CY1113469T1 - Συνθεσεις για την θεραπεια μιας φλεγμονωδους παθησης αυτο-ανοσιας - Google Patents
Συνθεσεις για την θεραπεια μιας φλεγμονωδους παθησης αυτο-ανοσιαςInfo
- Publication number
- CY1113469T1 CY1113469T1 CY20121101094T CY121101094T CY1113469T1 CY 1113469 T1 CY1113469 T1 CY 1113469T1 CY 20121101094 T CY20121101094 T CY 20121101094T CY 121101094 T CY121101094 T CY 121101094T CY 1113469 T1 CY1113469 T1 CY 1113469T1
- Authority
- CY
- Cyprus
- Prior art keywords
- diagnosis
- compositions
- treatment
- inflammatory
- inflammatory self
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 238000004092 self-diagnosis Methods 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464476—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με ένα φάρμακο που περιλαμβάνει ανθρώπινα κύτταρα Tr1 που κατευθύνονται σε μία ανθρώπινη HSP και μεθόδους για την θεραπεία μιας φλεγμονώδους πάθησης αυτό-ανοσίας.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08305134A EP2113254B1 (en) | 2008-04-28 | 2008-04-28 | Compositions for treating an inflammatory auto-immune condition |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113469T1 true CY1113469T1 (el) | 2016-06-22 |
Family
ID=39522295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121101094T CY1113469T1 (el) | 2008-04-28 | 2012-11-14 | Συνθεσεις για την θεραπεια μιας φλεγμονωδους παθησης αυτο-ανοσιας |
Country Status (13)
Country | Link |
---|---|
US (2) | US20110052535A1 (el) |
EP (2) | EP2113254B1 (el) |
JP (2) | JP5619727B2 (el) |
AU (1) | AU2009242297B2 (el) |
CA (1) | CA2722664A1 (el) |
CY (1) | CY1113469T1 (el) |
DK (1) | DK2113254T3 (el) |
ES (1) | ES2393936T3 (el) |
HR (1) | HRP20120924T1 (el) |
PL (1) | PL2113254T3 (el) |
PT (1) | PT2113254E (el) |
SI (1) | SI2113254T1 (el) |
WO (1) | WO2009132939A1 (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2113254T3 (da) * | 2008-04-28 | 2012-12-03 | Txcell | Sammensætninger til behandling af en inflammatorisk autoimmun sygdom |
EP2378287A1 (en) * | 2010-04-15 | 2011-10-19 | TXCell | New method for isolating Tr1 cells |
GB201020032D0 (en) * | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
US9597339B2 (en) * | 2013-02-01 | 2017-03-21 | Glialogix, Inc. | Compositions and methods for the treatment of neurodegenerative and other diseases |
US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
CA3044891A1 (en) * | 2016-12-01 | 2018-06-07 | Norbert Gretz | Means and methods for visualization of tissue structures |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6746670B2 (en) | 2000-08-15 | 2004-06-08 | Schering Corporation | Regulatory T cells; methods |
FR2824567B1 (fr) | 2001-05-11 | 2003-08-08 | Inst Nat Sante Rech Med | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
JP2004208548A (ja) * | 2002-12-27 | 2004-07-29 | Institute Of Physical & Chemical Research | 免疫反応の抗原特異的抑制 |
FR2856700B1 (fr) | 2003-06-24 | 2007-06-08 | Txcell | Procede d'identification de lymphocytes tr1 regulateurs par la presence et la surexpression de molecules specifiques et ses applications |
EP1712615A1 (en) | 2005-04-15 | 2006-10-18 | Txcell | In vitro production of a cell population using feeder cells |
EP1739166B1 (en) | 2005-07-01 | 2011-06-22 | TxCell S.A. | Obtention of food- or auto-antigen specific Tr1 cells from a leukocyte or PBMC population |
EP1962872B1 (en) * | 2005-12-05 | 2014-05-28 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin | Compositions and methods for modulating an immune response |
EP2380585B1 (en) * | 2006-04-12 | 2015-07-08 | Genzyme Corporation | Methods of treating autoimmune diseases |
JPWO2008126940A1 (ja) * | 2007-04-10 | 2010-09-24 | 国立大学法人 東京大学 | 新規t細胞 |
DK2113254T3 (da) * | 2008-04-28 | 2012-12-03 | Txcell | Sammensætninger til behandling af en inflammatorisk autoimmun sygdom |
-
2008
- 2008-04-28 DK DK08305134.2T patent/DK2113254T3/da active
- 2008-04-28 ES ES08305134T patent/ES2393936T3/es active Active
- 2008-04-28 SI SI200830821T patent/SI2113254T1/sl unknown
- 2008-04-28 EP EP08305134A patent/EP2113254B1/en not_active Not-in-force
- 2008-04-28 PL PL08305134T patent/PL2113254T3/pl unknown
- 2008-04-28 PT PT08305134T patent/PT2113254E/pt unknown
-
2009
- 2009-04-08 AU AU2009242297A patent/AU2009242297B2/en not_active Ceased
- 2009-04-08 US US12/989,878 patent/US20110052535A1/en not_active Abandoned
- 2009-04-08 CA CA2722664A patent/CA2722664A1/en not_active Abandoned
- 2009-04-08 WO PCT/EP2009/054228 patent/WO2009132939A1/en active Application Filing
- 2009-04-08 EP EP09737983A patent/EP2280724A1/en not_active Withdrawn
- 2009-04-08 JP JP2011505458A patent/JP5619727B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-14 CY CY20121101094T patent/CY1113469T1/el unknown
- 2012-11-15 HR HRP20120924AT patent/HRP20120924T1/hr unknown
-
2014
- 2014-05-14 JP JP2014100525A patent/JP2014167019A/ja active Pending
-
2015
- 2015-07-10 US US14/796,284 patent/US20150306143A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK2113254T3 (da) | 2012-12-03 |
US20110052535A1 (en) | 2011-03-03 |
JP2014167019A (ja) | 2014-09-11 |
JP2011518796A (ja) | 2011-06-30 |
JP5619727B2 (ja) | 2014-11-05 |
AU2009242297B2 (en) | 2014-09-04 |
US20150306143A1 (en) | 2015-10-29 |
CA2722664A1 (en) | 2009-11-05 |
SI2113254T1 (sl) | 2013-01-31 |
HRP20120924T1 (hr) | 2012-12-31 |
EP2280724A1 (en) | 2011-02-09 |
AU2009242297A1 (en) | 2009-11-05 |
EP2113254B1 (en) | 2012-08-15 |
ES2393936T3 (es) | 2013-01-02 |
WO2009132939A1 (en) | 2009-11-05 |
PL2113254T3 (pl) | 2013-01-31 |
EP2113254A1 (en) | 2009-11-04 |
PT2113254E (pt) | 2012-11-26 |
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