
| MX338063B (es) | 2009-10-06 | 2016-04-01 | Medimmune Ltd | Molecula de union especifica al rsv. |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| CN102753582A (zh) * | 2009-11-03 | 2012-10-24 | 莱戈赛特医药股份有限公司 | 嵌合RSV-F多肽、和慢病毒或α-反转录病毒GAG基VLP |
| WO2012089231A1 (en) | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
| DK2970398T3 (da) | 2013-03-13 | 2024-08-05 | Us Health | Præfusions-rsv-f-proteiner og anvendelse deraf |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| US9060975B2 (en) | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
-
2014
- 2014-01-31 SI SI201431530T patent/SI2950886T1/sl unknown
- 2014-01-31 CA CA2900110A patent/CA2900110A1/en not_active Abandoned
- 2014-01-31 PT PT147467500T patent/PT2950886T/pt unknown
- 2014-01-31 EP EP14746750.0A patent/EP2950886B1/en active Active
- 2014-01-31 PL PL14746750T patent/PL2950886T3/pl unknown
- 2014-01-31 AU AU2014212268A patent/AU2014212268B2/en active Active
- 2014-01-31 JP JP2015556154A patent/JP6450688B2/ja active Active
- 2014-01-31 LT LTEP14746750.0T patent/LT2950886T/lt unknown
- 2014-01-31 WO PCT/US2014/014054 patent/WO2014121021A1/en active Application Filing
- 2014-01-31 ES ES14746750T patent/ES2778899T3/es active Active
- 2014-01-31 US US14/764,635 patent/US10016496B2/en active Active
- 2014-01-31 DK DK14746750.0T patent/DK2950886T3/da active
- 2014-01-31 RS RS20200305A patent/RS60056B1/sr unknown
- 2014-01-31 CN CN201480007046.4A patent/CN105073196B/zh active Active
-
2020
- 2020-03-12 HR HRP20200404TT patent/HRP20200404T1/hr unknown
- 2020-03-18 CY CY20201100248T patent/CY1122937T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014121021A1 (en) | 2014-08-07 |
| EP2950886A4 (en) | 2016-09-07 |
| SI2950886T1 (sl) | 2020-06-30 |
| JP6450688B2 (ja) | 2019-01-09 |
| EP2950886A1 (en) | 2015-12-09 |
| CA2900110A1 (en) | 2014-08-07 |
| EP2950886B1 (en) | 2019-12-18 |
| CN105073196A (zh) | 2015-11-18 |
| HRP20200404T1 (hr) | 2020-06-12 |
| US10016496B2 (en) | 2018-07-10 |
| JP2016508503A (ja) | 2016-03-22 |
| CN105073196B (zh) | 2020-04-07 |
| ES2778899T3 (es) | 2020-08-12 |
| PL2950886T3 (pl) | 2020-06-01 |
| RS60056B1 (sr) | 2020-04-30 |
| DK2950886T3 (da) | 2020-03-23 |
| US20150366960A1 (en) | 2015-12-24 |
| AU2014212268B2 (en) | 2018-07-19 |
| PT2950886T (pt) | 2020-03-26 |
| AU2014212268A1 (en) | 2015-08-20 |
| LT2950886T (lt) | 2020-07-10 |
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