CY1116018T1 - Πλωτες φαρμακευτικες συνθεσεις ελεγχομενης απελευθερωσης - Google Patents

Πλωτες φαρμακευτικες συνθεσεις ελεγχομενης απελευθερωσης

Info

Publication number
CY1116018T1
CY1116018T1 CY20151100177T CY151100177T CY1116018T1 CY 1116018 T1 CY1116018 T1 CY 1116018T1 CY 20151100177 T CY20151100177 T CY 20151100177T CY 151100177 T CY151100177 T CY 151100177T CY 1116018 T1 CY1116018 T1 CY 1116018T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical
controlled free
compositions controlled
equal
less
Prior art date
Application number
CY20151100177T
Other languages
English (en)
Inventor
Catherine Castan
Philippe Caisse
Original Assignee
Flamel Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Technologies filed Critical Flamel Technologies
Publication of CY1116018T1 publication Critical patent/CY1116018T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μια φαρμακευτική σύνθεση περιλαμβάνουσα μία πληθώρα επικαλυμμένων μικροσωματιδίων ελεγχόμενης απελευθέρωσης, περιλαμβάνοντας έκαστο έναν πλωτό πυρήνα, στην επιφάνεια του οποίου εναποτίθεται ένα στρώμα περιέχον μία τουλάχιστον δραστική ουσία, επικαλυμμένο το εν λόγω στρώμα με μία επικάλυψη ελεγχόμενης απελευθέρωσης, χαρακτηριζόμενη από το ότι ο εν λόγω πλωτός πυρήνας αποτελείται από οξική φθαλική κυτταρίνη και παρουσιάζει φαινόμενη πυκνότητα μετά την καθίζηση, μικρότερη ή ίση των 0,6 g/mL, και τα εν λόγω επικαλυμμένα μικροσωματίδια παρουσιάζουν πυκνότητα μικρότερη ή ίση των 0,7 g/mL.
CY20151100177T 2009-05-29 2015-02-19 Πλωτες φαρμακευτικες συνθεσεις ελεγχομενης απελευθερωσης CY1116018T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0953601A FR2945947B1 (fr) 2009-05-29 2009-05-29 Compositions pharmaceutiques flottantes a liberation controlee
EP10728844.1A EP2435030B1 (fr) 2009-05-29 2010-05-28 Compositions pharmaceutiques flottantes à libération contrôlée

Publications (1)

Publication Number Publication Date
CY1116018T1 true CY1116018T1 (el) 2017-01-25

Family

ID=41470914

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100177T CY1116018T1 (el) 2009-05-29 2015-02-19 Πλωτες φαρμακευτικες συνθεσεις ελεγχομενης απελευθερωσης

Country Status (14)

Country Link
US (2) US9561179B2 (el)
EP (1) EP2435030B1 (el)
JP (1) JP5680627B2 (el)
CN (1) CN102448448A (el)
CA (1) CA2763539C (el)
CY (1) CY1116018T1 (el)
DK (1) DK2435030T3 (el)
ES (1) ES2530681T3 (el)
FR (1) FR2945947B1 (el)
HR (1) HRP20150123T1 (el)
PL (1) PL2435030T3 (el)
PT (1) PT2435030E (el)
SI (1) SI2435030T1 (el)
WO (1) WO2010136739A2 (el)

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FR2945947B1 (fr) 2009-05-29 2011-07-29 Flamel Tech Sa Compositions pharmaceutiques flottantes a liberation controlee
DK2714015T3 (en) * 2011-06-01 2017-06-19 Fmc Corp Fixed controlled release dosage forms
CN104797604B (zh) * 2012-08-24 2018-03-06 陶氏环球技术有限责任公司 在碱金属羧酸盐和脂族羧酸的存在下制备酯化纤维素醚的方法
WO2014055740A1 (en) * 2012-10-04 2014-04-10 Fmc Corporation Controlled release solid dose forms
WO2014055738A1 (en) * 2012-10-04 2014-04-10 Fmc Corporation Controlled release solid dose forms
EP2837391B1 (en) * 2013-08-12 2017-05-10 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
CN107184565B (zh) * 2017-06-01 2018-04-03 海南妙音春制药有限公司 一种布洛芬缓释胶囊的制备方法
CN109078186B (zh) * 2017-06-14 2021-09-03 江苏恒瑞医药股份有限公司 一种胃漂浮组合物及其制备方法
EP3740189A1 (en) 2017-12-18 2020-11-25 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release
WO2019126215A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
WO2019126214A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release
JP2022522270A (ja) 2019-03-01 2022-04-15 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
CN112385816A (zh) * 2020-11-09 2021-02-23 江苏里物食品科技有限公司 一种用于食品增鲜的酵母提取物
JP2022150038A (ja) 2021-03-25 2022-10-07 富士フイルムビジネスイノベーション株式会社 樹脂粒子
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

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Also Published As

Publication number Publication date
CA2763539A1 (fr) 2010-12-02
CN102448448A (zh) 2012-05-09
JP5680627B2 (ja) 2015-03-04
WO2010136739A3 (fr) 2011-11-10
CA2763539C (fr) 2018-10-23
US20100310667A1 (en) 2010-12-09
PL2435030T3 (pl) 2015-04-30
DK2435030T3 (en) 2015-02-23
EP2435030A2 (fr) 2012-04-04
US10092511B2 (en) 2018-10-09
FR2945947B1 (fr) 2011-07-29
US20160310420A1 (en) 2016-10-27
US9561179B2 (en) 2017-02-07
WO2010136739A2 (fr) 2010-12-02
HRP20150123T1 (hr) 2015-04-10
ES2530681T3 (es) 2015-03-04
EP2435030B1 (fr) 2014-11-26
SI2435030T1 (sl) 2015-04-30
JP2012528134A (ja) 2012-11-12
PT2435030E (pt) 2015-02-27
FR2945947A1 (fr) 2010-12-03

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