WO2010103550A3 - Process for the preparation of a thieno [3, 2-e] -1, 2-thiazine-l, 1-dioxide derivative - Google Patents

Process for the preparation of a thieno [3, 2-e] -1, 2-thiazine-l, 1-dioxide derivative Download PDF

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Publication number
WO2010103550A3
WO2010103550A3 PCT/IN2010/000148 IN2010000148W WO2010103550A3 WO 2010103550 A3 WO2010103550 A3 WO 2010103550A3 IN 2010000148 W IN2010000148 W IN 2010000148W WO 2010103550 A3 WO2010103550 A3 WO 2010103550A3
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WO
WIPO (PCT)
Prior art keywords
thiazine
thieno
preparation
dioxide derivative
dioxide
Prior art date
Application number
PCT/IN2010/000148
Other languages
French (fr)
Other versions
WO2010103550A2 (en
Inventor
Ketan Dhansukhlal Vyas
Vidyadhar Kashinath Jadhav
Manish Shridhar Tamhankar
Nitin Hanumant Gaikwad
Vinayak Shrikant Ekbote
Sharad Vishnu Sonawane
Aditi Milind Panandikar
Original Assignee
Indoco Remedies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Indoco Remedies Limited filed Critical Indoco Remedies Limited
Publication of WO2010103550A2 publication Critical patent/WO2010103550A2/en
Publication of WO2010103550A3 publication Critical patent/WO2010103550A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An improved process for the preparation of (5)-3,4-dihydro-6- chloro-4-hydroxy-2-(3- methoxypropyl)-4H-thieno[3,2-e]-l,2-thiazine 1,1 -dioxide of Formula (I) is disclosed.
PCT/IN2010/000148 2009-03-13 2010-03-12 Process for the preparation of intermediates WO2010103550A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5497MU2009 2009-03-13
IN5497MUM/2009 2009-03-13

Publications (2)

Publication Number Publication Date
WO2010103550A2 WO2010103550A2 (en) 2010-09-16
WO2010103550A3 true WO2010103550A3 (en) 2010-11-04

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ID=42676850

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Application Number Title Priority Date Filing Date
PCT/IN2010/000148 WO2010103550A2 (en) 2009-03-13 2010-03-12 Process for the preparation of intermediates

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WO (1) WO2010103550A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103755727B (en) * 2013-12-20 2015-12-30 南京华威医药科技开发有限公司 Preparation method of brinzolamide intermediate
CN109608431A (en) * 2018-12-11 2019-04-12 山东诚汇双达药业有限公司 A kind of preparation method of the chloro- 2- thiophene sulfanilamide of 3- acetyl bromide -5-
CN114149450B (en) * 2021-12-10 2022-12-09 上海彩迩文生化科技有限公司 Industrial preparation method of key intermediate of intraocular pressure resistant drug

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617038A1 (en) * 1993-02-18 1994-09-28 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
US5378703A (en) * 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470973A (en) 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378703A (en) * 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
EP0617038A1 (en) * 1993-02-18 1994-09-28 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CONROW RAYMOND E ET AL: "Enantioselective Synthesis of Brinzolamide (AL-4862), a New Topical Carbonic Anhydrase Inhibitor. The DCAT Route to Thiophenesulfonamides", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/OP9802125, vol. 3, no. 2, 19 March 1999 (1999-03-19), pages 114 - 120, XP002580749, ISSN: 1083-6160, [retrieved on 19990218] *

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Publication number Publication date
WO2010103550A2 (en) 2010-09-16

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