CY1118544T1 - Προσδιορισμος ολικου αιματος - Google Patents
Προσδιορισμος ολικου αιματοςInfo
- Publication number
- CY1118544T1 CY1118544T1 CY20171100101T CY171100101T CY1118544T1 CY 1118544 T1 CY1118544 T1 CY 1118544T1 CY 20171100101 T CY20171100101 T CY 20171100101T CY 171100101 T CY171100101 T CY 171100101T CY 1118544 T1 CY1118544 T1 CY 1118544T1
- Authority
- CY
- Cyprus
- Prior art keywords
- time
- sample
- dependent
- physical property
- test
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title abstract 2
- 230000036962 time dependent Effects 0.000 abstract 4
- 239000000523 sample Substances 0.000 abstract 3
- 238000012360 testing method Methods 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 210000003743 erythrocyte Anatomy 0.000 abstract 2
- 238000005534 hematocrit Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000000704 physical effect Effects 0.000 abstract 2
- 239000013076 target substance Substances 0.000 abstract 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- 239000012491 analyte Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 239000013610 patient sample Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Ecology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Μία μέθοδος και συσκευή για εκτίμηση της συγκέντρωσης μιας ουσίας στόχου (π.χ. Χοληστερόλης ή CRP) στο συστατικό πλάσματος ενός δείγματος ολικού αίματος χωρίς την ανάγκη διαχωρισμού των ερυθρών αιμοσφαιρίων από το πλάσμα πριν από την δοκιμασία, απλοποιώντας έτσι τον σχεδιασμό και την κατασκευή της συσκευής δοκιμασίας. Η εφεύρεση το επιτυγχάνει αυτό μέσω μέτρησης του υπό εξέταση αναλυτή σε μια χρονοεξαρτώμενη (βιο-/ανοσο-) χημική αντίδραση και μετρώντας ξεχωριστά, μια ουσία δείκτη (π.χ. αιμοσφαιρίνη) για την εκτίμηση του όγκου των ερυθρών αιμοσφαιρίων, χρησιμοποιώντας μια μη-χρονοεξαρτώμενη μεταβολή σε φυσική ιδιότητα του μείγματος της αντίδρασης (σε αυτή την περίπτωση, της διαπερατότητας) η οποία αποδίδεται σε εγγενείς επιδράσεις φίλτρου κατά την προσθήκη του δείγματος. Αυτές οι μη-χρονοεξαρτώμενες μεταβολές δεν αποτελούν μέρος της χημείας της αντίδρασης, και διαχωρίζονται από την χρονοεξαρτώμενη χρόνο μεταβολή στη φυσική ιδιότητα η οποία προκαλείται από την χημεία του προσδιορισμού με συνεχή μέτρηση και μαθηματική μοντελοποίηση. Αλγόριθμοι οι οποίοι συνδυάζουν αυτές τις δύο παραμέτρους χρησιμοποιούνται για εκτίμηση της ουσίας στόχου και αντιστάθμιση των διακυμάνσεων του ποσοστού του αιματοκρίτη του δείγματος. Η μέθοδος εξισώνει την απόκριση του προσδιορισμού για λεπτές διακυμάνσεις στο δείγμα του ασθενούς (π.χ. αιματοκρίτη).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0705495.0A GB0705495D0 (en) | 2007-03-22 | 2007-03-22 | Whole blood assay |
| PCT/GB2008/050204 WO2008114060A1 (en) | 2007-03-22 | 2008-03-20 | Whole blood assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118544T1 true CY1118544T1 (el) | 2017-07-12 |
Family
ID=38024627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100101T CY1118544T1 (el) | 2007-03-22 | 2017-01-24 | Προσδιορισμος ολικου αιματος |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7943331B2 (el) |
| EP (1) | EP2135075B8 (el) |
| JP (1) | JP5006441B2 (el) |
| CN (1) | CN101680876A (el) |
| CY (1) | CY1118544T1 (el) |
| DK (1) | DK2135075T3 (el) |
| GB (1) | GB0705495D0 (el) |
| LT (1) | LT2135075T (el) |
| PL (1) | PL2135075T3 (el) |
| WO (1) | WO2008114060A1 (el) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5806884B2 (ja) * | 2010-09-24 | 2015-11-10 | 株式会社堀場製作所 | 全血免疫測定装置及び全血免疫測定方法 |
| EP2751575B1 (en) | 2011-11-11 | 2018-09-12 | Axis-Shield AS | Blood sample assay method |
| JP6111323B2 (ja) * | 2012-04-19 | 2017-04-05 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 血液中の検体濃度を測定する方法および装置 |
| WO2014004935A2 (en) | 2012-06-27 | 2014-01-03 | Siscapa Assay Technologies, Inc. | Multipurpose mass spectrometric assay panels for peptides |
| CN103336130B (zh) * | 2013-06-21 | 2016-03-16 | 嘉善加斯戴克医疗器械有限公司 | 一种全血免疫分析装置及使用此装置的血液分析仪 |
| CN107656085B (zh) * | 2014-07-01 | 2021-04-09 | 深圳迈瑞生物医疗电子股份有限公司 | 一种血液检测仪 |
| CN105334243A (zh) * | 2014-07-04 | 2016-02-17 | 深圳迈瑞生物医疗电子股份有限公司 | 一种血液分析仪 |
| CN105652017A (zh) * | 2016-02-02 | 2016-06-08 | 潍坊三维生物工程集团有限公司 | 检测lambda轻链含量的试剂盒、方法及用途 |
| KR20190076624A (ko) * | 2017-12-22 | 2019-07-02 | 삼성전자주식회사 | 검사 장치 및 그 제어방법 |
| LU100795B1 (en) | 2018-05-14 | 2019-11-14 | Diatron MI PLC | Immunoassay for whole blood samples |
| WO2020142840A1 (en) * | 2019-01-07 | 2020-07-16 | 1866402 Ontario Inc. | Blood separation and analysis device and methods |
| CN110514656B (zh) * | 2019-09-03 | 2020-09-29 | 华中科技大学 | 用于分析低温等离子体处理溶液中长寿命活性成分的方法 |
| CN112816425B (zh) * | 2019-11-15 | 2024-02-13 | 上海奥普生物医药股份有限公司 | 一种利用hgb校准能力优化全血样本检测流程的方法 |
| DK180849B1 (en) * | 2019-12-31 | 2022-05-17 | Qlife Aps | Method and device for analysis of liquid samples |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH079427B2 (ja) * | 1985-10-21 | 1995-02-01 | 株式会社トクヤマ | 抗原又は抗体濃度の測定方法 |
| JP3780599B2 (ja) * | 1996-02-09 | 2006-05-31 | 日本光電工業株式会社 | 抗原抗体反応物質の測定方法 |
| US6475372B1 (en) * | 2000-02-02 | 2002-11-05 | Lifescan, Inc. | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
| JP2000262298A (ja) | 1999-03-15 | 2000-09-26 | Fuji Photo Film Co Ltd | 全血中のグルコース濃度もしくはコレステロール濃度の定量方法 |
| EP1467206A1 (en) * | 2003-04-08 | 2004-10-13 | Roche Diagnostics GmbH | Biosensor system |
| KR100554649B1 (ko) * | 2003-06-09 | 2006-02-24 | 주식회사 아이센스 | 전기화학적 바이오센서 |
| WO2005018443A1 (en) * | 2003-08-15 | 2005-03-03 | Animas Technologies Llc | Microprocessors, devices, and methods for use in monitoring of physiological analytes |
| WO2005074550A2 (en) * | 2004-01-30 | 2005-08-18 | 3Wave Optics, Llc | Non-invasive blood component measurement system |
| JP4805564B2 (ja) * | 2004-10-22 | 2011-11-02 | シスメックス株式会社 | 生体試料分析装置および方法 |
| GB0503836D0 (en) * | 2005-02-24 | 2005-04-06 | Axis Shield Asa | Method |
| US7964089B2 (en) * | 2005-04-15 | 2011-06-21 | Agamatrix, Inc. | Analyte determination method and analyte meter |
| US20060281187A1 (en) * | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
-
2007
- 2007-03-22 GB GBGB0705495.0A patent/GB0705495D0/en not_active Ceased
-
2008
- 2008-03-20 CN CN200880015805A patent/CN101680876A/zh active Pending
- 2008-03-20 EP EP08719049.2A patent/EP2135075B8/en active Active
- 2008-03-20 LT LTEP08719049.2T patent/LT2135075T/lt unknown
- 2008-03-20 DK DK08719049.2T patent/DK2135075T3/en active
- 2008-03-20 JP JP2010500366A patent/JP5006441B2/ja active Active
- 2008-03-20 PL PL08719049T patent/PL2135075T3/pl unknown
- 2008-03-20 WO PCT/GB2008/050204 patent/WO2008114060A1/en active Application Filing
- 2008-03-20 US US12/532,596 patent/US7943331B2/en active Active
-
2017
- 2017-01-24 CY CY20171100101T patent/CY1118544T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2135075T3 (pl) | 2017-05-31 |
| GB0705495D0 (en) | 2007-05-02 |
| EP2135075B1 (en) | 2016-10-26 |
| CN101680876A (zh) | 2010-03-24 |
| JP5006441B2 (ja) | 2012-08-22 |
| US7943331B2 (en) | 2011-05-17 |
| EP2135075B8 (en) | 2017-04-12 |
| JP2010522336A (ja) | 2010-07-01 |
| WO2008114060A1 (en) | 2008-09-25 |
| LT2135075T (lt) | 2017-02-10 |
| DK2135075T3 (en) | 2017-02-06 |
| US20100075338A1 (en) | 2010-03-25 |
| EP2135075A1 (en) | 2009-12-23 |
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