CY1114419T1 - Παραγωγα συντηγμενου θειαζολιου ως αναστολεις κινασης - Google Patents

Παραγωγα συντηγμενου θειαζολιου ως αναστολεις κινασης

Info

Publication number
CY1114419T1
CY1114419T1 CY20131100552T CY131100552T CY1114419T1 CY 1114419 T1 CY1114419 T1 CY 1114419T1 CY 20131100552 T CY20131100552 T CY 20131100552T CY 131100552 T CY131100552 T CY 131100552T CY 1114419 T1 CY1114419 T1 CY 1114419T1
Authority
CY
Cyprus
Prior art keywords
thiazolium
synthesised
production
suspensions
moving
Prior art date
Application number
CY20131100552T
Other languages
Greek (el)
English (en)
Inventor
Rikki Peter Alexander
Pavandeep Singh Aujla
Karen Viviane Lucile Crépy
Anne Marie Foley
Richard Jeremy Franklin
Original Assignee
Ucb Pharma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0612644A external-priority patent/GB0612644D0/en
Priority claimed from GB0620062A external-priority patent/GB0620062D0/en
Application filed by Ucb Pharma, S.A. filed Critical Ucb Pharma, S.A.
Publication of CY1114419T1 publication Critical patent/CY1114419T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CY20131100552T 2006-06-26 2013-07-03 Παραγωγα συντηγμενου θειαζολιου ως αναστολεις κινασης CY1114419T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0612644A GB0612644D0 (en) 2006-06-26 2006-06-26 Therapeutic agents
GB0620062A GB0620062D0 (en) 2006-10-10 2006-10-10 Therapeutic agents
EP08775774A EP2170906B1 (en) 2006-06-26 2008-06-24 Fused thiazole derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1114419T1 true CY1114419T1 (el) 2016-08-31

Family

ID=38671000

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100552T CY1114419T1 (el) 2006-06-26 2013-07-03 Παραγωγα συντηγμενου θειαζολιου ως αναστολεις κινασης

Country Status (20)

Country Link
US (3) US8242116B2 (enExample)
EP (2) EP2035436B1 (enExample)
CN (1) CN101687885B (enExample)
AT (1) ATE510840T1 (enExample)
AU (1) AU2008269577B2 (enExample)
CA (1) CA2692085C (enExample)
CO (1) CO6270229A2 (enExample)
CY (1) CY1114419T1 (enExample)
DK (1) DK2170906T3 (enExample)
EA (1) EA017187B1 (enExample)
ES (2) ES2365258T3 (enExample)
HR (1) HRP20130523T1 (enExample)
IL (1) IL202659A0 (enExample)
ME (1) ME01592B (enExample)
MX (1) MX2009013740A (enExample)
MY (1) MY148852A (enExample)
PL (1) PL2170906T3 (enExample)
PT (1) PT2170906E (enExample)
RS (1) RS52824B (enExample)
WO (1) WO2008001076A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009071890A1 (en) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Tricyclic kinase inhibitors
WO2009071895A1 (en) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Fused thiazole and thiophene derivatives as kinase inhibitors
WO2009085185A1 (en) 2007-12-19 2009-07-09 Amgen Inc. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
MX2010010975A (es) 2008-04-07 2010-11-01 Amgen Inc Amino piridinas/pirimidinas gem-disustituidas y espirociclicas como inhibidores de ciclo celular.
WO2009130900A1 (ja) * 2008-04-24 2009-10-29 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
US8603945B2 (en) * 2008-07-23 2013-12-10 The Regents Of The University Of California Methods and compositions for providing salicyclic acid-independent pathogen resistance in plants
US20110172217A1 (en) * 2008-09-05 2011-07-14 Shionogi & Co., Ltd. Ring-fused morpholine derivative having pi3k-inhibiting activity
MX2011008645A (es) 2009-02-17 2011-09-30 Vertex Pharma Inhibidores de tetrahidrotiazolopiridina de fosfatidilinositol 3 cinasa.
EP2408744A1 (en) * 2009-03-18 2012-01-25 Schering Corporation Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
UY32582A (es) * 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
US8410095B2 (en) 2009-05-20 2013-04-02 Glaxosmithkline Llc Thiazolopyrimidinone derivatives as PI3 kinase inhibitors
GB0912946D0 (en) 2009-07-24 2009-09-02 Addex Pharmaceuticals Sa New compounds 5
JP5746172B2 (ja) 2009-08-20 2015-07-08 カルス セラピューティクス リミテッド ホスホイノシチド３−キナーゼ阻害剤としての三環式複素環化合物
EA019980B1 (ru) 2009-12-18 2014-07-30 Янссен Фармацевтика Нв БИЦИКЛИЧЕСКИЕ ТИАЗОЛЫ В КАЧЕСТВЕ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR5
CN102666551B (zh) 2009-12-18 2014-12-10 詹森药业有限公司 作为mglur5受体的变构调节剂的双环噻唑
ES2575566T3 (es) 2010-06-15 2016-06-29 Bayer Intellectual Property Gmbh Nuevos derivados de arilamida orto-sustituidos
BR112013007056A2 (pt) 2010-10-01 2019-09-24 Basf Se compostos de imina
CA2814688A1 (en) * 2010-10-13 2012-04-19 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EA201390759A1 (ru) * 2010-11-24 2014-03-31 Экселиксис, Инк. БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПРОИЗВОДСТВА
CN102649777B (zh) * 2011-02-25 2014-03-12 中国中化股份有限公司 一种制备1-芳基-3-羧基-5-吡唑啉酮类化合物的方法
PT2688887E (pt) 2011-03-23 2015-07-06 Amgen Inc Inibidores duais tricíclicos fusionados de cdk 4/6 e flt3
IN2014CN04174A (enExample) 2011-12-22 2015-09-04 Novartis Ag
WO2014153208A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9447079B2 (en) 2013-03-14 2016-09-20 Epizyme, Inc. PRMT1 inhibitors and uses thereof
HRP20202008T1 (hr) 2013-03-14 2021-02-19 Epizyme, Inc. Inhibitori arginin-metiltransferaze i njihove uporabe
AU2014260433A1 (en) 2013-03-14 2015-09-10 Epizyme, Inc. Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
WO2014144659A1 (en) 2013-03-14 2014-09-18 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
WO2014153235A2 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9133189B2 (en) 2013-03-14 2015-09-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
JP2016518336A (ja) 2013-03-14 2016-06-23 エピザイム，インコーポレイティド Ｐｒｍｔ１阻害剤としてのピラゾール誘導体およびその使用
US9365527B2 (en) 2013-03-14 2016-06-14 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US20160257650A1 (en) * 2013-10-21 2016-09-08 Umicore Ag & Co. Kg Monoarylation of aromatic amines
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514754D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
CN108570043A (zh) * 2018-06-20 2018-09-25 王延娇 一种化合物及其作为选择性pi3k抑制剂在治疗肿瘤中的应用
WO2020056269A1 (en) 2018-09-13 2020-03-19 Stemline Therapeutics, Inc. Methods for treating centronuclear myopathy
NZ777871A (en) 2018-12-19 2024-11-29 Leo Pharma As Small molecule modulators of il-17
US12577217B2 (en) * 2019-01-08 2026-03-17 Kyorin Pharmaceutical Co., Ltd. 15-PGDH inhibitor
JP7532385B2 (ja) 2019-01-31 2024-08-13 杏林製薬株式会社 １５－ｐｇｄｈ阻害薬
GB201909468D0 (en) 2019-07-01 2019-08-14 Karus Therapeutics Ltd Compounds for treating cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0508471D0 (en) * 2005-04-26 2005-06-01 Celltech R&D Ltd Therapeutic agents

Also Published As

Publication number Publication date
CO6270229A2 (es) 2011-04-20
CA2692085A1 (en) 2008-12-31
CA2692085C (en) 2015-10-13
US8338592B2 (en) 2012-12-25
PL2170906T3 (pl) 2013-08-30
CN101687885A (zh) 2010-03-31
IL202659A0 (en) 2010-06-30
AU2008269577A1 (en) 2008-12-31
AU2008269577B2 (en) 2012-12-20
MY148852A (en) 2013-06-14
ME01592B (me) 2014-09-20
ATE510840T1 (de) 2011-06-15
ES2365258T3 (es) 2011-09-27
US8710054B2 (en) 2014-04-29
EP2170906B1 (en) 2013-04-03
EA201000038A1 (ru) 2010-06-30
US20100137302A1 (en) 2010-06-03
ES2416364T3 (es) 2013-07-31
EP2170906A1 (en) 2010-04-07
PT2170906E (pt) 2013-06-25
MX2009013740A (es) 2010-02-01
HRP20130523T1 (en) 2013-07-31
DK2170906T3 (da) 2013-06-24
CN101687885B (zh) 2012-08-22
US20110003785A1 (en) 2011-01-06
EP2035436B1 (en) 2011-05-25
US8242116B2 (en) 2012-08-14
EP2035436A1 (en) 2009-03-18
WO2008001076A1 (en) 2008-01-03
RS52824B (enExample) 2013-10-31
US20130079330A1 (en) 2013-03-28
EA017187B1 (ru) 2012-10-30

Similar Documents

Publication Publication Date Title
CY1114419T1 (el) Παραγωγα συντηγμενου θειαζολιου ως αναστολεις κινασης
MY146387A (en) Thieno-pyridine derivatives as mek inhibitors
ATE526021T1 (de) Kondensierte thiazol-derivate als kinase-hemmer
WO2009081105A3 (en) Quinoxaline and quinoline derivatives as kinase inhibitors
WO2010052448A3 (en) Fused pyrazine derivatives as kinase inhibitors
SMT201600089B (it) Composti di 3,4-diidropirazino[2,3-b]pirazin-2(1 h)-one come inibitori di chinasi mtor per indicazioni oncologiche e malattie associate al percorso mtor/p13k/akt
WO2008020206A3 (en) Fused thiophene derivatives as mek inhibitors
EA202192170A1 (ru) ТИЕНО[3,2-b]ПИРИДИН-7-АМИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ СЕМЕЙНОЙ ВЕГЕТО-СОСУДИСТОЙ ДИСТОНИИ
CL2008003280A1 (es) Compuestos derivados de 1h-pirazolo[3,4-b]piridina)-4-aril sustituidas; la composicion farmaceutica que los contiene; y sus procesos de preparacion.
MX358682B (es) Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
LT2794600T (lt) 2,3-dihidro-benzo[1,4]oksazino dariniai ir giminingi junginiai kaip fosfoinozitido-3 kinazės (pi3k) inhibitoriai, skirti gydymui, pavyzdžiui, reumatoidinio artrito
WO2010147957A3 (en) Dithiol compounds, derivatives, and uses therefor
MX350112B (es) Derivados de furo[3,2-b]- y tieno[3,2-b]piridina como inhibidores de tbk1 e ikk.
DK2124944T3 (da) Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer
IL194959A0 (en) Process for the production of benzopyran-2-ol derivatives
IL210063A0 (en) 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazine derivatives as met kinase inhibitors
WO2006098961A3 (en) Fused thieno [2, 3-b] pyridine and thiazolo [5, 4-b] pyridine compounds for inhibiting ksp kinesin activity
TW200745137A (en) Thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
IL182740A0 (en) Fluoridation process
WO2011016861A3 (en) Novel regulatory proteins and inhibitors
UA99469C2 (ru) Конденсированные производные тиазола как ингибиторы киназы
UY32280A (es) DERIVADOS DE 6-CICLOAMINO-3-(1H-PIRROLO[2,3-b]PIRIDIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACIÓN Y SU APLICACIÓN EN TERAPÉUTICA
WO2013142253A3 (en) TREATMENT OF PANCREATIC AND RELATED CANCERS WITH 5-ACYL-6,7-DIHYDROTHIENO[3,2-c]PYRIDINES
UA94743C2 (ru) Способ получения производных лизобактина
DOP2009000289A (es) Derivados de tiazol fusionados como inhibidores de quinasa