CY1117529T1 - Παραγωγα 6-κυκλοαμινο-3-(1η-πυρρολο[2,3-β]πυριδιν-4-υλ)ιμιδαζο [1,2-β]πυριδαζινης, παρασκευη αυτων και θεραπευτικη χρηση αυτων - Google Patents
Παραγωγα 6-κυκλοαμινο-3-(1η-πυρρολο[2,3-β]πυριδιν-4-υλ)ιμιδαζο [1,2-β]πυριδαζινης, παρασκευη αυτων και θεραπευτικη χρηση αυτωνInfo
- Publication number
- CY1117529T1 CY1117529T1 CY20161100152T CY161100152T CY1117529T1 CY 1117529 T1 CY1117529 T1 CY 1117529T1 CY 20161100152 T CY20161100152 T CY 20161100152T CY 161100152 T CY161100152 T CY 161100152T CY 1117529 T1 CY1117529 T1 CY 1117529T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- groups
- pyrrolo
- imidazo
- pyridin
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η εφεύρεση αφορά παράγωγα 6-κυκλοαμινο-3-(1Η-πυρρολο[2,3-b]πυριδιν-4-υλ)ιμιδαζο[1,2-b]πυριδαζίνης, τα οποία αντιστοιχούν στον γενικό τύπο (1) στον οποίο το R2 αντιπροσωπεύει μια αρυλ ομάδα προαιρετικώς υποκατεστημένη από ένα ή περισσότερα άτομα αλογόνου ή C1-6-αλκυλ, C1-6-αλκυλοξυ, C1-6-αλκυλθειο, C1-6-φθοροαλκυλ, C1-6-φθοροαλκυλοξυ, -CN ομάδες ή το R2 αντιπροσωπεύει μια ομάδα η οποία επιλέγεται μεταξύ των ομάδων C1-6-αλκυλ, C1-6-φθοροαλκυλ, C3-7-κυκλοαλκυλ ή C3-7-κυκλοαλκυλ-C1-6-αλκυλ, το Α αντιπροσωπεύει μια C1-7-αλκυλενο ομάδα, το Β αντιπροσωπεύει μια C1-7-αλκυλενο ομάδα, το L αντιπροσωπεύει, είτε ένα άτομο αζώτου προαιρετικώς υποκατεστημένο από μια ομάδα Rc ή Rd, είτε ένα άτομο άνθρακα υποκατεστημένο από μια ομάδα Rc1 και μια ομάδα Rd ή δυο ομάδες Re2, με τα άτομα άνθρακα των Α και Β να είναι προαιρετικώς υποκατεστημένα από μια ή περισσότερες ομάδες Rf οι οποίες μπορεί να είναι ίδιες ή διαφορετικές η μια από την άλλη. Διαδικασία παρασκευής και θεραπευτική χρήση.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806723A FR2939134A1 (fr) | 2008-12-01 | 2008-12-01 | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
| EP09797121.2A EP2370446B1 (fr) | 2008-12-01 | 2009-11-30 | DÉRIVÉS DE 6-CYCLOAMINO-3-(1H-PYRROLO[2,3-b]PYRIDIN-4-YL)IMIDAZO[1,2-b]-PYRIDAZINE, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117529T1 true CY1117529T1 (el) | 2017-04-26 |
Family
ID=40383902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100152T CY1117529T1 (el) | 2008-12-01 | 2016-02-24 | Παραγωγα 6-κυκλοαμινο-3-(1η-πυρρολο[2,3-β]πυριδιν-4-υλ)ιμιδαζο [1,2-β]πυριδαζινης, παρασκευη αυτων και θεραπευτικη χρηση αυτων |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8546395B2 (el) |
| EP (1) | EP2370446B1 (el) |
| JP (1) | JP5677309B2 (el) |
| KR (1) | KR20110082094A (el) |
| CN (1) | CN102232079A (el) |
| AR (1) | AR074237A1 (el) |
| AU (1) | AU2009323968A1 (el) |
| BR (1) | BRPI0922760A2 (el) |
| CA (1) | CA2743560A1 (el) |
| CY (1) | CY1117529T1 (el) |
| DK (1) | DK2370446T3 (el) |
| ES (1) | ES2563085T3 (el) |
| FR (1) | FR2939134A1 (el) |
| HR (1) | HRP20160173T1 (el) |
| HU (1) | HUE028525T2 (el) |
| IL (1) | IL213208A0 (el) |
| MX (1) | MX2011005808A (el) |
| PA (1) | PA8849801A1 (el) |
| PL (1) | PL2370446T3 (el) |
| PT (1) | PT2370446E (el) |
| RS (1) | RS54656B1 (el) |
| RU (1) | RU2011126981A (el) |
| SG (1) | SG172757A1 (el) |
| SI (1) | SI2370446T1 (el) |
| TW (1) | TW201033209A (el) |
| UY (1) | UY32280A (el) |
| WO (1) | WO2010063929A1 (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20090188A1 (es) * | 2007-03-15 | 2009-03-20 | Novartis Ag | Compuestos heterociclicos como moduladores de la senda de hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| WO2012175591A1 (en) * | 2011-06-22 | 2012-12-27 | Bayer Intellectual Property Gmbh | Heterocyclyl aminoimidazopyridazines |
| WO2021190615A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Compounds as casein kinase inhibitors |
| IL312114A (en) | 2021-10-14 | 2024-06-01 | Incyte Corp | Quinoline compounds as Kras inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1747220T3 (da) | 2003-12-11 | 2009-08-10 | Aventis Pharma Inc | Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon |
| US7750000B2 (en) * | 2005-09-02 | 2010-07-06 | Bayer Schering Pharma Ag | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments |
| DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| AR064420A1 (es) * | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| JP2010526120A (ja) * | 2007-05-09 | 2010-07-29 | ノバルティス アーゲー | Ｐｉ３ｋ脂質キナーゼ阻害剤としての置換イミダゾピリダジン |
| TW200902008A (en) * | 2007-05-10 | 2009-01-16 | Smithkline Beecham Corp | Quinoxaline derivatives as PI3 kinase inhibitors |
| AR067326A1 (es) * | 2007-05-11 | 2009-10-07 | Novartis Ag | Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido |
| FR2918061B1 (fr) * | 2007-06-28 | 2010-10-22 | Sanofi Aventis | Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique. |
| FR2918986B1 (fr) * | 2007-07-19 | 2009-09-04 | Sanofi Aventis Sa | Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique |
-
2008
- 2008-12-01 FR FR0806723A patent/FR2939134A1/fr active Pending
-
2009
- 2009-11-25 PA PA20098849801A patent/PA8849801A1/es unknown
- 2009-11-30 MX MX2011005808A patent/MX2011005808A/es not_active Application Discontinuation
- 2009-11-30 ES ES09797121.2T patent/ES2563085T3/es active Active
- 2009-11-30 US US13/128,998 patent/US8546395B2/en not_active Expired - Fee Related
- 2009-11-30 HU HUE09797121A patent/HUE028525T2/hu unknown
- 2009-11-30 TW TW098140839A patent/TW201033209A/zh unknown
- 2009-11-30 CA CA2743560A patent/CA2743560A1/fr not_active Abandoned
- 2009-11-30 EP EP09797121.2A patent/EP2370446B1/fr active Active
- 2009-11-30 SI SI200931370T patent/SI2370446T1/sl unknown
- 2009-11-30 PL PL09797121T patent/PL2370446T3/pl unknown
- 2009-11-30 WO PCT/FR2009/052336 patent/WO2010063929A1/fr active Application Filing
- 2009-11-30 KR KR1020117015085A patent/KR20110082094A/ko not_active Application Discontinuation
- 2009-11-30 SG SG2011038361A patent/SG172757A1/en unknown
- 2009-11-30 RS RS20160093A patent/RS54656B1/en unknown
- 2009-11-30 BR BRPI0922760-1A patent/BRPI0922760A2/pt not_active IP Right Cessation
- 2009-11-30 JP JP2011538042A patent/JP5677309B2/ja not_active Expired - Fee Related
- 2009-11-30 DK DK09797121.2T patent/DK2370446T3/en active
- 2009-11-30 AU AU2009323968A patent/AU2009323968A1/en not_active Abandoned
- 2009-11-30 CN CN2009801481699A patent/CN102232079A/zh active Pending
- 2009-11-30 AR ARP090104598A patent/AR074237A1/es unknown
- 2009-11-30 RU RU2011126981/04A patent/RU2011126981A/ru unknown
- 2009-11-30 PT PT97971212T patent/PT2370446E/pt unknown
- 2009-12-01 UY UY0001032280A patent/UY32280A/es not_active Application Discontinuation
-
2011
- 2011-05-29 IL IL213208A patent/IL213208A0/en unknown
-
2016
- 2016-02-16 HR HRP20160173T patent/HRP20160173T1/hr unknown
- 2016-02-24 CY CY20161100152T patent/CY1117529T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2743560A1 (fr) | 2010-06-10 |
| RU2011126981A (ru) | 2013-01-10 |
| CN102232079A (zh) | 2011-11-02 |
| HRP20160173T1 (hr) | 2016-03-25 |
| JP5677309B2 (ja) | 2015-02-25 |
| EP2370446A1 (fr) | 2011-10-05 |
| TW201033209A (en) | 2010-09-16 |
| PT2370446E (pt) | 2016-03-22 |
| JP2012510453A (ja) | 2012-05-10 |
| AU2009323968A1 (en) | 2010-06-10 |
| US8546395B2 (en) | 2013-10-01 |
| DK2370446T3 (en) | 2016-02-22 |
| SG172757A1 (en) | 2011-08-29 |
| EP2370446B1 (fr) | 2015-11-25 |
| PL2370446T3 (pl) | 2016-05-31 |
| HUE028525T2 (hu) | 2016-12-28 |
| SI2370446T1 (sl) | 2016-03-31 |
| BRPI0922760A2 (pt) | 2018-11-06 |
| FR2939134A1 (fr) | 2010-06-04 |
| ES2563085T3 (es) | 2016-03-10 |
| IL213208A0 (en) | 2011-07-31 |
| KR20110082094A (ko) | 2011-07-15 |
| WO2010063929A1 (fr) | 2010-06-10 |
| RS54656B1 (en) | 2016-08-31 |
| UY32280A (es) | 2010-06-30 |
| US20120010208A1 (en) | 2012-01-12 |
| MX2011005808A (es) | 2011-10-11 |
| PA8849801A1 (es) | 2010-07-27 |
| AR074237A1 (es) | 2010-12-29 |
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